References

TL1A (TNFSF15) and DR3 (TNFRSF25): A co-stimulatory system of cytokines with diverse functions in gut mucosal immunity

10.3389/fimmu.2019.00583 · 2019 · External reference

The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases

10.1016/j.immuni.2008.04.021 · 2008 · External reference

The TNF family member TL1A induces IL-22 secretion in committed human T(h)17 cells via IL-9 induction

10.1189/jlb.3a0316-129r · 2017 · External reference

Tumor necrosis factor-like ligand 1A/death receptor 3 signaling regulates the generation of pathogenic t helper 9 cells in experimental Crohn’s disease

10.1053/j.gastro.2025.03.035 · 2025 · External reference

Microbiota-induced TNF-like ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis

10.1016/j.immuni.2018.10.014 · 2018 · External reference

A novel role for TL1A/DR3 in protection against intestinal injury and infection

10.4049/jimmunol.1502466 · 2016 · External reference

Death receptor 3 signaling controls the balance between regulatory and effector lymphocytes in SAMP1/YitFc mice with Crohn’s disease-like ileitis

10.3389/fimmu.2018.00362 · 2018 · External reference

A genome-wide association study identifies 2 susceptibility Loci for Crohn’s disease in a Japanese population

10.1053/j.gastro.2012.12.021 · 2013 · External reference

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

10.1038/ng.3359 · 2015 · External reference

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein

10.1371/journal.pone.0004719 · 2009 · External reference

The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells

10.1038/mi.2013.114 · 2014 · External reference

CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

10.1084/jem.20140678 · 2014 · External reference

Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils

10.1016/j.immuni.2025.12.008 · 2026 · External reference

Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation

10.1016/j.clim.2004.02.007 · 2004 · External reference

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1

10.1073/pnas.1404178111 · 2014 · External reference

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

10.1038/s41598-020-75168-5 · 2020 · External reference

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome

10.1038/s41385-018-0055-y · 2018 · External reference

Antitumor necrosis factor-like ligand 1A therapy targets tissue inflammation and fibrosis pathways and reduces gut pathobionts in ulcerative colitis

10.1093/ibd/izab193 · 2022 · External reference

Anti-TL1A antibody, afimkibart, in moderately-to-severely active ulcerative colitis (TUSCANY-2): a multicentre, double-blind, treat-through, multi-dose, randomised, placebo-controlled, phase 2b trial

10.1016/s2468-1253(25)00129-3 · 2025 · External reference

Phase 2 Trial of anti-TL1A monoclonal antibody tulisokibart for ulcerative colitis

10.1056/nejmoa2314076 · 2024 · External reference

Safety and efficacy of the anti-TL1A monoclonal antibody tulisokibart for Crohn’s disease: a phase 2a induction trial

10.1016/s2468-1253(25)00071-8 · 2025 · External reference

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

10.1172/jci42933 · 2010 · External reference