Research graph
References from Myeloid TLR2 signaling amplifies immunopathology in influenza-infected murine neonates. Local targets link to admitted publications; unresolved targets remain external evidence.
Innate immune recognition
10.1146/annurev.immunol.20.083001.084359 · 2002 · External reference
Evolution of the immune system in humans from infancy to old age
10.1098/rspb.2014.3085 · 2015 · External reference
Innate immunity
10.1016/j.iac.2021.07.003 · 2021 · External reference
Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG
10.1371/journal.ppat.1008072 · 2019 · External reference
Intestinal bacteria maintain adult enteric nervous system and nitrergic neurons via toll-like receptor 2-induced neurogenesis in mice
10.1053/j.gastro.2020.03.050 · 2020 · External reference
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
10.1016/j.immuni.2011.05.006 · 2011 · External reference
The role of TLR2 in infection and immunity
10.3389/fimmu.2012.00079 · 2012 · External reference
Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-kB pathway in the airway epithelium
10.3389/fimmu.2023.1118721 · 2023 · External reference
Toll-like receptor 2 release by macrophages: an anti-inflammatory program induced by glucocorticoids and lipopolysaccharide
10.3389/fimmu.2019.01634 · 2019 · External reference
TLR2-dependent signaling for IL-15 production is essential for the homeostasis of intestinal intraepithelial lymphocytes
10.1155/2016/4281865 · 2016 · External reference
Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses
10.1186/1743-422x-8-97 · 2011 · External reference
Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge
10.1128/iai.73.5.3044-3052.2005 · 2005 · External reference
Rapid evolution of the CD8+ TCR repertoire in neonatal mice
10.4049/jimmunol.1502126 · 2016 · External reference
Unresolved reference
External reference
Microbiota regulates immune defense against respiratory tract influenza a virus infection
10.1073/pnas.1019378108 · 2011 · External reference
Intranasal administration of live Lactobacillus species facilitates protection against influenza virus infection in mice
10.1016/j.antiviral.2011.11.004 · 2012 · External reference
Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice
10.1016/j.intimp.2010.06.012 · 2010 · External reference
Neonatal innate TLR-mediated responses are distinct from those of adults
10.4049/jimmunol.0901481 · 2009 · External reference
Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood
10.1016/j.jaut.2003.08.003 · 2003 · External reference
Imidazoquinoline toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways
10.1016/j.jaci.2012.02.042 · 2012 · External reference
TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis
10.1016/j.jped.2013.12.012 · 2014 · External reference
Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling
10.1086/509892 · 2007 · External reference
Neutrophils and Ly6Chi monocytes collaborate in generating an optimal cytokine response that protects against pulmonary Legionella pneumophila infection
10.1371/journal.ppat.1006309 · 2017 · External reference
Alveolar macrophages: plasticity in a tissue-specific context
10.1038/nri3600 · 2014 · External reference
Neonatal pulmonary macrophage depletion coupled to defective mucus clearance increases susceptibility to pneumonia and alters pulmonary immune responses
10.1165/rcmb.2014-0111oc · 2016 · External reference
Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis
10.3389/fimmu.2020.583042 · 2020 · External reference
Promoter specificity and efficacy in conditional and inducible transgenic targeting of lung macrophages
10.3389/fimmu.2017.01618 · 2017 · External reference
Global role and burden of influenza in pediatric respiratory hospitalizations, 1982-2012: a systematic analysis
10.1371/journal.pmed.1001977 · 2016 · External reference
Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study
10.1016/s2214-109x(19)30545-5 · 2020 · External reference
Who and when to vaccinate against influenza
10.1016/j.ijid.2020.02.040 · 2020 · External reference
Influenza and influenza vaccine: a review
10.1111/jmwh.13203 · 2021 · External reference
TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis
10.4049/jimmunol.1301752 · 2013 · External reference
The role of toll-like receptors in the host response to viruses
10.1016/j.molimm.2004.11.007 · 2005 · External reference
Recognition of microbial infection by toll-like receptors
10.1016/s0952-7915(03)00080-3 · 2003 · External reference
Attenuated innate immune defenses in very premature neonates during the neonatal period
10.1038/pr.2015.132 · 2015 · External reference
TLR2 and TLR4 expression and inflammatory cytokines are altered in the airway epithelium of those with alcohol use disorders
10.1111/acer.12803 · 2015 · External reference
Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina
10.1128/iai.74.3.1857-1864.2006 · 2006 · External reference
Cutting edge: recognition of gram-positive bacterial cell wall components by the innate immune system occurs via toll-like receptor 2
10.4049/jimmunol.163.1.1 · 1999 · External reference
Accessory molecules for toll-like receptors and their function
10.1038/nri3151 · 2012 · External reference
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
10.1016/s1074-7613(00)80119-3 · 1999 · External reference
Discrimination of bacterial lipoproteins by toll-like receptor 6
10.1093/intimm/13.7.933 · 2001 · External reference
Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins
10.4049/jimmunol.169.1.10 · 2002 · External reference
The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis
10.1086/340511 · 2002 · External reference
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
10.1186/s12929-022-00832-z · 2022 · External reference
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
10.1038/s41590-021-00937-x · 2021 · External reference
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2
10.1016/j.virol.2024.110018 · 2024 · External reference
Extracellular nucleoprotein exacerbates influenza virus pathogenesis by activating toll-like receptor 4 and the NLRP3 inflammasome
10.1038/s41423-022-00862-5 · 2022 · External reference
Respiratory syncytial virus activates innate immunity through toll-like receptor 2
10.1128/jvi.00671-08 · 2009 · External reference
Neonatal adaptive immunity comes of age
10.1038/nri1394 · 2004 · External reference
Protecting the newborn and young infant from infectious diseases: Lessons from immune ontogeny
10.1016/j.immuni.2017.03.009 · 2017 · External reference
Maternal immunization
10.1097/aog.0000000000003161 · 2019 · External reference
Influenza vaccination of pregnant women and protection of their infants
10.1056/nejmoa1401480 · 2014 · External reference
Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways
10.4049/jimmunol.180.6.4308 · 2008 · External reference
Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions
10.1002/jlb.3a0820-207r · 2021 · External reference
Alveolar macrophage chemokine secretion mediates neutrophilic lung injury in Nox2-deficient mice
10.1007/s10753-018-0883-7 · 2019 · External reference
Ontogeny of toll-like receptors Tlr2 and Tlr4 in mice
10.1203/00006450-200101000-00018 · 2001 · External reference
The toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
10.1038/44605 · 1999 · External reference
Toll-like receptors and agonist responses in the developing fetal sheep lung
10.1203/pdr.0b013e3181647b3a · 2008 · External reference
MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection
10.4049/jimmunol.178.9.5820 · 2007 · External reference
Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice
10.1128/jvi.01210-07 · 2008 · External reference
How neutrophils shape adaptive immune responses
10.3389/fimmu.2015.00471 · 2015 · External reference
Recent advances on the crosstalk between neutrophils and B or T lymphocytes
10.1111/imm.13005 · 2019 · External reference
TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion
10.1093/eurheartj/ehv044 · 2015 · External reference
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2
10.1038/s41467-022-28172-4 · 2022 · External reference
Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis
10.15252/embj.201592649 · 2016 · External reference
Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level
10.7150/ijbs.49332 · 2020 · External reference
