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References from Advanced quantitative CT for coronary artery disease: integrating stenosis quantification, plaque quantification, and fractional flow reserve-CT. Local targets link to admitted publications; unresolved targets remain external evidence.
Using artificial intelligence to study atherosclerosis from computed tomography imaging: a state-of-the-art review of the current literature
10.1016/j.atherosclerosis.2024.117580 · 2024 · External reference
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a consensus statement from the QCI Study Group
10.1038/s41569-025-01191-6 · 2025 · External reference
Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study
10.1016/s2589-7500(22)00022-x · 2022 · External reference
Artificial intelligence for advanced analysis of coronary plaque
10.1093/eurheartjsupp/suad038 · 2023 · External reference
Comprehensive plaque assessment by coronary CT angiography
10.1038/nrcardio.2014.60 · 2014 · External reference
Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome
10.1016/j.jacc.2009.02.068 · 2009 · External reference
From subclinical atherosclerosis to plaque progression and acute coronary events
10.1016/j.jacc.2019.08.012 · 2019 · External reference
Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: Results from the multicenter SCOT-HEART trial (Scottish Computed Tomography of the HEART)
10.1161/circulationaha.119.044720 · 2020 · External reference
Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study
10.1016/j.jacc.2018.10.066 · 2019 · External reference
Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland
10.1016/s0140-6736(24)02679-5 · 2025 · External reference
Use of high-risk coronary atherosclerotic plaque detection for risk stratification of patients with stable chest pain: a secondary analysis of the PROMISE randomized clinical trial
10.1001/jamacardio.2017.4973 · 2018 · External reference
Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: the long-term coronary computed tomography angiography CONFIRM registry
10.1093/ehjci/jez322 · 2020 · External reference
Atherosclerosis quantification and cardiovascular risk: the ISCHEMIA trial
10.1093/eurheartj/ehae471 · 2024 · External reference
The high-risk criteria low-attenuation plaque <60 HU and the napkin-ring sign are the most powerful predictors of MACE: a long-term follow-up study
10.1093/ehjci/jew167 · 2017 · External reference
Rationale and design of SCOT-HEART 2 trial
10.1016/j.jcmg.2024.05.016 · 2024 · External reference
Standards for quantitative assessments by coronary computed tomography angiography (CCTA)
10.1016/j.jcct.2024.05.232 · 2024 · External reference
SCCT guidelines for the interpretation and reporting of coronary CT angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee
10.1016/j.jcct.2014.07.003 · 2014 · External reference
Prospective deep learning–based quantitative assessment of coronary plaque by computed tomography angiography compared with intravascular ultrasound: the REVEALPLAQUE study
10.1093/ehjci/jeae115 · 2024 · External reference
Central core laboratory versus site interpretation of coronary CT angiography: agreement and association with cardiovascular events in the PROMISE trial
10.1148/radiol.2017172181 · 2018 · External reference
Diagnostic performance of 64-Multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease
10.1016/j.jacc.2008.07.031 · 2008 · External reference
Society of cardiovascular computed tomography / North American society of cardiovascular imaging—expert consensus document on coronary CT imaging of atherosclerotic plaque
10.1016/j.jcct.2020.11.002 · 2021 · External reference
Standardized volumetric plaque quantification and characterization from coronary CT angiography: a head-to-head comparison with invasive intravascular ultrasound
10.1007/s00330-019-06219-3 · 2019 · External reference
Automated three-dimensional quantification of noncalcified coronary plaque from coronary CT angiography: comparison with intravascular US
10.1148/radiol.10100681 · 2010 · External reference
Percent atheroma volume: optimal variable to report whole-heart atherosclerotic plaque burden with coronary CTA, the PARADIGM study
10.1016/j.jcct.2020.01.012 · 2020 · External reference
