Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Context-dependent regulation of cytotoxic T lymphocytes by nuclear receptors. Local targets link to admitted publications; unresolved targets remain external evidence.
CD8(+) T cells in the cancer-immunity cycle
10.1016/j.immuni.2023.09.005 · 2023 · External reference
Cellular and molecular waypoints along the path of T cell exhaustion
10.1126/sciimmunol.adg3868 · 2023 · External reference
Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells
10.1097/coh.0b013e32834ddcf2 · 2012 · External reference
Immunometabolism of CD8(+) T cell differentiation in cancer
10.1016/j.trecan.2024.03.010 · 2024 · External reference
Transcriptional control of effector and memory CD8+ T cell differentiation
10.1038/nri3307 · 2012 · External reference
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
10.1002/eji.200838289 · 2008 · External reference
Effector and memory T-cell differentiation: implications for vaccine development
10.1038/nri778 · 2002 · External reference
Nutrients: Signal 4 in T cell immunity
10.1084/jem.20221839 · 2024 · External reference
Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer
10.3109/10408363.2015.1094443 · 2016 · External reference
Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications
10.1016/s0165-6147(00)01548-0 · 2000 · External reference
NR4A transcription factors limit CAR T cell function in solid tumours
10.1038/s41586-019-0985-x · 2019 · External reference
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
10.1016/j.cell.2008.04.052 · 2008 · External reference
Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity
10.1016/j.immuni.2022.07.016 · 2022 · External reference
Endogenous glucocorticoid signaling regulates CD8(+) T cell differentiation and development of dysfunction in the tumor microenvironment
10.1016/j.immuni.2020.08.005 · 2020 · External reference
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
10.1084/jem.20252290 · 2026 · External reference
Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection
10.4049/jimmunol.1301949 · 2014 · External reference
The nuclear receptor NR1B1/RARalpha arrests the differentiation of anti-tumor effector cytotoxic T cells
10.1002/advs.202410241 · 2025 · External reference
NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment
10.1016/j.celrep.2024.113898 · 2024 · External reference
Vitamin D receptor expression controls proliferation of naive CD8+ T cells and development of CD8 mediated gastrointestinal inflammation
10.1186/1471-2172-15-6 · 2014 · External reference
Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
10.1146/annurev.pharmtox.46.120604.141156 · 2006 · External reference
The liver X receptors
2005 · External reference
Nuclear receptor 4A (NR4A) family: orphans no more
10.1016/j.jsbmb.2015.04.016 · 2016 · External reference
DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B
10.1038/8276 · 1999 · External reference
Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation
10.1128/mcb.19.11.7549 · 1999 · External reference
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
10.1621/nrs.07003 · 2009 · External reference
Structural aspects of vitamin D endocrinology
10.1016/j.mce.2017.02.046 · 2017 · External reference
Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D
10.3390/nu7105392 · 2015 · External reference
The human glucocorticoid receptor: molecular basis of biologic function
10.1016/j.steroids.2009.09.002 · 2010 · External reference
Immune regulation by glucocorticoids
10.1038/nri.2017.1 · 2017 · External reference
Structural perspectives on the androgen receptor, the elusive shape-shifter
10.1016/j.steroids.2024.109501 · 2024 · External reference
Low testosterone in men with type 2 diabetes: significance and treatment
10.1210/jc.2011-0118 · 2011 · External reference
Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors
10.1096/fj.14-259804 · 2015 · External reference
The nuclear receptor superfamily: the second decade
10.1016/0092-8674(95)90199-x · 1995 · External reference
Nuclear retinoid receptors and the transcription of retinoid-target genes
10.1016/j.gene.2003.12.005 · 2004 · External reference
Evolution of non-genomic nuclear receptor function
10.1016/j.mce.2021.111468 · 2022 · External reference
Influence of retinoic acid on the differentiation pathway of T cells in the thymus
10.1006/cimm.1997.1203 · 1997 · External reference
DNA vaccination with all-trans retinoic acid treatment induces long-term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model
10.1182/blood-2007-08-109009 · 2010 · External reference
Topical treatment of all-trans retinoic acid inhibits murine melanoma partly by promoting CD8(+) T-cell immunity
10.1111/imm.12768 · 2017 · External reference
Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8(+) T cell-mediated immunity in colorectal cancer
10.1016/j.immuni.2016.08.008 · 2016 · External reference
Retinoic acid modulates hyperactive T cell responses and protects vitamin A-deficient mice against persistent lymphocytic choriomeningitis virus infection
10.4049/jimmunol.1901091 · 2020 · External reference
Retinoic acid imprints gut-homing specificity on T cells
10.1016/j.immuni.2004.08.011 · 2004 · External reference
Vitamin D controls T cell antigen receptor signaling and activation of human T cells
10.1038/ni.1851 · 2010 · External reference
Vitamin D receptor signals regulate effector and memory CD8 T cell responses to infections in mice
