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References from Intoxication, inflammaging, and injury: my journey through leukocyte biology. Local targets link to admitted publications; unresolved targets remain external evidence.
Enhanced interleukin-1 production by human monocyte cell lines following treatment with 5-azacytidine
10.1002/jlb.41.1.40 · 1987 · External reference
Secretion of macrophage-derived growth factor during acute lung injury induced by bleomycin
10.1002/jlb.37.1.1 · 1985 · External reference
Writing a first grant proposal
10.1038/ni.2183 · 2012 · External reference
Street smarts of science for students
10.1038/ni.2989 · 2014 · External reference
The impact of substance use on mortality and morbidity from thermal injury
10.1097/00005373-199506000-00019 · 1995 · External reference
Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury
10.1097/bcr.0b013e31818481bc · 2008 · External reference
Implications of formal alcohol screening in burn patients
10.1097/bcr.0b013e3181921f31 · 2009 · External reference
Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysis
10.1097/bcr.0b013e3182644c58 · 2013 · External reference
Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function
10.1016/j.alcohol.2023.01.002 · 2023 · External reference
The systemic immune response to trauma: an overview of pathophysiology and treatment
10.1016/s0140-6736(14)60687-5 · 2014 · External reference
Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury
10.1097/bcr.0b013e3182223c9e · 2011 · External reference
Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury
10.1002/jlb.62.6.733 · 1997 · External reference
Acute ethanol exposure prior to thermal injury results in decreased T-cell responses mediated in part by increased production of IL-6
10.1097/00024382-199808000-00009 · 1998 · External reference
Ethanol exacerbates T cell dysfunction after thermal injury
10.1016/s0741-8329(00)00093-8 · 2000 · External reference
Glucocorticoids protect against suppression of t cell responses in a murine model of acute ethanol exposure and thermal injury by regulating IL-6
10.1002/jlb.64.6.724 · 1998 · External reference
Anti-interleukin-6 antibody treatment restores cell-mediated immune function in mice with acute ethanol exposure before burn trauma
10.1111/j.1530-0277.2000.tb02108.x · 2000 · External reference
Cellular immunity after ethanol exposure and burn injury: dose and time dependence
10.1016/s0741-8329(00)00100-2 · 2000 · External reference
Impaired respiratory function and heightened pulmonary inflammation in episodic binge ethanol intoxication and burn injury
10.1016/j.alcohol.2015.06.006 · 2015 · External reference
Unresolved reference
External reference
Elevation in pulmonary neutrophils and prolonged production of pulmonary macrophage inflammatory protein-2 after burn injury with prior alcohol exposure
10.1165/ajrcmb.20.6.3491 · 1999 · External reference
Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats
10.1152/ajplung.00408.2006 · 2007 · External reference
Ethanol intoxication prolongs post-burn pulmonary inflammation: role of alveolar macrophages
10.1189/jlb.3ma0316-111r · 2016 · External reference
Effects of multiday ethanol intoxication on postburn inflammation, lung function, and alveolar macrophage phenotype
10.1097/shk.0000000000001188 · 2019 · External reference
Decreased pulmonary inflammation after ethanol exposure and burn injury in intercellular adhesion molecule-1 knockout mice
10.1097/bcr.0b013e3181e4c58c · 2010 · External reference
Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling
10.1111/j.1530-0277.2010.01260.x · 2010 · External reference
Ethanol exacerbates pulmonary complications after burn injury in mice, regardless of frequency of ethanol exposures
10.1016/j.burns.2023.07.008 · 2023 · External reference
Post-burn lung inflammation is associated with induction of pulmonary cathelicidin-related antimicrobial peptide and s100a8 in mice
10.1093/jbcr/iraf069 · 2025 · External reference
Effects of ethanol on pulmonary inflammation in postburn intratracheal infection
10.1097/bcr.0b013e3181667599 · 2008 · External reference
An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice
10.1152/ajpgi.00185.2014 · 2014 · External reference
Kupffer cell p38 mitogen-activated protein kinase signaling drives postburn hepatic damage and pulmonary inflammation when alcohol intoxication precedes burn injury
10.1097/ccm.0000000000001817 · 2016 · External reference
Alcohol modulation of the postburn hepatic response
10.1097/bcr.0000000000000279 · 2017 · External reference