Artificial intelligence–enabled quantitative coronary plaque and hemodynamic analysis for predicting acute coronary syndrome
10.1016/j.jcmg.2024.03.015 · 2024 · External reference
Diagnostic performance of AI-enabled plaque quantification from coronary CT angiography compared with intravascular ultrasound
10.1148/ryct.230312 · 2024 · External reference
Virtual transcriptomics: noninvasive phenotyping of atherosclerosis by decoding plaque biology from computed tomography angiography imaging
10.1161/atvbaha.121.315969 · 2021 · External reference
Development and validation of a quantitative coronary CT angiography model for diagnosis of vessel-specific coronary ischemia
10.1016/j.jcmg.2024.01.007 · 2024 · External reference
Determination of lipid-rich plaques by artificial intelligence-enabled quantitative computed tomography using near-infrared spectroscopy as reference
10.1016/j.atherosclerosis.2023.117363 · 2023 · External reference
Quantitative assessment of atherosclerotic plaque, recent progress and current limitations
10.1016/j.jcct.2021.07.001 · 2022 · External reference
Quantitative coronary plaque analysis in clinical practice: 2025 ACC scientific statement
10.1016/j.jcmg.2025.11.008s1936878x25006540 · 2025 · External reference
Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary syndrome
10.1016/j.jacc.2013.02.065 · 2013 · External reference
Quantitative global plaque characteristics from coronary computed tomography angiography for the prediction of future cardiac mortality during long-term follow-up
10.1093/ehjci/jex183 · 2017 · External reference
Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry
10.1016/j.jcct.2018.04.011 · 2018 · External reference
AI-Guided quantitative plaque staging predicts long-term cardiovascular outcomes in patients at risk for atherosclerotic CVD
10.1016/j.jcmg.2023.05.020 · 2024 · External reference
CVIT 2025 clinical expert consensus document on intravascular ultrasound
10.1007/s12928-025-01090-0 · 2025 · External reference
Accuracy of OCT, grayscale IVUS, and their combination for the diagnosis of coronary TCFA
10.1016/j.jcmg.2014.10.015 · 2015 · External reference
Direct comparison of virtual-histology intravascular ultrasound and optical coherence tomography imaging for identification of thin-cap fibroatheroma
10.1161/circimaging.115.003487 · 2015 · External reference
Plaque quantification from coronary computed tomography angiography in predicting cardiovascular events: a systematic review and meta-analysis
10.1016/j.jcct.2025.05.003 · 2025 · External reference
Patient-Specific myocardial infarction risk thresholds from AI-enabled coronary plaque analysis
10.1161/circimaging.124.016958 · 2024 · External reference
CCTA-Derived coronary plaque burden offers enhanced prognostic value over CAC scoring in suspected CAD patients
10.1093/ehjci/jeaf093 · 2025 · External reference
Unresolved reference
2025 · External reference
CAD-RADSTM 2.0–2022 coronary artery disease-reporting and data system
10.1016/j.jcmg.2022.07.002 · 2022 · External reference
A systematic review on deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction
10.1016/j.ejro.2025.100652 · 2025 · External reference
Evaluating machine learning accuracy in detecting significant coronary stenosis using CCTA-derived fractional flow reserve: Meta-analysis and systematic review
10.1016/j.ijcha.2024.101528 · 2024 · External reference
Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment
10.1136/openhrt-2024-003115 · 2025 · External reference
Artificial intelligence–based coronary stenosis quantification at coronary CT angiography versus quantitative coronary angiography
10.1148/ryct.230124 · 2023 · External reference
Impact of deep learning–based artificial intelligence assistance on reader agreement in coronary CT angiography interpretation
10.1148/ryct.240563 · 2025 · External reference
SCCT 2021 expert consensus document on coronary computed tomographic angiography: a report of the society of cardiovascular computed tomography
10.1016/j.jcct.2020.11.001 · 2021 · External reference
2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of cardiology/American heart association task force on clinical practice guidelines
