Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination
10.1016/j.celrep.2023.112326 · 2023 · External reference
AGHmatrix: genetic relationship matrices in R
10.1093/bioinformatics/btad445 · 2023 · External reference
Bronchoalveolar lavage single-cell transcriptomics reveals immune dysregulations driving COVID-19 severity
10.1371/journal.pone.0309880 · 2025 · External reference
Multifaceted regulation of T cells by CD44
10.4161/cib.3.6.13495 · 2010 · External reference
Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans
10.1002/iid3.541 · 2022 · External reference
Optimal predictive model selection
10.1214/009053604000000238 · 2004 · External reference
The moderator–mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations
10.1037//0022-3514.51.6.1173 · 1986 · External reference
Fitting linear mixed-effects models using lme4
10.18637/jss.v067.i01 · 2015 · External reference
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice
10.1073/pnas.0808116105 · 2008 · External reference
Controlling the false discovery rate: a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
Immunopathology of RSV: an updated review
10.3390/v13122478 · 2021 · External reference
The X chromosome in quantitative trait locus mapping
10.1534/genetics.106.061176 · 2006 · External reference
R/qtl: qTL mapping in experimental crosses
10.1093/bioinformatics/btg112 · 2003 · External reference
Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity
10.1038/s41467-023-44250-7 · 2024 · External reference
Human immunopathogenesis of severe acute respiratory syndrome (SARS)
10.1016/j.virusres.2007.02.014 · 2008 · External reference
COVID-19: immunopathology and its implications for therapy
10.1038/s41577-020-0308-3 · 2020 · External reference
Climate change increases cross-species viral transmission risk
10.1038/s41586-022-04788-w · 2022 · External reference
Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells
10.4049/jimmunol.176.12.7511 · 2006 · External reference
Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-Infected mice
10.1016/j.chom.2016.01.007 · 2016 · External reference
Sex differences in immune responses to viruses, bacteria and vaccines
10.1038/s41590-026-02470-1 · 2026 · External reference
A shift in lung macrophage composition is associated with COVID-19 severity and recovery
10.1126/scitranslmed.abn5168 · 2022 · External reference
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
10.1038/s41587-020-0602-4 · 2020 · External reference
Host susceptibility to severe influenza a virus infection
10.1186/s13054-019-2566-7 · 2019 · External reference
The genome architecture of the collaborative cross mouse genetic reference population
10.1534/genetics.111.132639 · 2012 · External reference
QTL mapping on a background of variance heterogeneity
10.1534/g3.118.200790 · 2018 · External reference
Mapping the human genetic architecture of COVID-19
10.1038/s41586-021-03767-x · 2021 · External reference
A Bayesian model selection approach to mediation analysis
10.1371/journal.pgen.1010184 · 2022 · External reference
Immunopathology in influenza virus infection: uncoupling the friend from foe
10.1016/j.clim.2012.05.005 · 2012 · External reference
Tissue-specific immunopathology in fatal COVID-19
10.1164/rccm.202008-3265oc · 2021 · External reference
Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies
10.1086/423738 · 2004 · External reference
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross
10.1371/journal.ppat.1003196 · 2013 · External reference
Regularization paths for generalized linear models via coordinate descent
10.18637/jss.v033.i01 · 2010 · External reference
R-squared for Bayesian regression models
10.1080/00031305.2018.1549100 · 2019 · External reference
Inference from iterative simulation using multiple sequences
10.1214/ss/1177011136 · 1992 · External reference
Variable selection via Gibbs sampling
10.1080/01621459.1993.10476353 · 1993 · External reference
Approaches for Bayesian variable selection
1997 · External reference
Bayesian variable selection under collinearity
10.1080/00031305.2015.1031827 · 2015 · External reference
Complex immune Dysregulation in COVID-19 patients with severe respiratory failure
10.1016/j.chom.2020.04.009 · 2020 · External reference
Large upward bias in estimation of locus-specific effects from genomewide scans
10.1086/324471 · 2001 · External reference
Influenza pathogenesis: the effect of host factors on severity of disease
10.4049/jimmunol.1801010 · 2019 · External reference
Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury
10.1128/mbio.00271-13 · 2013 · External reference
Genome wide identification of SARS-CoV susceptibility loci using the collaborative cross
10.1371/journal.pgen.1005504 · 2015 · External reference
Allelic variation in the toll-like receptor adaptor protein ticam2 contributes to SARS-coronavirus pathogenesis in mice
10.1534/g3.117.041434 · 2017 · External reference
Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
10.1038/s41586-020-03148-w · 2021 · External reference
Oas1b-dependent immune transcriptional profiles of west Nile virus infection in the collaborative cross
10.1534/g3.117.041624 · 2017 · External reference
A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
10.1038/hdy.1992.131 · 1992 · External reference
Fatal COVID-19 is associated with reduced HLA-DR, CD123 or CD11c expression on circulating dendritic cells
10.2147/jir.s360207 · 2022 · External reference
Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study
10.1186/1471-2334-6-106 · 2006 · External reference
Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation
10.26719/2013.19.supp1.s12 · 2013 · External reference
10.1007/978-0-387-92407-6
10.1007/978-0-387-92407-6 · 2009 · External reference
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
10.1038/s41588-021-01006-7 · 2022 · External reference
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
10.1016/s0140-6736(20)30183-5 · 2020 · External reference
ACE1 polymorphism and progression of SARS
10.1016/j.bbrc.2004.08.208 · 2004 · External reference
An RR2 statistic for fixed effects in the generalized linear mixed model
10.1080/02664763.2016.1193725 · 2017 · External reference
10.1007/978-1-4614-7138-7
10.1007/978-1-4614-7138-7 · 2013 · External reference
Unresolved reference
1961 · External reference
Do men have a higher case fatality rate of severe acute respiratory syndrome than women do?
