Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Vasculogenesis
10.1146/annurev.cb.11.110195.000445 · 1995 · External reference
Angiogenesis in health and disease
10.1038/nm0603-653 · 2003 · External reference
Signal transduction by vascular endothelial growth factor receptors
10.1042/bj20110301 · 2011 · External reference
The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
10.1016/s0002-9440(10)63711-x · 2004 · External reference
Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division
10.1182/blood.v99.7.2397 · 2002 · External reference
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
10.1038/376066a0 · 1995 · External reference
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
10.1073/pnas.95.20.11709 · 1998 · External reference
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
10.1016/s0021-9258(18)47298-5 · 1994 · External reference
Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
10.1093/jb/mvs136 · 2013 · External reference
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
10.1073/pnas.95.16.9349 · 1998 · External reference
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
10.1038/376062a0 · 1995 · External reference
Alternative polyadenylation regulation in cardiac development and cardiovascular disease
10.1093/cvr/cvad014 · 2023 · External reference
Usefulness of soluble Fms-like tyrosine kinase-1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction
10.1016/j.amjcard.2009.07.016 · 2009 · External reference
Soluble Fms-like tyrosine kinase-1 (sFlt-1) is associated with subclinical and clinical atherosclerotic cardiovascular disease: the Dallas Heart Study
10.1016/j.atherosclerosis.2022.02.026 · 2022 · External reference
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction
10.1038/s41467-022-35331-0 · 2022 · External reference
The natriuretic peptide/guanylyl cyclase–a system functions as a stress-responsive regulator of angiogenesis in mice
10.1172/jci37430 · 2009 · External reference
A mouse lymphoid endothelial cell line immortalized by simian virus 40 binds lymphocytes and retains functional characteristics of normal endothelial cells
10.4049/jimmunol.144.2.521 · 1990 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
2011 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing
2020 · External reference
Integrative genomics viewer
10.1038/nbt.1754 · 2011 · External reference
Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation
10.1016/j.molcel.2011.08.009 · 2011 · External reference
Splicing mutations in human genetic disorders: examples, detection, and confirmation
10.1007/s13353-018-0444-7 · 2018 · External reference
Mechanisms of angiogenesis and arteriogenesis
10.1038/74651 · 2000 · External reference
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction
10.1093/cvr/cvac113 · 2023 · External reference
From remodeling to quiescence: the transformation of the vascular network
10.1016/j.cdev.2021.203735 · 2021 · External reference
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
10.1074/mcp.m111.014647 · 2012 · External reference
Full functional knockout of placental growth factor by knockin with an inactive variant able to heterodimerize with VEGF-A
10.1016/j.celrep.2018.05.067 · 2018 · External reference
A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress
10.1016/j.immuni.2025.02.013 · 2025 · External reference
Transcription factors regulating vasculogenesis and angiogenesis
10.1002/dvdy.575 · 2024 · External reference
The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes
10.1007/s00125-017-4322-3 · 2017 · External reference
The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands
10.1126/scisignal.2003905 · 2013 · External reference
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
10.1182/blood.v87.8.3336.bloodjournal8783336 · 1996 · External reference
FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia
10.1038/s41598-017-11639-6 · 2017 · External reference
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
10.1126/science.abc8479 · 2021 · External reference
Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice
10.1161/circulationaha.112.091603 · 2012 · External reference
The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
10.1083/jcb.200709114 · 2008 · External reference
Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation
10.1093/cvr/cvw091 · 2016 · External reference
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment
10.1161/atvbaha.107.150433 · 2008 · External reference
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype
10.1182/blood-2007-08-108597 · 2008 · External reference
Cardioimmunology: the immune system in cardiac homeostasis and disease
10.1038/s41577-018-0065-8 · 2018 · External reference
Myeloid cell contributions to cardiovascular health and disease
10.1038/s41591-018-0064-0 · 2018 · External reference
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
10.1038/nm740 · 2002 · External reference
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
10.1007/s10456-025-09980-w · 2025 · External reference
Suppressed production of soluble Fms-like tyrosine kinase-1 contributes to myocardial remodeling and heart failure
10.1161/hypertensionaha.116.07371 · 2016 · External reference
Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease
10.1038/ki.2013.339 · 2014 · External reference
Angiogenesis after acute myocardial infarction
10.1093/cvr/cvaa287 · 2021 · External reference
VEGFA stop-gained variant deteriorates cardiac remodeling in myocardial infarction
10.1161/circgen.124.004879 · 2025 · External reference
Flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
2024 · External reference
VEGF-B promotes endocardium-derived coronary vessel development and cardiac regeneration
10.1161/circulationaha.120.050635 · 2021 · External reference
Cardiac fibroblastic niches in homeostasis and inflammation
10.1161/circresaha.124.323892 · 2024 · External reference
Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact
10.1016/j.matbio.2024.08.008 · 2024 · External reference
Targeting immune-fibroblast cell communication in heart failure
10.1038/s41586-024-08008-5 · 2024 · External reference
Twist mechanics of the left ventricle: principles and application
10.1016/j.jcmg.2008.02.006 · 2008 · External reference
Predictive value of the sFlt-1/PlGF ratio in women with suspected preeclampsia: an update (review)
10.3892/ijmm.2023.5292 · 2023 · External reference
Placenta growth factor and neuropilin-1 collaborate in promoting melanoma aggressiveness
10.3892/ijo.2016.3362 · 2016 · External reference
Gene transfer as a tool to induce therapeutic vascular growth
10.1038/nm0603-694 · 2003 · External reference
Endothelial cells regulate physiological cardiomyocyte growth via VEGFR2-mediated paracrine signaling
10.1161/circulationaha.118.036099 · 2019 · External reference
Contribution of VEGF-B-induced endocardial endothelial cell lineage in physiological versus pathological cardiac hypertrophy
10.1161/circresaha.123.324136 · 2024 · External reference
Susceptibility to cardiac arrhythmias and sympathetic nerve growth in VEGF-B overexpressing myocardium
10.1016/j.ymthe.2020.03.011 · 2020 · External reference
Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue
10.1016/j.jhep.2023.01.014 · 2023 · External reference
VEGFB/VEGFR1-induced expansion of adipose vasculature counteracts obesity and related metabolic complications
10.1016/j.cmet.2016.03.004 · 2016 · External reference
Reduction in insulin uncovers a novel effect of VEGFB on cardiac substrate utilization
10.1161/atvbaha.123.319972 · 2024 · External reference
Cardiovascular disease: new nanomedicines for treating atherosclerotic plaques
10.1038/nrendo.2015.35 · 2015 · External reference
Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia
10.1016/j.cyto.2014.08.005 · 2015 · External reference
Alternative polyadenylation: new insights from global analyses
10.1261/rna.035899.112 · 2012 · External reference