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References from Molecular targeted therapies for pediatric low-grade gliomas: current perspectives and future directions. Local targets link to admitted publications; unresolved targets remain external evidence.
CBTRUS statistical report: Pediatric Brain Tumor Foundation childhood and adolescent primary brain and other central nervous system tumors diagnosed in the United States in 2014-2018
10.1093/neuonc/noac161 · 2022 · External reference
The 2021 WHO classification of Tumors of the central nervous system: a summary
10.1093/neuonc/noab106 · 2021 · External reference
The 2021 WHO classification of Tumors of the central nervous system: an update on pediatric low-grade gliomas and glioneuronal tumors
10.1111/bpa.13060 · 2022 · External reference
Integrated molecular and clinical analysis of 1,000 Pediatric low-grade gliomas
10.1016/j.ccell.2020.03.011 · 2020 · External reference
Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children’s oncology group
10.1227/neu.0b013e318214a66e · 2011 · External reference
Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German speaking Society of Pediatric Oncology and Hematology
10.1093/neuonc/nos202 · 2012 · External reference
Low grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy -- report from the multicenter treatment study for children and adolescents with a low grade glioma -- HIT-LGG 1996 -- of the Society of Pediatric Oncology and Hematology (GPOH)
10.1055/s-2004-832355 · 2004 · External reference
Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: a population-based study
10.1002/cncr.29907 · 2016 · External reference
Pediatric low-grade glioma: targeted therapeutics and clinical trials in the molecular era
10.1016/j.neo.2022.100857 · 2023 · External reference
Pediatric low-grade glioma: state-of-the-art and ongoing challenges
10.1093/neuonc/noad195 · 2024 · External reference
Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas
10.3171/jns.1997.86.5.0747 · 1997 · External reference
Phase II study of weekly vinblastine in recurrent or refractory pediatric low-grade glioma
10.1200/jco.2011.34.5843 · 2012 · External reference
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
10.1038/ng.2611 · 2013 · External reference
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
10.1038/ng.2682 · 2013 · External reference
Diencephalic pediatric low-grade glioma harboring the BRAF V600E mutation presenting with various morphologies in sequential biopsy specimens
10.1007/s10014-017-0298-4 · 2017 · External reference
Pediatric low-grade glioma in the era of molecular diagnostics
10.1186/s40478-020-00902-z · 2020 · External reference
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
10.1038/onc.2009.73 · 2009 · External reference
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
10.1158/0008-5472.can-08-2097 · 2008 · External reference
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
10.1007/s00401-011-0802-6 · 2011 · External reference
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
10.1158/0008-5472.can-09-1851 · 2010 · External reference
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology
10.1007/s00401-016-1539-z · 2016 · External reference
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
10.1038/s41467-025-61820-z · 2025 · External reference
Association of the FGFR1 mutation with spontaneous hemorrhage in low-grade gliomas in pediatric and young adult patients
10.3171/2019.12.jns192155 · 2021 · External reference
Fibroblast growth factor receptor 1 gene mutation as a potential risk factor for spontaneous intracranial hemorrhage in pediatric low-grade glioma patients
10.1093/noajnl/vdae074 · 2024 · External reference
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway
10.1007/s00401-016-1639-9 · 2017 · External reference
Polymorphous low-grade neuroepithelial tumor of the young: rare tumor and review of the literature
10.1177/20363613221083360 · 2022 · External reference
NF1 gene and neurofibromatosis 1
10.1093/oxfordjournals.aje.a010118 · 2000 · External reference
Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study
10.1038/bjc.2012.535 · 2013 · External reference
Cancer and central nervous system tumor surveillance in Pediatric Neurofibromatosis 1
10.1158/1078-0432.ccr-17-0589 · 2017 · External reference
Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations
10.1002/ana.21107 · 2007 · External reference
ALK in cancer: from function to therapeutic targeting
10.1038/s41568-025-00797-9 · 2025 · External reference
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
10.1038/s41467-019-12187-5 · 2019 · External reference
On Trk--the TrkB signal transduction pathway is an increasingly important target in cancer biology
10.1158/1078-0432.ccr-08-0651 · 2009 · External reference
Molecular and clinicopathologic features of gliomas harboring NTRK fusions
10.1186/s40478-020-00980-z · 2020 · External reference
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism
10.1038/ng.3500 · 2016 · External reference
A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration
10.1007/s00401-019-02081-1 · 2019 · External reference
Dabrafenib and Trametinib in patients with Tumors with BRAF(V600E) mutations: results of the NCI-MATCH trial subprotocol H
10.1200/jco.20.00762 · 2020 · External reference
