Research graph
References from Liver X receptor (LXR) signalling in macrophage inflammation and cardiometabolic disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Antiinflammatory therapy with canakinumab for atherosclerotic disease
10.1056/nejmoa1707914 · 2017 · External reference
Efficacy and safety of low-dose colchicine after myocardial infarction
10.1056/nejmoa1912388 · 2019 · External reference
Low-dose colchicine for secondary prevention of cardiovascular disease
10.1016/j.jacc.2012.10.027 · 2013 · External reference
Colchicine in patients with chronic coronary disease
10.1056/nejmoa2021372 · 2020 · External reference
Macrophage in chronic kidney disease
10.1093/ckj/sfw096 · 2016 · External reference
Macrophage functional diversity in NAFLD - more than inflammation
10.1038/s41574-022-00675-6 · 2022 · External reference
Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy
10.1093/eurheartj/ehag117 · 2026 · External reference
Abandoning M1/M2 for a network model of macrophage function
10.1161/circresaha.116.309194 · 2016 · External reference
Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics
10.1161/circresaha.120.316770 · 2020 · External reference
Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis
10.1093/cvr/cvac161 · 2023 · External reference
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
10.1016/j.cell.2021.12.018 · 2022 · External reference
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
10.1038/s41586-019-1631-3 · 2019 · External reference
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
10.1016/j.cell.2019.05.054 · 2019 · External reference
Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis
10.1093/ndt/gfae292 · 2025 · External reference
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases
10.1016/j.tem.2024.04.009 · 2024 · External reference
Monocyte and macrophage lipid accumulation results in down-regulated type-I interferon responses
10.3389/fcvm.2022.829877 · 2022 · External reference
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
2007 · External reference
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses
10.1016/j.cell.2012.06.054 · 2012 · External reference
X-ray structures of the LXRα LBD in its homodimeric form and implications for heterodimer signaling
10.1016/j.jmb.2010.04.005 · 2010 · External reference
LXR, a nuclear receptor that defines a distinct retinoid response pathway
10.1101/gad.9.9.1033 · 1995 · External reference
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages
10.1186/1471-2164-13-50 · 2012 · External reference
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
10.1016/j.molcel.2010.05.004 · 2010 · External reference
Liver X receptors interact with corepressors to regulate gene expression
10.1210/me.2002-0399 · 2003 · External reference
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
10.1128/mcb.23.16.5780-5789.2003 · 2003 · External reference
Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases
10.3389/fmolb.2023.1190094 · 2023 · External reference
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
10.1016/j.ccell.2015.05.007 · 2015 · External reference
Research resource: comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells
10.1210/me.2010-0384 · 2011 · External reference
Common and differential transcriptional actions of nuclear receptors liver X receptors α and β in macrophages
10.1128/mcb.00376-18 · 2019 · External reference
Structural characterisation of the mouse nuclear oxysterol receptor genes LXRα and LXRβ
10.1016/s0378-1119(99)00555-7 · 2000 · External reference
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
10.1074/jbc.m603781200 · 2006 · External reference
Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
10.1073/pnas.96.1.266 · 1999 · External reference
The challenges and promise of targeting the liver X receptors for treatment of inflammatory disease
10.1016/j.pharmthera.2017.07.010 · 2018 · External reference
Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease
10.1016/j.bbrc.2016.09.036 · 2016 · External reference
Inhibition of LXR signaling in human foam cells impairs macrophage-to-endothelial cell cross talk and promotes endothelial cell inflammation
10.1161/atvbaha.125.322448 · 2025 · External reference
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
10.1007/s00018-023-04745-4 · 2023 · External reference
Current understanding on the role of lipids in macrophages and associated diseases
10.3390/ijms24010589 · 2022 · External reference
Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
10.1161/atvbaha.107.156935 · 2008 · External reference
Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice
10.1161/circresaha.113.301086 · 2013 · External reference
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