10.1161/cir.0000000000000678 · 2019 · External reference
2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
10.1093/eurheartj/ehz455 · 2020 · External reference
2021 ESC guidelines on cardiovascular disease prevention in clinical practice
10.1093/eurheartj/ehab484 · 2021 · External reference
Interplay of coronary artery calcium and risk factors for predicting CVD/CHD mortality
10.1016/j.jcmg.2019.08.024 · 2020 · External reference
Age- and sex-specific nomographic CT quantitative plaque data from a large international cohort
10.1016/j.jcmg.2023.05.011 · 2024 · External reference
State of the art: evaluation and medical management of nonobstructive coronary artery disease in patients with chest pain: a scientific statement from the American Heart Association
10.1161/cir.0000000000001394 · 2025 · External reference
Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies
10.1186/s12916-015-0459-4 · 2015 · External reference
Atherosclerotic coronary plaque regression from lipid-lowering therapies: a meta-analysis and meta-regression
10.1016/j.ajpc.2024.100645 · 2024 · External reference
Pleiotropic effects of statins on the cardiovascular system
10.1161/circresaha.116.308537 · 2017 · External reference
Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: a prospective, placebo-controlled randomized trial (EVAPORATE): interim results
10.1093/cvr/cvaa184 · 2021 · External reference
Effect of evolocumab on coronary plaque composition
10.1016/j.jacc.2018.06.078 · 2018 · External reference
CT angiography, healthy lifestyle behaviors, and preventive therapy: a nested substudy of the SCOT-HEART 2 randomized clinical trial
10.1001/jamacardio.2025.1763 · 2025 · External reference
Impact of statin therapy on coronary plaque burden and composition assessed by coronary computed tomographic angiography: a systematic review and meta-analysis
10.1093/ehjci/jey012 · 2018 · External reference
Cardiac imaging with photon counting CT
10.1259/bjr.20230407 · 2023 · External reference
Photon-counting CT: a step change leading to a revolution in coronary imaging
10.1148/radiol.231234 · 2023 · External reference
Ultra-high resolution photon-counting detector coronary CT minimizes overestimation bias compared to invasive reference
10.1016/j.ejrad.2025.112154 · 2025 · External reference
Coronary plaque quantification with ultrahigh-spatial-resolution photon-counting detector CT: intraindividual comparison with energy-integrating detector CT
10.1148/radiol.241479 · 2025 · External reference
Photon-counting computed tomography in cardiac imaging
10.1016/j.jcmg.2025.07.022s1936878x25004759 · 2025 · External reference
Comprehensive assessment of coronary artery stenoses
10.1016/j.jacc.2008.05.024 · 2008 · External reference
Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation
10.1161/01.cir.101.15.1840 · 2000 · External reference
Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial
10.1093/eurheartj/ehv452 · 2015 · External reference
Angiographic versus functional severity of coronary artery stenoses in the FAME study
10.1016/j.jacc.2009.11.096 · 2010 · External reference
Artificial intelligence in estimating fractional flow reserve: a systematic literature review of techniques
10.1186/s12872-023-03447-w · 2023 · External reference
10.1109/embc.2012.6347523
10.1109/embc.2012.6347523 · 2012 · External reference
Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms
10.1016/j.jacc.2011.06.066 · 2011 · External reference
Diagnostic accuracy of fractional flow reserve from anatomic CT angiography
10.1001/2012.jama.11274 · 2012 · External reference
Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease
10.1016/j.jacc.2013.11.043 · 2014 · External reference
Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFRCT : outcome and resource impacts study
10.1093/eurheartj/ehv444 · 2015 · External reference
Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis
10.1016/j.jacc.2018.10.056 · 2019 · External reference
Comparison of an initial Risk-Based testing strategy vs usual testing in stable symptomatic patients with suspected coronary artery disease: the PRECISE randomized clinical trial
10.1001/jamacardio.2023.2595 · 2023 · External reference
Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial
