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References from A novel mouse model of cerebral microbleeds by targeted Col4a1 editing in adult brain microvessels. Local targets link to admitted publications; unresolved targets remain external evidence.
Cerebral small vessel disease: A review
10.17219/acem/131216 · 2021 · External reference
Small vessel disease: Mechanisms and clinical implications
10.1016/s1474-4422(19)30079-1 · 2019 · External reference
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
10.1016/s1474-4422(13)70124-8 · 2013 · External reference
Small-vessel disease relates to poor poststroke survival in a 12-year follow-up
10.1212/wnl.0b013e31820db666 · 2011 · External reference
Prognostic impact of cerebral small vessel disease on stroke outcome
10.5853/jos.2015.17.2.101 · 2015 · External reference
Cerebral microbleeds and recurrent stroke risk: Systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts
10.1161/strokeaha.111.000038 · 2013 · External reference
Modeling subcortical ischemic white matter injury in rodents: Unmet need for a breakthrough in translational research
10.4103/1673-5374.295313 · 2021 · External reference
Basement membrane and stroke
10.1177/0271678x18801467 · 2019 · External reference
The vascular basement membrane in the healthy and pathological brain
10.1177/0271678x17722436 · 2017 · External reference
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly
10.1126/science.1109418 · 2005 · External reference
Role of COL4A1 in small-vessel disease and hemorrhagic stroke
10.1056/nejmoa053727 · 2006 · External reference
Neonatal porencephaly and adult stroke related to mutations in collagen IV A1
10.1002/ana.20715 · 2006 · External reference
A dominantly inherited mutation in collagen IV A1 (COL4A1) causing childhood onset stroke without porencephaly
10.1016/j.ejpn.2009.04.010 · 2010 · External reference
COL4A1 mutations as a monogenic cause of cerebral small vessel disease: A systematic review
10.1161/strokeaha.110.581918 · 2010 · External reference
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
10.15252/emmm.201506078 · 2016 · External reference
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease
10.1038/s41536-022-00219-6 · 2022 · External reference
Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in mice
2019 · External reference
Cas-analyzer: An online tool for assessing genome editing results using NGS data
10.1093/bioinformatics/btw561 · 2017 · External reference
Retro-orbital injections in mice
10.1038/laban0511-155 · 2011 · External reference
Transfection of brain capillary endothelial cells in primary culture with defined blood–brain barrier properties
10.1186/s12987-015-0015-9 · 2015 · External reference
N-Acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model
10.1038/s41467-023-36759-8 · 2023 · External reference
Object recognition in rats and mice: A one-trial non-matching-to-sample learning task to study ‘recognition memory’
10.1038/nprot.2006.205 · 2006 · External reference
Interaction between hypertension and cerebral hypoperfusion in the development of cognitive dysfunction and white matter pathology in rats
10.1016/j.neuroscience.2015.06.056 · 2015 · External reference
Astrocytes are involved in the formation of corpora amylacea-like structures from neuronal debris in the CA1 region of the rat hippocampus after ischemia
10.3389/fncel.2023.1308247 · 2023 · External reference
Baseline clinical and biomarker characteristics of Biobank innovations for chronic cerebrovascular disease with Alzheimer’s Disease Study: BICWALZS
10.30773/pi.2021.0335 · 2022 · External reference
Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation
10.1001/jamaneurol.2015.4078 · 2016 · External reference
Cerebral microbleeds: Incidence, imaging characteristics, common and uncommon causes
10.31728/jnn.2018.00022 · 2018 · External reference
Cerebral microbleeds: Causes, clinical relevance, and imaging approach – A narrative review
10.25259/jnrp_351_2023 · 2024 · External reference
Cerebral microbleeds: A guide to detection and interpretation
10.1016/s1474-4422(09)70013-4 · 2009 · External reference
The Korea Biobank Array: Design and identification of coding variants associated with blood biochemical traits
10.1038/s41598-018-37832-9 · 2019 · External reference
PLINK: A tool set for whole-genome association and population-based linkage analyses
10.1086/519795 · 2007 · External reference
Characteristics of cerebral microbleeds
10.12779/dnd.2018.17.3.73 · 2018 · External reference
Capability of hematoxylin and eosin stain to demonstrate hemosiderin in bone marrow trephine biopsy
10.4172/2157-7099.1000144 · 2012 · External reference
A rotarod test for evaluation of motor skill learning
10.1016/j.jneumeth.2010.03.026 · 2010 · External reference
Influence of cerebral microbleeds on mechanical thrombectomy outcomes
10.1038/s41598-022-07432-9 · 2022 · External reference
Number of cerebral microbleeds and risk of intracerebral hemorrhage after intravenous thrombolysis
10.1161/strokeaha.114.006448 · 2014 · External reference
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP
10.1042/bj20030557 · 2003 · External reference
Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations
10.1016/j.matbio.2016.10.003 · 2017 · External reference
Molecular and genetic analyses of collagen type IV mutant mouse models of spontaneous intracerebral hemorrhage identify mechanisms for stroke prevention
10.1161/circulationaha.114.013395 · 2015 · External reference
The basement membrane as a structured surface – role in vascular health and disease
10.1242/jcs.239889 · 2020 · External reference
COL4A1 and COL4A2 mutations and disease: Insights into pathogenic mechanisms and potential therapeutic targets
10.1093/hmg/dds346 · 2012 · External reference
Clinical and brain MRI follow-up study of a family with COL4A1 mutation
10.1212/01.wnl.0000295994.46586.e7 · 2007 · External reference
The expanding phenotype of COL4A1 and COL4A2 mutations: Clinical data on 13 newly identified families and a review of the literature
10.1038/gim.2014.210 · 2015 · External reference
A murine model of inflammation-induced cerebral microbleeds
10.1186/s12974-016-0693-5 · 2016 · External reference
Rodent models of cerebral microinfarct and microhemorrhage
10.1161/strokeaha.117.016995 · 2018 · External reference
Cerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study
10.1212/wnl.0b013e3182452928 · 2012 · External reference
Brain microbleeds and global cognitive function in adults without neurological disorder
10.1161/strokeaha.108.516112 · 2008 · External reference
Roles of neuropathology-associated reactive astrocytes: A systematic review
10.1186/s40478-023-01526-9 · 2023 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization
10.1172/jci164199 · 2023 · External reference
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
10.1016/j.stemcr.2023.10.014 · 2023 · External reference