10.1172/jci32057 · 2007 · External reference
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
10.1038/nm.4479 · 2018 · External reference
Liver X receptors in lipid signalling and membrane homeostasis
10.1038/s41574-018-0037-x · 2018 · External reference
SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism
10.1016/j.cmet.2016.11.009 · 2017 · External reference
Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis
10.1161/atvbaha.115.305539 · 2015 · External reference
Regulated necrosis in atherosclerosis
10.1161/atvbaha.122.318177 · 2022 · External reference
Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms
10.3389/fcvm.2022.845942 · 2022 · External reference
Prevalence of coronary heart disease in the Framingham Offspring Study: role of lipoprotein cholesterols
10.1016/0002-9149(80)90516-0 · 1980 · External reference
HDL and reverse cholesterol transport
10.1161/circresaha.119.312617 · 2019 · External reference
Myeloid LXR (liver X receptor) deficiency induces inflammatory gene expression in foamy macrophages and accelerates atherosclerosis
10.1161/atvbaha.122.317583 · 2022 · External reference
Activation of liver X receptor decreases atherosclerosis in ldlr⁻/⁻ mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells
10.1161/atvbaha.113.302781 · 2014 · External reference
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
10.1073/pnas.2107682118 · 2021 · External reference
LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms
10.1194/jlr.m800374-jlr200 · 2009 · External reference
DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice
10.1016/j.isci.2024.109830 · 2024 · External reference
Beneficial and adverse effects of an LXR agonist on human lipid and lipoprotein metabolism and circulating neutrophils
10.1016/j.cmet.2016.07.016 · 2016 · External reference
Synthetic high-density lipoprotein-mediated targeted delivery of liver X receptors agonist promotes atherosclerosis regression
10.1016/j.ebiom.2017.12.021 · 2018 · External reference
Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development
10.1016/j.bcp.2013.09.019 · 2013 · External reference
Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis
10.1002/cti2.1446 · 2023 · External reference
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
10.1074/jbc.m204887200 · 2002 · External reference
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
10.15252/emmm.202216845 · 2023 · External reference
Lipid droplet accumulation is associated with an increase in hyperglycemia-induced renal damage: prevention by liver X receptors
10.1016/j.ajpath.2012.11.033 · 2013 · External reference
Improvement of LXR-mediated lipid metabolism in nephrotic model kidney accompanied by suppression of inflammation and fibrosis
10.1016/j.bbrc.2023.05.019 · 2023 · External reference
An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial
10.1038/s41591-025-04169-6 · 2026 · External reference
A liver-selective LXR inverse agonist that suppresses hepatic steatosis
10.1021/cb300541g · 2013 · External reference
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis
10.1016/j.molmet.2015.01.009 · 2015 · External reference
Liver X receptor inverse agonist SR9243 suppresses nonalcoholic steatohepatitis intrahepatic inflammation and fibrosis
10.1155/2018/8071093 · 2018 · External reference
Inhibition of hepatotoxicity by a LXR inverse agonist in a model of alcoholic liver disease
10.1021/acsptsci.8b00003 · 2018 · External reference
A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis
10.1371/journal.pone.0249316 · 2021 · External reference
Antihyperlipidemic activity of gut-restricted LXR inverse agonists
10.1021/acschembio.2c00057 · 2022 · External reference
Sophoricoside is a selective LXRβ antagonist with potent therapeutic effects on hepatic steatosis of mice
10.1002/ptr.6747 · 2020 · External reference
Macrophages in atherosclerosis regression
10.1161/atvbaha.119.312802 · 2020 · External reference
Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity
10.1016/j.immuni.2019.09.002 · 2019 · External reference
Liver X receptors and liver physiology
10.1016/j.bbadis.2021.166121 · 2021 · External reference
Liver X receptors as integrators of metabolic and inflammatory signaling
10.1172/jci27883 · 2006 · External reference
Role of LXRs in control of lipogenesis
10.1101/gad.850400 · 2000 · External reference
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
10.1073/pnas.1714518115 · 2018 · External reference
Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
10.1073/pnas.1911992116 · 2019 · External reference
New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase
10.1016/j.ejmech.2017.08.011 · 2017 · External reference
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants
10.1177/0091270009335768 · 2009 · External reference
Development of LXR inverse agonists to treat MAFLD, NASH, and other metabolic diseases
10.3389/fmed.2023.1102469 · 2023 · External reference
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health
10.1038/s42255-024-01126-4 · 2024 · External reference
Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
10.1038/s41581-023-00741-w · 2023 · External reference
An overview of chronic kidney disease pathophysiology: the impact of gut dysbiosis and oral disease
10.3390/biomedicines11113033 · 2023 · External reference
Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism
10.1186/s12882-018-0814-8 · 2018 · External reference
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARγ
10.1016/j.molcel.2006.11.022 · 2007 · External reference
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
10.1101/gad.1773109 · 2009 · External reference
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling
10.7554/elife.08009 · 2015 · External reference
LXR suppresses inflammatory gene expression and neutrophil migration through cis-repression and cholesterol efflux
10.1016/j.celrep.2018.11.100 · 2018 · External reference
Reprogramming of the LXRα transcriptome sustains macrophage secondary inflammatory responses
10.1002/advs.202307201 · 2024 · External reference
Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2
10.1186/s12974-015-0247-2 · 2015 · External reference
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion
10.1093/cvr/cvac189 · 2023 · External reference
Cholesterol efflux pathways suppress inflammasome activation, NETosis, and atherogenesis
10.1161/circulationaha.117.032636 · 2018 · External reference
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
10.1126/scitranslmed.aad6100 · 2016 · External reference
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
10.4049/jimmunol.180.5.3305 · 2008 · External reference
The nuclear receptor LXR limits bacterial infection of host macrophages through a mechanism that impacts cellular NAD metabolism
10.1016/j.celrep.2017.01.007 · 2017 · External reference
LXR-Dependent Gene expression is important for macrophage survival and the innate immune response
10.1016/j.cell.2004.09.032 · 2004 · External reference
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
10.1172/jci35288 · 2009 · External reference
Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture
10.1089/sur.2010.066 · 2011 · External reference
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
10.1016/j.jaut.2021.102723 · 2021 · External reference
Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages
10.1161/circresaha.106.135814 · 2007 · External reference
LXR activation induces a proinflammatory trained innate immunity-phenotype in human monocytes
10.3389/fimmu.2020.00353 · 2020 · External reference
LXRα regulates oxLDL-induced trained immunity in macrophages
10.3390/ijms23116166 · 2022 · External reference
Activation of LXR nuclear receptors impairs the anti-inflammatory gene and functional profile of M-CSF-dependent human monocyte-derived macrophages
10.3389/fimmu.2022.835478 · 2022 · External reference
Defining GM-CSF– and macrophage-CSF–dependent macrophage responses by in vitro models
10.4049/jimmunol.1103426 · 2012 · External reference
Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunity
10.3389/fimmu.2025.1685796 · 2026 · External reference
Interplay between liver X receptor and hypoxia inducible factor 1α potentiates interleukin-1β production in human macrophages
10.1016/j.celrep.2020.107665 · 2020 · External reference
Autoregulation of the human liver X receptor α promoter
10.1128/mcb.21.22.7558-7568.2001 · 2001 · External reference
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells
10.1093/nar/gkt034 · 2013 · External reference
Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation
10.1038/s41418-020-00652-4 · 2021 · External reference
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
10.1038/s44161-023-00354-3 · 2023 · External reference
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
10.1016/j.neuron.2019.12.007 · 2020 · External reference
TREM2 in cardiovascular diseases: mechanisms and therapeutic perspectives
10.1016/j.arr.2025.102774 · 2025 · External reference
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications
10.1038/s44161-023-00295-x · 2023 · External reference
Complement receptor targeted liposomes encapsulating the liver X receptor agonist GW3965 accumulate in and stabilize atherosclerotic plaques
10.1002/adhm.202000043 · 2020 · External reference
Targeted delivery of liver X receptor agonist to inhibit neointimal hyperplasia by differentially regulating cell behaviors
10.1039/d2bm01041k · 2022 · External reference