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References from Multiparameter flow cytometry of CSF identifies elevated CD8+ effector memory and TEMRA T-cells in immune-mediated neurologic disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
CSF and blood biomarkers in neuroinflammatory and neurodegenerative diseases: implications for treatment
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis
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Human T cell development, localization, and function throughout life
10.1016/j.immuni.2018.01.007 · 2018 · External reference
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10.1007/978-1-4939-9650-6_8 · 2019 · External reference
The who’s who of T-cell differentiation: human memory T-cell subsets
10.1002/eji.201343751 · 2013 · External reference
Generation and maintenance of immunological memory
10.1016/j.smim.2004.08.013 · 2004 · External reference
Autoimmune effector memory T cells: the bad and the good
10.1007/s12026-013-8448-1 · 2013 · External reference
Expanding role of T cells in human autoimmune diseases of the Central nervous system
10.3389/fimmu.2017.00652 · 2017 · External reference
The immunology of multiple sclerosis
10.1038/s41577-022-00718-z · 2022 · External reference
Immuno-pathogenesis of neuromyelitis optica and emerging therapies
10.1007/s00281-022-00941-9 · 2022 · External reference
MOG CNS autoimmunity and MOGAD
10.1212/nxi.0000000000200275 · 2024 · External reference
Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing–remitting multiple sclerosis compared to healthy controls
10.1016/j.jneuroim.2006.09.008 · 2007 · External reference
Increased peripheral inflammatory responses in myelin oligodendrocyte glycoprotein associated disease and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder
10.3389/fimmu.2022.1037812 · 2022 · External reference
Lymphocytes in autoimmune encephalitis: pathogenesis and therapeutic target
10.1016/j.nbd.2024.106632 · 2024 · External reference
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
10.2353/ajpath.2008.070690 · 2008 · External reference
Acute axonal injury in multiple sclerosis: correlation with demyelination and inflammation
10.1093/brain/123.6.1174 · 2000 · External reference
Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons
10.1126/scitranslmed.abl6157 · 2022 · External reference
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
10.1038/s41467-023-38703-2 · 2023 · External reference
Transcriptomic and clonal characterization of T cells in the human Central nervous system
10.1126/sciimmunol.abb8786 · 2020 · External reference
Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation
10.1016/j.xcrm.2024.101733 · 2025 · External reference
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with Central nervous system autoimmunity
10.1126/sciimmunol.adj9730 · 2024 · External reference
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
10.1016/s1474-4422(17)30470-2 · 2018 · External reference
Proposed diagnostic criteria and nosology of acute transverse myelitis
10.1212/wnl.59.4.499 · 2002 · External reference
A clinical approach to diagnosis of autoimmune encephalitis
10.1016/s1474-4422(15)00401-9 · 2016 · External reference
Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: international MOGAD panel proposed criteria
10.1016/s1474-4422(22)00431-8 · 2023 · External reference
Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria
10.1093/brain/awt285 · 2014 · External reference
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
10.1212/wnl.0000000000001729 · 2015 · External reference
Comprehensive phenotyping of T cells using flow cytometry
10.1002/cyto.a.23724 · 2019 · External reference
Comprehensive phenotyping of human peripheral blood B lymphocytes in pathological conditions
10.1002/cyto.a.24518 · 2022 · External reference
Central memory CD4+ T cells dominate the normal cerebrospinal fluid
10.1002/cyto.b.20542 · 2011 · External reference
Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
10.1002/ana.410190610 · 1986 · External reference
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
10.1093/brain/awf059 · 2002 · External reference
Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases
10.1007/s00415-013-7145-2 · 2014 · External reference
Resident memory-like CD8+ T cells are involved in chronic inflammatory and neurodegenerative diseases in the CNS
10.1212/nxi.0000000000200172 · 2024 · External reference
Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders
10.1016/j.ebiom.2025.106088 · 2026 · External reference
Spatial map of human T cell compartmentalization and maintenance over decades of life
10.1016/j.cell.2014.10.026 · 2014 · External reference
Helping the CD8+ T-cell response
10.1038/nri1413 · 2004 · External reference
CD8+ T cells in neurodegeneration: friend or foe?
10.1186/s13024-022-00563-7 · 2022 · External reference
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions
10.1093/brain/awaa117 · 2020 · External reference
Tissue-resident CD8 T cells in Central nervous system inflammatory diseases: present at the crime scene and …guilty
10.1016/j.coi.2022.102211 · 2022 · External reference
Evidence for resident memory T cells in Rasmussen encephalitis
10.3389/fimmu.2016.00064 · 2016 · External reference
Tissue-resident memory T cells populate the human brain
10.1038/s41467-018-07053-9 · 2018 · External reference
Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin
10.1073/pnas.1433000100 · 2003 · External reference
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
10.1016/j.it.2005.07.004 · 2005 · External reference
Human cerebrospinal fluid contains CD4+ memory T cells expressing gut- or skin-specific trafficking determinants: relevance for immunotherapy
10.1186/1471-2172-7-14 · 2006 · External reference
Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
10.1186/s12987-019-0165-2 · 2020 · External reference
ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro
1996 · External reference
Features of human CD3+CD20+ T cells
10.4049/jimmunol.1600089 · 2016 · External reference
CD20 positive CD8 T cells are a unique and transcriptionally-distinct subset of T cells with distinct transmigration properties
10.1038/s41598-021-00007-0 · 2021 · External reference
Robust T-Cell responses in anti-CD20-treated patients following COVID-19 vaccination: a prospective cohort study
10.1093/cid/ciab954 · 2022 · External reference
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy
10.1038/s41591-021-01507-2 · 2021 · External reference
The immunology of low-grade gliomas
10.3171/2021.11.focus21587 · 2022 · External reference
Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens
10.1038/s41598-019-51063-6 · 2019 · External reference
Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
10.1016/s1074-7613(03)00112-2 · 2003 · External reference
Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection
10.1038/s41590-020-0711-8 · 2020 · External reference
Adaptive immunology of Cryptococcus neoformans infections—an update
10.3389/fimmu.2023.1174967 · 2023 · External reference
