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References from Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation. Local targets link to admitted publications; unresolved targets remain external evidence.
The integrated stress response: from mechanism to disease
10.1126/science.aat5314 · 2020 · External reference
Structural basis for eIF2B inhibition in integrated stress response
10.1126/science.aaw4104 · 2019 · External reference
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response
10.1126/science.aaw2922 · 2019 · External reference
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition
10.1016/j.cell.2005.06.041 · 2005 · External reference
eIF2alpha kinases provide a new solution to the puzzle of substrate specificity
10.1038/nsmb1005-835 · 2005 · External reference
HRI protein kinase in cytoplasmic heme sensing and mitochondrial stress response: relevance to hematological and mitochondrial diseases
2025 · External reference
Elucidation of the heme binding site of heme-regulated eukaryotic initiation factor 2alpha kinase and the role of the regulatory motif in heme sensing by spectroscopic and catalytic studies of mutant proteins
10.1074/jbc.m801400200 · 2008 · External reference
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion
10.1074/jbc.275.7.5171 · 2000 · External reference
The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress
10.1111/j.1432-1033.1997.t01-1-00461.x · 1997 · External reference
The eIF2alpha kinase HRI in innate immunity, proteostasis, and mitochondrial stress
10.1111/febs.15553 · 2021 · External reference
The eIF2alpha kinase HRI triggers the autophagic clearance of cytosolic protein aggregates
10.1074/jbc.ra120.014415 · 2021 · External reference
The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
10.7554/elife.52714 · 2020 · External reference
Heme sensor proteins
10.1074/jbc.r112.422642 · 2013 · External reference
Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
10.1038/s42003-021-01987-5 · 2021 · External reference
Heme binds to a short sequence that serves a regulatory function in diverse proteins
10.1002/j.1460-2075.1995.tb07005.x · 1995 · External reference
Regulation by heme of mitochondrial protein transport through a conserved amino acid motif
10.1126/science.8424176 · 1993 · External reference
The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta
10.1371/journal.pbio.1000043 · 2009 · External reference
Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase
10.1074/jbc.c300464200 · 2004 · External reference
Autophosphorylation of heme-regulated eukaryotic initiation factor 2alpha kinase and the role of the modification in catalysis
10.1111/j.1742-4658.2011.08007.x · 2011 · External reference
Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI
10.1021/bi034005v · 2003 · External reference
A critical evaluation of protein kinase regulation by activation loop autophosphorylation
10.7554/elife.88210 · 2023 · External reference
The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity
10.1016/j.jbc.2022.102451 · 2022 · External reference
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation
10.1182/bloodadvances.2020002475 · 2020 · External reference
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
10.1126/science.aao0932 · 2018 · External reference
Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems
10.1016/s0006-3495(02)75469-6 · 2002 · External reference
Unresolved reference
1992 · External reference
Mass photometry enables label-free tracking and mass measurement of single proteins on lipid bilayers
10.1038/s41592-021-01261-w · 2021 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
The conformational plasticity of protein kinases
10.1016/s0092-8674(02)00741-9 · 2002 · External reference
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR
10.1016/j.cell.2005.06.044 · 2005 · External reference
The structure of the PERK kinase domain suggests the mechanism for its activation
10.1107/s0907444911006445 · 2011 · External reference
Characterization of heme-regulated eIF2alpha kinase: roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition
10.1021/bi060556k · 2006 · External reference
Probing structure-function relations in heme-containing oxygenases and peroxidases
10.1126/science.3358128 · 1988 · External reference
Heme-containing oxygenases
10.1021/cr9500500 · 1996 · External reference
Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase
10.1021/bi300863a · 2012 · External reference
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme
10.1021/bi700605m · 2007 · External reference
Structural analysis of cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
10.1371/journal.pone.0217292 · 2019 · External reference
Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS
10.1042/bcj20253072 · 2025 · External reference
Structural basis of protein kinase R autophosphorylation
10.1021/acs.biochem.9b00161 · 2019 · External reference
Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop
10.1074/jbc.m113.527796 · 2014 · External reference
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2
10.1128/mcb.18.4.2282 · 1998 · External reference
