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References from Somatic PIK3CA and PTEN mutations with endothelial PI3K/AKT/mTOR activation in RAS-negative brain arteriovenous malformations. Local targets link to admitted publications; unresolved targets remain external evidence.
The molecular regulation of arteriovenous specification and maintenance
10.1002/dvdy.24252 · 2015 · External reference
Somatic activating KRAS mutations in arteriovenous malformations of the brain
10.1056/nejmoa1709449 · 2018 · External reference
Somatic mutations in intracranial arteriovenous malformations
10.1371/journal.pone.0226852 · 2019 · External reference
Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype
10.3171/2020.11.jns202031 · 2022 · External reference
Somatic activating PIK3CA mutations cause venous malformation
2015 · External reference
PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation
10.1002/ajmg.a.36836 · 2015 · External reference
Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice
10.1073/pnas.0802743105 · 2008 · External reference
The PI3K pathway in human disease
10.1016/j.cell.2017.07.029 · 2017 · External reference
RAS proteins and their regulators in human disease
10.1016/j.cell.2017.06.009 · 2017 · External reference
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
10.1038/nature03952 · 2005 · External reference
Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
10.1126/sciadv.ade8939 · 2023 · External reference
PI3K/AKT/mTOR pathway in angiogenesis
10.3389/fnmol.2011.00051 · 2011 · External reference
The functions and regulation of the PTEN tumour suppressor
10.1038/nrm3330 · 2012 · External reference
Are cavernous sinus hemangiomas and cavernous malformations different entities?
10.3171/foc.2006.21.1.7 · 2006 · External reference
Radiation-induced cavernous hemangiomas of the brain: a late effect predominantly in children
10.1002/cncr.10596 · 2002 · External reference