Research graph
References from Irisin as a metabolic regulator of male reproduction. Local targets link to admitted publications; unresolved targets remain external evidence.
Fertility and infertility: definition and epidemiology
10.1016/j.clinbiochem.2018.03.012 · 2018 · External reference
Unresolved reference
2023 · External reference
Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study
10.1186/s12889-023-16793-3 · 2023 · External reference
The metabolic syndrome--a new worldwide definition
10.1016/s0140-6736(05)67402-8 · 2005 · External reference
Metabolic syndrome update
10.1016/j.tcm.2015.10.004 · 2016 · External reference
Metabolic syndrome: pathophysiology, management, and modulation by natural compounds
10.1177/1753944717711379 · 2017 · External reference
Metabolic syndrome: updates on pathophysiology and management in 2021
10.3390/ijms23020786 · 2022 · External reference
Obesity: global epidemiology and pathogenesis
10.1038/s41574-019-0176-8 · 2019 · External reference
The impact of obesity and metabolic health on male fertility: a systematic review
10.1016/j.fertnstert.2023.10.017 · 2023 · External reference
Obesity and male fertility disorders
10.1016/j.mam.2024.101273 · 2024 · External reference
White adipose tissue Browning: a double-edged sword
10.1016/j.tem.2016.06.006 · 2016 · External reference
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
10.1038/nature10777 · 2012 · External reference
Detection and quantitation of circulating human irisin by tandem mass spectrometry
10.1016/j.cmet.2015.08.001 · 2015 · External reference
Irisin and its role in the reproductive physiology: a review
10.1590/1519-6984.291896 · 2025 · External reference
Role of irisin administration in modulating testicular function in adult obese albino rats
10.21608/mjcu.2018.65747 · 2018 · External reference
Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway
10.1186/s12958-021-00821-1 · 2021 · External reference
Irisin mediates effects on bone and fat via αV integrin receptors
10.1016/j.cell.2018.10.025 · 2018 · External reference
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α
10.1016/j.molcel.2023.05.008 · 2023 · External reference
The role of irisin throughout Women's life span
10.3390/biomedicines11123260 · 2023 · External reference
Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction
10.1530/rep-22-0037 · 2022 · External reference
Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes
10.1016/s0378-1119(02)00828-4 · 2002 · External reference
Irisin: still chasing shadows
10.1016/j.molmet.2020.01.016 · 2020 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
10.1093/nar/gkab1061 · 2022 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
A single-cell type transcriptomics map of human tissues
10.1126/sciadv.abh2169 · 2021 · External reference
Evidence against a beneficial effect of irisin in humans
10.1371/journal.pone.0073680 · 2013 · External reference
Progress and challenges in the biology of FNDC5 and irisin
10.1210/endrev/bnab003 · 2021 · External reference
Detection and quantitation of irisin in human cerebrospinal fluid by tandem mass spectrometry
10.1016/j.peptides.2018.03.013 · 2018 · External reference
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
10.1016/j.cmet.2013.09.008 · 2013 · External reference
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
10.1038/s41591-018-0275-4 · 2019 · External reference
Cleavage of FNDC5 and insights into its maturation process
10.1016/j.mce.2020.110840 · 2020 · External reference
Proposed acquisition of an animal protein domain by bacteria
10.1073/pnas.89.19.8990 · 1992 · External reference
Fibronectin structure and assembly
10.1016/0955-0674(94)90090-6 · 1994 · External reference
Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP
10.1016/s0969-2126(03)00096-0 · 2003 · External reference
Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains
10.1021/bi800036h · 2008 · External reference
The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation
10.1074/jbc.m113.516641 · 2013 · External reference
Irisin - a myth rather than an exercise-inducible myokine
10.1038/srep08889 · 2015 · External reference
Irisin: a true, circulating hormone
10.1016/j.metabol.2015.09.001 · 2015 · External reference
Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines
10.1016/j.metabol.2013.04.007 · 2013 · External reference
CD81 controls beige fat progenitor cell growth and energy balance via FAK Signaling
10.1016/j.cell.2020.06.021 · 2020 · External reference
Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling
10.2337/db13-1106 · 2014 · External reference
Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
10.1096/fj.12-225755 · 2013 · External reference
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
10.1016/j.metabol.2012.09.002 · 2012 · External reference
Irisin-immunoreactivity in neural and non-neural cells of the rodent
10.1016/j.neuroscience.2013.02.050 · 2013 · External reference
Three new players in energy regulation: preptin, adropin and irisin
10.1016/j.peptides.2014.03.021 · 2014 · External reference
The effect of iloprost and sildenafil, alone and in combination, on myocardial ischaemia and nitric oxide and irisin levels
10.5830/cvja-2017-025 · 2017 · External reference
Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running
10.1016/j.peptides.2013.09.011 · 2013 · External reference
Irisin, energy homeostasis and male reproduction
10.3389/fphys.2021.746049 · 2021 · External reference
Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures
10.1016/j.mce.2019.110670 · 2020 · External reference
Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?
