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References from Modulating immune toxicity in ulcerative colitis using a small molecule RAB27A inhibitor. Local targets link to admitted publications; unresolved targets remain external evidence.
ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension
10.1016/s2468-1253(22)00233-3 · 2022 · External reference
Ustekinumab adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn’s disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial
10.1016/s0140-6736(22)00688-2 · 2022 · External reference
Selective depletion of neutrophils by a monoclonal antibody, RP-3, suppresses dextran sulphate sodium-induced colitis in rats
10.1111/j.1440-1746.1997.tb00375.x · 1997 · External reference
Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease
10.1016/j.abb.2018.03.012 · 2018 · External reference
The dual role of neutrophils in inflammatory bowel diseases
10.3390/jcm5120118 · 2016 · External reference
Neutrophils as emerging therapeutic targets
10.1038/s41573-019-0054-z · 2020 · External reference
Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease
10.1093/ibd/izae032 · 2025 · External reference
Use of granulocyte/monocytapheresis in ulcerative colitis: a practical review from a European perspective
10.3748/wjg.v27.i10.908 · 2021 · External reference
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase
10.1042/bj20050380 · 2005 · External reference
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules
10.1111/j.1600-0854.2008.00838.x · 2008 · External reference
Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis
10.1128/mcb.00417-13 · 2013 · External reference
Exosome in intestinal mucosal immunity
10.1111/jgh.13413 · 2016 · External reference
The role of Rab27a in the regulation of neutrophil function
10.1111/cmi.12328 · 2014 · External reference
Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells
10.1371/journal.pone.0012870 · 2010 · External reference
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
10.1038/ncb1552 · 2007 · External reference
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis
10.1111/jcmm.15726 · 2020 · External reference
Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a
10.1074/jbc.m116.741884 · 2016 · External reference
Nitro-group-containing drugs
10.1021/acs.jmedchem.8b00147 · 2019 · External reference
Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment
10.1186/s40168-024-01857-2 · 2024 · External reference
Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats
10.1172/jci118878 · 1996 · External reference
Targeted nanoparticles modify neutrophil function
10.3389/fimmu.2022.1003871 · 2022 · External reference
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation
10.1371/journal.pone.0044328 · 2012 · External reference
The Anti-Hiv candidate Abx464 dampens intestinal inflammation by triggering Il-22 production in activated macrophages
10.1038/s41598-017-04071-3 · 2017 · External reference
Treatment of moderately to severely active ulcerative colitis with RO7790121 demonstrates early clinical response and symptom improvement – results from the phase 2B Tuscany-2 trial
10.1093/ibd/izae282.028 · 2025 · External reference
The emerging role of neutrophil extracellular traps in ulcerative colitis
10.3389/fimmu.2024.1425251 · 2024 · External reference
Identifying neutrophil-associated subtypes in ulcerative colitis and confirming neutrophils promote colitis-associated colorectal cancer
10.3389/fimmu.2023.1095098 · 2023 · External reference
Adsorptive granulocyte and monocyte apheresis versus prednisolone in patients with corticosteroid-dependent moderately severe ulcerative colitis
10.1159/000080079 · 2004 · External reference
A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis
10.1053/j.gastro.2008.04.023 · 2008 · External reference
Griscelli syndrome type 2 sine albinism: unraveling differential RAB27A effector engagement
10.3389/fimmu.2020.612977 · 2020 · External reference
Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial
10.1186/s12931-023-02444-z · 2023 · External reference
Neutrophils in chronic inflammatory diseases
10.1038/s41423-021-00832-3 · 2022 · External reference
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases
10.1007/s00011-022-01627-6 · 2022 · External reference
