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References from Temporal type I IFN signaling orchestrates protective and pathogenic inflammation post-influenza. Local targets link to admitted publications; unresolved targets remain external evidence.
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice
10.1371/journal.ppat.1001304 · 2011 · External reference
Type I interferons in infectious disease
10.1038/nri3787 · 2015 · External reference
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
10.1126/science.abc2061 · 2020 · External reference
Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection
10.1128/jvi.00333-14 · 2014 · External reference
Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes
10.1084/jem.20140825 · 2015 · External reference
Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice
10.1016/j.chom.2016.01.007 · 2016 · External reference
The role of type I interferons in the pathogenesis and treatment of COVID-19
10.3389/fimmu.2020.595739 · 2020 · External reference
Pathogenic potential of interferon αβ in acute influenza infection
10.1038/ncomms4864 · 2014 · External reference
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
10.1172/jci35412 · 2009 · External reference
Type I IFN signaling is essential for preventing IFN-gamma hyperproduction and subsequent deterioration of antibacterial immunity during postinfluenza pneumococcal infection
10.4049/jimmunol.2101135 · 2022 · External reference
Type I interferon targets alveolar macrophages to promote bacterial pneumonia after viral infection
10.1165/rcmb.2024-0552oc · 2025 · External reference
Influenza-induced type I interferon enhances susceptibility to gram-negative and gram-positive bacterial pneumonia in mice
10.1152/ajplung.00338.2014 · 2015 · External reference
Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection
10.1542/peds.2008-1336 · 2008 · External reference
Bacterial and viral co-infections complicating severe influenza: incidence and impact among 507 U.S. patients, 2013-14
10.1016/j.jcv.2016.04.008 · 2016 · External reference
Pulmonary infections complicating ARDS
10.1007/s00134-020-06292-z · 2020 · External reference
Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza
10.1016/j.ijid.2012.01.003 · 2012 · External reference
Current and evolving standards of care for patients with ARDS
10.1007/s00134-020-06299-6 · 2020 · External reference
Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia
10.1084/jem.20150514 · 2016 · External reference
A tale of two cytokines: IL-10 blocks IFN-γ in influenza a virus–Staphylococcus aureus coinfection
10.1165/rcmb.2024-0154ed · 2024 · External reference
IL-10 counteracts IFN-γ to alleviate acute lung injury in a viral-bacterial superinfection model
10.1165/rcmb.2023-0437oc · 2024 · External reference
IFN-gamma drives TNF-alpha hyperproduction and lethal lung inflammation during antibiotic treatment of postinfluenza Staphylococcus aureus pneumonia
10.4049/jimmunol.2100328 · 2021 · External reference
IFN-γ transforms the transcriptomic landscape and triggers myeloid cell hyperresponsiveness to cause lethal lung injury
10.3389/fimmu.2022.1011132 · 2022 · External reference
Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection
10.1002/eji.201646548 · 2016 · External reference
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
10.1038/nm.1929 · 2009 · External reference
Linezolid attenuates lethal lung damage during post-influenza methicillin-resistant Staphylococcus aureus pneumonia
10.1128/iai.00538-19 · 2019 · External reference
CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality
10.4049/jimmunol.180.4.2562 · 2008 · External reference
TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection
10.1073/pnas.0900655106 · 2009 · External reference
Monocytes represent one source of bacterial shielding from antibiotics following influenza virus infection
10.4049/jimmunol.1801471 · 2019 · External reference
Disease-promoting effects of type I interferons in viral, bacterial, and coinfections
10.1089/jir.2014.0227 · 2015 · External reference
Differential type I interferon signaling is a master regulator of susceptibility to postinfluenza bacterial superinfection
10.1128/mbio.00506-16 · 2016 · External reference
The role of type I IFNs in influenza: antiviral superheroes or immunopathogenic villains?
10.1159/000508379 · 2020 · External reference
Infection-induced type I interferons critically modulate the homeostasis and function of CD8(+) naive T cells
10.1038/s41467-021-25645-w · 2021 · External reference
A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infection
10.1128/jvi.02408-09 · 2010 · External reference
Type I interferon governs immunometabolic checkpoints that coordinate inflammation during staphylococcal infection
10.1016/j.celrep.2024.114607 · 2024 · External reference
Trial of anifrolumab in active systemic lupus erythematosus
10.1056/nejmoa1912196 · 2020 · External reference
The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza A(H1N1)pdm09
10.1186/s12879-018-3548-0 · 2018 · External reference
Difficulties in modelling ARDS (2017 Grover Conference Series)
10.1177/2045894018766737 · 2018 · External reference
