Research graph
References from The Wnt5a-PKCδ-GluA1 axis controls synapse-specific plasticity in HIV-1 gp120-induced pain pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurologic complications of HIV disease and their treatment
2010 · External reference
Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
10.1038/s41582-023-00879-y · 2023 · External reference
Chronic pain in people with HIV: A common comorbidity and threat to quality of life
10.2217/pmt-2020-0004 · 2020 · External reference
Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain
10.1177/17448069231195975 · 2023 · External reference
Pathogenic mechanisms of human immunodeficiency virus (HIV)-associated pain
10.1038/s41380-023-02294-7 · 2023 · External reference
Gp120 in the pathogenesis of human immunodeficiency virus-associated pain
10.1002/ana.24139 · 2014 · External reference
Establishment of a rodent model of HIV-associated sensory neuropathy
10.1523/jneurosci.3135-06.2006 · 2006 · External reference
A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis
10.1093/brain/awac015 · 2022 · External reference
Microglia mediate HIV-1 gp120-induced synaptic degeneration in spinal pain neural circuits
10.1523/jneurosci.2851-18.2019 · 2019 · External reference
Neural circuitry polarization in the spinal dorsal horn (SDH): A novel form of dysregulated circuitry plasticity during pain pathogenesis
10.3390/cells13050398 · 2024 · External reference
Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential
10.1038/nrn.2018.2 · 2018 · External reference
Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain
10.1097/j.pain.0000000000000538 · 2016 · External reference
Glyr alpha3: An essential target for spinal PGE2-mediated inflammatory pain sensitization
10.1126/science.1094925 · 2004 · External reference
Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats
10.1097/00006123-199608000-00026 · 1996 · External reference
Release of BDNF and GABA in the dorsal horn of neuropathic rats
10.1046/j.1460-9568.2003.02848.x · 2003 · External reference
Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones
10.1016/0006-8993(82)90497-8 · 1982 · External reference
Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn
10.7554/elife.49753 · 2019 · External reference
Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia
10.1523/jneurosci.3923-08.2009 · 2009 · External reference
The contribution of GABAA and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord
10.1152/jn.1994.72.1.169 · 1994 · External reference
Neuronal model of tactile allodynia produced by spinal strychnine: Effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist
10.1016/s0304-3959(96)03130-2 · 1996 · External reference
GABAergic mechanisms can redress the tilted balance between excitation and inhibition in damaged spinal networks
10.1007/s12035-021-02370-5 · 2021 · External reference
Long-term changes in expressions of spinal glutamate transporters after spinal cord injury
10.1016/j.brainres.2011.03.037 · 2011 · External reference
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis
10.1186/s12974-016-0609-4 · 2016 · External reference
Differential rearrangement of excitatory inputs to the medial prefrontal cortex in chronic pain models
10.3389/fncir.2021.791043 · 2021 · External reference
Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
10.1038/367188a0 · 1994 · External reference
Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury
10.1126/science.1223821 · 2012 · External reference
Wnt5a-ror-dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
10.1073/pnas.1200421109 · 2012 · External reference
Modulation of mechanical and thermal nociceptive sensitivity in the laboratory mouse by behavioral state
10.1016/j.jpain.2007.10.011 · 2008 · External reference
Low-intensity, kilohertz frequency spinal cord stimulation differently affects excitatory and inhibitory neurons in the rodent superficial dorsal horn
10.1016/j.neuroscience.2019.12.031 · 2020 · External reference
Suppression of presynaptic glutamate release by postsynaptic metabotropic NMDA receptor signalling to pannexin-1
10.1523/jneurosci.0257-19.2019 · 2020 · External reference
AMPAR removal underlies abeta-induced synaptic depression and dendritic spine loss
10.1016/j.neuron.2006.10.035 · 2006 · External reference
Identification of a reactive astrocyte subpopulation during HIV-associated pain pathogenesis in mouse models
10.1038/s41467-025-67368-2 · 2026 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling
10.1038/s41380-022-01815-0 · 2023 · External reference
Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn
10.1113/jphysiol.2013.264937 · 2014 · External reference
Identifying functional populations among the interneurons in laminae I–III of the spinal dorsal horn
10.1177/1744806917693003 · 2017 · External reference
CKAMP44 controls synaptic function and strength of relay neurons during early development of the dorsal lateral geniculate nucleus
10.1113/jp283172 · 2022 · External reference
Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders
10.3389/fncir.2021.711564 · 2021 · External reference
Reducing auditory nerve excitability by acute antagonism of Ca(2+)-permeable AMPA receptors
10.3389/fnsyn.2021.680621 · 2021 · External reference
Trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex containing Ca2+/calmodulin-activated kinase II (CaMKII) and PICK1 protein and by release of Ca2+ from internal stores
10.1074/jbc.m113.511246 · 2014 · External reference
Glutamate receptor ion channels: Structure, regulation, and function
10.1124/pr.109.002451 · 2010 · External reference