10.1093/eurheartj/ehab444 · 2021 · External reference
Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE registry
10.1093/eurheartj/ehy530 · 2018 · External reference
Prognostic value of coronary computed tomography angiographic derived fractional flow reserve: a systematic review and meta-analysis
10.1136/heartjnl-2021-319773 · 2022 · External reference
Prognostic value of coronary CT angiography–derived fractional flow reserve on 3-year outcomes in patients with stable angina
10.1148/radiol.230524 · 2023 · External reference
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines
10.1161/cir.0000000000001029 · 2021 · External reference
Implementation of a national AI technology program on cardiovascular outcomes and the health system
10.1038/s41591-025-03620-y · 2025 · External reference
Diagnostic accuracy of a machine-learning approach to coronary computed tomographic angiography–based fractional flow reserve: result from the MACHINE Consortium
10.1161/circimaging.117.007217 · 2018 · External reference
On-Site computed tomography–derived fractional flow reserve to guide management of patients with stable coronary artery disease: the TARGET randomized trial
10.1161/circulationaha.123.063996 · 2023 · External reference
Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice
10.1016/j.jcct.2017.06.002 · 2017 · External reference
Trans-lesional fractional flow reserve gradient as derived from coronary CT improves patient management: ADVANCE registry
10.1016/j.jcct.2021.08.003 · 2022 · External reference
Change in computed tomography-derived fractional flow reserve across the lesion improve the diagnostic performance of functional coronary stenosis
10.3389/fcvm.2021.788703 · 2022 · External reference
Anatomic and hemodynamic plaque characteristics for subsequent coronary events
10.3389/fcvm.2022.871450 · 2022 · External reference
Detecting lesion-specific ischemia in patients with coronary artery disease with computed tomography fractional flow reserve measured at different sites
10.1186/s12880-023-01031-4 · 2023 · External reference
CT-derived plaque physiology and characterization
10.1016/j.jcmg.2023.08.018 · 2024 · External reference
Non-invasive imaging innovation: FFR-CT combined with plaque characterization, safeguarding your cardiac health
10.1016/j.jcct.2024.08.008 · 2025 · External reference
Coronary plaque quantification and fractional flow reserve by coronary computed tomography angiography identify ischaemia-causing lesions
10.1093/eurheartj/ehv690 · 2016 · External reference
Impact of coronary computerized tomography angiography-derived plaque quantification and machine-learning computerized tomography fractional flow reserve on adverse cardiac outcome
10.1016/j.amjcard.2019.07.061 · 2019 · External reference
Interaction of AI-enabled quantitative coronary plaque volumes on coronary CT angiography, FFRCT, and clinical outcomes: a retrospective analysis of the ADVANCE registry
10.1161/circimaging.123.016143 · 2024 · External reference
Endothelial shear stress computed from coronary computed tomography angiography: a direct comparison to intravascular ultrasound
10.1016/j.jcct.2023.03.009 · 2023 · External reference
Prognostic time frame of plaque and hemodynamic characteristics and integrative risk prediction for acute coronary syndrome
10.1016/j.jcmg.2025.02.003 · 2025 · External reference
Coronary artery axial plaque stress and its relationship with lesion geometry
10.1016/j.jcmg.2015.04.024 · 2015 · External reference
Fractional flow reserve derived from coronary computed tomography angiography safely defers invasive coronary angiography in patients with stable coronary artery disease
10.3390/jcm9020604 · 2020 · External reference
Quantification of low-attenuation plaque burden from coronary CT angiography: a head-to-head comparison with near-infrared spectroscopy intravascular US
10.1148/ryct.230090 · 2023 · External reference
Evolving role of calcium density in coronary artery calcium scoring and atherosclerotic cardiovascular disease risk
10.1016/j.jcmg.2022.02.026 · 2022 · External reference
Association of high-density calcified 1K plaque with risk of acute coronary syndrome
10.1001/jamacardio.2019.5315 · 2020 · External reference
