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References from TGF-β downregulates E-cadherin expression via a novel ZEB1-dependent mechanism. Local targets link to admitted publications; unresolved targets remain external evidence.
EMT: 2016
10.1016/j.cell.2016.06.028 · 2016 · External reference
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
10.1083/jcb.113.1.173 · 1991 · External reference
Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ
10.1002/(sici)1096-9896(199712)183:4<404::aid-path1148>3.0.co;2-9 · 1997 · External reference
Re-evaluating E-cadherin and β-catenin: a pan-cancer proteomic approach with an emphasis on breast cancer
10.1016/j.ajpath.2018.05.003 · 2018 · External reference
The role of E-cadherin as a prognostic biomarker in head and neck squamous carcinoma: a systematic review and meta-analysis
10.1007/s40291-018-0351-y · 2018 · External reference
Multifactorial regulation of E-cadherin expression: an integrative study
10.1158/1535-7163.mct-09-0321 · 2010 · External reference
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
10.1136/gutjnl-2011-300060 · 2012 · External reference
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP
10.1038/onc.2011.493 · 2012 · External reference
WNT7a induces E-cadherin in lung cancer cells
10.1073/pnas.1734137100 · 2003 · External reference
The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
10.1038/embor.2010.117 · 2010 · External reference
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms
10.1074/jbc.m114.589432 · 2014 · External reference
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
10.1038/ncb3513 · 2017 · External reference
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
10.1038/nature16064 · 2015 · External reference
ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
10.1080/15384101.2015.1006048 · 2015 · External reference
ZEB1 drives epithelial-to-mesenchymal transition in lung cancer
10.1172/jci76725 · 2016 · External reference
Prognostic value of ZEB-1 in solid tumors: a meta-analysis
10.1186/s12885-019-5830-y · 2019 · External reference
ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation
10.1111/cas.14701 · 2021 · External reference
New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites
10.1093/emboj/18.18.5073 · 1999 · External reference
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
10.1038/sj.onc.1208429 · 2005 · External reference
Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta
10.1091/mbc.e07-03-0249 · 2007 · External reference
ZEB represses transcription through interaction with the corepressor CtBP
10.1073/pnas.96.12.6683 · 1999 · External reference
Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1
10.1128/mcb.19.12.8581 · 1999 · External reference
MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP
10.1016/j.molcel.2015.01.023 · 2015 · External reference
Interaction of ZEB and histone deacetylase with the PLDLS-binding cleft region of monomeric C-terminal binding protein 2
10.1186/1471-2199-10-89 · 2009 · External reference
Molecular mechanisms of epithelial-mesenchymal transition
10.1038/nrm3758 · 2014 · External reference
Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling
10.1016/j.jbc.2024.107256 · 2024 · External reference
ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor
10.1186/1476-4598-10-91 · 2011 · External reference
Indole-derived compound SIS3 targets a subset of activated Smad complexes
10.1093/jb/mvac104 · 2023 · External reference
Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression
10.1371/journal.pone.0187236 · 2017 · External reference
Role of Ras signaling in the induction of snail by transforming growth factor-beta
10.1074/jbc.m804777200 · 2009 · External reference
δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells
10.1002/cam4.347 · 2015 · External reference
Targeted in situ genome-wide profiling with high efficiency for low cell numbers
10.1038/nprot.2018.015 · 2018 · External reference
Improved CUT&RUN chromatin profiling tools
10.7554/elife.46314 · 2019 · External reference
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a
10.1038/sj.embor.7400048 · 2004 · External reference
Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II
10.1074/jbc.m503304200 · 2006 · External reference
Notch signaling is necessary for epithelial growth arrest by TGF-beta
10.1083/jcb.200612129 · 2007 · External reference
ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat
10.15252/emmm.201404396 · 2015 · External reference
ZEB1 is regulated by K811 acetylation to promote stability, NuRD complex interactions, EMT, and NSCLC metastasis
10.1158/1541-7786.mcr-22-0503 · 2023 · External reference
ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
10.1038/onc.2010.102 · 2010 · External reference
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
10.1038/s41467-019-12832-z · 2019 · External reference
Zeb2 recruits HDAC-NuRD to inhibit notch and controls Schwann cell differentiation and remyelination
10.1038/nn.4322 · 2016 · External reference
TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
10.1038/s41467-020-19877-5 · 2020 · External reference
Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin
10.1074/jbc.m300597200 · 2003 · External reference