Research graph
References from Convex approaches to isolate the shared and distinct genetic components of complex traits. Local targets link to admitted publications; unresolved targets remain external evidence.
Principal component analysis
10.1002/wics.101 · 2010 · External reference
10.1101/2024.04.29.24306535
10.1101/2024.04.29.24306535 · 2024 · External reference
Heritability of type 2 diabetes in the Washington State Twin Registry
10.1017/thg.2019.11 · 2019 · External reference
Shared components of heritability across genetically correlated traits
10.1016/j.ajhg.2022.04.003 · 2022 · External reference
Cross-trait assortative mating is widespread and inflates genetic correlation estimates
10.1126/science.abo2059 · 2022 · External reference
Robust PCA via principal component pursuit: a review for a comparative evaluation in video surveillance
10.1016/j.cviu.2013.11.009 · 2014 · External reference
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
10.1038/ng.3211 · 2015 · External reference
Open targets platform: facilitating therapeutic hypotheses building in drug discovery
10.1093/nar/gkae1128 · 2025 · External reference
A singular value thresholding algorithm for matrix completion
10.1137/080738970 · 2010 · External reference
Robust principal component analysis?
10.1145/1970392.1970395 · 2011 · External reference
The specious art of single-cell genomics
10.1371/journal.pcbi.1011288 · 2023 · External reference
Pleiotropy-based decomposition of genetic risk scores: association and interaction analysis for type 2 diabetes and CAD
10.1016/j.ajhg.2020.03.011 · 2020 · External reference
graph-GPA: a graphical model for prioritizing GWAS results and investigating pleiotropic architecture
10.1371/journal.pcbi.1005388 · 2017 · External reference
The effect of CETP inhibitors on new-onset diabetes: a systematic review and meta-analysis
10.1093/ehjcvp/pvac025 · 2022 · External reference
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci
10.1038/s41380-022-01709-1 · 2022 · External reference
The role of TCF7L2 in type 2 diabetes
10.2337/db20-0573 · 2021 · External reference
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
10.1038/s41588-022-01285-8 · 2023 · External reference
Unresolved reference
2018 · External reference
ERBB4 polymorphism and family history of psychiatric disorders on age-related cortical changes in healthy children
10.1007/s11682-015-9363-y · 2015 · External reference
The approximation of one matrix by another of lower rank
10.1007/bf02288367 · 1936 · External reference
Unresolved reference
2002 · External reference
Partitioning heritability by functional annotation using genome-wide association summary statistics
10.1038/ng.3404 · 2015 · External reference
Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
10.1038/s41380-019-0590-2 · 2021 · External reference
An algorithm for quadratic programming
10.1002/nav.3800030109 · 1956 · External reference
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
10.1038/s41467-019-10310-0 · 2019 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
10.1093/bioinformatics/btz931 · 2020 · External reference
Principal component analysis
10.1080/00401706.1988.10488412 · 1988 · External reference
Generalized procrustes analysis
10.1007/bf02291478 · 1975 · External reference
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
10.1038/s41562-019-0566-x · 2019 · External reference
Mapping the genetic landscape across 14 psychiatric disorders
10.1038/s41586-025-09820-3 · 2026 · External reference
Identification of common genetic risk variants for autism spectrum disorder
10.1038/s41588-019-0344-8 · 2019 · External reference
Unresolved reference
External reference
Analysis of a complex of statistical variables into principal components
10.1037/h0071325 · 1933 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
2013 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2005 · External reference
Unresolved reference
2013 · External reference
10.1101/2024.05.03.592285
10.1101/2024.05.03.592285 · 2025 · External reference
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
10.1038/s41588-023-01563-z · 2023 · External reference
Unresolved reference
2010 · External reference
Altered volume, morphology and composition of the pancreas in type 2 diabetes
10.1371/journal.pone.0126825 · 2015 · External reference
Unresolved reference
External reference
Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank
10.3390/genes11111326 · 2020 · External reference
Scalable robust matrix recovery: Frank–Wolfe meets proximal methods
10.1137/15m101628x · 2016 · External reference
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
10.1038/s41588-024-01707-9 · 2024 · External reference
Genomics yields biological and phenotypic insights into bipolar disorder
10.1038/s41586-024-08468-9 · 2025 · External reference
Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components
10.1016/j.ajhg.2025.07.003 · 2025 · External reference
SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update)
10.1093/nar/gkaa420 · 2020 · External reference
PLINK: a tool set for whole-genome association and population-based linkage analyses
10.1086/519795 · 2007 · External reference
KIRREL3-related disorders: a case report confirming the radiological features and expanding the clinical spectrum to a less severe phenotype
10.1186/s13052-023-01488-7 · 2023 · External reference
10.1101/2024.02.23.24303236
10.1101/2024.02.23.24303236 · 2024 · External reference
Pleiotropy in complex traits: challenges and strategies
10.1038/nrg3461 · 2013 · External reference
Genome-wide association study of obsessive–compulsive symptoms including 33,943 individuals from the general population
10.1038/s41380-024-02489-6 · 2024 · External reference
Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology
10.1038/s41467-019-11953-9 · 2019 · External reference
A global reference for human genetic variation
10.1038/nature15393 · 2015 · External reference
An accelerated proximal gradient algorithm for nuclear norm regularized linear least squares problems
2010 · External reference
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
10.1038/s41562-024-01851-6 · 2024 · External reference
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
10.1038/s41586-022-04434-5 · 2022 · External reference
Visualizing data using t-SNE
2008 · External reference
GW-SEM: a statistical package to conduct genome-wide structural equation modeling
10.1007/s10519-017-9842-6 · 2017 · External reference
Information theoretic measures for clusterings comparison: variants, properties, normalization and correction for chance
2010 · External reference
Functional mapping and annotation of genetic associations with FUMA
10.1038/s41467-017-01261-5 · 2017 · External reference
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
10.1038/s41588-019-0439-2 · 2019 · External reference
Unresolved reference
2024 · External reference
Unresolved reference
2009 · External reference
Unresolved reference
2010 · External reference
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
10.1038/s41467-018-04951-w · 2018 · External reference
Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis
10.1186/1471-2105-15-51 · 2014 · External reference
Nuclear norm regularization
10.1002/wics.70013 · 2025 · External reference
Interrogating the genetic determinants of Tourette’s syndrome and other tic disorders through genome-wide association studies
10.1176/appi.ajp.2018.18070857 · 2019 · External reference
A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics
10.1016/j.ajhg.2023.09.015 · 2023 · External reference
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
10.1038/s41591-023-02653-5 · 2023 · External reference