10.1093/aje/kwh056 · 2004 · External reference
On the importance of temporal precedence in mediational analyses
10.1037/ccp0000152 · 2017 · External reference
Sex differences in immune responses
10.1038/nri.2016.90 · 2016 · External reference
Whole-genome sequencing reveals host factors underlying critical COVID-19
10.1038/s41586-022-04576-6 · 2022 · External reference
Comprehensive mapping of immune perturbations associated with severe COVID-19
10.1126/sciimmunol.abd7114 · 2020 · External reference
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
10.1073/pnas.2018587118 · 2021 · External reference
A dynamic COVID-19 immune signature includes associations with poor prognosis
10.1038/s41591-020-1038-6 · 2020 · External reference
A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice
10.1016/j.cell.2020.09.050 · 2020 · External reference
Sarbecovirus disease susceptibility is conserved across viral and host models
10.1016/j.virusres.2024.199399 · 2024 · External reference
The MHC class II transactivator CIITA: not (quite) the odd-one-Out anymore among NLR proteins
10.3390/ijms22031074 · 2021 · External reference
Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome
10.1086/381535 · 2004 · External reference
Occurrences and functions of ly6Chi and ly6Clo macrophages in health and disease
10.3389/fimmu.2022.901672 · 2022 · External reference
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
10.1038/s41591-020-0901-9 · 2020 · External reference
Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
10.1038/s41467-022-34638-2 · 2022 · External reference
Association of HLA class I with severe acute respiratory syndrome coronavirus infection
10.1186/1471-2350-4-9 · 2003 · External reference
The role of host genetic factors in coronavirus susceptibility: review of animal and systematic review of human literature
10.1016/j.ajhg.2020.08.007 · 2020 · External reference
Longitudinal analyses reveal immunological misfiring in severe COVID-19
10.1038/s41586-020-2588-y · 2020 · External reference
Mediation analysis
10.1146/annurev.psych.58.110405.085542 · 2007 · External reference
Bayesian diallel analysis reveals mx1 -dependent and mx1 -independent effects on response to influenza a virus in mice
10.1534/g3.117.300438 · 2018 · External reference
A molecular single-cell lung atlas of lethal COVID-19
10.1038/s41586-021-03569-1 · 2021 · External reference
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
10.1038/nm.3985 · 2015 · External reference
Immune regulation by monocytes
10.1016/j.smim.2017.12.005 · 2018 · External reference
A general and simple method for obtaining RR2 from generalized linear mixed-effects models
10.1111/j.2041-210x.2012.00261.x · 2013 · External reference
Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells
10.1038/mi.2015.91 · 2016 · External reference
Lung pathology of fatal severe acute respiratory syndrome
10.1016/s0140-6736(03)13413-7 · 2003 · External reference
Complex genetic architecture underlies regulation of influenza-a-virus-specific antibody responses in the collaborative cross
10.1016/j.celrep.2020.107587 · 2020 · External reference
Genetic factors that affect spontaneous clearance of hepatitis C or B virus, response to treatment, and disease progression
10.1053/j.gastro.2018.09.052 · 2019 · External reference
Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype
10.1128/jvi.71.11.8860-8863.1997 · 1997 · External reference
Genetic diversity between mouse strains allows identification of CC027/GeniUnc as an orally reactive model of peanut allergy
10.1016/j.jaci.2018.10.009 · 2019 · External reference
Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity
10.1002/cti2.70026 · 2025 · External reference
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
10.1038/s41586-023-06034-3 · 2023 · External reference
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection
10.1053/j.gastro.2012.07.097 · 2012 · External reference
Using the emerging collaborative cross to probe the immune system
10.1038/gene.2013.59 · 2014 · External reference
Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection
10.1038/s44298-025-00100-5 · 2025 · External reference
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
10.1126/science.1259595 · 2014 · External reference
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
