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References from An essential role of the AMPK-related kinase snrk in regulating Drosophila sleep. Local targets link to admitted publications; unresolved targets remain external evidence.
Unearthing the phylogenetic roots of sleep
10.1016/j.cub.2008.06.033 · 2008 · External reference
Molecular mechanisms of sleep homeostasis in flies and mammals
10.1101/cshperspect.a027730 · 2017 · External reference
The Drosophila circuitry of sleep-wake regulation
10.1016/j.conb.2017.03.004 · 2017 · External reference
The glial perspective on sleep and circadian rhythms
10.1146/annurev-neuro-091819-094557 · 2020 · External reference
Anaplastic lymphoma kinase acts in the Drosophila mushroom body to negatively regulate sleep
10.1371/journal.pgen.1005611 · 2015 · External reference
Sleep-wake cycles drive daily dynamics of synaptic phosphorylation
10.1126/science.aav3617 · 2019 · External reference
The Drosophila fragile X mental retardation gene regulates sleep need
10.1523/jneurosci.4830-08.2009 · 2009 · External reference
Central AMPK contributes to sleep homeostasis in mice
10.1016/j.neuropharm.2009.07.015 · 2009 · External reference
The genetic and molecular regulation of sleep: from fruit flies to humans
10.1038/nrn2683 · 2009 · External reference
Is sleep essential?
10.1371/journal.pbio.0060216 · 2008 · External reference
Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism
10.1242/bio.20149811 · 2015 · External reference
Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms
10.1523/jneurosci.3072-08a.2008 · 2008 · External reference
D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep
10.1038/s41467-019-09544-9 · 2019 · External reference
Molecular resolution of a behavioral paradox: sleep and arousal are regulated by distinct acetylcholine receptors in different neuronal types in Drosophila
10.1093/sleep/zsab017 · 2021 · External reference
Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness
10.1523/jneurosci.3981-11.2011 · 2011 · External reference
Chemoconnectomics: mapping chemical transmission in Drosophila
10.1016/j.neuron.2019.01.045 · 2019 · External reference
Inducing sleep by remote control facilitates memory consolidation in Drosophila
10.1126/science.1202249 · 2011 · External reference
Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila
10.1073/pnas.1112623109 · 2012 · External reference
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
10.1038/nn1957 · 2007 · External reference
Forward-genetics analysis of sleep in randomly mutagenized mice
10.1038/nature20142 · 2016 · External reference
Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure
10.1242/dev.022244 · 2008 · External reference
Neuromodulatory control of sleep in Drosophila melanogaster: integration of competing and complementary behaviors
10.1016/j.conb.2013.05.003 · 2013 · External reference
Dysregulation of protein kinase CaMKI leads to autism-related phenotypes in synaptic connectivity, sleep, sociality, and aging-dependent degeneration in Drosophila
10.3390/biology14091228 · 2025 · External reference
Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus
10.1016/j.brainres.2004.05.032 · 2004 · External reference
An internal thermal sensor controlling temperature preference in Drosophila
10.1038/nature07001 · 2008 · External reference
Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations
10.1093/sleep/33.1.19 · 2010 · External reference
Rest in Drosophila is a sleep-like state
10.1016/s0896-6273(00)80877-6 · 2000 · External reference
A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis
10.1038/nn743 · 2001 · External reference
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice
10.1073/pnas.1810823115 · 2018 · External reference
Induction of mutant Sik3Sleepy allele in neurons in late infancy increases sleep need
10.1523/jneurosci.1004-20.2020 · 2021 · External reference
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate
10.1016/j.febslet.2005.01.042 · 2005 · External reference
Sleep in Drosophila is regulated by adult mushroom bodies
10.1038/nature04811 · 2006 · External reference
Kinase signalling in excitatory neurons regulates sleep quantity and depth
10.1038/s41586-022-05450-1 · 2022 · External reference
Circadian rhythms of locomotor activity in Drosophila
10.1016/s0376-6357(03)00133-5 · 2003 · External reference
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
10.1016/s0092-8674(00)81225-8 · 1998 · External reference
A wake-promoting circadian output circuit in Drosophila
10.1016/j.cub.2018.07.024 · 2018 · External reference
Neuromodulation of brain states
10.1016/j.neuron.2012.09.012 · 2012 · External reference
Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats
10.1016/s0091-3057(98)00038-0 · 1998 · External reference
Sucrose nonfermenting-related kinase regulates both adipose inflammation and energy homeostasis in mice and humans
10.2337/db17-0745 · 2018 · External reference
Insomniac links the development and function of a sleep-regulatory circuit
10.7554/elife.65437 · 2021 · External reference
Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation
10.2337/db12-1081 · 2013 · External reference
Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3
10.1093/genetics/iyad136 · 2023 · External reference
