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References from Metabolic alterations in cystic fibrosis lymphocyte memory accompany restoration of CFTR function. Local targets link to admitted publications; unresolved targets remain external evidence.
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial
10.1016/s0140-6736(19)32597-8 · 2019 · External reference
Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele
10.1056/nejmoa1908639 · 2019 · External reference
Clinical effectiveness of elexacaftor/tezacftor/ivacaftor in people with cystic fibrosis: a clinical trial
10.1164/rccm.202108-1986oc · 2021 · External reference
Cystic fibrosis
10.1038/s41572-024-00538-6 · 2024 · External reference
Unresolved reference
2021 · External reference
Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation
10.1164/rccm.200909-1421oc · 2010 · External reference
Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis
10.1136/thx.2011.161117 · 2011 · External reference
Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
10.1016/j.jcf.2012.03.009 · 2012 · External reference
Respiratory infection and the impact of pulmonary immunity on lung health and disease
10.1164/rccm.201206-1063pp · 2012 · External reference
Immunology: memory cells sound the alarm
10.1038/497194b · 2013 · External reference
Mitochondrial dynamics controls T cell fate through metabolic programming
10.1016/j.cell.2016.05.035 · 2016 · External reference
High peripheral blood th17 percent associated with poor lung function in cystic fibrosis
10.1371/journal.pone.0120912 · 2015 · External reference
Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
10.1016/j.jaci.2012.05.036 · 2013 · External reference
T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis
10.1371/journal.pone.0090263 · 2014 · External reference
CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation
10.1172/jci.insight.191098 · 2025 · External reference
Airway inflammation and host responses in the era of CFTR modulators
10.3390/ijms21176379 · 2020 · External reference
mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes
10.1016/j.molimm.2012.03.029 · 2012 · External reference
Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing
10.1002/jcp.24101 · 2012 · External reference
The role of inflammation in the pathophysiology of CF lung disease
10.1385/criai:23:1:005 · 2002 · External reference
Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis
10.1016/j.jaci.2005.09.023 · 2006 · External reference
The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type
10.1034/j.1600-0463.2000.d01-64.x · 2000 · External reference
A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection
10.1164/rccm.201206-1150oc · 2013 · External reference
The relationship between metabolomic profiles and clinical outcomes after CFTR rescue
10.1016/s1569-1993(23)01480-7 · 2023 · External reference
Defining a pulmonary exacerbation in cystic fibrosis
10.1067/mpd.2001.117288 · 2001 · External reference
Definitions of pulmonary exacerbation in people with cystic fibrosis: a scoping review
10.1136/bmjresp-2024-002456 · 2024 · External reference
AD model builder: using automatic differentiation for statistical inference of highly parameterized complex nonlinear models
10.1080/10556788.2011.597854 · 2012 · External reference
More powerful procedures for multiple significance testing
10.1002/sim.4780090710 · 1990 · External reference
Controlling the false discovery rate: a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit
10.1093/nar/gkx356 · 2017 · External reference
The role of circulating T cells with a tissue resident phenotype (ex-T(RM)) in health and disease
10.3389/fimmu.2024.1415914 · 2024 · External reference
Integrating resident memory into T cell differentiation models
10.1016/j.coi.2020.01.001 · 2020 · External reference
Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals
10.1126/sciimmunol.aav8995 · 2019 · External reference
Developmental plasticity allows outside-in immune responses by resident memory T cells
10.1038/s41590-020-0607-7 · 2020 · External reference
Tissue-resident memory CD8(+) T cells shape local and systemic secondary T cell responses
10.1038/s41590-020-0723-4 · 2020 · External reference
CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination
10.1016/j.vaccine.2017.06.013 · 2017 · External reference
Monocyte signature associated with herpes simplex virus reactivation and neurological recovery after brain injury
10.1164/rccm.202110-2324oc · 2022 · External reference
Gene expression correlated with severe asthma characteristics reveals heterogeneous mechanisms of severe disease
10.1164/rccm.201607-1407oc · 2017 · External reference
Complete mitochondrial complex I deficiency induces an up-regulation of respiratory fluxes that is abolished by traces of functional complex I
10.1104/pp.15.00589 · 2015 · External reference
CircANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells by sponging MiR-330
10.1007/s10753-021-01480-5 · 2021 · External reference
Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