Dabrafenib plus trametinib in patients with BRAF(V600E)-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial
10.1016/s1470-2045(21)00578-7 · 2022 · External reference
Efficacy and safety of Trametinib monotherapy or in combination with Dabrafenib in Pediatric BRAF V600-mutant low-grade glioma
10.1200/jco.22.01000 · 2023 · External reference
Dabrafenib plus Trametinib in Pediatric glioma with BRAF V600 mutations
10.1056/nejmoa2303815 · 2023 · External reference
Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
10.1073/pnas.1219232110 · 2013 · External reference
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
10.1038/nature08833 · 2010 · External reference
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
10.1038/nature08902 · 2010 · External reference
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial
10.1016/s1470-2045(19)30277-3 · 2019 · External reference
A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade glioma without NF1: a Pediatric brain tumor consortium study
10.1093/neuonc/noab047 · 2021 · External reference
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial
10.1038/s41591-023-02668-y · 2024 · External reference
LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration
10.1186/s12885-024-11820-x · 2024 · External reference
Activity of Selumetinib in Neurofibromatosis type 1-related plexiform Neurofibromas
10.1056/nejmoa1605943 · 2016 · External reference
Fibroblast growth factor receptors (FGFRs): structures and small molecule inhibitors
10.3390/cells8060614 · 2019 · External reference
Debio1347, an Oral FGFR inhibitor: results from a single-Center study in Pediatric patients with recurrent or refractory FGFR-altered gliomas
10.1200/po.20.00444 · 2021 · External reference
Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial
10.1038/s41591-024-02934-7 · 2024 · External reference
Actionable tumor alterations and treatment protocol Enrollment of Pediatric and Young adult patients with refractory cancers in the National Cancer Institute-Children’s oncology group Pediatric MATCH trial
10.1200/jco.21.02838 · 2022 · External reference
FGFR alterations and potential role of FGFR inhibitors in pediatric brain tumors
10.1093/noajnl/vdaf113 · 2026 · External reference
Slipped capital femoral epiphyses: a major on-target adverse event associated with FGFR tyrosine kinase inhibitors in pediatric patients
10.1002/pbc.30410 · 2023 · External reference
Novel activating SNRNP70-ALK fusion in congenital infant-type hemispheric glioma displays clinical response to lorlatinib: a case-report
10.1038/s41698-026-01336-x · 2026 · External reference
Case report: ATIC-ALK fusion in infant-type hemispheric glioma and response to lorlatinib
10.3389/fonc.2023.1123378 · 2023 · External reference
Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG)
10.1093/neuonc/noac087 · 2022 · External reference
Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors
10.1093/neuonc/noab274 · 2022 · External reference
Role of surgery for optic pathway/hypothalamic astrocytomas in children
10.1215/15228517-2008-033 · 2008 · External reference
Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations
10.1093/neuonc/noz022 · 2019 · External reference
Opportunities for the treatment of NF1-associated low-grade gliomas: how to decide on the best treatment options for patients?
10.1093/neuonc/noaa201 · 2020 · External reference
Natural history of Pediatric low-grade glioma disease - first multi-state model analysis
10.7150/jca.33463 · 2019 · External reference
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
10.1158/1078-0432.ccr-11-0034 · 2011 · External reference
Management of pediatric low-grade glioma
10.1097/mop.0000000000000717 · 2019 · External reference
Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas
10.1158/1078-0432.ccr-11-0127 · 2011 · External reference
The senescence-associated secretory phenotype mediates oncogene-induced senescence in Pediatric Pilocytic astrocytoma
10.1158/1078-0432.ccr-18-1965 · 2019 · External reference
Canadian consensus for treatment of BRAF V600E mutated Pediatric and AYA gliomas
10.3390/curroncol31070299 · 2024 · External reference
Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma
10.3389/fonc.2025.1520316 · 2025 · External reference
Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma
10.1007/s11060-020-03592-8 · 2020 · External reference
Clinical experience with tovorafenib in adults with treatment-refractory high- and low-grade gliomas
10.1093/nop/npaf068 · 2025 · External reference
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines
10.1007/s11060-024-04672-9 · 2024 · External reference
Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition
2020 · External reference
Integrated response analysis of pediatric low-grade gliomas during and after targeted therapy treatment
10.1093/noajnl/vdac182 · 2023 · External reference
Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: a modified Delphi approach to build international consensus-based definitions-International Pediatric Low-Grade Glioma Coalition
10.1093/neuonc/noae074 · 2024 · External reference
Rebound regrowth phenomenon in patients with pediatric low-grade gliomas treated with MAPK inhibitors - a systematic review
10.3389/or.2026.1815932 · 2026 · External reference