Sleep drive is encoded by neural plastic changes in a dedicated circuit
10.1016/j.cell.2016.04.013 · 2016 · External reference
LKB1 is physiologically required for sleep from Drosophila melanogaster to the Mus musculus
10.1093/genetics/iyac082 · 2022 · External reference
The neurobiological basis of sleep: insights from Drosophila
10.1016/j.neubiorev.2018.01.015 · 2018 · External reference
Evolutionarily conserved regulation of sleep by the protein translational regulator PERK
10.1016/j.cub.2020.02.030 · 2020 · External reference
Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission
10.7554/elife.91927 · 2024 · External reference
Research resources for Drosophila: the expanding universe
10.1038/nrg1554 · 2005 · External reference
Spatiotemporal rescue of memory dysfunction in Drosophila
10.1126/science.1089035 · 2003 · External reference
Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
10.1126/stke.2202004pl6 · 2004 · External reference
ERK signaling pathway regulates sleep duration through activity-induced gene expression during wakefulness
10.1126/scisignal.aai9219 · 2017 · External reference
Acetylcholine from visual circuits modulates the activity of arousal neurons in Drosophila
10.1523/jneurosci.1571-15.2015 · 2015 · External reference
AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance
10.1371/journal.pgen.1007623 · 2018 · External reference
Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila
10.1523/jneurosci.1337-11.2011 · 2011 · External reference
A conditional tissue-specific transgene expression system using inducible GAL4
10.1073/pnas.221303298 · 2001 · External reference
PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit
10.1016/j.neuron.2008.10.042 · 2008 · External reference
Dissecting metabolic regulation of behaviors and physiology during aging in Drosophila
10.1007/s10522-025-10306-y · 2025 · External reference
Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila
10.1371/journal.pgen.1003003 · 2012 · External reference
A dynamic role for the mushroom bodies in promoting sleep in Drosophila
10.1038/nature04739 · 2006 · External reference
Loss of p21-activated kinase mbt/PAK4 causes Parkinson-like phenotypes in Drosophila
10.1242/dmm.047811 · 2021 · External reference
Sleep homeostasis regulated by 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body of Drosophila
10.7554/elife.26519 · 2017 · External reference
P[switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster
10.1073/pnas.221303998 · 2001 · External reference
Comparative genomics of the eukaryotes
10.1126/science.287.5461.2204 · 2000 · External reference
Sleep state switching
10.1016/j.neuron.2010.11.032 · 2010 · External reference
Neural circuitry of wakefulness and sleep
10.1016/j.neuron.2017.01.014 · 2017 · External reference
The regulation of Drosophila sleep
10.1016/j.cub.2020.10.082 · 2021 · External reference
Correlates of sleep and waking in Drosophila melanogaster
10.1126/science.287.5459.1834 · 2000 · External reference
Propagation of homeostatic sleep signals by segregated synaptic microcircuits of the Drosophila mushroom body
10.1016/j.cub.2015.09.017 · 2015 · External reference
DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization
10.1161/circulationaha.123.066002 · 2023 · External reference
Pan-neuronal knockdown of the c-jun N-terminal kinase (JNK) results in a reduction in sleep and longevity in Drosophila
10.1016/j.bbrc.2011.12.040 · 2012 · External reference
Involvement of ca(2+)-dependent hyperpolarization in sleep duration in mammals
10.1016/j.neuron.2016.02.032 · 2016 · External reference
SNRK: a metabolic regulator with multifaceted role in development and disease
10.20517/2574-1209.2020.18 · 2020 · External reference
Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster
10.1523/jneurosci.5860-10.2011 · 2011 · External reference
Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep
10.1371/journal.pbio.3001813 · 2022 · External reference
Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
10.1016/j.neuron.2013.12.025 · 2014 · External reference
Drosophila tools and assays for the study of human diseases
10.1242/dmm.023762 · 2016 · External reference
ERK phosphorylation regulates sleep and plasticity in Drosophila
10.1371/journal.pone.0081554 · 2013 · External reference
DBT affects sleep in both circadian and non-circadian neurons
10.1371/journal.pgen.1010035 · 2022 · External reference
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need
10.1038/s41586-018-0218-8 · 2018 · External reference
Circuit-based interrogation of sleep control
10.1038/nature19773 · 2016 · External reference
SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission
10.1016/j.cub.2014.02.026 · 2014 · External reference
Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep
10.1038/s42003-024-07449-y · 2025 · External reference
A subset of cholinergic mushroom body neurons requires go signaling to regulate sleep in Drosophila
10.5665/sleep.3206 · 2013 · External reference
A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions
10.1371/journal.pbio.2006409 · 2019 · External reference
A signalling pathway for transcriptional regulation of sleep amount in mice
10.1038/s41586-022-05510-6 · 2022 · External reference