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References from Mutations in dfrA and its upstream region are associated with para -aminosalicylic acid resistance in Mycobacterium tuberculosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Drug-resistant tuberculosis: a persistent global health concern
10.1038/s41579-024-01025-1 · 2024 · External reference
Effect of combined therapy (dihydrostreptomycin and PAS) on the emergence of streptomycin-resistant strains of tubercle bacilli
10.1056/nejm195201242460404 · 1952 · External reference
Availability of streptomycin and para-aminosalicylic acid—United States
10.1001/jama.1992.03480190029009 · 1992 · External reference
Unresolved reference
External reference
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
10.1126/science.1228980 · 2013 · External reference
para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis
10.1074/jbc.m113.475798 · 2013 · External reference
The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria
10.1111/j.1365-2958.2004.04120.x · 2004 · External reference
Binding pocket alterations in dihydrofolate synthase confer resistance to para-aminosalicylic acid in clinical isolates of Mycobacterium tuberculosis
10.1128/aac.01775-13 · 2014 · External reference
Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012
10.1128/aac.03695-14 · 2015 · External reference
Association between mutations in a thyX-hsdS.1 region and para-aminosalicylic acid resistance in Mycobacterium tuberculosis clinical isolates
10.1080/22221751.2023.2276339 · 2023 · External reference
Determination of critical concentration for drug susceptibility testing of Mycobacterium tuberculosis against para-aminosalicylic acid with clinical isolates with thyA, folC and dfrA mutations
10.1186/s12941-022-00537-z · 2022 · External reference
Leaderless transcripts and small proteins are common features of the mycobacterial translational landscape
10.1371/journal.pgen.1005641 · 2015 · External reference
PremPS: predicting the impact of missense mutations on protein stability
10.1371/journal.pcbi.1008543 · 2020 · External reference
Pharmacokinetics of para-aminosalicylic acid in HIV-uninfected and HIV-coinfected tuberculosis patients receiving antiretroviral therapy, managed for multidrug-resistant and extensively drug-resistant tuberculosis
10.1128/aac.03073-14 · 2014 · External reference
Dose regimen of para-aminosalicylic acid gastro-resistant formulation (PAS-GR) in multidrug-resistant tuberculosis
10.1007/s40261-014-0172-7 · 2014 · External reference
Whole-genome sequencing-based analyses of drug-resistant Mycobacterium tuberculosis from Taiwan
10.1038/s41598-023-29652-3 · 2023 · External reference
Whole-genome sequencing for surveillance of fluoroquinolone resistance in rifampicin-susceptible tuberculosis in a rural district of Shanghai: a 10-year retrospective study
10.3389/fpubh.2022.990894 · 2022 · External reference
Prediction of drug resistance profile of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB) isolates from newly diagnosed case by whole genome sequencing (WGS): a study from a high tuberculosis burden country
10.1186/s12879-022-07482-4 · 2022 · External reference
Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates
10.1107/s205979831900901x · 2019 · External reference
Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis
10.1128/aac.01197-08 · 2009 · External reference
Dfra thyA double deletion in para-aminosalicylic acid-resistant Mycobacterium tuberculosis Beijing strains
10.1128/aac.00253-16 · 2016 · External reference
The T120P or M172V mutation on rv2172c confers high level para-aminosalicylic acid resistance in Mycobacterium tuberculosis
10.1080/22221751.2024.2374030 · 2024 · External reference
Decreased methylenetetrahydrofolate reductase activity leads to increased sensitivity to para-aminosalicylic acid in Mycobacterium tuberculosis
10.1128/aac.01465-21 · 2022 · External reference
Unresolved reference
External reference