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References from A multiplex droplet digital PCR assay for chromosome copy-number determination in Candida albicans. Local targets link to admitted publications; unresolved targets remain external evidence.
Tetraploidy accelerates adaptation under drug selection in a fungal pathogen
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Digital assays part I: partitioning statistics and digital PCR
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Rapid mechanisms for generating genome diversity: whole ploidy shifts, aneuploidy, and loss of heterozygosity
10.1101/cshperspect.a019604 · 2014 · External reference
A human-curated annotation of the Candida albicans genome
10.1371/journal.pgen.0010001 · 2005 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
Global incidence and mortality of severe fungal disease
10.1016/s1473-3099(23)00692-8 · 2024 · External reference
Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
10.1073/pnas.1806002115 · 2018 · External reference
The cryptic sexual strategies of human fungal pathogens
10.1038/nrmicro3236 · 2014 · External reference
Large-scale chromosomal changes and associated fitness consequences in pathogenic fungi
10.1007/s12281-014-0181-2 · 2014 · External reference
Rapid phenotypic and genotypic diversification after exposure to the oral host niche in Candida albicans
10.1534/genetics.118.301019 · 2018 · External reference
The evolution of drug resistance in clinical isolates of Candida albicans
10.7554/elife.00662 · 2015 · External reference
Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in the fungal pathogen Histoplasma
10.1371/journal.pbio.3003224 · 2026 · External reference
The ‘obligate diploid’ Candida albicans forms mating-competent haploids
10.1038/nature11865 · 2013 · External reference
Absolute quantification by droplet digital PCR versus analog real-time PCR
10.1038/nmeth.2633 · 2013 · External reference
The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata
10.1093/nar/gkr945 · 2012 · External reference
Aneuploidy and gene dosage regulate filamentation and host colonization by Candida albicans
10.1073/pnas.2218163120 · 2023 · External reference
Unresolved reference
2026 · External reference
The sequence alignment/map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Minimap2: pairwise alignment for nucleotide sequences
10.1093/bioinformatics/bty191 · 2018 · External reference
Effects of aneuploidy on cell behaviour and function
10.1038/s41580-021-00436-9 · 2022 · External reference
Three-color crystal digital PCR
10.1016/j.bdq.2016.10.002 · 2016 · External reference
Poisson plus quantification for digital PCR systems
10.1038/s41598-017-09183-4 · 2017 · External reference
Digital PCR modeling for maximal sensitivity, dynamic range and measurement precision
10.1371/journal.pone.0118833 · 2015 · External reference
The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
10.1101/gr.107524.110 · 2010 · External reference
Ploidy variation as an adaptive mechanism in human pathogenic fungi
10.1016/j.semcdb.2013.01.008 · 2013 · External reference
DNA isolation protocol effects on nuclear DNA analysis by microarrays, droplet digital PCR, and whole genome sequencing, and on mitochondrial DNA copy number estimation
10.1371/journal.pone.0180467 · 2017 · External reference
Invasive candidiasis
10.1038/nrdp.2018.26 · 2018 · External reference
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
10.1038/nature09529 · 2010 · External reference
Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor
10.1016/j.cell.2008.09.039 · 2008 · External reference
Gene flow contributes to diversification of the major fungal pathogen Candida albicans
10.1038/s41467-018-04787-4 · 2018 · External reference
Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
10.1038/s41467-018-04926-x · 2018 · External reference
10.1101/2023.05.10.540190
10.1101/2023.05.10.540190 · 2023 · External reference
10.1101/2025.06.29.662174
10.1101/2025.06.29.662174 · 2025 · External reference
Aneuploidy and isochromosome formation in drug-resistant Candida albicans
10.1126/science.1128242 · 2006 · External reference
Genomic plasticity of the human fungal pathogen Candida albicans
10.1128/ec.00060-10 · 2010 · External reference
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
10.1111/j.1365-2958.2008.06176.x · 2008 · External reference
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis
10.1172/jci124516 · 2019 · External reference
Antifungal drug concentration impacts the spectrum of adaptive mutations in Candida albicans
10.1093/molbev/msad009 · 2023 · External reference
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
10.7554/elife.58349 · 2020 · External reference
Genome plasticity in Candida albicans is driven by long repeat sequences
10.7554/elife.45954 · 2019 · External reference
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
10.1126/science.1142210 · 2007 · External reference
Aneuploidy: cells losing their balance
10.1534/genetics.108.090878 · 2008 · External reference
Hypo-osmotic-like stress underlies general cellular defects of aneuploidy
10.1038/s41586-019-1187-2 · 2019 · External reference
A double-edged sword: aneuploidy is a prevalent strategy in fungal adaptation
10.3390/genes10100787 · 2019 · External reference
Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans
10.1371/journal.ppat.1012497 · 2024 · External reference
The dynamic fungal genome: polyploidy, aneuploidy and copy number variation in response to stress
10.1146/annurev-micro-041320-112443 · 2023 · External reference
Aneuploidy as a promoter and suppressor of malignant growth
10.1038/s41568-020-00321-1 · 2021 · External reference
Caspofungin paradoxical growth in Candida albicans requires stress pathway activation and promotes unstable echinocandin resistance mediated by aneuploidy
10.3389/fcimb.2025.1618815 · 2025 · External reference
Fundamentals of multiplexing with digital PCR
10.1016/j.bdq.2016.05.002 · 2016 · External reference
Aneuploidy enables cross-adaptation to unrelated drugs
10.1093/molbev/msz104 · 2019 · External reference
Tunicamycin potentiates antifungal drug tolerance via aneuploidy in Candida albicans
10.1128/mbio.02272-21 · 2021 · External reference
The fitness costs and benefits of trisomy of each Candida albicans chromosome
10.1093/genetics/iyab056 · 2021 · External reference
Digital bioassays: theory, applications, and perspectives
10.1021/acs.analchem.6b04290 · 2017 · External reference
Cellular stress associated with aneuploidy
10.1016/j.devcel.2018.02.002 · 2018 · External reference
