Research graph
References from CTH522/CAF01 vaccination elicits clonally related Th17 subsets that mediate IL-17A–dependent protection against Chlamydia trachomatis. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results
10.1097/00007435-199207000-00001 · 1992 · External reference
Pathogenesis of genital tract disease due to Chlamydia trachomatis
10.1086/652397 · 2010 · External reference
The global roadmap for advancing development of vaccines against sexually transmitted infections: update and next steps
10.1016/j.vaccine.2016.03.111 · 2016 · External reference
Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response
10.1128/iai.65.3.1032-1044.1997 · 1997 · External reference
Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways
10.4049/jimmunol.158.7.3344 · 1997 · External reference
Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice
10.1128/iai.65.6.2145-2152.1997 · 1997 · External reference
Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma
10.1086/432070 · 2005 · External reference
Identification of Chlamydia trachomatis antigens recognized by T cells from highly exposed women who limit or resist genital tract infection
10.1093/infdis/jiw485 · 2016 · External reference
An adaptive Chlamydia trachomatis-specific IFN-gamma-producing CD4(+) T cell response is associated with protection against chlamydia reinfection in women
10.3389/fimmu.2018.01981 · 2018 · External reference
Cervical cytokines associated with Chlamydia trachomatis susceptibility and protection
10.1093/infdis/jiz087 · 2019 · External reference
Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice
10.1371/journal.ppat.1010333 · 2022 · External reference
Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells
10.1371/journal.ppat.1011914 · 2024 · External reference
T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.
10.1172/jci.insight.189388 · External reference
Cytotoxic CD4+ T cells are induced during infection with Chlamydia trachomatis
10.4049/jimmunol.2300131 · 2024 · External reference
Cytokine profiling of samples positive for Chlamydia trachomatis and human papillomavirus
10.1371/journal.pone.0279390 · 2023 · External reference
Spontaneous secretion of interleukin-17 and -22 by human cervical cells in Chlamydia trachomatis infection
10.1016/j.micinf.2010.10.012 · 2011 · External reference
Immune signature of Chlamydia vaccine CTH522/CAF®01 translates from mouse-to-human and induces durable protection in mice
10.1038/s41467-024-45526-2 · 2024 · External reference
Parenteral vaccination protects against transcervical infection with Chlamydia trachomatis and generate tissue-resident T cells post-challenge
10.1038/s41541-020-0157-x · 2020 · External reference
Th1/Th17 T cell tissue-resident immunity increases protection, but is not required in a vaccine strategy against genital infection with Chlamydia trachomatis
10.3389/fimmu.2021.790463 · 2021 · External reference
Post-exposure vaccine protection of CTH522/CAF((R))01 against reinfection with Chlamydia trachomatis requires Th1/Th17 but not Th2-immunity
10.1038/s41541-025-01117-w · 2025 · External reference
The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization
10.1371/journal.pone.0076664 · 2013 · External reference
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection
10.1128/iai.00984-10 · 2011 · External reference
Intravaginal Chlamydia trachomatis challenge infection elicits TH1 and TH17 immune responses in mice that promote pathogen clearance and genital tract damage
10.1371/journal.pone.0162445 · 2016 · External reference
Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling
10.1038/icb.2013.92 · 2014 · External reference
IL-17 and IL-17-producing cells in protection versus pathology
10.1038/s41577-022-00746-9 · 2023 · External reference
Plasticity of Th17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses
10.1038/ni.2552 · 2013 · External reference
Fate mapping of IL-17-producing T cells in inflammatory responses
10.1038/ni.1993 · 2011 · External reference
Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype
10.1016/j.jaut.2024.103174 · 2024 · External reference
Peyer’s patch T(H)17 cells are dispensable for gut IgA responses to oral immunization
10.1126/sciimmunol.abc5500 · 2022 · External reference
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in infection
10.1371/journal.ppat.1010430 · 2022 · External reference
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
10.1038/nature14452 · 2015 · External reference
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract
10.4049/jimmunol.1103032 · 2012 · External reference
Normalization of mass cytometry data with bead standards
10.1002/cyto.a.22271 · 2013 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
External reference
RNA velocity of single cells
10.1038/s41586-018-0414-6 · 2018 · External reference
VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
10.1126/science.aaa8205 · 2015 · External reference
Intravascular staining for discrimination of vascular and tissue leukocytes