10.1111/andr.12459 · 2018 · External reference
FNDC5/irisin: physiology and pathophysiology
10.3390/molecules27031118 · 2022 · External reference
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
10.1093/nar/gky1131 · 2019 · External reference
Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway
10.1038/ijo.2015.199 · 2016 · External reference
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
10.1016/j.cell.2008.07.043 · 2008 · External reference
Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 Signaling pathway activation
10.3390/ijms18040701 · 2017 · External reference
Circulating irisin in relation to insulin resistance and the metabolic syndrome
10.1210/jc.2013-2373 · 2013 · External reference
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
10.1210/er.2002-0012 · 2003 · External reference
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
10.1038/nn1073 · 2003 · External reference
Brown adipose tissue: function and physiological significance
10.1152/physrev.00015.2003 · 2004 · External reference
FGF-21 as a novel metabolic regulator
10.1172/jci23606 · 2005 · External reference
New insights into the cellular activities of Fndc5/irisin and its signaling pathways
10.1186/s13578-020-00413-3 · 2020 · External reference
Mitochondrial function in Leydig cell steroidogenesis
10.1196/annals.1336.014 · 2005 · External reference
ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor Leydig cells
10.1095/biolreprod.110.087460 · 2011 · External reference
Energy metabolism and spermatogenesis
10.1016/j.heliyon.2024.e38591 · 2024 · External reference
Irisin regulates thermogenesis and lipolysis in 3T3-L1 adipocytes
10.1016/j.bbagen.2022.130085 · 2022 · External reference
Irisin and energy metabolism and the role of irisin on metabolic syndrome
10.2174/1389557523666230411105506 · 2023 · External reference
Molecular basis of irisin regulating the effects of exercise on insulin resistance
10.3390/app12125837 · 2022 · External reference
Irisin in reproduction: its roles and therapeutic potential in male and female fertility disorders
10.3390/biom14101222 · 2024 · External reference
Role of the myokine irisin on bone homeostasis: review of the current evidence
10.3390/ijms22179136 · 2021 · External reference
Irisin, an effective treatment for cardiovascular diseases?
10.3390/jcdd9090305 · 2022 · External reference
The physiological role of irisin in the regulation of muscle glucose homeostasis
10.3390/endocrines2030025 · 2021 · External reference
Irisin promotes human umbilical vein endothelial cell proliferation through the ERK signaling pathway and partly suppresses high glucose-induced apoptosis
10.1371/journal.pone.0110273 · 2014 · External reference
Irisin, a novel myokine, regulates glucose uptake in skeletal muscle cells via AMPK
10.1210/me.2014-1353 · 2015 · External reference
Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways
10.1038/srep18732 · 2016 · External reference
Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis
10.1210/jc.2015-1208 · 2015 · External reference
The association of serum irisin with anthropometric, metabolic, and bone parameters in obese children and adolescents
10.3389/fendo.2023.1326851 · 2023 · External reference
Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients
10.1007/s12020-014-0170-9 · 2014 · External reference
Relationship between circulating irisin levels and overweight/obesity: a meta-analysis
10.12998/wjcc.v7.i12.1444 · 2019 · External reference
Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis
10.1186/s13098-022-00922-w · 2022 · External reference
Irisin may have a role in pubertal development and regulation of reproductive function in rats
10.1530/rep-20-0072 · 2020 · External reference
Central irisin Signaling is required for Normal timing of puberty in female mice
10.1210/endocr/bqac208 · 2022 · External reference
Effects of irisin on reproductive hormones, lipid profiles, and oxidative stress biomarkers IN male rats
10.4183/aeb.2025.37 · 2025 · External reference
Beneficial effects of irisin in experimental paroxetine-induced hyperprolactinemia
10.1007/s12020-022-03010-1 · 2022 · External reference
Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans
10.1038/ijo.2014.42 · 2014 · External reference
Lower irisin level in patients with type 2 diabetes mellitus: a case-control study and meta-analysis
10.1111/1753-0407.12256 · 2016 · External reference
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
10.1038/nrendo.2011.147 · 2011 · External reference
Central inhibitory effects on feeding induced by the adipo-myokine irisin
10.1016/j.ejphar.2016.09.011 · 2016 · External reference
Effects of Kisspeptin-10 on hypothalamic neuropeptides and neurotransmitters involved in appetite control
10.3390/molecules23123071 · 2018 · External reference
Irisin stimulates gonadotropins gene expression in tilapia (Oreochromis niloticus) pituitary cells
10.1016/j.anireprosci.2017.06.018 · 2017 · External reference
Reproductive effects of irisin: initial in vitro studies
10.1016/j.repbio.2017.05.011 · 2017 · External reference
Effects of intracerebroventricular administration of irisin on the hypothalamus-pituitary-gonadal axis in male rats
10.1002/jcp.27541 · 2019 · External reference
Irisin in the primate hypothalamus and its effect on GnRH in vitro
10.1530/joe-18-0574 · 2019 · External reference
Irisin as an emerging target in the regulation of reproductive functions in health and disease
10.1016/j.ygcen.2024.114529 · 2024 · External reference
Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic
10.1016/j.fertnstert.2009.01.100 · 2010 · External reference
Association of body mass index with some fertility markers among male partners of infertile couples
2013 · External reference
Male obesity-related secondary hypogonadism - pathophysiology
2019 · External reference
Adipose tissue dysfunction and obesity-related male hypogonadism
10.3390/ijms23158194 · 2022 · External reference
Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha
10.1128/mcb.24.7.2593-2604.2004 · 2004 · External reference
Reactive oxygen species in male reproduction: a boon or a bane?
