Research graph
References from Constitutive neuronal expression and disease-associated upregulation of chitinases in amyotrophic lateral sclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Chitin, chitinases, and chitin lectins: Emerging roles in human pathophysiology
10.1016/j.pathophys.2018.02.005 · 2018 · External reference
Chitinase family GH18: Evolutionary insights from the genomic history of a diverse protein family
10.1186/1471-2148-7-96 · 2007 · External reference
Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma
10.1016/j.jaci.2005.06.028 · 2005 · External reference
Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis
10.1177/1352458510392619 · 2011 · External reference
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells
10.1074/jbc.m805574200 · 2008 · External reference
Multi-omic landscaping of human midbrains identifies disease-relevant molecular targets and pathways in advanced-stage Parkinson’s disease
10.1002/ctm2.692 · 2022 · External reference
Role of chitotriosidase (chitinase 1) under normal and disease conditions
10.2174/1875044301205010001 · 2012 · External reference
Role of mammalian chitinases in inflammatory conditions
10.2302/kjm.56.21 · 2007 · External reference
Chitinases and chitinase-like proteins as biomarkers in neurologic disorders
10.1212/nxi.0000000000000921 · 2021 · External reference
The chitinases as biomarkers for amyotrophic lateral sclerosis: Signals from the CNS and beyond
10.3389/fneur.2020.00377 · 2020 · External reference
Amyotrophic lateral sclerosis—A multisystem neurodegenerative disorder
10.1038/s41582-018-0103-y · 2019 · External reference
Chitinases, neuroinflammation and biomarkers in ALS
10.1136/jnnp-2019-322520 · 2020 · External reference
Spectrum and frequency of genetic variants in sporadic amyotrophic lateral sclerosis
10.1093/braincomms/fcad152 · 2023 · External reference
Amyotrophic lateral sclerosis: Translating genetic discoveries into therapies
10.1038/s41576-023-00592-y · 2023 · External reference
Amyotrophic lateral sclerosis
10.1016/s0140-6736(17)31287-4 · 2017 · External reference
Amyotrophic lateral sclerosis
10.1038/nrdp.2017.71 · 2017 · External reference
Disrupted neuronal trafficking in amyotrophic lateral sclerosis
10.1007/s00401-019-01964-7 · 2019 · External reference
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression
10.1136/jnnp-2017-317138 · 2018 · External reference
CSF chitinase proteins in amyotrophic lateral sclerosis
10.1136/jnnp-2019-320442 · 2019 · External reference
Cerebrospinal fluid chitinases as biomarkers for amyotrophic lateral sclerosis
10.3390/diagnostics11071210 · 2021 · External reference
Inflammatory markers in cerebrospinal fluid: Independent prognostic biomarkers in amyotrophic lateral sclerosis?
2019 · External reference
Chitinase dysregulation predicts disease aggressiveness in ALS: Insights from the D50 progression model
10.1136/jnnp-2022-330318 · 2023 · External reference
Monocyte-derived macrophages contribute to chitinase dysregulation in amyotrophic lateral sclerosis: A pilot study
10.3389/fneur.2021.629332 · 2021 · External reference
Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes
10.1136/jnnp-2019-321916 · 2020 · External reference
A revision of the El Escorial criteria—2015
10.3109/21678421.2015.1049183 · 2015 · External reference
Amyotrophic lateral sclerosis—Frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria
10.1080/21678421.2016.1267768 · 2017 · External reference
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss
10.1007/s00401-017-1711-0 · 2017 · External reference
Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
10.1007/s00401-015-1460-x · 2015 · External reference
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
10.1073/pnas.93.7.3155 · 1996 · External reference
Completion of neuronal remodeling prompts myelination along developing motor axon branches
10.1083/jcb.201911114 · 2021 · External reference
Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination
10.1016/j.neuron.2016.09.049 · 2016 · External reference
10.17504/protocols.io.3fkgjkw
10.17504/protocols.io.3fkgjkw · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Whole transcriptome profiling reveals the RNA content of motor axons
10.1093/nar/gkv1027 · 2016 · External reference
Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
10.1016/j.nbd.2018.03.010 · 2018 · External reference
A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS
10.3389/fcell.2023.996952 · 2023 · External reference
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
10.1038/s41467-017-02299-1 · 2018 · External reference
High content organelle trafficking enables disease state profiling as powerful tool for disease modelling
10.1038/sdata.2018.241 · 2018 · External reference
The ImageJ ecosystem: An open platform for biomedical image analysis
10.1002/mrd.22489 · 2015 · External reference
Sex difference in CHI3L1 expression levels in human brain aging and in Alzheimer’s disease
10.1016/j.brainres.2019.146305 · 2019 · External reference
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
10.1038/s41598-022-16896-8 · 2022 · External reference
Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease
10.1212/wnl.0000000000004029 · 2017 · External reference
Cerebrospinal fluid biomarkers of disease activity and progression in amyotrophic lateral sclerosis
10.1136/jnnp-2021-327503 · 2022 · External reference
Neurofilaments and neurofilament proteins in health and disease
10.1101/cshperspect.a018309 · 2017 · External reference
Cerebrospinal fluid neurofilament light chain (NfL) predicts disease aggressiveness in amyotrophic lateral sclerosis: An application of the D50 disease progression model
10.3389/fnins.2021.651651 · 2021 · External reference
Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis
10.1212/wnl.0000000000004761 · 2018 · External reference
Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis
10.1002/ana.25143 · 2018 · External reference
Neurogranin and YKL-40: Independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
10.1186/s13195-015-0161-y · 2015 · External reference
Longitudinal measurements of cerebrospinal fluid biomarkers in Parkinson’s disease
10.1002/mds.26578 · 2016 · External reference
Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics
10.1038/s41598-021-01499-6 · 2021 · External reference
Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: A multicenter study
10.1080/21678421.2020.1861023 · 2021 · External reference
Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
10.1136/jnnp-2018-318868 · 2019 · External reference
Cerebrospinal fluid phosphorylated neurofilament heavy chain and chitotriosidase in primary lateral sclerosis
10.1136/jnnp-2020-324059 · 2021 · External reference
Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion
10.1136/jnnp-2019-322476 · 2020 · External reference
YKL-40: A novel prognostic fluid biomarker for preclinical Alzheimer’s disease
10.1016/j.biopsych.2010.08.025 · 2010 · External reference
Potential role of CHI3L1+ astrocytes in progression in MS
10.1212/nxi.0000000000000972 · 2021 · External reference
Chitotriosidase—A putative biomarker for sporadic amyotrophic lateral sclerosis
10.1186/1559-0275-10-19 · 2013 · External reference
Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis
10.1212/nxi.0000000000000829 · 2020 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation
10.1111/j.1750-3639.2011.00550.x · 2012 · External reference
Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation
10.1186/s12974-020-01909-y · 2020 · External reference
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
10.1073/pnas.1914593117 · 2020 · External reference
Chitinase 3-like 1 is neurotoxic in primary cultured neurons
10.1038/s41598-020-64093-2 · 2020 · External reference
CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis
10.1002/acn3.51114 · 2020 · External reference
Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis
10.1016/j.immuni.2025.02.024 · 2025 · External reference
Trial of antisense oligonucleotide tofersen for SOD1 ALS
10.1056/nejmoa2204705 · 2022 · External reference
