Research graph
References from Tigecycline displays bactericidal activity against multidrug-resistant <i>Neisseria gonorrhoeae</i> and enhances clearance from a mouse infection model. Local targets link to admitted publications; unresolved targets remain external evidence.
Gonorrhoea
10.1038/s41572-019-0128-6 · 2019 · External reference
Antibiotic resistance and treatment options for multidrug-resistant gonorrhea
10.1097/im9.0000000000000024 · 2020 · External reference
WHO global gonococcal antimicrobial surveillance programmes, 2019–22: a retrospective observational study
10.1016/j.lanmic.2025.101181 · 2025 · External reference
Neisseria gonorrhoeae host adaptation and pathogenesis
10.1038/nrmicro.2017.169 · 2018 · External reference
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future
10.1128/cmr.00010-14 · 2014 · External reference
Global transmission of the penA allele 60.001-containing high-level ceftriaxone-resistant gonococcal FC428 clone and antimicrobial therapy of associated cases: a review
10.1097/im9.0000000000000113 · 2023 · External reference
British association of sexual health and HIV UK national guideline for the management of infection with Neisseria gonorrhoeae, 2025
10.1177/09564624251345195 · 2025 · External reference
Sexually transmitted infections treatment guidelines, 2021
10.15585/mmwr.rr7004a1 · 2021 · External reference
Guidelines for diagnosis and treatment of syphilis, gonorrhea and genital Chlamydia trachomatis infection (2020)
10.35541/cjd.20190808 · 2020 · External reference
Unresolved reference
2024 · External reference
Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022
10.2807/1560-7917.es.2022.27.50.2200899 · 2022 · External reference
Genetic characterization and enhanced surveillance of ceftriaxone-resistant Neisseria gonorrhoeae strain, Alberta, Canada, 2018
10.3201/eid2509.190407 · 2019 · External reference
Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain
10.1093/jac/dks162 · 2012 · External reference
Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022
10.2807/1560-7917.es.2022.27.46.2200803 · 2022 · External reference
New clinical strain of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone, Japan
10.3201/eid2201.150868 · 2016 · External reference
Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain
10.3201/eid2404.171873 · 2018 · External reference
A new multidrug-resistant strain of Neisseria gonorrhoeae in Australia
10.1056/nejmc1408109 · 2014 · External reference
The WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) identifies high levels of ceftriaxone resistance across Vietnam, 2023
10.1016/j.lanwpc.2024.101125 · 2024 · External reference
Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
10.2807/1560-7917.es.2022.27.24.2200455 · 2022 · External reference
Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-Eastern Asia, France, June 2019
10.2807/1560-7917.es.2019.24.36.1900528 · 2019 · External reference
Novel strain of multidrug non-susceptible Neisseria gonorrhoeae in the USA
10.1016/s1473-3099(23)00785-5 · 2024 · External reference
Pena alleles associated with gonococcal ceftriaxone resistance in Cambodia, China and Vietnam
10.1093/cid/ciaf530 · 2025 · External reference
Surge in ceftriaxone-resistant Neisseria gonorrhoeae FC428-like strains, Asia-Pacific region, 2015–2022
10.3201/eid3008.240139 · 2024 · External reference
High-level ceftriaxone resistance due to transfer of penA allele 60.001 into endemic gonococcal lineages in Hangzhou, China
10.1093/jac/dkae297 · 2024 · External reference
Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
10.1128/aac.00325-11 · 2011 · External reference
New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan
10.1128/aac.00504-16 · 2016 · External reference
The enhanced gonococcal surveillance programme, Cambodia
10.1016/s1473-3099(23)00479-6 · 2023 · External reference
Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018
10.2807/1560-7917.es.2019.24.10.1900147 · 2019 · External reference
Ceftriaxone-resistant Neisseria gonorrhoeae, Canada, 2017
10.3201/eid2402.171756 · 2018 · External reference
Emergence, evolution and temporal spread of ceftriaxone-resistant Neisseria gonorrhoeae in China from 2002 to 2022: a retrospective genomic surveillance study
10.1080/22221751.2025.2579397 · 2025 · External reference
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
10.2807/1560-7917.es.2018.23.27.1800323 · 2018 · External reference
Lessons learnt from ceftriaxone-resistant gonorrhoea in the UK and Australia
10.1016/s1473-3099(20)30055-4 · 2020 · External reference
Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017
10.2807/1560-7917.es.2018.23.21.1800264 · 2018 · External reference
Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010
10.2807/ese.16.06.19792-en · 2011 · External reference
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
10.1016/s1473-3099(17)30753-3 · 2018 · External reference
Antimicrobial susceptibility of clinical isolates of Neisseria gonorrhoeae to alternative antimicrobials with therapeutic potential
10.1093/jac/dkx147 · 2017 · External reference
Evaluation of alternative antibiotics for susceptibility of gonococcal isolates from China
10.1016/j.ijantimicag.2019.11.003 · 2020 · External reference
Tigecycline
10.1093/jac/dki248 · 2005 · External reference
Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review
10.1007/s10096-020-04121-1 · 2022 · External reference
Tigecycline: a critical safety review
10.1517/14740338.2015.997206 · 2015 · External reference
Tigecycline: what is it, and where should it be used?
