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References from Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Transcriptional architecture of the mammalian circadian clock
10.1038/nrg.2016.150 · 2017 · External reference
Post-translational modifications are required for circadian clock regulation in vertebrates
10.2174/1389202919666191014094349 · 2019 · External reference
Plasticity and specificity of the circadian epigenome
10.1038/nn.2668 · 2010 · External reference
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
10.1038/nature01314 · 2003 · External reference
Circadian regulator CLOCK is a histone acetyltransferase
10.1016/j.cell.2006.03.033 · 2006 · External reference
CLOCK-mediated acetylation of BMAL1 controls circadian function
10.1038/nature06394 · 2007 · External reference
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
10.1016/j.cell.2008.07.002 · 2008 · External reference
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
10.1016/j.cell.2008.06.050 · 2008 · External reference
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
10.1038/nsmb.1961 · 2010 · External reference
The polycomb group protein EZH2 is required for mammalian circadian clock function
10.1074/jbc.m603722200 · 2006 · External reference
Temporal orchestration of repressive chromatin modifiers by circadian clock period complexes
10.1038/nsmb.2746 · 2014 · External reference
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock
10.1126/science.1206022 · 2011 · External reference
Phosphorylation of LSD1 by PKCα is crucial for circadian rhythmicity and phase resetting
10.1016/j.molcel.2014.01.028 · 2014 · External reference
Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome
10.1016/j.cmet.2012.11.004 · 2012 · External reference
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging
10.1038/s41467-018-03073-7 · 2018 · External reference
10.1007/978-3-319-55530-0_52
10.1007/978-3-319-55530-0_52 · 2019 · External reference
S-adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1
10.1016/j.celrep.2017.11.092 · 2017 · External reference
The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention
10.1016/j.cell.2017.05.003 · 2017 · External reference
RNA methyltransferase METTL16: targets and function
10.1002/wrna.1681 · 2022 · External reference
Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs
10.15252/embr.201744940 · 2017 · External reference
Rethinking m(6)A readers, writers, and erasers
10.1146/annurev-cellbio-100616-060758 · 2017 · External reference
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
10.1038/nchembio.687 · 2011 · External reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · 2013 · External reference
The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation
10.1042/bst20221154 · 2023 · External reference
CDK1-cyclin B1 activates RNMT, coordinating mRNA cap methylation with G1 phase transcription
10.1016/j.molcel.2016.02.008 · 2016 · External reference
RNA modifications modulate gene expression during development
10.1126/science.aau1646 · 2018 · External reference
Uncovering the human methyltransferasome
10.1074/mcp.m110.000976 · 2011 · External reference
S-adenosylmethionine in liver health, injury, and cancer
10.1152/physrev.00047.2011 · 2012 · External reference
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
10.1016/s0168-8278(00)80122-1 · 2000 · External reference
Changes in methionine adenosyltransferase during liver regeneration in the rat
1998 · External reference
Adenosylhomocysteinase plays multiple roles in maintaining the identity and pluripotency of mouse embryonic stem cells
10.1093/biolre/ioad165 · 2024 · External reference
Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation
10.1126/sciadv.aav2448 · 2019 · External reference
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
10.1126/sciadv.abc5629 · 2020 · External reference
The AHCY-adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis
10.1038/s41422-025-01213-5 · 2026 · External reference
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
10.1038/s41467-022-31809-z · 2022 · External reference
Folic acid: UK to fortify flour to protect against birth defects
2024 · External reference
Methyl metabolism and the clock: an ancient story with new perspectives
10.1177/07487304221083507 · 2022 · External reference
10.1007/978-3-319-55530-0_43
10.1007/978-3-319-55530-0_43 · 2019 · External reference
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
10.1016/j.cmet.2015.08.024 · 2015 · External reference
Methyl-metabolite depletion elicits adaptive responses to support heterochromatin stability and epigenetic persistence
10.1016/j.molcel.2020.03.004 · 2020 · External reference
Clock regulation of metabolites reveals coupling between transcription and metabolism
10.1016/j.cmet.2017.04.023 · 2017 · External reference
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
10.1038/nature13198 · 2014 · External reference
A high-resolution, sex-stratified atlas of transcriptional and alternative splicing dynamics in the fasting mouse liver
10.64898/2026.04.28.720569 · 2026 · External reference
A circadian gene expression atlas in mammals: implications for biology and medicine
10.1073/pnas.1408886111 · 2014 · External reference
Fasting imparts a switch to alternative daily pathways in liver and muscle
10.1016/j.celrep.2018.11.077 · 2018 · External reference
A mouse circadian proteome atlas
10.1016/j.molcel.2025.12.020 · 2026 · External reference
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
10.1146/annurev-physiol-021909-135821 · 2010 · External reference
The circadian regulation of food intake
10.1038/s41574-019-0210-x · 2019 · External reference
Hypothalamic clocks and rhythms in feeding behaviour
10.1016/j.tins.2012.12.007 · 2013 · External reference
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
10.1101/gad.183500 · 2000 · External reference
Dietary methionine/choline deficiency affects behavioural and molecular circadian rhythms
10.1101/2024.01.04.574014 · 2024 · External reference
Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge
10.1073/pnas.2016589117 · 2020 · External reference
Methylation deficiency disrupts biological rhythms from bacteria to humans
10.1038/s42003-020-0942-0 · 2020 · External reference
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
10.1101/gad.1524107 · 2007 · External reference
RNA-methylation-dependent RNA processing controls the speed of the circadian clock
10.1016/j.cell.2013.10.026 · 2013 · External reference
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine
10.1038/s42003-022-03280-5 · 2022 · External reference
Circadian clock regulation of hepatic lipid metabolism by modulation of m(6)A mRNA methylation
10.1016/j.celrep.2018.10.068 · 2018 · External reference
S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury
1998 · External reference
Nonalcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in mice
10.1016/j.jcmgh.2023.05.008 · 2023 · External reference
S-adenosyl-methionine (SAM) alters the transcriptome and methylome and specifically blocks growth and invasiveness of liver cancer cells
10.18632/oncotarget.22942 · 2017 · External reference
The diverse roles of the circadian clock in cancer
10.1038/s43018-025-00981-8 · 2025 · External reference
Age-related decline in circadian output
10.1523/jneurosci.0451-11.2011 · 2011 · External reference
Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila
10.1101/gad.282277.116 · 2016 · External reference
Circadian clock control by polyamine levels through a mechanism that declines with age
10.1016/j.cmet.2015.09.011 · 2015 · External reference
S-adenosylmethionine: a metabolite critical to the regulation of autophagy
10.1111/cpr.12891 · 2020 · External reference
One-carbon metabolism in health and disease
10.1016/j.cmet.2016.08.009 · 2017 · External reference
Chronic insomnia in the setting of MTHFR polymorphism
10.5664/jcsm.9794 · 2022 · External reference
Human blood metabolite timetable indicates internal body time
10.1073/pnas.1207768109 · 2012 · External reference
Identification of a preliminary plasma metabolome-based biomarker for circadian phase in humans
10.1177/07487304211025402 · 2021 · External reference
