References

The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

10.1165/rcmb.f296 · 2005 · External reference

Predictors of mortality in patients with emphysema and severe airflow obstruction

10.1164/rccm.200510-1677oc · 2006 · External reference

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

10.1016/s0002-9440(10)63589-4 · 2003 · External reference

Elastin fragments drive disease progression in a murine model of emphysema

10.1172/jci25617 · 2006 · External reference

Role of necroptosis in airflow limitation in chronic obstructive pulmonary disease: focus on small-airway disease and emphysema

10.1038/s41420-022-01154-7 · 2022 · External reference

Rip3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease

10.1172/jci.insight.144689 · 2021 · External reference

Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease

10.1164/rccm.202009-3442oc · 2021 · External reference

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by rip3

10.1016/j.molcel.2014.03.003 · 2014 · External reference

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

10.1016/j.cell.2011.11.031 · 2012 · External reference

Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: implications for treatment

10.1186/2047-783x-15-s2-27 · 2010 · External reference

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

10.1038/nm0598-615 · 1998 · External reference

Leukocyte elastase induces lung epithelial apoptosis via a par-1-, nf-kappab-, and p53-dependent pathway

10.1165/rcmb.2008-0157oc · 2009 · External reference

Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice

10.1038/labinvest.3780397 · 2002 · External reference

Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte-derived macrophages

10.1111/cts.13671 · 2023 · External reference

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

10.1016/j.cell.2021.04.016 · 2021 · External reference

Increased expression of senescence markers in cystic fibrosis airways

10.1152/ajplung.00091.2012 · 2013 · External reference

Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis

10.4161/auto.29190 · 2014 · External reference

Generation of tumor-reactive t cells by co-culture of peripheral blood lymphocytes and tumor organoids

10.1016/j.cell.2018.07.009 · 2018 · External reference

Puma amplifies necroptosis signaling by activating cytosolic DNA sensors

10.1073/pnas.1717190115 · 2018 · External reference

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

10.1038/s41467-021-27860-x · 2022 · External reference

Structure-function relations in an elastase-induced mouse model of emphysema

10.1165/rcmb.2010-0473oc · 2011 · External reference

Variable susceptibility to cigarette smoke-induced emphysema in 34 inbred strains of mice implicates abi3bp in emphysema susceptibility

10.1165/rcmb.2016-0220oc · 2017 · External reference

Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1

10.1152/ajplung.00067.2007 · 2007 · External reference

Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species

10.1165/ajrcmb.26.4.4473 · 2002 · External reference

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

10.1083/jcb.201006052 · 2010 · External reference

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

10.1038/nm.2084 · 2010 · External reference

Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin g by cancer cells

10.1074/jbc.m112.385617 · 2012 · External reference

Loss of MLKL (mixed lineage kinase domain-like protein) decreases necrotic core but increases macrophage lipid accumulation in atherosclerosis

10.1161/atvbaha.119.313640 · 2020 · External reference

Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers

10.1183/09031936.00063112 · 2013 · External reference

Cellular senescence as a mechanism and target in chronic lung diseases

10.1164/rccm.201810-1975tr · 2019 · External reference

Senescence and apoptosis: Dueling or complementary cell fates?

10.15252/embr.201439245 · 2014 · External reference

Quantum proteolysis resulting from release of single granules by human neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity

10.4049/jimmunol.157.6.2624 · 1996 · External reference

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

10.1038/s41418-023-01237-7 · 2024 · External reference

Flotillin-mediated endocytosis and alix-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis

10.1126/scisignal.aaw3423 · 2019 · External reference

MLKL, the protein that mediates necroptosis, also regulates endosomal trafficking and extracellular vesicle generation

10.1016/j.immuni.2017.06.001 · 2017 · External reference

ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences

10.1016/j.cell.2017.03.020 · 2017 · External reference

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

10.1038/s42003-017-0007-1 · 2018 · External reference

Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights

10.1183/09031936.00096508 · 2009 · External reference