Research graph
References from Autophagy, the ubiquitin proteasome system, and the MAPK pathway control the temperature dependence of synaptic growth. Local targets link to admitted publications; unresolved targets remain external evidence.
Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release.
10.1016/j.cub.2025.05.024 · 2025 · External reference
Control and regulation of the cellular responses to cold shock: the responses in yeast and mammalian systems.
10.1042/bj20060166 · 2006 · External reference
Cortactin is a regulator of activity-dependent synaptic plasticity controlled by wingless.
10.1523/jneurosci.1375-16.2017 · 2017 · External reference
Brain temperature and hippocampal function.
10.1002/hipo.450050602 · 1995 · External reference
Synaptic plasticity induced by differential manipulation of tonic and phasic motoneurons in drosophila.
10.1523/jneurosci.0925-20.2020 · 2020 · External reference
An axonal stress response pathway: degenerative and regenerative signaling by DLK
10.1016/j.conb.2018.07.002 · 2018 · External reference
Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae.
10.1002/neu.480240803 · 1993 · External reference
P62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.
10.4161/auto.7.6.14943 · 2011 · External reference
Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity.
10.1523/jneurosci.6075-11.2013 · 2013 · External reference
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila.
10.1016/j.cell.2007.10.048 · 2007 · External reference
Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.
10.1038/s41467-019-09262-2 · 2019 · External reference
JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs.
10.1016/j.ydbio.2005.01.002 · 2005 · External reference
Maturation and degeneration of the fat body in the Drosophila larva and pupa as revealed by morphometric analysis.
10.1016/0040-8166(88)90047-x · 1988 · External reference
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
10.1016/j.redox.2019.101181 · 2019 · External reference
Developmental temperature selectively regulates a voltage-activated potassium current in Drosophila.
10.1002/neu.480250204 · 1994 · External reference
Highwire restrains synaptic growth by attenuating a MAP kinase signal.
10.1016/j.neuron.2006.05.026 · 2006 · External reference
NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.
10.1038/s41467-021-23133-9 · 2021 · External reference
A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons
10.7554/elife.108282 · 2025 · External reference
Identification of human haploinsufficient genes and their genomic proximity to segmental duplications.
10.1038/ejhg.2008.111 · 2008 · External reference
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast
10.1534/genetics.104.036871 · 2005 · External reference
Ubiquitination-dependent mechanisms regulate synaptic growth and function.
10.1038/35086595 · 2001 · External reference
Axon self-destruction: new links among SARM1, MAPKs, and NAD+ metabolism.
10.1016/j.neuron.2015.12.023 · 2016 · External reference
A screen for synaptic growth mutants reveals mechanisms that stabilize synaptic strength.
10.1523/jneurosci.2601-18.2019 · 2019 · External reference
The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse.
10.1016/s0960-9822(09)00451-5 · 1996 · External reference
Axon regeneration requires a conserved MAP kinase pathway.
10.1126/science.1165527 · 2009 · External reference
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression.
10.1128/mcb.18.6.3527 · 1998 · External reference
Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons.
10.1523/jneurosci.0046-23.2023 · 2023 · External reference
Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature.
10.1523/jneurosci.0222-12.2012 · 2012 · External reference
Single-cell analysis of Drosophila larval neuromuscular synapses.
10.1006/dbio.2000.9983 · 2001 · External reference
Measurement of current–voltage relations in the membrane of the giant axon of Loligo.
10.1113/jphysiol.1952.sp004716 · 1952 · External reference
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.
10.1074/jbc.272.40.24994 · 1997 · External reference
Structural remodeling of active zones is associated with synaptic homeostasis.
10.1523/jneurosci.2002-19.2020 · 2020 · External reference
Injury-induced inhibition of bystander neurons requires dSarm and signaling from Glia.
10.1016/j.neuron.2020.11.012 · 2021 · External reference
10.1017/9781009157940.005
10.1017/9781009157940.005 · 2022 · External reference
Unresolved reference
2023 · External reference
Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons.
10.1016/j.neuron.2023.07.019 · 2023 · External reference
Ultrastructure of neuromuscular junctions in Drosophila: comparison of wild type and mutants with increased excitability.
10.1002/neu.480240804 · 1993 · External reference
Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae.
10.1523/jneurosci.09-02-00710.1989 · 1989 · External reference
The Drosophila neuromuscular junction: a model system for studying synaptic development and function.
10.1146/annurev.neuro.19.1.545 · 1996 · External reference
Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover.
10.7554/elife.96592 · 2024 · External reference
Thermal effects on neurons during stimulation of the brain.
10.1088/1741-2552/ac9339 · 2022 · External reference
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring
10.1038/s41467-020-14781-4 · 2020 · External reference
Brain connectivity inversely scales with developmental temperature in Drosophila.
10.1016/j.celrep.2021.110145 · 2021 · External reference
Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.
10.1523/jneurosci.5160-12.2013 · 2013 · External reference
The effects of temperature on cellular physiology.
10.1146/annurev-biophys-112221-074832 · 2022 · External reference
Physiological temperatures reduce the rate of vesicle pool depletion and short-term depression via an acceleration of vesicle recruitment.
10.1523/jneurosci.3889-05.2006 · 2006 · External reference
Hypoxia induces autophagy through translational up-regulation of lysosomal proteins in human colon cancer cells.
10.1371/journal.pone.0153627 · 2016 · External reference
Steroid regulation of midgut cell death during Drosophila development.
10.1006/dbio.2002.0784 · 2002 · External reference
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.