10.3945/jn.114.202895 · 2014 · External reference
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice
10.1073/pnas.0808700106 · 2008 · External reference
1alpha, 25(OH)(2)D(3) reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells
10.1136/jitc-2021-003477 · 2022 · External reference
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
10.1038/383728a0 · 1996 · External reference
Oxysterols: modulators of cholesterol metabolism and other processes
10.1152/physrev.2000.80.1.361 · 2000 · External reference
Control of the immune system by oxysterols and cancer development
10.1016/j.coph.2012.07.003 · 2012 · External reference
Nuclear receptor LXRbeta controls fitness and functionality of activated T cells
10.1084/jem.20201311 · 2021 · External reference
LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
10.1038/s41598-019-56038-1 · 2019 · External reference
Cholesterol negatively regulates IL-9-producing CD8(+) T cell differentiation and antitumor activity
10.1084/jem.20171576 · 2018 · External reference
LXR/ApoE activation restricts innate immune suppression in cancer
10.1016/j.cell.2017.12.026 · 2018 · External reference
ROR agonist hampers the proliferation and survival of postactivated CD8(+) T cells through the downregulation of cholesterol synthesis-related genes
10.1111/imcb.12406 · 2021 · External reference
Retinoic acid receptor-related orphan receptor alpha regulates bystander activation of memory CD8(+) T cells
10.3389/fimmu.2025.1647746 · 2025 · External reference
RORalpha regulates cholesterol metabolism of CD8(+) T cells for anticancer immunity
10.3390/cancers12071733 · 2020 · External reference
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
10.1038/nature17412 · 2016 · External reference
The circadian clock component RORA increases immunosurveillance in melanoma by inhibiting PD-L1 expression
10.1158/0008-5472.can-23-3942 · 2024 · External reference
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
10.1172/jci85329 · 2016 · External reference
Early precursors and molecular determinants of tissue-resident memory CD8(+) T lymphocytes revealed by single-cell RNA sequencing
10.1126/sciimmunol.aaz6894 · 2020 · External reference
The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T-cell generation
10.1093/immhor/vlaf087 · 2026 · External reference
Nr4a1 and Nr4a3 reporter mice are differentially sensitive to T cell receptor signal strength and duration
10.1016/j.celrep.2020.108328 · 2020 · External reference
BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion
10.1126/scitranslmed.abn7336 · 2022 · External reference
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
10.1038/ni.2520 · 2013 · External reference
Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators
10.14670/hh-18-689 · 2024 · External reference
Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy
10.1016/j.molcel.2017.03.008 · 2017 · External reference
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells
10.1210/me.2014-1102 · 2014 · External reference
Cytosporone B is an agonist for nuclear orphan receptor Nur77
10.1038/nchembio.106 · 2008 · External reference
The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3
10.1038/srep09059 · 2015 · External reference
Cutting edge: the orphan nuclear receptor Nr4a1 regulates CD8+ T cell expansion and effector function through direct repression of Irf4
10.4049/jimmunol.1403027 · 2015 · External reference
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
10.1038/s41586-019-0979-8 · 2019 · External reference
Unresolved reference
2026 · External reference
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion
10.1073/pnas.1905675116 · 2019 · External reference
Glucocorticoid hormones are both a major circadian signal and major stress signal: how this shared signal contributes to a dynamic relationship between the circadian and stress systems
10.1016/j.yfrne.2017.12.005 · 2018 · External reference
A glucocorticoid-FAS axis controls immune evasion during metastatic seeding
10.1038/s41586-026-10222-2 · 2026 · External reference
Divergent effects of a transient corticosteroid therapy on virus-specific quiescent and effector CD8(+) T cells
10.3389/fimmu.2019.01521 · 2019 · External reference
Epigenetic landscapes reveal transcription factors that regulate CD8(+) T cell differentiation
10.1038/ni.3706 · 2017 · External reference
Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
10.4049/jimmunol.168.5.2212 · 2002 · External reference
Glucocorticoid-mediated suppression of effector programming assists the memory transition of virus-specific CD8+ T cells
10.4049/jimmunol.2300513 · 2024 · External reference
RISING STARS: androgens and immune cell function
10.1530/joe-23-0398 · 2024 · External reference
Testosterone deficiency is a risk factor for severe COVID-19
10.3389/fendo.2021.694083 · 2021 · External reference
The epidemiology of melanoma in young adults
10.1586/17469872.2013.844465 · 2013 · External reference
Androgen receptor-mediated CD8(+) T cell stemness programs drive sex differences in antitumor immunity
10.1016/j.immuni.2022.05.012 · 2022 · External reference
Androgen conspires with the CD8(+) T cell exhaustion program and contributes to sex bias in cancer
10.1126/sciimmunol.abq2630 · 2022 · External reference
Androgen receptor signaling induces CD8(+) T cell dysfunction that is reversed by androgen deprivation therapy in male head and neck squamous cell carcinoma
10.1158/0008-5472.can-25-2384 · 2026 · External reference
