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References from Furin inhibition protects against acute lung injury in a mouse model of Pseudomonas aeruginosa infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Microbial cause of ICU-acquired pneumonia: hospital-acquired pneumonia versus ventilator-associated pneumonia
10.1097/mcc.0000000000000526 · 2018 · External reference
The epidemiology and pathogenesis and treatment of Pseudomonas aeruginosa infections: an update
10.1007/s40265-021-01635-6 · 2021 · External reference
Unresolved reference
2023 · External reference
Clinical outcomes after initial Pseudomonas acquisition in cystic fibrosis
10.1002/ppul.23036 · 2015 · External reference
Impact of CFTR modulation on Pseudomonas aeruginosa infection in people with cystic fibrosis
10.1093/infdis/jiae051 · 2024 · External reference
Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
10.1086/533452 · 2008 · External reference
The virulence of Pseudomonas aeruginosa
10.1093/clinids/6.supplement_3.s617 · 1984 · External reference
A systematic review and meta-analysis on Exo-toxins prevalence in hospital acquired Pseudomonas aeruginosa isolates
10.1016/j.meegid.2019.104037 · 2019 · External reference
Association of systemic immune complexes, complement activation, and antibodies to Pseudomonas aeruginosa lipopolysaccharide and exotoxin a with mortality in cystic fibrosis
10.1164/arrd.1986.133.4.648 · 1986 · External reference
Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo
10.1128/iai.15.1.138-144.1977 · 1977 · External reference
Furin activates Pseudomonas exotoxin a by specific cleavage in vivo and in vitro
10.1016/s0021-9258(18)31770-8 · 1994 · External reference
Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases
10.1128/iai.63.1.82-87.1995 · 1995 · External reference
Association of the exotoxin a and exoenzyme S with antimicrobial resistance in Pseudomonas aeruginosa strains
10.1016/j.burns.2016.02.012 · 2016 · External reference
Exoenzyme T plays a pivotal role in the IFN-gamma production after Pseudomonas challenge in IL-12 primed natural killer cells
10.3389/fimmu.2017.01283 · 2017 · External reference
Pseudomonas aeruginosa ExoT induces mitochondrial apoptosis in target host cells in a manner that depends on its GTPase-activating protein (GAP) domain activity
10.1074/jbc.m115.689950 · 2015 · External reference
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease
10.1016/j.chembiol.2022.02.001 · 2022 · External reference
Codelivery of synergistic antimicrobials with polyelectrolyte nanocomplexes to treat bacterial biofilms and lung infections
10.1126/sciadv.ade8039 · 2023 · External reference
Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis
10.1165/rcmb.2008-0295oc · 2009 · External reference
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury
10.1172/jci.insight.98178 · 2018 · External reference
NIH Image to ImageJ: 25 years of image analysis
10.1038/nmeth.2089 · 2012 · External reference
Epithelial sodium channels are activated by furin-dependent proteolysis
10.1074/jbc.c400080200 · 2004 · External reference
Regulation of toxA by PtxR in Pseudomonas aeruginosa PA103
10.1139/w03-058 · 2003 · External reference
Use of cellular glucose-6-phosphate dehydrogenase for cell quantitation: applications in cytotoxicity and apoptosis assays
10.1016/j.ab.2004.02.007 · 2004 · External reference
Extracellular histones are major mediators of death in sepsis
10.1038/nm.2053 · 2009 · External reference
Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis
10.1371/journal.pone.0148142 · 2016 · External reference
Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa
10.1152/ajplung.00335.2013 · 2014 · External reference
New insights on Pseudomonas aeruginosa exotoxin A-based immunotoxins in targeted cancer therapeutic delivery
10.4155/tde-2022-0055 · 2023 · External reference
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin a in vivo
10.1128/iai.70.12.7136-7139.2002 · 2002 · External reference
Development and prospects of furin inhibitors for therapeutic applications
10.3390/ijms25179199 · 2024 · External reference
Semaphorin 3E-plexin D1 axis drives lung fibrosis through ErbB2-mediated fibroblast activation
10.1002/advs.202415007 · 2025 · External reference
Pseudomonas aeruginosa: infections and novel approaches to treatment “knowing the enemy” the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment
10.1016/j.imj.2023.05.003 · 2023 · External reference
COPD immunopathology
10.1007/s00281-016-0561-5 · 2016 · External reference
Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia
10.1128/iai.66.7.3164-3169.1998 · 1998 · External reference
Alveolar macrophage phagocytosis and bacteria clearance in mice
10.3791/59088 · 2019 · External reference
Effects of CFTR modulators on Pseudomonas aeruginosa infections in cystic fibrosis
10.3390/idr17040080 · 2025 · External reference
Depletion of alveolar macrophages increases pulmonary neutrophil infiltration, tissue damage, and sepsis in a murine model of Acinetobacter baumannii pneumonia
10.1128/iai.00128-20 · 2020 · External reference
Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis
10.1186/s12964-020-00597-8 · 2020 · External reference
Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function
10.1182/blood-2018-03-838474 · 2018 · External reference
Neutrophil extracellular traps induce MCP-1 at the culprit site in ST-segment elevation myocardial infarction
10.3389/fcell.2020.564169 · 2020 · External reference
Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
10.1172/jci18125 · 2003 · External reference
Innate lymphoid cells and natural killer cells in bacterial infections: function, dysregulation, and therapeutic targets
10.3389/fcimb.2021.733564 · 2021 · External reference
NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice
10.4049/jimmunol.172.5.3034 · 2004 · External reference
Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease
10.1371/journal.pone.0103840 · 2014 · External reference
Lung dendritic cells drive natural killer cytotoxicity in chronic obstructive pulmonary disease via IL-15Ralpha
10.1164/rccm.201712-2513oc · 2018 · External reference
Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury
10.1172/jci137047 · 2021 · External reference
Depletion of natural killer cells increases mice susceptibility in a Pseudomonas aeruginosa pneumonia model
10.1097/ccm.0000000000000311 · 2014 · External reference
BOS-318 treatment enhances elexacaftor-tezacaftor-ivacaftor-mediated improvements in airway hydration and mucociliary transport
10.1183/23120541.00445-2024 · 2025 · External reference
Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice
10.1186/1465-9921-11-166 · 2010 · External reference
A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia
10.1203/00006450-198712000-00017 · 1987 · External reference
Mouse models of chronic lung infection with Pseudomonas aeruginosa: models for the study of cystic fibrosis
10.1002/1099-0496(200011)30:5<413::aid-ppul8>3.0.co;2-9 · 2000 · External reference
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin
10.1242/dev.125.24.4863 · 1998 · External reference
Proprotein convertases: lessons from knockouts
10.1096/fj.05-5491rev · 2006 · External reference
Loss of endothelial furin leads to cardiac malformation and early postnatal death
10.1128/mcb.06331-11 · 2012 · External reference