Research graph
References from The interleukin-10/interleukin-10Rα axis in fibroblasts limits large intestinal pathology by suppressing Type I interferon signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
10.1016/s2468-1253(19)30333-4 · 2020 · External reference
Gut microbiota and IBD: causation or correlation?
10.1038/nrgastro.2017.88 · 2017 · External reference
Epidemiology and risk factors for IBD
10.1038/nrgastro.2015.34 · 2015 · External reference
Intestinal Foxl1+ cell-derived CXCL12 maintains epithelial homeostasis by modulating cellular metabolism
10.1093/intimm/dxae068 · 2025 · External reference
Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling
10.1016/j.cell.2024.03.013 · 2024 · External reference
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
10.1016/j.cell.2018.08.067 · 2018 · External reference
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
10.1016/j.cell.2019.06.029 · 2019 · External reference
Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice
10.1038/s41598-019-50656-5 · 2019 · External reference
A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease
10.1038/s41586-021-03484-5 · 2021 · External reference
IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
10.1038/s41591-021-01520-5 · 2021 · External reference
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
10.1038/s41467-024-46076-3 · 2024 · External reference
Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn's disease
10.1016/j.devcel.2020.11.010 · 2020 · External reference
Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways
10.1016/j.cell.2019.10.027 · 2019 · External reference
Cells of the human intestinal tract mapped across space and time
10.1038/s41586-021-03852-1 · 2021 · External reference
Targeting immune cell circuits and trafficking in inflammatory bowel disease
10.1038/s41590-019-0415-0 · 2019 · External reference
Strategies for targeting cytokines in inflammatory bowel disease
10.1038/s41577-024-01008-6 · 2024 · External reference
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
10.1038/ng.3359 · 2015 · External reference
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
10.1038/nature11582 · 2012 · External reference
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
10.1038/ng.3760 · 2017 · External reference
Fine-mapping inflammatory bowel disease loci to single-variant resolution
10.1038/nature22969 · 2017 · External reference
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
10.1038/ng.203 · 2008 · External reference
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
10.1038/ng.549 · 2010 · External reference
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
10.1136/gut.2008.166918 · 2009 · External reference
3rd European evidence-based consensus on the diagnosis and management of Crohn's disease 2016: part 1: diagnosis and medical management
10.1093/ecco-jcc/jjw168 · 2017 · External reference
Magnetic resonance enterographic predictors of one-year outcome in ileal and ileocolonic Crohn's disease treated with anti-tumor necrosis factor antibodies
10.1038/srep10223 · 2015 · External reference
A simple index to predict the efficiency of Adalimumab treatment in Crohn disease with a limited duration of therapy
10.20452/pamw.15507 · 2020 · External reference
Therapeutic drug monitoring of biologics during induction to prevent primary non-response
10.1093/ecco-jcc/jjz162 · 2020 · External reference
Revisiting fibrosis in inflammatory bowel disease: the gut thickens
10.1038/s41575-021-00543-0 · 2022 · External reference
Inflammatory bowel disease-associated intestinal fibrosis
10.4132/jptm.2022.11.02 · 2023 · External reference
Stromal cell regulation of intestinal inflammatory fibrosis
10.1016/j.jcmgh.2024.01.007 · 2024 · External reference
Mechanism of fibrosis and stricture formation in Crohn's disease
10.1111/sji.12990 · 2020 · External reference
Pathology of fibrosis in Crohn's disease-contribution to understanding its pathogenesis
10.3389/fmed.2020.00167 · 2020 · External reference
Efficacy of Adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study
10.1136/gutjnl-2016-312581 · 2018 · External reference
Trends in surgery for Crohn's disease in the era of infliximab
10.1097/sla.0b013e3181e61df5 · 2010 · External reference
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
10.1016/s1074-7613(02)00274-1 · 2002 · External reference
Regulatory T cells reinforce intestinal homeostasis
10.1016/j.immuni.2009.08.011 · 2009 · External reference
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
10.1038/ni1511 · 2007 · External reference
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
10.1038/ni.1791 · 2009 · External reference
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
10.1016/j.immuni.2014.03.012 · 2014 · External reference
Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10
10.1093/intimm/dxq449 · 2010 · External reference
STING-dependent signaling underlies IL-10 controlled inflammatory colitis
10.1016/j.celrep.2017.11.101 · 2017 · External reference
Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice
10.1172/jci174910 · 2025 · External reference
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
10.1126/science.aal3535 · 2017 · External reference
Myd88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
10.1038/ncomms2113 · 2012 · External reference
IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis
10.1038/mi.2013.103 · 2014 · External reference
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
10.1016/j.immuni.2014.03.011 · 2014 · External reference
Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor
10.7554/elife.27652 · 2017 · External reference
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
10.1172/jci17085 · 2003 · External reference
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
10.1016/s1074-7613(00)80005-9 · 1999 · External reference
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma in colitis
10.1038/srep10536 · 2015 · External reference
Technical note: is fecal consistency scoring an accurate measure of fecal dry matter in dairy calves?