10.1016/s0140-6736(22)01109-6 · 2022 · External reference
A mutation in themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice
10.1016/j.jaci.2024.03.027 · 2024 · External reference
A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice
10.1371/journal.ppat.0030005 · 2007 · External reference
The collaborative cross as a resource for modeling human disease: cC011/unc, a new mouse model for spontaneous colitis
10.1007/s00335-013-9499-2 · 2014 · External reference
A multitrait locus regulates sarbecovirus pathogenesis
10.1128/mbio.01454-22 · 2022 · External reference
Genetic loci regulate Sarbecovirus pathogenesis: a comparison across mice and humans
10.1016/j.virusres.2024.199357 · 2024 · External reference
Mapping of susceptibility loci for Ebola virus pathogenesis in mice
10.1016/j.celrep.2024.114127 · 2024 · External reference
Severe COVID-19 is marked by a Dysregulated myeloid cell compartment
10.1016/j.cell.2020.08.001 · 2020 · External reference
Elucidating mechanisms of tolerance to salmonella typhimurium across long-term infections using the collaborative cross
10.1128/mbio.01120-22 · 2022 · External reference
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
10.3389/fmolb.2024.1335174 · 2024 · External reference
Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19
10.1016/j.cell.2020.08.002 · 2020 · External reference
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
10.7554/elife.74419 · 2022 · External reference
Unresolved reference
2020 · External reference
Lethal influenza in two related adults with inherited GATA2 deficiency
10.1007/s10875-018-0512-0 · 2018 · External reference
Immunological and inflammatory profiles in mild and severe cases of COVID-19
10.1038/s41467-020-17240-2 · 2020 · External reference
IFITM3 restricts the morbidity and mortality associated with influenza
10.1038/nature10921 · 2012 · External reference
Genetic mechanisms of critical illness in COVID-19
10.1038/s41586-020-03065-y · 2021 · External reference
Genomewide association study of severe covid-19 with respiratory failure
10.1056/nejmoa2020283 · 2020 · External reference
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
10.1038/nature08463 · 2009 · External reference
Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
10.1534/genetics.104.039313 · 2006 · External reference
CCR2 signaling restricts SARS-CoV-2 infection
10.1128/mbio.02749-21 · 2021 · External reference
Presence of genetic variants among young men with severe COVID-19
10.1001/jama.2020.13719 · 2020 · External reference
Partially collapsed gibbs samplers: theory and methods
10.1198/016214508000000409 · 2008 · External reference
Efficient methods to compute genomic predictions
10.3168/jds.2007-0980 · 2008 · External reference
Practical Bayesian model evaluation using leave-one-out cross-validation and WAIC
10.1007/s11222-016-9696-4 · 2017 · External reference
Double-negative T cells: setting the stage for disease control or progression
10.1111/imm.13441 · 2022 · External reference
Concepts, estimation and interpretation of SNP-based heritability
10.1038/ng.3941 · 2017 · External reference
MERS, SARS and other coronaviruses as causes of pneumonia
10.1111/resp.13196 · 2018 · External reference
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
10.1126/science.abd4570 · 2020 · External reference
TLR3 deficiency in patients with herpes simplex encephalitis
10.1126/science.1139522 · 2007 · External reference
Inborn errors of RNA lariat metabolism in humans with brainstem viral infection
10.1016/j.cell.2018.02.019 · 2018 · External reference
Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity
10.1007/s00439-020-02127-5 · 2020 · External reference
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003
10.1016/s0140-6736(03)14630-2 · 2003 · External reference
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
10.1016/s0140-6736(20)30566-3 · 2020 · External reference
A pneumonia outbreak associated with a new coronavirus of probable bat origin
10.1038/s41586-020-2012-7 · 2020 · External reference
Heightened innate immune responses in the respiratory tract of COVID-19 patients
10.1016/j.chom.2020.04.017 · 2020 · External reference
lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals
10.1186/s12859-018-2057-x · 2018 · External reference