10.1111/and.13577 · 2021 · External reference
Role of antioxidants in fertility preservation of sperm - a narrative review
10.5713/ab.22.0325 · 2023 · External reference
Role of endoplasmic reticulum stress in the male reproductive system
2023 · External reference
HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells
10.1111/jcmm.14143 · 2019 · External reference
Obesity impairs male fertility through long-term effects on spermatogenesis
10.1186/s12894-018-0360-5 · 2018 · External reference
Oxidative stress-induced apoptosis and autophagy: balancing the contrary forces in spermatogenesis
10.1016/j.bbadis.2023.166742 · 2023 · External reference
Fibronectin type III domain-containing 5 attenuates liver fibrosis via inhibition of hepatic stellate cell activation
10.1159/000491722 · 2018 · External reference
FNDC5 alleviates Hepatosteatosis by restoring AMPK/mTOR-mediated autophagy, fatty acid oxidation, and lipogenesis in mice
10.2337/db16-0356 · 2016 · External reference
Crosstalk between adipokines and myokines in fat browning
10.1111/apha.12686 · 2017 · External reference
The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats
10.1080/13813455.2020.1722706 · 2022 · External reference
Metabolic control of female puberty: potential therapeutic targets
10.1080/14728222.2016.1212015 · 2016 · External reference
Metabolic impact on the hypothalamic kisspeptin-Kiss1r Signaling pathway
10.3389/fendo.2018.00123 · 2018 · External reference
Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues
10.1038/ijo.2015.200 · 2016 · External reference
Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway
10.1016/j.intimp.2019.05.011 · 2019 · External reference
A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: an introductory review
10.1016/j.phrs.2018.01.012 · 2018 · External reference
FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT
10.1038/s41418-019-0372-z · 2020 · External reference
CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice
10.1042/cs20180179 · 2018 · External reference
Impact of testosterone treatment on circulating irisin in men with late-onset hypogonadism and metabolic syndrome
10.1080/13685538.2020.1770721 · 2020 · External reference
The impact of obesity on various semen parameters and sex hormones in Iranian men with infertility: a cross-sectional study
2020 · External reference
Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells
10.1186/s41232-022-00203-z · 2022 · External reference
Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males
10.1038/aja.2013.10 · 2013 · External reference
Influence of increasing body mass index on semen and reproductive hormonal parameters in a multi-institutional cohort of subfertile men
10.1016/j.fertnstert.2016.06.041 · 2016 · External reference
Impact of body mass index on seminal oxidative stress
10.1111/j.1439-0272.2009.01032.x · 2011 · External reference
Obesity and sexual functioning
10.1007/s13679-018-0319-6 · 2018 · External reference
Irisin improves high-fat diet-induced sexual dysfunction in obese male rats
10.1159/000523689 · 2022 · External reference
Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats
10.1016/j.psyneuen.2021.105597 · 2022 · External reference
SirT1 is required in the male germ cell for differentiation and fecundity in mice
10.1242/dev.110627 · 2014 · External reference
SIRT1 expression and regulation in the primate testis
10.3390/ijms22063207 · 2021 · External reference
Antidepressant-associated sexual dysfunction: impact, effects, and treatment
10.2147/dhps.s7634 · 2010 · External reference
Sexual dysfunction in selective serotonin reuptake inhibitors (SSRIs) and potential solutions: a narrative literature review
10.9740/mhc.2016.07.191 · 2016 · External reference
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