10.1038/s41467-020-16394-3 · 2020 · External reference
Zcchc11-dependent uridylation of microRNA directs cytokine expression
10.1038/ncb1931 · 2009 · External reference
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism
10.1016/j.bbalip.2016.07.009 · 2016 · External reference
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse
10.1016/j.immuni.2006.03.022 · 2006 · External reference
Abstract PR004: Cancer cell intrinsic SSBP4 enables tumor immune evasion by promoting cholesterol biosynthesis
10.1158/2326-6074.io2025-pr004 · 2025 · External reference
Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover
10.1042/bj20100344 · 2010 · External reference
Emerging concepts of T cell metabolism as a target of immunotherapy
10.1038/ni.3415 · 2016 · External reference
Dual proteolytic pathways govern glycolysis and immune competence
10.1016/j.cell.2014.12.001 · 2014 · External reference
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
10.1038/nm.1982 · 2009 · External reference
A SEPT1-based scaffold is required for Golgi integrity and function
10.1242/jcs.225557 · 2019 · External reference
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation
10.1038/ni.3330 · 2016 · External reference
Differential contributions of phosphotransferases CEPT1 and CHPT1 to phosphatidylcholine homeostasis and lipid droplet biogenesis
10.1016/j.jbc.2023.104578 · 2023 · External reference
The roles of metallothioneins in carcinogenesis
10.1186/s13045-018-0645-x · 2018 · External reference
Metallothioneins: emerging modulators in immunity and infection
10.3390/ijms18102197 · 2017 · External reference
Differential contributions of central and effector memory T cells to recall responses
10.1084/jem.20050137 · 2005 · External reference
Mitochondrial stress responses and “mito-inflammation” in cystic fibrosis
10.3389/fphar.2020.581114 · 2020 · External reference
CFTR deletion confers mitochondrial dysfunction and disrupts lipid homeostasis in intestinal epithelial cells
10.3390/nu10070836 · 2018 · External reference
An intriguing involvement of mitochondria in cystic fibrosis
10.3390/jcm8111890 · 2019 · External reference
Modulation of glucose-related metabolic pathways controls glucose level in airway surface liquid and fight oxidative stress in cystic fibrosis cells
10.1007/s10863-019-09797-5 · 2019 · External reference
Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function
10.1007/s10863-016-9663-y · 2016 · External reference
Aberrant GSH reductase and NOX activities concur with defective CFTR to pro-oxidative imbalance in cystic fibrosis airways
10.1007/s10863-018-9748-x · 2018 · External reference
The mitochondrial complex I activity is reduced in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function
10.1371/journal.pone.0048059 · 2012 · External reference
CFTR activity and mitochondrial function
10.1016/j.redox.2012.11.007 · 2013 · External reference
CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells
10.1016/j.biocel.2021.105976 · 2021 · External reference
The histone demethylase JMJD1C regulates CAMKK2-AMPK signaling to participate in cardiac hypertrophy
10.3389/fphys.2020.00539 · 2020 · External reference
mTOR regulation of glycolytic metabolism in T cells
10.3389/fcell.2018.00122 · 2018 · External reference
JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis
10.1038/s41375-018-0354-z · 2019 · External reference
JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension
10.1038/s41420-023-01390-5 · 2023 · External reference
The key role of the WNT/beta-catenin pathway in metabolic reprogramming in cancers under normoxic conditions
2021 · External reference
Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
10.15252/embj.201488598 · 2014 · External reference
The emerging role of m6A modification in regulating the immune system and autoimmune diseases
10.3389/fcell.2021.755691 · 2021 · External reference
Recent advances in the biology of WASP and WIP
10.1007/s12026-008-8086-1 · 2009 · External reference
ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing
10.1038/s41598-019-50566-6 · 2019 · External reference
Metabolic regulation of T lymphocytes
10.1146/annurev-immunol-032712-095956 · 2013 · External reference
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
10.1172/jci69589 · 2013 · External reference
Synchronizing transcriptional control of T cell metabolism and function
10.1038/nri3874 · 2015 · External reference
A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription
10.15252/embj.2021108544 · 2022 · External reference
tRNA-m(1)a modification promotes T cell expansion via efficient MYC protein synthesis
10.1038/s41590-022-01301-3 · 2022 · External reference
Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III
10.4049/jimmunol.168.2.763 · 2002 · External reference
Longitudinal improvements in clinical and functional outcomes following initiation of elexacaftor/tezacaftor/ivacaftor in patients with cystic fibrosis
10.1016/j.heliyon.2024.e29188 · 2024 · External reference
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist
10.1172/jci167957 · 2023 · External reference
