Research graph
References from Beyond the vessel wall: single-cell dissection of epicardial fat–myocardial crosstalk in coronary artery disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s0140-6736(24)00367-2 · 2024 · External reference
Modulation of cardiac arrhythmogenesis by epicardial adipose tissue: JACC state-of-the-art review
10.1016/j.jacc.2021.08.037 · 2021 · External reference
Epicardial adipose tissue in contemporary cardiology
10.1038/s41569-022-00679-9 · 2022 · External reference
Single-nucleus transcriptomic atlas of human pericoronary epicardial adipose tissue in normal and pathological conditions
10.1161/atvbaha.124.320923 · 2024 · External reference
The role of epicardial adipose tissue in cardiac biology: classic concepts and emerging roles
10.1113/jp273049 · 2017 · External reference
Epicardial adipose tissue as a predictor of coronary artery disease in asymptomatic subjects
10.1016/j.amjcard.2012.04.024 · 2012 · External reference
Uncovering the role of epicardial adipose tissue in heart failure with preserved ejection fraction
10.1016/j.jacadv.2023.100657 · 2023 · External reference
The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction
10.1093/cvr/cvaf056 · 2025 · External reference
Cardiovascular risk reduction throughout GLP-1 receptor agonist and SGLT2 inhibitor modulation of epicardial fat
10.1007/s40618-021-01687-1 · 2022 · External reference
The role of the epicardium during heart development and repair
10.1161/circresaha.119.315857 · 2020 · External reference
The role of inflammation in cardiovascular disease
10.3390/ijms232112906 · 2022 · External reference
Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis
10.4103/2321-3868.123072 · 2013 · External reference
From systemic inflammation to myocardial fibrosis: the heart failure with preserved ejection fraction paradigm revisited
10.1161/circresaha.121.318159 · 2021 · External reference
Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features
10.1016/j.tem.2011.07.003 · 2011 · External reference
Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain
10.1186/s12916-023-02836-4 · 2023 · External reference
Epicardial adipose tissue and cardiac arrhythmias: focus on atrial fibrillation
10.3389/fcvm.2022.932262 · 2022 · External reference
Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium
10.1016/j.jacc.2018.03.509 · 2018 · External reference
Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing
10.1007/s00395-022-00913-y · 2022 · External reference
Fast, sensitive and accurate integration of single-cell data with harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics
10.1038/s41596-024-01045-4 · 2025 · External reference
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
10.1152/physrev.00034.2017 · 2018 · External reference
Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity
10.7554/elife.97981.3 · 2025 · External reference
Cells of the adult human heart
10.1038/s41586-020-2797-4 · 2020 · External reference
Unveiling adipose populations linked to metabolic health in obesity
10.1016/j.cmet.2024.11.006 · 2025 · External reference
a knowledge portal integrating clinical and experimental data from human adipose tissue
10.1016/j.cmet.2025.01.012 · 2025 · External reference
Association of epicardial adipose tissue with progression of coronary artery calcification is more pronounced in the early phase of atherosclerosis: results from the Heinz Nixdorf recall study
10.1016/j.jcmg.2014.07.002 · 2014 · External reference
Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis
2024 · External reference
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
10.7554/elife.39636 · 2018 · External reference
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis
10.1016/j.devcel.2021.03.026 · 2021 · External reference
A stromal cell population that inhibits adipogenesis in mammalian fat depots
10.1038/s41586-018-0226-8 · 2018 · External reference
Pathogenic role of adipose tissue-derived mesenchymal stem cells in obesity and obesity-related inflammatory diseases
10.3390/cells12030348 · 2023 · External reference
Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling
10.1093/jmcb/mjaa016 · 2020 · External reference
Role of the transcription factor FOSL1 in organ development and tumorigenesis
10.3390/ijms23031521 · 2022 · External reference
Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome
10.1016/j.metabol.2015.07.016 · 2015 · External reference
Thrombospondin 1 in metabolic diseases
10.3389/fendo.2021.638536 · 2021 · External reference
Adipose stem cells-derived small extracellular vesicles transport thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus
10.1186/s13098-024-01276-1 · 2024 · External reference
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
10.1084/jem.20211314 · 2022 · External reference
Semaphorins 4A and 4D in chronic inflammatory diseases
10.1007/s00011-016-0983-5 · 2017 · External reference
Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
10.1152/ajpendo.00011.2002 · 2002 · External reference
Secretory products from epicardial adipose tissue from patients with type 2 diabetes impair mitochondrial beta-oxidation in cardiomyocytes via activation of the cardiac renin-angiotensin system and induction of miR-208a
10.1007/s00395-016-0591-0 · 2017 · External reference
Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction
10.1161/circulationaha.111.039586 · 2012 · External reference
Establishment of an induced pluripotent stem cell line DHMi005-A from a healthy male proband
10.1016/j.scr.2022.102662 · 2022 · External reference
Chemically defined generation of human cardiomyocytes
10.1038/nmeth.2999 · 2014 · External reference
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex
10.1038/nsmb.2416 · 2012 · External reference
Inflammation and cardiovascular diseases in the elderly: the role of epicardial adipose tissue
10.3389/fmed.2022.844266 · 2022 · External reference
Dietary cholesterol effects on adipose tissue inflammation
10.1097/mol.0000000000000260 · 2016 · External reference
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
10.2337/db06-0911 · 2007 · External reference
Fat tissue, aging, and cellular senescence
10.1111/j.1474-9726.2010.00608.x · 2010 · External reference
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
10.1172/jci129191 · 2019 · External reference
Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells
10.1182/blood-2013-01-482315 · 2013 · External reference
The role of semaphorins in metabolic disorders
2020 · External reference
The role of semaphorins in cardiovascular diseases: potential therapeutic targets and novel biomarkers
10.1096/fj.202200844r · 2022 · External reference
Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus
10.4070/kcj.2012.42.2.100 · 2012 · External reference
Statins and inflammation
10.1007/s11883-021-00977-6 · 2021 · External reference
Effect of statins on the plasma/serum levels of inflammatory markers in patients with cardiovascular disease; a systematic review and meta-analysis of randomized clinical trials
10.1007/s10787-022-00926-y · 2022 · External reference
Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis
10.5114/aoms/189575 · 2024 · External reference
Efficacy of cardiometabolic drugs in reduction of epicardial adipose tissue: a systematic review and meta-analysis
10.1186/s12933-023-01738-2 · 2023 · External reference
IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk
10.1038/s44161-025-00700-7 · 2025 · External reference
Semaglutide modulates proinflammatory epicardial adipogenesis with paracrine effects on hiPSC-atrial cardiomyocytes
2025 · External reference
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
10.1016/j.ymthe.2022.11.017 · 2023 · External reference