Recent alcohol intake impacts microbiota in adult burn patients
10.1016/j.alcohol.2024.04.003 · 2024 · External reference
Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation
10.1371/journal.pone.0129996 · 2015 · External reference
Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice
10.1016/j.alcohol.2022.08.011 · 2023 · External reference
The first line of defense: the effects of alcohol on post-burn intestinal barrier, immune cells, and microbiome
10.35946/arcr.v37.2.06 · 2015 · External reference
Interleukin-22 prevents microbial dysbiosis and promotes intestinal barrier regeneration following acute injury
10.1097/shk.0000000000000900 · 2017 · External reference
Ethanol exacerbates post-burn neuroinflammation and gut-brain barrier dysfunction which are associated with microbiome changes
10.1016/j.alcohol.2026.04.007 · 2026 · External reference
Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury
10.1152/ajpgi.00157.2012 · 2012 · External reference
Intestinal REG3G protects against gastrointestinal dysfunction in a murine model of ethanol intoxication and burn injury
10.1097/shk.0000000000002737 · 2026 · External reference
Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6
10.1016/j.alcohol.2013.01.004 · 2013 · External reference
Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury
10.1097/shk.0b013e318289d6c6 · 2013 · External reference
Estrogen restores cellular immunity in injured male mice via suppression of interleukin-6 production
10.1189/jlb.70.6.887 · 2001 · External reference
Interleukin-4 treatment restores cellular immunity after ethanol exposure and burn injury
10.1111/j.1530-0277.2002.tb02570.x · 2002 · External reference
Mesenchymal stem cell treatment attenuates liver and lung inflammation after ethanol intoxication and burn injury
10.1016/j.alcohol.2018.09.001 · 2019 · External reference
Inflamm-aging. An evolutionary perspective on immunosenescence
10.1111/j.1749-6632.2000.tb06651.x · 2000 · External reference
Aging and animal models of systemic insult: trauma, burn, and sepsis
10.1097/shk.0b013e318180f508 · 2009 · External reference
Survival and cell mediated immunity after burn injury in aged mice
10.1007/s11357-002-0001-4 · 2002 · External reference
Aging, traumatic injury, and estrogen treatment
10.1016/j.exger.2005.04.009 · 2005 · External reference
Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice
10.1016/s0305-4179(03)00070-6 · 2003 · External reference
Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes
10.1016/j.exger.2017.10.022 · 2018 · External reference
Aging and innate immune cells
10.1189/jlb.1103592 · 2004 · External reference
The aging innate immune system
10.1016/j.coi.2005.07.013 · 2005 · External reference
Innate immunity and aging
10.1016/j.exger.2008.05.016 · 2008 · External reference
Age-related differences in the neutrophil response to pulmonary Pseudomonas infection
10.1016/j.exger.2013.12.010 · 2014 · External reference
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
10.1189/jlb.0803389 · 2003 · External reference
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
10.1016/j.mad.2005.07.009 · 2005 · External reference
Interleukin-6 contributes to age-related alteration of cytokine production by macrophages
10.1155/2010/475139 · 2010 · External reference
Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
10.1097/01.ccm.0000251639.05135.e0 · 2007 · External reference
Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration
10.1097/shk.0b013e318180feb8 · 2009 · External reference
Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking
10.1152/ajplung.00385.2012 · 2013 · External reference
The aging lung
10.2147/cia.s51152 · 2013 · External reference
Advanced age negatively influences mesenteric lymph node T cell responses after burn injury
10.1016/s0165-2478(03)00022-1 · 2003 · External reference
Aging enhances lymphocyte cytokine defects after injury
10.1096/fj.02-0452fje · 2003 · External reference
Immunosuppression after injury in aged mice is associated with a TH1–TH2 shift, which can be restored by estrogen treatment
10.1016/j.mad.2003.11.007 · 2004 · External reference
Estrogen replacement, aging, and cell-mediated immunity after injury
10.1189/jlb.1103538 · 2004 · External reference
Aging and estrogen: modulation of inflammatory responses after injury
10.1016/j.exger.2006.11.013 · 2007 · External reference
Ethanol and burn injury: estrogen modulation of immunity
10.1016/j.alcohol.2004.05.005 · 2004 · External reference
Influence of alcohol and gender on immune response
2002 · External reference
Evidence of oxidative injury during aging of the liver in a mouse model
