Research graph
References from Piezo1 mediates stretch-induced Wnt/β-catenin signaling and extracellular matrix remodeling in aging asthmatic airway smooth muscle. Local targets link to admitted publications; unresolved targets remain external evidence.
Sex differences in frailty: a systematic review and meta-analysis
10.1016/j.exger.2016.12.021 · 2017 · External reference
The effects of aging on lung structure and function
10.1016/j.cger.2017.06.001 · 2017 · External reference
Airway smooth muscle in airway reactivity and remodeling: what have we learned?
10.1152/ajplung.00259.2013 · 2013 · External reference
Sex steroids effects on asthma: a network perspective of immune and airway cells
10.3390/cells11142238 · 2022 · External reference
Airway structural components drive airway smooth muscle remodeling in asthma
10.1513/pats.200907-056dp · 2009 · External reference
Incidence and outcomes of asthma in the elderly. A population-based study in Rochester, Minnesota
10.1378/chest.111.2.303 · 1997 · External reference
Asthma prevalence and phenotyping in the general population: the LEAD (Lung, hEart, sociAl, boDy) study
10.2147/jaa.s402326 · 2023 · External reference
Comparative clinical, physiological, and inflammatory characteristics of elderly subjects with or without asthma and young subjects with asthma
10.1016/j.chest.2017.09.019 · 2017 · External reference
The effect of age and duration of disease on airway structure in fatal asthma
10.1164/ajrccm.162.2.9907151 · 2000 · External reference
The extracellular matrix—the under-recognized element in lung disease?
10.1002/path.4808 · 2016 · External reference
Airway remodelling in asthma: from benchside to clinical practice
10.1155/2010/318029 · 2010 · External reference
Airway remodeling in asthma: what really matters
10.1007/s00441-016-2566-8 · 2017 · External reference
Airway smooth muscle—its relationship to the extracellular matrix
10.1016/s1569-9048(03)00157-5 · 2003 · External reference
Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle
10.1371/journal.pone.0254710 · 2021 · External reference
Age-associated differences in the human lung extracellular matrix
10.1152/ajplung.00334.2022 · 2023 · External reference
Piezo channel mechanisms in health and disease
10.1113/jp274395 · 2018 · External reference
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
10.7554/elife.12088 · 2015 · External reference
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
10.1126/science.1193270 · 2010 · External reference
Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain
10.1097/j.pain.0000000000002356 · 2021 · External reference
Piezo channels in stretch effects on developing human airway smooth muscle
10.1152/ajplung.00008.2023 · 2023 · External reference
Mechanosensitive piezo channels mediate the physiological and pathophysiological changes in the respiratory system
10.1186/s12931-022-02122-6 · 2022 · External reference
Interactions between calcium regulatory pathways and mechanosensitive channels in airways
10.1080/17476348.2023.2276732 · 2023 · External reference
Role of STIM1 in stretch-induced signaling in human airway smooth muscle
10.1152/ajplung.00370.2023 · 2024 · External reference
Piezo channels modulate human lung fibroblast function
10.1152/ajplung.00356.2023 · 2024 · External reference
Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (review)
10.3892/mmr.2025.13565 · 2025 · External reference
Mechanisms of mechanotransduction and physiological roles of PIEZO channels
10.1038/s41580-024-00773-5 · 2024 · External reference
Mechanoactivation of Wnt/beta-catenin pathways in health and disease
10.1042/etls20180042 · 2018 · External reference
Wnt-5A/B signaling in hematopoiesis throughout life
10.3390/cells9081801 · 2020 · External reference
The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets
10.1016/j.pharmthera.2013.01.002 · 2013 · External reference
Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction
10.1038/srep30676 · 2016 · External reference
Cooperative signaling by TGF-beta1 and WNT-11 drives sm-alpha-actin expression in smooth muscle via rho kinase-actin-MRTF-A signaling
10.1152/ajplung.00387.2015 · 2016 · External reference
Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation
10.1038/s41598-020-63741-x · 2020 · External reference
Nicotinic alpha7 acetylcholine receptor (alpha7nAChR) in human airway smooth muscle
10.1016/j.abb.2021.108897 · 2021 · External reference
Functional α7 nicotinic receptors in human airway smooth muscle increase intracellular calcium concentration and contractility in asthmatics
10.1152/ajplung.00260.2022 · 2023 · External reference
Airway innervation and plasticity in asthma
10.1152/physiol.00050.2018 · 2019 · External reference
Morphology of the aging lung on computed tomography
10.1097/rti.0000000000000211 · 2016 · External reference
Normative aging of the respiratory system
10.1016/s0749-0690(02)00063-0 · 2003 · External reference
The stress of lung aging: endoplasmic reticulum and senescence Tete-a-Tete
10.1152/physiol.00039.2020 · 2021 · External reference
Update in chronic obstructive pulmonary disease 2018
10.1164/rccm.201902-0374up · 2019 · External reference
Interstitial lung disease in the elderly
10.1016/j.chest.2016.11.003 · 2017 · External reference
Idiopathic pulmonary fibrosis and the elderly: diagnosis and management considerations
10.1007/s40266-016-0366-1 · 2016 · External reference
Non-invasive versus invasive respiratory support in preterm infants
10.1016/j.semperi.2024.151885 · 2024 · External reference
Non-invasive ventilation in neonates: a review of current literature
10.3389/fped.2023.1248836 · 2023 · External reference
Physiological changes in respiratory function associated with ageing
10.1183/09031936.99.14614549 · 1999 · External reference
The aging respiratory system—pulmonary structure, function and neural control
10.1016/j.resp.2013.03.012 · 2013 · External reference
Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice
10.1038/s41390-021-01540-4 · 2022 · External reference
Inflammation and lung maturation from stretch injury in preterm fetal sheep
10.1152/ajplung.00294.2010 · 2011 · External reference
Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure
10.1038/pr.2015.90 · 2015 · External reference
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
10.1152/ajplung.00146.2022 · 2022 · External reference
Mechanical control of tissue morphogenesis
10.1161/circresaha.108.175331 · 2008 · External reference
Exploring the structural attributes of Yoda1 for the development of new-generation Piezo1 agonist Yaddle1 as a vaccine adjuvant targeting optimal T cell activation
10.1021/acs.jmedchem.4c00322 · 2024 · External reference