10.1038/nprot.2014.005 · 2014 · External reference
CXCR3 and CCR5 are both required for T cell-mediated protection against infection in the murine genital mucosa
10.1038/mi.2010.58 · 2011 · External reference
Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
10.1038/mi.2009.100 · 2009 · External reference
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn’s disease
10.1084/jem.20011956 · 2002 · External reference
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
10.1146/annurev.iy.07.040189.001045 · 1989 · External reference
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation
10.1371/journal.pone.0017739 · 2011 · External reference
Cytotoxic CD4(+) T cells in cancer: expanding the immune effector toolbox
10.1016/j.immuni.2021.11.015 · 2021 · External reference
Molecular mechanism and function of CD40/CD40L engagement in the immune system
10.1111/j.1600-065x.2009.00782.x · 2009 · External reference
Th17 cells are long lived and retain a stem cell-like molecular signature
10.1016/j.immuni.2011.09.019 · 2011 · External reference
Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion
10.1172/jci.insight.90772 · 2017 · External reference
Human TH17 cells are long-lived effector memory cells
10.1126/scitranslmed.3002949 · 2011 · External reference
Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy
10.1016/j.immuni.2009.04.017 · 2009 · External reference
Fine-tuning of CD8(+) T cell mitochondrial metabolism by the respiratory chain repressor MCJ dictates protection to influenza virus
10.1016/j.immuni.2016.02.018 · 2016 · External reference
TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
10.1038/s41421-024-00766-w · 2025 · External reference
Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism
10.1152/ajpendo.00228.2009 · 2009 · External reference
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses
10.1126/sciimmunol.abo0981 · 2022 · External reference
Absence of the adaptor protein PEA-15 is associated with altered pattern of Th cytokines production by activated CD4+ T lymphocytes in vitro, and defective red blood cell alloimmune response in vivo
10.1371/journal.pone.0136885 · 2015 · External reference
Comprehensive analysis of the expression and prognosis of YPEL family members in clear cell renal cell cancer
10.3892/or.2022.8345 · 2022 · External reference
The single-cell transcriptional landscape of mammalian organogenesis
10.1038/s41586-019-0969-x · 2019 · External reference
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
10.1186/s12864-018-4772-0 · 2018 · External reference
Generalizing RNA velocity to transient cell states through dynamical modeling
10.1038/s41587-020-0591-3 · 2020 · External reference
CellRank for directed single-cell fate mapping
10.1038/s41592-021-01346-6 · 2022 · External reference
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
10.1126/science.1065544 · 2002 · External reference
Stem-like Intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
10.1016/j.cell.2021.11.018 · 2021 · External reference
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
10.1073/pnas.1415675112 · 2015 · External reference
Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
10.1126/science.abb9847 · 2020 · External reference
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
10.1038/nm.1982 · 2009 · External reference
A human memory T cell subset with stem cell-like properties
10.1038/nm.2446 · 2011 · External reference
Emergence and fate of stem cell-like Tcf7(+) CD8(+) T cells during a primary immune response to viral infection
10.1126/sciimmunol.adh3113 · 2023 · External reference
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
10.1371/journal.ppat.1011983 · 2024 · External reference
Single-cell genomics unveils critical regulators of Th17 cell pathogenicity
10.1016/j.cell.2015.11.009 · 2015 · External reference
Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity
10.1038/s41385-022-00497-9 · 2022 · External reference
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species
10.1128/iai.00403-09 · 2009 · External reference
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum
10.4049/jimmunol.0803075 · 2009 · External reference
Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection
10.1128/iai.64.11.4830-4833.1996 · 1996 · External reference
Neutrophils are central to antibody-mediated protection against genital chlamydia
10.1128/iai.00409-17 · 2017 · External reference
IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function
10.4049/jimmunol.0901584 · 2009 · External reference
The role of IFN-gamma in the outcome of chlamydial infection
10.1016/s0952-7915(02)00361-8 · 2002 · External reference
Cutting edge: lung mucosal Th17-mediated responses induce polymeric Ig receptor expression by the airway epithelium and elevate secretory IgA levels
10.4049/jimmunol.0900237 · 2009 · External reference
Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis
10.4049/jimmunol.1200955 · 2012 · External reference