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References from Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Recovery after critical illness and acute kidney injury
10.2215/cjn.19601220 · 2021 · External reference
Immune checkpoint signaling and cancer immunotherapy
10.1038/s41422-020-0343-4 · 2020 · External reference
The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers
10.3389/fimmu.2022.964442 · 2022 · External reference
PD-1/PD-L1 pathway: current researches in cancer
2020 · External reference
Risk factors analysis of AKI in patients with primary non-small cell lung cancer treated with PD-1/PD-L1 inhibitor
10.52547/ijkd.7964 · 2024 · External reference
Acute kidney injury associated with anti-PD-1 and anti-PD-L1 drugs: a meta-analysis of randomized clinical trials
10.1080/08923973.2024.2360071 · 2024 · External reference
Immune checkpoint inhibitor nephrotoxicity: update 2020
10.34067/kid.0000852019 · 2020 · External reference
Immune checkpoint inhibitors and immune-related adverse renal events
10.1016/j.ekir.2020.04.018 · 2020 · External reference
Inflammation in acute kidney injury
10.1159/000142934 · 2008 · External reference
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury
10.1681/asn.2008111160 · 2009 · External reference
Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney
10.1038/ki.2010.12 · 2010 · External reference
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection
10.1681/asn.2012010070 · 2012 · External reference
Regulatory T cells in acute and chronic kidney diseases
10.1152/ajprenal.00236.2017 · 2018 · External reference
Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury
10.1038/ki.2009.259 · 2009 · External reference
Both PD-1 ligands protect the kidney from ischemia reperfusion injury
10.4049/jimmunol.1400497 · 2015 · External reference
Metabolic control of Treg cell stability, plasticity, and tissue-specific heterogeneity
10.3389/fimmu.2019.02716 · 2019 · External reference
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
10.4049/jimmunol.1003613 · 2011 · External reference
Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments
10.1016/j.cmet.2016.12.018 · 2017 · External reference
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
10.1038/ni.3577 · 2016 · External reference
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
10.1128/mcb.25.21.9543-9553.2005 · 2005 · External reference
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
10.1038/ncomms7692 · 2015 · External reference
IL233, A novel IL-2 and IL-33 hybrid cytokine, ameliorates renal injury
10.1681/asn.2016121272 · 2017 · External reference
A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury
10.4049/jimmunol.174.8.5040 · 2005 · External reference
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury
10.4049/jimmunol.178.9.5899 · 2007 · External reference
In vitro Treg suppression assays
10.1007/978-1-61737-979-6_2 · 2011 · External reference
PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
10.1038/s41590-022-01170-w · 2022 · External reference
Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer
10.1002/eji.201948470 · 2020 · External reference
Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation
10.1016/j.cmet.2018.06.002 · 2018 · External reference
Rare targetable drivers (RTDs) in non-small cell lung cancer (NSCLC): outcomes with immune check-point inhibitors (ICPi)
10.1016/j.lungcan.2018.07.044 · 2018 · External reference
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance
10.1038/s41590-022-01141-1 · 2022 · External reference
Immune-checkpoint inhibitors in melanoma and kidney cancer: from sequencing to rational selection
10.1177/1758835918777427 · 2018 · External reference
Immune checkpoint inhibitors efficacy across solid cancers and the utility of PD-L1 as a biomarker of response: a systematic review and meta-analysis
10.3389/fmed.2023.1192762 · 2023 · External reference
All-cause and immune checkpoint inhibitor–associated acute kidney injury in immune checkpoint inhibitor users: a meta-analysis of occurrence rate, risk factors and mortality
10.1093/ckj/sfad292 · 2024 · External reference
Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes
10.1136/jitc-2019-000467 · 2020 · External reference
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
10.1182/blood-2010-03-275446 · 2010 · External reference
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
10.1093/intimm/dxl151 · 2007 · External reference
Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model
10.1007/s00262-016-1906-6 · 2016 · External reference
The response to anti–PD-1 and anti–LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming
10.1126/scitranslmed.adk3702 · 2025 · External reference
Programmed death-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma
10.1165/rcmb.2009-0258oc · 2010 · External reference
Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice
10.1371/journal.pone.0093280 · 2014 · External reference
Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation
10.1161/atvbaha.111.224709 · 2011 · External reference
Programmed death protein 1 is essential for maintaining the anti-inflammatory function of infiltrating regulatory T cells in a murine spinal cord injury model
10.1016/j.jneuroim.2021.577546 · 2021 · External reference
Differences in T regulatory cells between mouse strains frequently used in immunological research: Treg cell quantities and subpopulations in NOD, B6 and BALB/c mice
10.1016/j.imlet.2020.04.006 · 2020 · External reference
Reduced PD-1 expression on circulating follicular and conventional FOXP3+ Treg cells in children with new onset type 1 diabetes and autoantibody-positive at-risk children
10.1016/j.clim.2019.108319 · 2020 · External reference
Type 1 diabetes related to immune checkpoint inhibitors
10.1016/j.beem.2022.101657 · 2022 · External reference
Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
10.1186/s13073-018-0581-y · 2018 · External reference
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy
10.1182/blood-2016-09-741629 · 2017 · External reference
PD-1 receptor (+) T cells are associated with the efficacy of the combined treatment with regulatory t cells and rituximab in type 1 diabetes children via regulatory t cells suppressive activity amelioration
10.1016/j.intimp.2024.111919 · 2024 · External reference
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4 + CD25Hi regulatory T cells
10.1093/intimm/dxp072 · 2009 · External reference
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells
10.1038/s41590-022-01373-1 · 2023 · External reference
Deciphering the immune landscape of head and neck squamous cell carcinoma: a single cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapy
10.1371/journal.pone.0295863 · 2023 · External reference
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis
10.1080/2162402x.2018.1445949 · 2018 · External reference
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
10.1073/pnas.1608873113 · 2016 · External reference
PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis
10.3389/fimmu.2023.997376 · 2023 · External reference
Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression
10.1136/jitc-2024-009435 · 2025 · External reference
Regulatory T cells as crucial trigger and potential target for hyperprogressive disease subsequent to PD-1/PD-L1 blockade for cancer treatment
10.1016/j.intimp.2024.111934 · 2024 · External reference
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
10.1073/pnas.1822001116 · 2019 · External reference
PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice
10.1172/jci171154 · 2024 · External reference
Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
10.1016/s0006-3495(99)77214-0 · 1999 · External reference
Metabolic coordination of T cell quiescence and activation
10.1038/s41577-019-0203-y · 2020 · External reference
PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2
10.1128/mcb.00319-13 · 2013 · External reference
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
10.1038/ni.3076 · 2015 · External reference
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
10.1038/ni.3077 · 2015 · External reference
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies
10.1038/s41590-020-0769-3 · 2020 · External reference
PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma
10.1038/s41590-025-02172-0 · 2025 · External reference
PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
10.1084/jem.20182232 · 2021 · External reference
mTOR complex 1 signaling regulates the generation and function of central and effector Foxp3+ regulatory T cells
10.4049/jimmunol.1701477 · 2018 · External reference
Immune checkpoint molecule TIGIT regulates kidney T cell functions and contributes to AKI
10.1681/asn.0000000000000063 · 2023 · External reference
The importance of immune checkpoint molecule TIGIT in AKI
10.1681/asn.0000000000000088 · 2023 · External reference
