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References from A glycolysis–calcineurin regulatory axis orchestrates titan cell formation in Cryptococcus neoformans. Local targets link to admitted publications; unresolved targets remain external evidence.
Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae
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Cryptococcus neoformans mating and virulence are regulated by the G- protein α subunit GPA1 and cAMP
10.1101/gad.11.23.3206 · 1997 · External reference
The cyclin Cln1 controls polyploid titan cell formation following a stress-induced G2 arrest in cryptococcus
10.1128/mbio.02509-21 · 2021 · External reference
Phosphatidic acid biosynthesis in the model organism yeast Saccharomyces cerevisiae—a survey
10.1016/j.bbalip.2021.158907 · 2021 · External reference
Redundant systems of phosphatidic acid biosynthesis via acylation of glycerol-3-phosphate or dihydroxyacetone phosphate in the yeast Saccharomyces cerevisiae
10.1128/jb.181.5.1458-1463.1999 · 1999 · External reference
The versatility and universality of calcium signalling
10.1038/35036035 · 2000 · External reference
Scaling of biosynthesis and metabolism with cell size
10.1091/mbc.e21-12-0627 · 2022 · External reference
The cAMP/protein kinase a pathway regulates virulence and adaptation to host conditions in Cryptococcus neoformans
10.3389/fcimb.2019.00212 · 2019 · External reference
The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans
10.7554/elife.82563 · 2022 · External reference
Yeast phosphofructokinase-1 subunit Pfk2p is necessary for pH homeostasis and glucose-dependent vacuolar ATPase reassembly
10.1074/jbc.m114.569855 · 2014 · External reference
Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines
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Epidemiology of fungal infections in China
10.1007/s11684-017-0601-0 · 2018 · External reference
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
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Titan cell production enhances the virulence of Cryptococcus neoformans
10.1128/iai.00507-12 · 2012 · External reference
2-Desoxy-D-glucose as an antagonist of glucose in yeast fermentation
10.1016/0016-0032(52)90852-1 · 1952 · External reference
Cryptococcus neoformans of unusual morphology
10.1128/aem.25.2.309-312.1973 · 1973 · External reference
Acidic calcium stores of Saccharomyces cerevisiae
10.1016/j.ceca.2011.01.010 · 2011 · External reference
Calcineurin-dependent growth control in Saccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases
10.1083/jcb.124.3.351 · 1994 · External reference
The Cryptococcus neoformans titan cell is an inducible and regulated morphotype underlying pathogenesis
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Cell wall integrity pathway involved in morphogenesis, virulence and antifungal susceptibility in Cryptococcus neoformans
10.3390/jof7100831 · 2021 · External reference
The bidirectional relationship between metabolism and cell cycle control
10.1016/j.tcb.2023.05.012 · 2024 · External reference
Conserved cAMP signaling cascades regulate fungal development and virulence
10.1016/s0168-6445(01)00058-4 · 2001 · External reference
Glucose promotes stress resistance in the fungal pathogen Candida albicans
10.1091/mbc.e09-01-0002 · 2010 · External reference
Transient increase in Ca2+ influx in Saccharomyces cerevisiae in response to glucose: effects of intracellular acidification and cAMP levels
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Synthesis and assembly of fungal melanin
10.1007/s00253-011-3777-2 · 2012 · External reference
Dynamic changes in the morphology of Cryptococcus neoformans during murine pulmonary infection
10.1099/00221287-147-8-2355 · 2001 · External reference
The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses
10.1111/cmi.12488 · 2016 · External reference
Accumulation of endogenous free radicals is required to induce titan-like cell formation in Cryptococcus neoformans
10.1128/mbio.02549-23 · 2024 · External reference
Cryptococcal titan cells: when yeast cells are all grown up
10.1007/82_2018_145 · 2019 · External reference
PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans
10.1128/ec.00146-08 · 2008 · External reference
Glucose-induced calcium influx in budding yeast involves a novel calcium transport system and can activate calcineurin
10.1016/j.ceca.2011.03.006 · 2011 · External reference
CRZ1 transcription factor is involved in cell survival, stress tolerance, and virulence in fungi
10.1007/s12038-022-00294-3 · 2022 · External reference
Protein kinase C in fungi-more than just cell wall integrity
10.1093/femsre/fux051 · 2018 · External reference
Calcineurin: structure, function, and inhibition
10.1007/bf02737887/metrics · 1999 · External reference
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
10.1038/16711 · 1999 · External reference
Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators
10.1371/journal.ppat.1006982 · 2018 · External reference
Activity of the calcium channel pore Cch1 is dependent on a modulatory region of the subunit Mid1 in Cryptococcus neoformans
10.1128/ec.00130-12 · 2013 · External reference
Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection
10.1111/j.1365-2958.2008.06374.x · 2008 · External reference
Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans
10.1128/ec.00214-06 · 2007 · External reference
Cell cycle control by Ca2+ in Saccharomyces cerevisiae
10.1016/s0021-9258(17)45348-8 · 1990 · External reference
Puf4 mediates post-transcriptional regulation of cell wall biosynthesis and caspofungin resistance in Cryptococcus neoformans
10.1128/mbio.03225-20 · 2021 · External reference
Metabolic control of the cell cycle
10.1080/15384101.2015.1090068 · 2015 · External reference
Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C
10.1161/01.res.87.12.1095 · 2000 · External reference
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
10.1186/s13072-024-00551-9/figures/6 · 2024 · External reference
Glycolysis: a multifaceted metabolic pathway and signaling hub
10.1016/j.jbc.2024.107906 · 2024 · External reference
The vacuolar Ca2+ exchanger vcx1 is involved in calcineurin-dependent Ca2+ tolerance and virulence in Cryptococcus neoformans
10.1128/ec.00114-10 · 2010 · External reference
Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans
10.1128/ec.05087-11 · 2011 · External reference
Hexokinase and glucokinases are essential for fitness and virulence in the pathogenic yeast Candida albicans
10.3389/fmicb.2019.00327 · 2019 · External reference
The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
10.1371/journal.pone.0051403 · 2012 · External reference
Monitoring glycolysis and respiration highlights metabolic inflexibility of Cryptococcus neoformans
10.3390/pathogens9090684 · 2020 · External reference
Cell wall integrity signaling in Saccharomyces cerevisiae
10.1128/mmbr.69.2.262-291.2005 · 2005 · External reference
Cryptococcus neoformans Ca2+ homeostasis requires a chloride channel/antiporter Clc1 in JEC21, but not in H99
10.1111/j.1567-1364.2011.00763.x · 2012 · External reference
Calcium signaling mediates antifungal activity of triazole drugs in the Aspergilli
10.1016/j.fgb.2014.12.005 · 2014 · External reference
Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments
10.1128/ec.00158-06 · 2006 · External reference
Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets
10.1128/ec.00271-14 · 2015 · External reference
The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase
10.1074/jbc.m303871200 · 2004 · External reference
Calcium transport systems as virulence determinants: mechanistic insights into fungal pathogenicity and antifungal resistance
10.1080/21505594.2025.2569624 · 2025 · External reference
Roles of different signaling pathways in Cryptococcus neoformans virulence
10.3390/jof10110786 · 2024 · External reference
Polarity and permeation profiles in lipid membranes
10.1073/pnas.131023798 · 2001 · External reference
Measurement of the Intracellular Calcium Concentration with Fura-2 AM Using a Fluorescence Plate Reader
10.21769/bioprotoc.2411 · 2017 · External reference
Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans
10.1371/journal.pone.0313444 · 2024 · External reference
Megakaryocyte and polyploidization
10.1016/j.exphem.2017.10.001 · 2018 · External reference
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores
10.1016/s0021-9258(18)83165-9 · 1989 · External reference
Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection
10.1016/j.tcsw.2017.12.001 · 2018 · External reference
The contribution of melanin to microbial pathogenesis
10.1046/j.1462-5814.2003.00268.x · 2003 · External reference
Cryptococcal cell morphology affects host cell interactions and pathogenicity
10.1371/journal.ppat.1000953 · 2010 · External reference
Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli
10.1128/ec.05179-11 · 2011 · External reference
Titan cells confer protection from phagocytosis in Cryptococcus neoformans infections
10.1128/ec.00121-12 · 2012 · External reference
The Cryptococcus neoformans capsule: a sword and a shield
10.1128/cmr.00001-12 · 2012 · External reference
Calcium-calmodulin-calcineurin signaling: a globally conserved virulence cascade in eukaryotic microbial pathogens
10.1016/j.chom.2019.08.004 · 2019 · External reference
Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
10.1038/s41467-017-01019-z · 2017 · External reference
The V-ATPase regulates localization of the TRP Ca2+ channel Yvc1 in response to oxidative stress in Candida albicans
10.1016/j.ijmm.2020.151466 · 2020 · External reference
Karyotyping of Cryptococcus neoformans as an epidemiological tool
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Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host
10.1128/mbio.00103-11/suppl_file/mbio.00103-11-s1.pdf · 2011 · External reference
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade
10.1128/ec.4.1.190-201.2005 · 2005 · External reference
Cyclic AMP signaling in Cryptococcus neoformans
10.1016/s1567-1356(03)00241-1 · 2004 · External reference
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis
10.1016/s1473-3099(17)30243-8 · 2017 · External reference
Glucose sensing network in Candida albicans: a sweet spot for fungal morphogenesis
10.1128/ec.00138-09 · 2009 · External reference
Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi
10.7554/elife.109075 · 2026 · External reference
Ricin B lectin-like proteins mediate thermotolerance, cell wall integrity, and fungal virulence in Cryptococcus neoformans
10.1016/j.tcsw.2026.100173 · 2026 · External reference
Calcium binding protein Ncs1 is calcineurin regulated in Cryptococcus neoformans and essential for cell division and virulence
10.1128/msphere.00761-20 · 2020 · External reference
Calcium: a central player in Cryptococcus biology
10.1016/j.fbr.2021.03.004 · 2021 · External reference
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
10.1371/journal.ppat.1007007 · 2018 · External reference
The Cch1-Mid1 high-affinity calcium channel contributes to the virulence of Cryptococcus neoformans by mitigating oxidative stress
10.1128/ec.00100-15 · 2015 · External reference
Confocal imaging of ionised calcium in living plant cells
10.1016/0143-4160(90)90006-g · 1990 · External reference
GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G(α) subunit and functions in a Ras-independent pathway
10.1093/emboj/17.7.1996 · 1998 · External reference
Calcineurin: the Achilles’ heel of fungal pathogens
10.1371/journal.ppat.1011445 · 2023 · External reference
AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate
10.1016/s0021-9258(18)33871-7 · 1982 · External reference
Gene expression of diverse cryptococcus isolates during infection of the human central nervous system
10.1128/mbio.02313-21 · 2021 · External reference
Subcellular organization of the camp signaling pathway
10.1124/pharmrev.120.000086 · 2021 · External reference
Chapter 4 the capsule of the fungal pathogen Cryptococcus neoformans
10.1016/s0065-2164(09)01204-0 · 2009 · External reference
Fungal cell gigantism during mammalian infection
10.1371/journal.ppat.1000945 · 2010 · External reference
Basic principles of the virulence of Cryptococcus
10.1080/21505594.2019.1614383 · 2019 · External reference
Titan cells in Cryptococcus neoformans: cells with a giant impact
10.1016/j.mib.2013.03.006 · 2013 · External reference
Cryptococcus neoformans, a global threat to human health
10.1186/s40249-023-01073-4 · 2023 · External reference
The Cryptococcus neoformans titan cell: from in vivo phenomenon to in vitro model
10.1007/s40588-018-0107-9 · 2018 · External reference