10.3168/jds.2020-18907 · 2020 · External reference
Extensive histopathological characterization of inflamed bowel in the dextran sulfate sodium mouse model with emphasis on clinically relevant biomarkers and targets for drug development
10.3390/ijms22042028 · 2021 · External reference
OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation
10.1126/sciimmunol.adm6843 · 2025 · External reference
10.1038/s41467-019-09234-6
10.1038/s41467-019-09234-6 · External reference
Causal analysis approaches in ingenuity pathway analysis
10.1093/bioinformatics/btt703 · 2014 · External reference
BioJupies: automated generation of interactive notebooks for RNA-Seq data analysis in the cloud
10.1016/j.cels.2018.10.007 · 2018 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Decoupler: ensemble of computational methods to infer biological activities from omics data
10.1093/bioadv/vbac016 · 2022 · External reference
Induction and maintenance of clinical remission by interferon-beta in patients with steroid-refractory active ulcerative colitis-an open long-term pilot trial
10.1046/j.1365-2036.2002.01264.x · 2002 · External reference
Successful treatment of steroid refractory active ulcerative colitis with natural interferon-beta–an open long-term trial
10.1055/s-2007-963378 · 2007 · External reference
Case series: ulcerative colitis, multiple sclerosis, and interferon-beta 1a
10.1002/ibd.21242 · 2010 · External reference
[Crohn's disease during the course of multiple sclerosis: role of interferon-beta therapy]
10.1016/j.revmed.2008.11.008 · 2009 · External reference
Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a
10.3748/wjg.v13.i26.3638 · 2007 · External reference
Acute ulcerative colitis during successful interferon/ribavirin treatment for chronic hepatitis
10.1136/gut.2004.049940 · 2005 · External reference
A case of exacerbation of ulcerative colitis induced by combination therapy with PEG-interferon alpha-2b and ribavirin
10.1136/gut.2006.105197 · 2006 · External reference
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease
10.1038/nm.4307 · 2017 · External reference
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon
10.1016/j.immuni.2023.01.002 · 2023 · External reference
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
10.1038/s41590-024-01994-8 · 2024 · External reference
Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn's disease
10.1172/jci173835 · 2024 · External reference
Role of interleukin-17 in pathogenesis of intestinal fibrosis in mice
10.1007/s10620-019-05969-w · 2020 · External reference
IL-17A Promotes initiation and development of intestinal fibrosis through EMT
10.1007/s10620-018-5234-x · 2018 · External reference
Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation
10.1172/jci.insight.90299 · 2017 · External reference
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
10.1371/journal.pone.0227505 · 2020 · External reference
Inhibition of fibroblast activation protein restores a balanced extracellular matrix and reduces fibrosis in Crohn's disease strictures ex vivo
10.1093/ibd/izx008 · 2018 · External reference
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche
10.1016/j.stem.2023.03.004 · 2023 · External reference
Metabolic instruction of immunity
10.1016/j.cell.2017.04.004 · 2017 · External reference
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
10.1182/blood-2009-10-249540 · 2010 · External reference
IL-10 constrains sphingolipid metabolism to limit inflammation
10.1038/s41586-024-07098-5 · 2024 · External reference
Activation and regulation of interferon-β in immune responses
10.1007/s12026-012-8293-7 · 2012 · External reference
