Research graph
References from Neddylation inhibition alleviates polycystic ovary syndrome by regulating granulosa cell function and androgen synthesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Polycystic ovary syndrome as a metabolic disease
10.1038/s41574-024-01057-w · 2025 · External reference
The latest reports and treatment methods on polycystic ovary syndrome
10.1080/07853890.2024.2357737 · 2024 · External reference
The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells
10.1210/me.2002-0323 · 2003 · External reference
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
10.1038/nature07884 · 2009 · External reference
Anticancer drug discovery by targeting cullin neddylation
10.1016/j.apsb.2019.09.005 · 2020 · External reference
The double-edged effects of MLN4924: rethinking anti-cancer drugs targeting the neddylation pathway
10.3390/biom14070738 · 2024 · External reference
Insight into the post-translational modifications in pregnancy and related complications
10.1093/biolre/ioae149 · 2025 · External reference
Neddylation inhibition affects early embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function in mice
10.1016/j.theriogenology.2024.02.029 · 2024 · External reference
Neddylation inhibition causes impaired mouse embryo quality and blastocyst hatching failure through elevated oxidative stress and reduced IL-1β
10.3389/fimmu.2022.1081546 · 2022 · External reference
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Polycystic ovary syndrome: the impact of androgen excess on metabolic health
10.1530/rep-25-0102 · 2025 · External reference
The role of androgen and its related signals in PCOS
10.1111/jcmm.16205 · 2020 · External reference
Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells
10.1016/j.neo.2020.02.002 · 2020 · External reference
[research progress of the roles of ubiquitination/Deubiquitination in androgen receptor abnormalities and prostate cancer]. Zhongguo yi xue ke xue yuan xue bao
10.3881/j.issn.1000-503x.11482 · 2020 · External reference
Comprehensive analysis of ovarian granulosa cell proteomics and phosphoproteomics in PCOS patients without insulin resistance
10.1093/molehr/gaae005 · 2024 · External reference
Majorbio cloud 2024: update single-cell and multiomics workflows
10.1002/imt2.217 · 2024 · External reference
Majorbio cloud: a one-stop, comprehensive bioinformatic platform for multiomics analyses
10.1002/imt2.12 · 2022 · External reference
Dihydrotestosterone induces reactive oxygen species accumulation and mitochondrial fission leading to apoptosis of granulosa cells
10.1016/j.tox.2024.153958 · 2024 · External reference
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome
10.1186/s10020-025-01092-x · 2025 · External reference
(Sangzhi) alkaloids reduce polycystic ovary syndrome by improving hypothalamic-pituitary-ovarian axis function
10.1016/j.phymed.2026.158243 · 2026 · External reference
Evaluation of representativeness and sustainability of PCOS rat models induced by letrozole with or without high-fat diet
10.1038/s41598-025-15026-4 · 2025 · External reference
A rat model of polycystic ovary syndrome with insulin resistance induced by letrozole combined with high fat diet
10.12659/msm.927674 · 2020 · External reference
Suppression of tumor angiogenesis by targeting the protein neddylation pathway
10.1038/cddis.2014.21 · 2014 · External reference
Inhibition of Cullin3 neddylation alleviates diabetic retinopathy by activating Nrf2 Signaling to combat ROS-induced oxidative stress and inflammation
10.1007/s10753-025-02259-8 · 2025 · External reference
Comparative analysis of letrozole and Estradiol valerate PCOS models: reproductive and metabolic outcomes with and without high-fat diet
10.3390/biology14060592 · 2025 · External reference
Electroacupuncture ameliorates hepatic defects in a rat model of polycystic ovary syndrome induced by letrozole and a high-fat diet
10.1177/09645284231207863 · 2023 · External reference
MicroRNA let-7i inhibits granulosa-luteal cell proliferation and oestradiol biosynthesis by directly targeting IMP2
10.1016/j.rbmo.2022.01.016 · 2022 · External reference
CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells
10.1530/rep-20-0451 · 2021 · External reference
Unresolved reference
2020 · External reference
Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells
10.1002/jcp.30777 · 2022 · External reference
Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the metabolic dysregulation in rabbit granulosa cells
10.1186/s12864-024-11156-7 · 2024 · External reference
Association of Insulin Resistance and Elevated Androgen Levels with polycystic ovarian syndrome (PCOS): a review of literature
2022 · External reference
CYP17A1 and androgen-receptor expression in prostate carcinoma tissues and cancer cell lines
10.1159/000499276 · 2019 · External reference
Selenium nanoparticles modulate steroidogenesis-related genes and improve ovarian functions via regulating androgen receptors expression in polycystic ovary syndrome rat model
10.1007/s12011-023-03616-0 · 2023 · External reference
Luteolin alleviates PCOS by inhibiting AR/STAT3/NLRP3-mediated granulosa cell pyroptosis
10.1186/s13048-025-01952-4 · 2026 · External reference
Cryptotanshinone reverses reproductive and metabolic disturbances in PCOS model rats via regulating the expression of CYP17 and AR
10.1155/2014/670743 · 2014 · External reference
Post-translational modifications of steroid receptors
10.1016/j.biopha.2006.07.082 · 2006 · External reference
Zebrafish Nedd8 facilitates ovarian development and the maintenance of female secondary sexual characteristics via suppression of androgen receptor activity
10.1242/dev.194886 · 2020 · External reference
Neddylation inactivation facilitates FOXO3a nuclear export to suppress Estrogen receptor transcription and improve Fulvestrant sensitivity
10.1158/1078-0432.ccr-18-2434 · 2019 · External reference
Fundamental mechanisms of cell death for polycystic ovary syndrome
2025 · External reference
Impact of low frequency electro-acupuncture on glucose and lipid metabolism in unmarried PCOS women: a randomized controlled trial
10.1007/s11655-021-3482-z · 2021 · External reference
TIGAR relieves PCOS by inhibiting granulosa cell apoptosis and oxidative stress through activating Nrf2
10.1016/j.mce.2024.112381 · 2024 · External reference
A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice
10.1186/s12964-024-01939-6 · 2024 · External reference
Expression of neddylation-related proteins in melanoma cell lines and the effect of neddylation on melanoma proliferation
10.3892/ol.2014.1953 · 2014 · External reference
Neddylation inhibition activates the extrinsic apoptosis pathway through ATF4–CHOP–DR5 Axis in human Esophageal cancer cells
10.1158/1078-0432.ccr-15-2254 · 2016 · External reference