10.1007/s11357-001-0007-3 · 2001 · External reference
Aberrant acute-phase response in aged interleukin-6 knockout mice
10.1097/01.shk.000029553.39081.ec · 2006 · External reference
Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
10.1038/s42003-023-04964-2 · 2023 · External reference
Sirtuin expression in age-associated hepatic response to burn trauma: translational and clinical insights from a murine model
10.7759/cureus.82663 · 2025 · External reference
Burn-induced apoptosis in the livers of aged mice is associated with caspase cleavage of Bcl-xL
10.1016/j.jss.2023.04.020 · 2023 · External reference
Delayed hepatic response and impaired cytokine dynamics in aged mice following burn injury: implications for elderly patient care
10.1371/journal.pone.0316813 · 2025 · External reference
Burn-induced mitochondrial dysfunction in hepatocytes: the role of methylation-controlled J protein silencing
10.1097/ta.0000000000004537 · 2025 · External reference
Advanced age exacerbates intestinal epithelial permeability after burn injury in mice
10.1016/j.exger.2021.111654 · 2022 · External reference
Aging, cutaneous burn injury and multi-organ complications: the role of the gut
10.20900/agmr20220004 · 2022 · External reference
Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice
10.1152/ajpgi.00176.2025 · 2026 · External reference
Advanced age impairs intestinal antimicrobial peptide response and worsens fecal microbiome dysbiosis following burn injury in mice
10.1097/shk.0000000000001321 · 2020 · External reference
Age and injury size influence the magnitude of fecal dysbiosis in adult burn patients
10.1093/jbcr/irac001 · 2022 · External reference
Age-related changes in intestinal immunity and the microbiome
10.1002/jlb.3ri0620-405rr · 2021 · External reference
Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome
10.1096/fj.202401020r · 2024 · External reference
Advanced age worsens respiratory function and pulmonary inflammation after burn injury and this correlates with changes in the fecal microbiome in mice
10.1093/jbcr/irae101 · 2025 · External reference
An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition
10.1189/jlb.1007672 · 2008 · External reference
Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary inflammation
10.1189/jlb.1007672 · 2012 · External reference
Age-related intestinal dysbiosis and enrichment of gut-specific bacteria in the lung are associated with increased susceptibility to Streptococcus pneumoniae infection in mice
10.3389/fragi.2022.859991 · 2022 · External reference
Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury
10.1002/jlb.3hi0620-399rr · 2022 · External reference
Innate immune responses in the ageing lung
10.1111/cei.12881 · 2017 · External reference
10.1007/978-3-319-99375-1_91
10.1007/978-3-319-99375-1_91 · 2019 · External reference
Threshold age and burn size associated with poor outcomes in the elderly after burn injury
10.1016/j.burns.2015.12.008 · 2016 · External reference
Chronic inflammation and cognitive frailty in older adults: a narrative review
10.1016/j.exger.2025.112875 · 2025 · External reference
Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice
10.1016/j.exger.2022.111975 · 2022 · External reference
Measurement of central nervous system-related biomarkers in plasma of burn patients
10.1097/shk.0000000000002747 · 2026 · External reference
Remote burn injury in aged mice induces colonic lymphoid aggregate expansion and dysbiosis of the fecal microbiome which correlates with neuroinflammation
10.1097/shk.0000000000002202 · 2023 · External reference
Aging and impairment of innate immunity
10.1159/000136358 · 2008 · External reference
Advanced age alters monocyte and macrophage responses
10.1089/ars.2016.6691 · 2016 · External reference
Alcohol and aging—an area of increasing concern
10.1016/j.alcohol.2022.07.005 · 2023 · External reference
Unresolved reference
1998 · External reference
Alcohol, aging, and innate immunity
10.1189/jlb.4ru1016-450r · 2017 · External reference
A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues
10.1111/acer.14979 · 2023 · External reference
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
10.1016/j.bbi.2023.12.034 · 2024 · External reference
Suppression of NF-κB/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation
10.1093/jleuko/qiaf024 · 2025 · External reference
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
10.1186/s12979-021-00247-8 · 2021 · External reference
Multi-omics analysis of alcohol effects on the liver in young and aged mice
10.1111/adb.13342 · 2023 · External reference