10.1016/j.neuron.2007.09.009 · 2007 · External reference
Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104
10.7554/elife.24271 · 2017 · External reference
Cold-sensing regulates Drosophila growth through insulin-producing cells.
10.1038/ncomms10083 · 2015 · External reference
Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology
10.1002/(sici)1097-4695(200005)43:2<186::aid-neu8>3.0.co;2-n · 2000 · External reference
High-probability neurotransmitter release sites represent an energy-efficient design
10.1016/j.cub.2016.07.032 · 2016 · External reference
The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain
10.1016/j.modgep.2005.07.006 · 2006 · External reference
Adar is essential for optimal presynaptic function.
10.1016/j.mcn.2012.10.009 · 2013 · External reference
A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ.
10.1371/journal.pone.0260553 · 2021 · External reference
Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.
10.1016/j.neuron.2004.07.001 · 2004 · External reference
Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a drosophila pax3/7 homolog
10.1523/jneurosci.5467-09.2010 · 2010 · External reference
The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction.
10.1016/s0896-6273(03)00426-4 · 2003 · External reference
Genetic and environmental control of neurodevelopmental robustness in Drosophila.
10.1371/journal.pone.0155957 · 2016 · External reference
Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals.
10.1523/jneurosci.1801-05.2005 · 2005 · External reference
Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction.
10.1523/jneurosci.0164-08.2008 · 2008 · External reference
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
10.1038/nn.2290 · 2009 · External reference
Effects of temperature on lifespan of Drosophila melanogaster from different genetic backgrounds: links between metabolic rate and longevity.
10.3390/insects11080470 · 2020 · External reference
Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila.
10.4161/auto.27442 · 2014 · External reference
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.
10.1016/j.cell.2004.12.017 · 2005 · External reference
Input-specific plasticity and homeostasis at the Drosophila larval neuromuscular junction.
10.1016/j.neuron.2017.02.028 · 2017 · External reference
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.
10.1083/jcb.200711108 · 2008 · External reference
The influence of postsynaptic structure on missing quanta at the Drosophila neuromuscular junction.
10.1186/s12868-016-0290-7/figures/5 · 2016 · External reference
Temperature-robust neural function from activity-dependent ion channel regulation.
10.1016/j.cub.2016.08.061 · 2016 · External reference
Thermal constraints on in vivo optogenetic manipulations.
10.1038/s41593-019-0422-3 · 2019 · External reference
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
10.1074/jbc.m702824200 · 2007 · External reference
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins.
10.1146/annurev.ge.27.120193.002253 · 1993 · External reference
Temperature-dependent developmental plasticity of Drosophila neurons: cell-autonomous roles of membrane excitability, Ca2+ influx, and cAMP signaling.
10.1523/jneurosci.2179-07.2007 · 2007 · External reference
Cold-shock response and cold-shock proteins.
10.1016/s1369-5274(99)80031-9 · 1999 · External reference
Autophagy and metabolism.
10.1126/science.1193497 · 2010 · External reference
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.
10.1016/j.devcel.2004.07.005 · 2004 · External reference
Rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.
10.1016/s0896-6273(00)81168-x · 2000 · External reference
Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling.
10.1152/jn.00298.2010 · 2010 · External reference
Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth.
10.1016/s0896-6273(00)80197-x · 1996 · External reference
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death.
10.1016/j.cub.2006.10.053 · 2007 · External reference
Autophagy promotes synapse development in Drosophila.
10.1083/jcb.200907109 · 2009 · External reference
Experience-dependent strengthening of Drosophila neuromuscular junctions.
10.1523/jneurosci.23-16-06546.2003 · 2003 · External reference
Therapeutic opportunities and pitfalls in the treatment of axon degeneration.
10.1097/wco.0000000000000621 · 2018 · External reference
KIF1A/UNC-104 transports ATG-9 to regulate neurodevelopment and autophagy at synapses.
10.1016/j.devcel.2016.06.012 · 2016 · External reference
PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth.
10.1016/j.celrep.2025.115483 · 2025 · External reference
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac.
10.1038/ng1314 · 2004 · External reference
Hsp70: nuclear concentration during environmental stress and cytoplasmic storage during recovery.
10.1016/0092-8674(84)90345-3 · 1984 · External reference
Highwire regulates synaptic growth in Drosophila.
10.1016/s0896-6273(00)81166-6 · 2000 · External reference
Brain temperature and its fundamental properties: a review for clinical neuroscientists.
10.3389/fnins.2014.00307 · 2014 · External reference
Structural and functional synaptic plasticity induced by convergent synapse loss in the Drosophila neuromuscular circuit.
10.1523/jneurosci.1492-20.2020 · 2021 · External reference
Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila
10.7554/elife.29338 · 2017 · External reference
Exploring the connection between autophagy and heat-stress tolerance in Drosophila melanogaster.
10.1098/rspb.2023.1305 · 2023 · External reference
A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
10.1016/j.neuron.2014.09.030 · 2014 · External reference
DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth.
10.1186/1749-8104-2-16 · 2007 · External reference
Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury.
10.1083/jcb.201006039 · 2010 · External reference
The highwire ubiquitin ligase promotes axonal degeneration by tuning levels of nmnat protein.
10.1371/journal.pbio.1001440 · 2012 · External reference
The maintenance of synaptic homeostasis at the Drosophila neuromuscular junction is reversible and sensitive to high temperature
10.1523/eneuro.0220-17.2017 · 2017 · External reference
Impact of developmental temperature on neural growth, connectivity, and function.
10.1126/sciadv.adp9587 · 2025 · External reference