10.1093/jac/dki291 · 2005 · External reference
The tigecycline resistance mechanisms in Gram-negative bacilli
10.3389/fcimb.2024.1471469 · 2024 · External reference
Safety and efficacy of intravenous tigecycline in treatment of community-acquired pneumonia: results from a double-blind randomized phase 3 comparison study with levofloxacin
10.1016/j.diagmicrobio.2008.09.001 · 2009 · External reference
Effectiveness and safety of high dose tigecycline for the treatment of severe infections: a systematic review and meta-analysis
10.1007/s12325-020-01235-y · 2020 · External reference
Current perspectives on tigecycline resistance in Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance
10.1016/j.ijantimicag.2016.04.017 · 2016 · External reference
Evaluation of Neisseria gonorrhoeae isolates susceptibility to tetracycline antibiotics from 9 provinces in China since 2020
10.2147/idr.s352932 · 2022 · External reference
Tigecycline in treatment of multidrug-resistant Gram-negative bacillus urinary tract infections: a systematic review
10.1093/jac/dku189 · 2014 · External reference
Role of tigecycline in the treatment of urinary tract infections: a systematic review of published case reports
10.53854/liim-3004-5 · 2022 · External reference
Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose
10.1093/jac/dkl403 · 2006 · External reference
High prevalence of Neisseria gonorrhoeae with high-level resistance to azithromycin in Hangzhou, China
10.1093/jac/dkw131 · 2016 · External reference
High percentage of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone among isolates from a single hospital in Hangzhou, China
10.1093/jac/dkaa526 · 2021 · External reference
Increasing prevalence of Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone and resistance to azithromycin in Hangzhou, China (2015–17)
10.1093/jac/dky412 · 2019 · External reference
Moenomycin is broadly active against multidrug-resistant Neisseria gonorrhoeae and clears an infection from a murine vaginal tract infection model
10.1093/jac/dkac202 · 2022 · External reference
Antimicrobial activity of auranofin, cannabidivarin, and tolfenamic acid against multidrug-resistant Neisseria gonorrhoeae
10.1128/spectrum.03952-22 · 2022 · External reference
2-Hydroxychalcone is a gonococcal-specific antimicrobial with activity against elongation factor Tu and butanediol dehydrogenase
10.1016/j.lfs.2025.123994 · 2025 · External reference
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
10.1128/iai.71.10.5576-5582.2003 · 2003 · External reference
Synergy, antagonism, and what the chequerboard puts between them
10.1093/jac/dkg301 · 2003 · External reference
Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test
10.1128/aac.40.8.1914 · 1996 · External reference
Determination of in vitro synergy for dual antimicrobial therapy against resistant Neisseria gonorrhoeae using Etest and agar dilution
10.1016/j.ijantimicag.2014.10.020 · 2015 · External reference
The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea
10.1093/cid/ciu521 · 2014 · External reference
Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial
10.1016/s0140-6736(18)32817-4 · 2019 · External reference
Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial
10.1016/s1473-3099(21)00625-3 · 2022 · External reference
Gentamicin alone is inadequate to eradicate Neisseria gonorrhoeae from the pharynx
10.1093/cid/ciz1109 · 2020 · External reference
Activity of ertapenem against Neisseria gonorrhoeae
10.1093/jac/dkh272 · 2004 · External reference
In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants: ertapenem for treatment of gonorrhea?
10.1128/aac.00326-12 · 2012 · External reference