Ca2+ permeability of KA-AMPA–gated glutamate receptor channels depends on subunit composition
10.1126/science.1709304 · 1991 · External reference
Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
10.1016/0896-6273(92)90120-3 · 1992 · External reference
The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain
10.1016/j.neuron.2004.10.029 · 2004 · External reference
alpha2delta-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly
10.1016/j.celrep.2021.109396 · 2021 · External reference
Molecular and anatomical characterization of parabrachial neurons and their axonal projections
10.7554/elife.81868 · 2022 · External reference
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain
10.1182/blood.v97.1.324 · 2001 · External reference
Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurons
10.1523/jneurosci.20-09-03354.2000 · 2000 · External reference
Wnt/Ca2+ signaling pathway: A brief overview
10.1093/abbs/gmr079 · 2011 · External reference
ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents
10.1152/jn.00340.2003 · 2003 · External reference
Phosphorylation-dependent regulation of Ca(2+)-permeable AMPA receptors during hippocampal synaptic plasticity
10.3389/fnsyn.2020.00008 · 2020 · External reference
Integrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
10.1186/s12974-024-03161-0 · 2024 · External reference
Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior
10.1016/j.celrep.2018.02.003 · 2018 · External reference
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
10.1038/39639 · 1997 · External reference
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus
10.1523/jneurosci.0628-05.2005 · 2005 · External reference
Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain
10.1038/s41467-022-28429-y · 2022 · External reference
The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders
10.1016/s0166-2236(97)01100-4 · 1997 · External reference
Glua1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex
10.1523/jneurosci.1431-14.2014 · 2014 · External reference
Loss of Ca(2+)-permeable AMPA receptors in synapses of tonic firing substantia gelatinosa neurons in the chronic constriction injury model of neuropathic pain
10.1016/j.expneurol.2016.03.001 · 2016 · External reference
Inflammatory-induced changes in synaptic drive and postsynaptic AMPARs in lamina II dorsal horn neurons are cell-type specific
10.1097/01.j.pain.0000460318.65734.00 · 2015 · External reference
Opioid receptors inhibit the spinal AMPA receptor Ca(2+) permeability that mediates latent pain sensitization
10.1016/j.expneurol.2019.01.003 · 2019 · External reference
N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation
10.1111/j.1460-9568.2008.06293.x · 2008 · External reference
Persistent inflammation induces GluR2 internalization via NMDA receptor-triggered PKC activation in dorsal horn neurons
10.1523/jneurosci.4514-08.2009 · 2009 · External reference
Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat
10.1113/jphysiol.2007.145581 · 2008 · External reference
Wnt signaling in the pathogenesis of multiple sclerosis-associated chronic pain
10.1007/s11481-012-9370-3 · 2012 · External reference
A Wnt5a signaling pathway in the pathogenesis of HIV-1 gp120-induced pain
10.1097/j.pain.0000000000000177 · 2015 · External reference
Wnt signaling in the pathogenesis of human HIV-associated pain syndromes
10.1007/s11481-013-9474-4 · 2013 · External reference
Wnt5a/ryk signaling contributes to bone cancer pain by sensitizing the peripheral nociceptors through JNK-mediated TRPV1 pathway in rats
10.1097/j.pain.0000000000003426 · 2025 · External reference
Spinal Wnt5a plays a key role in spinal dendritic spine remodeling in neuropathic and inflammatory pain models and in the proalgesic effects of peripheral Wnt3a
10.1523/jneurosci.2942-19.2020 · 2020 · External reference
GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation
10.1126/scitranslmed.abh2557 · 2022 · External reference
Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways
10.1074/jbc.m112.381046 · 2013 · External reference
Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM
10.7554/elife.66765 · 2023 · External reference
Calcium-permeable AMPA receptors govern PV neuron feature selectivity
10.1038/s41586-024-08027-2 · 2024 · External reference
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
10.1073/pnas.1010011107 · 2010 · External reference
Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
10.3389/fnmol.2022.1024034 · 2022 · External reference
Wnt5a modulates dendritic spine dynamics through the regulation of cofilin via small rho GTPase activity in hippocampal neurons
10.1111/jnc.15448 · 2021 · External reference
Wnt-frizzled signaling regulates activity-mediated synapse formation
10.3389/fnmol.2021.683035 · 2021 · External reference
Preferential generation of Ca(2+)-permeable AMPA receptors by AKAP79-anchored protein kinase C proceeds via GluA1 subunit phosphorylation at Ser-831
10.1074/jbc.ra118.004340 · 2019 · External reference
Dorsal horn circuits for persistent mechanical pain
10.1016/j.neuron.2015.07.029 · 2015 · External reference
Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia
10.1097/j.pain.0000000000000323 · 2015 · External reference
Network disruption in the preclinical stages of Alzheimer’s disease: From subjective cognitive decline to mild cognitive impairment
10.1142/s0129065717500411 · 2017 · External reference
Excitatory/inhibitory imbalance in autism spectrum disorders: Implications for interventions and therapeutics
10.3109/15622975.2015.1085597 · 2016 · External reference
Epilepsy, E/I balance and GABA(A) receptor plasticity
10.3389/neuro.02.005.2008 · 2008 · External reference
