Research graph
References from Transcription factor TBX2 is a key regulator of vascular calcification. Local targets link to admitted publications; unresolved targets remain external evidence.
Medial vascular calcification revisited: review and perspectives
10.1093/eurheartj/ehu163 · 2014 · External reference
Medial arterial calcification in ageing and disease: current evidence and knowledge gaps
10.1093/eurheartj/ehaf341 · 2025 · External reference
Vascular calcification: pathobiology of a multifaceted disease
10.1161/circulationaha.107.743161 · 2008 · External reference
Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study
10.1161/01.cir.0000148131.41425.e9 · 2004 · External reference
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
10.1056/nejmoa041031 · 2004 · External reference
Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors
10.1001/jama.293.14.1737 · 2005 · External reference
Chronic kidney disease-mineral and bone disorder: conclusions from a kidney disease: improving global outcomes (KDIGO) controversies conference
10.1016/j.kint.2024.11.013 · 2025 · External reference
Interventions to attenuate vascular calcification progression in chronic kidney disease: a systematic review of clinical trials
10.1681/asn.2021101327 · 2022 · External reference
Mechanisms of vascular calcification in CKD-evidence for premature ageing?
10.1038/nrneph.2013.176 · 2013 · External reference
Transcriptional programming in arteriosclerotic disease: a multifaceted function of the Runx2 (runt-related transcription factor 2)
10.1161/atvbaha.120.313791 · 2021 · External reference
Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification
10.1161/circresaha.112.267237 · 2012 · External reference
Pathophysiology of vascular calcification in chronic kidney disease
10.1161/01.res.0000141775.67189.98 · 2004 · External reference
Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization
10.1161/circresaha.110.238808 · 2011 · External reference
Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization
10.1161/circresaha.108.181305 · 2008 · External reference
Runx2 (runt-related transcription factor 2)-mediated microcalcification is a novel pathological characteristic and potential mediator of abdominal aortic aneurysm
10.1161/atvbaha.119.314113 · 2020 · External reference
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
10.1073/pnas.1111101108 · 2011 · External reference
Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?
10.1161/01.res.0000171451.88616.c2 · 2005 · External reference
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
10.1126/science.adp4753 · 2025 · External reference
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
10.1038/s41588-022-01069-0 · 2022 · External reference
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
10.1242/dev.01832 · 2005 · External reference
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
10.1038/s41588-024-01802-x · 2024 · External reference
Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci
10.1016/j.xgen.2023.100465 · 2024 · External reference
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
10.1038/s41588-018-0205-x · 2018 · External reference
Genetics of 35 blood and urine biomarkers in the UK Biobank
10.1038/s41588-020-00757-z · 2021 · External reference
Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture
10.1038/s41467-023-43400-1 · 2023 · External reference
Genetic variants associated with circulating fibroblast growth factor 23
10.1681/asn.2018020192 · 2018 · External reference
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
10.1038/s41588-020-0640-3 · 2020 · External reference
FinnGen provides genetic insights from a well-phenotyped isolated population
10.1038/s41586-022-05473-8 · 2023 · External reference
Exploring and visualizing large-scale genetic associations by using PheWeb
10.1038/s41588-020-0622-5 · 2020 · External reference
Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis
10.1093/ehjopen/oeab043 · 2022 · External reference
PlaqView 2.0: a comprehensive web portal for cardiovascular single-cell genomics
10.3389/fcvm.2022.969421 · 2022 · External reference
Case report: a novel de novo loss of function variant in the DNA-binding domain of TBX2 causes severe osteochondrodysplasia
10.3389/fgene.2022.1117500 · 2022 · External reference
Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder
10.1093/hmg/ddy146 · 2018 · External reference
A novel osteochondrodysplasia with empty sella associates with a TBX2 variant
10.3389/fendo.2022.845889 · 2022 · External reference
Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
10.1172/jci44350 · 2011 · External reference
Vascular, valvular and kidney calcification manifested in mouse models of adenine-induced chronic kidney disease
10.1080/0886022x.2023.2228920 · 2023 · External reference
Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function
10.1073/pnas.2417512122 · 2025 · External reference
The T-box family
10.1186/gb-2002-3-6-reviews3008 · 2002 · External reference
TBX2 controls a proproliferative gene expression program in melanoma
10.1101/gad.348746.121 · 2021 · External reference
Regulatory mechanisms in vascular calcification
10.1038/nrcardio.2010.115 · 2010 · External reference
Physiology and pathophysiology of the calcium-sensing receptor in the kidney
10.1152/ajprenal.00608.2009 · 2010 · External reference
Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells
10.1371/journal.pone.0097565 · 2014 · External reference
Effect of particle size on hydroxyapatite crystal-induced tumor necrosis factor alpha secretion by macrophages
10.1016/j.atherosclerosis.2007.02.005 · 2008 · External reference
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
10.1038/nature08938 · 2010 · External reference
Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
10.1056/nejm200005183422003 · 2000 · External reference
NT5E mutations and arterial calcifications
10.1056/nejmoa0912923 · 2011 · External reference
Mutations in ENPP1 are associated with ‘idiopathic’ infantile arterial calcification
10.1038/ng1221 · 2003 · External reference
Matrix gla protein gene polymorphism is associated with increased coronary artery calcification progression
10.1161/atvbaha.112.300491 · 2013 · External reference
The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter
10.1093/nar/gku712 · 2014 · External reference
CCAAT/Enhancer-binding protein beta (C/EBPbeta) regulates calcium deposition in smooth muscle cells
10.3390/ijms252413667 · 2024 · External reference
Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene
10.1359/jbmr.061110 · 2007 · External reference
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial
10.1016/s2665-9913(20)30065-5 · 2020 · External reference
Cardiovascular calcification heterogeneity in chronic kidney disease
10.1161/circresaha.123.321760 · 2023 · External reference
