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References from Mitochondrial transfer-driven immune evasion in the tumor microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
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From mice to humans: developments in cancer immunoediting
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Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
10.1056/nejmoa1200694 · 2012 · External reference
Targeting cancer metabolism in the era of precision oncology
10.1038/s41573-021-00339-6 · 2022 · External reference
Metabolic barriers to cancer immunotherapy
10.1038/s41577-021-00541-y · 2021 · External reference
T cell exhaustion
10.1146/annurev-immunol-090222-110914 · 2024 · External reference
Obstacles for T-lymphocytes in the tumour microenvironment: therapeutic challenges, advances and opportunities beyond immune checkpoint
10.1016/j.ebiom.2022.104216 · 2022 · External reference
Metabolic control of CD8+ T cell fate decisions and antitumor immunity
10.1016/j.molmed.2017.11.005 · 2018 · External reference
The multifaceted contributions of mitochondria to cellular metabolism
10.1038/s41556-018-0124-1 · 2018 · External reference
Mitochondria in health, disease, and aging
10.1152/physrev.00058.2021 · 2023 · External reference
Mitochondria are the powerhouses of immunity
10.1038/ni.3704 · 2017 · External reference
Metabolic interventions in the immune response to cancer
10.1038/s41577-019-0140-9 · 2019 · External reference
CD8+ T cell metabolism in infection and cancer
10.1038/s41577-021-00537-8 · 2021 · External reference
Mitochondrial transfer at the crossroads of cancer, stromal, and immune cells
10.1016/j.tcb.2025.10.004 · 2026 · External reference
Mitochondrial transfer in the tumor microenvironment
10.1111/cas.70342 · 2026 · External reference
The power and potential of mitochondria transfer
10.1038/s41586-023-06537-z · 2023 · External reference
Targeting organelle function in T cells for cancer immunotherapy
10.1038/s41577-025-01223-9 · 2026 · External reference
Recommendations for mitochondria transfer and transplantation nomenclature and characterization
10.1038/s42255-024-01200-x · 2025 · External reference
Mitochondria on the move: horizontal mitochondrial transfer in disease and health
10.1083/jcb.202211044 · 2023 · External reference
Horizontal mitochondrial transfer in cancer biology: potential clinical relevance
10.1016/j.ccell.2025.03.002 · 2025 · External reference
Immune evasion through mitochondrial transfer in the tumour microenvironment
10.1038/s41586-024-08439-0 · 2025 · External reference
Cancer cells hijack T-cell mitochondria
10.1038/s41565-021-01006-y · 2022 · External reference
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
10.1016/j.cmet.2025.12.014 · 2026 · External reference
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
10.1016/j.immuni.2012.10.020 · 2013 · External reference
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
10.1038/s41590-020-0793-3 · 2020 · External reference
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
10.1016/j.immuni.2011.12.007 · 2012 · External reference
Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion
10.1016/j.immuni.2016.07.008 · 2016 · External reference
The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
10.1016/j.immuni.2016.07.009 · 2016 · External reference
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
10.1172/jci.insight.93411 · 2017 · External reference
The role of metabolic dysfunction in T-cell exhaustion during chronic viral infection
10.3389/fimmu.2022.843242 · 2022 · External reference
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
10.1038/ncomms7692 · 2015 · External reference
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
10.1126/science.aax0860 · 2020 · External reference
The maintenance of mitochondrial DNA integrity—critical analysis and update
10.1101/cshperspect.a012641 · 2013 · External reference
Mitochondrial DNA variation and cancer
10.1038/s41568-021-00358-w · 2021 · External reference
Mitochondrial DNA is a major source of driver mutations in cancer
10.1016/j.trecan.2022.08.001 · 2022 · External reference
Comprehensive molecular characterization of mitochondrial genomes in human cancers
10.1038/s41588-019-0557-x · 2020 · External reference
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
10.1126/science.1156906 · 2008 · External reference
Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells
10.1038/s41565-021-01000-4 · 2022 · External reference
Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer
10.1038/s41598-019-44346-5 · 2019 · External reference
Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells
10.18632/oncotarget.9504 · 2016 · External reference
Tunneling-nanotube development in astrocytes depends on p53 activation
10.1038/cdd.2010.147 · 2011 · External reference
Nanotube action between human mesothelial cells reveals novel aspects of inflammatory responses
10.1371/journal.pone.0029537 · 2011 · External reference
Extracellular vesicles and nanoparticles: emerging complexities
10.1016/j.tcb.2023.01.002 · 2023 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
MitoEVs: a new player in multiple disease pathology and treatment
10.1002/jev2.12320 · 2023 · External reference
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
10.1182/blood-2014-05-573543 · 2014 · External reference
The role of ROS in tumour development and progression
10.1038/s41568-021-00435-0 · 2022 · External reference
Molecular mechanisms and physiological functions of mitophagy
10.15252/embj.2020104705 · 2021 · External reference
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
10.1038/nature13418 · 2014 · External reference
USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria
10.1038/ncb3097 · 2015 · External reference
Imperial strategy of cancer cells through mitochondrial transfer
10.1002/1878-0261.70142 · 2025 · External reference
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
10.1038/nature19330 · 2016 · External reference
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
10.1038/s41590-019-0312-6 · 2019 · External reference
Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
10.1016/j.immuni.2018.12.021 · 2019 · External reference
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
10.1016/j.cell.2024.08.029 · 2024 · External reference
MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation
10.1038/s43018-025-01038-6 · 2025 · External reference
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · 2020 · External reference
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy
10.1038/s41467-024-53908-9 · 2024 · External reference
Metabolic targeting of cancer-associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas
10.1038/s41467-024-46504-4 · 2024 · External reference
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer
10.1158/2159-8290.cd-19-1384 · 2020 · External reference
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
10.1038/s41467-025-63659-w · 2025 · External reference
Programs, origins and immunomodulatory functions of myeloid cells in glioma
10.1038/s41586-025-08633-8 · 2025 · External reference
Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases
10.1038/s42003-023-04525-7 · 2023 · External reference
Myeloid cells induce infiltration and activation of B cells and CD4+ T follicular helper cells to sensitize brain metastases to combination immunotherapy
10.1158/0008-5472.can-24-2274 · 2025 · External reference
Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia
10.1158/2326-6066.cir-16-0103 · 2017 · External reference
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
10.1073/pnas.1620433114 · 2017 · External reference
Combination bezafibrate and nivolumab treatment of patients with advanced non-small cell lung cancer
10.1126/scitranslmed.abq0021 · 2022 · External reference
Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
10.1126/science.abj3510 · 2022 · External reference
