Research graph
References from Dual Notch-1 pathway regulation mitigates glial activation and preserves myelin integrity: neuroprotective and anticonvulsant actions of pentoxifylline in PTZ kindling model. Local targets link to admitted publications; unresolved targets remain external evidence.
Pentylenetetrazole-induced seizures are increased after kindling, exhibiting vitamin-responsive correlations to the post-seizures behavior, amino acids metabolism and key metabolic regulators in the rat brain
10.3390/ijms241512405 · 2023 · External reference
The role of glial cells in the pathophysiology of epilepsy
10.3390/cells14020094 · 2025 · External reference
A hypothesis for the role of axon demyelination in seizure generation
10.1111/epi.16824 · 2021 · External reference
Epilepsy and demyelination: towards a bidirectional relationship
10.1016/j.pneurobio.2024.102588 · 2024 · External reference
Maladaptive myelination promotes generalized epilepsy progression
10.1038/s41593-022-01052-2 · 2022 · External reference
Myelin damage of hippocampus and cerebral cortex in rat pentylenetetrazol model
10.1016/j.brainres.2011.01.011 · 2011 · External reference
Not(ch) just development: notch signalling in the adult brain
10.1038/nrn3024 · 2011 · External reference
Notch signaling activation promotes seizure activity in temporal lobe epilepsy
10.1007/s12035-013-8545-0 · 2014 · External reference
Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence
10.4103/1673-5374.130083 · 2014 · External reference
Notch signaling regulates microglial activation and inflammatory reactions in a rat model of temporal lobe epilepsy
10.1007/s11064-018-2544-5 · 2018 · External reference
Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
10.1038/s41467-019-12789-z · 2019 · External reference
Contactins in the central nervous system: role in health and disease
10.4103/1673-5374.244776 · 2019 · External reference
Discrepancies of notch 1 receptor during development of chronic seizures
10.1002/jcp.28056 · 2019 · External reference
Pentoxifylline neuroprotective effects are possibly related to its anti-inflammatory and TNF-alpha inhibitory properties, in the 6-OHDA model of Parkinson’s disease
10.1155/2015/108179 · 2015 · External reference
Effects of dexamethasone and pentoxifylline on mania-like and depression-like Behaviors in rats
10.3390/ph15091063 · 2022 · External reference
Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
10.1007/s00210-025-03845-1 · 2025 · External reference
Pentoxifylline, possibly by modulating expression of claudins in the hippocampus attenuates autistic-related behaviours in male mice subjected to maternal separation stress
10.1080/15622975.2026.2677901 · 2026 · External reference
Anticonvulsant effects of pentoxifylline on seizures induced by pentylenetetrazole and maximal electroshock in male mice: the role of the nitrergic pathway
10.1016/j.ibneur.2024.11.013 · 2024 · External reference
Pentoxifylline as adjuvant therapy in patients with generalized epilepsy treated with phenytoin: a randomized controlled study
10.1007/s12035-025-05214-8 · 2025 · External reference
Pentoxifylline inhibits angiogenesis via decreasing Dll4 and Notch1 expression in mouse proepicardial explant cultures
10.1016/j.ejphar.2018.03.015 · 2018 · External reference
Thymoquinone and pentoxifylline enhance the chemotherapeutic effect of cisplatin by targeting notch signaling pathway in mice
10.1016/j.lfs.2020.117299 · 2020 · External reference
Protective effects of pentoxifylline on lipopolysaccharide-induced white matter injury in a rat model of periventricular leukomalasia
10.3109/14767058.2013.798290 · 2013 · External reference
Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance
10.1186/s12974-022-02480-4 · 2022 · External reference
Carbamazepine attenuates astroglial L-glutamate release induced by pro-inflammatory cytokines via chronically activation of adenosine A2A receptor
10.3390/ijms20153727 · 2019 · External reference
Anti-inflammatory and antioxidant strategies in epilepsy: from molecular mechanisms to threshold management
10.3390/ijms27156606 · 2026 · External reference
Resatorvid as a promising neuroprotective agent in pentylenetetrazol-kindling rat model: suppressing neuroinflammation and enhancing cognitive and motor functions
10.1016/j.ejphar.2025.178160 · 2025 · External reference
Oridonin exerts anticonvulsant profile and neuroprotective activity in epileptic mice by inhibiting NLRP3-mediated pyroptosis
10.1016/j.intimp.2024.112247 · 2024 · External reference
Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols
10.1111/j.1528-1167.2007.01263.x · 2007 · External reference
Role of rho kinase inhibition in the protective effect of Fasudil and simvastatin against 3-Nitropropionic acid-induced striatal neurodegeneration and mitochondrial dysfunction in rats
10.1007/s12035-015-9303-2 · 2016 · External reference
Genetically epilepsy-prone rats display anxiety-like behaviors and neuropsychiatric comorbidities of epilepsy
10.3389/fneur.2018.00476 · 2018 · External reference
Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats
10.1007/s00213-012-2718-9 · 2012 · External reference
The tragedy of alzheimer’s disease: towards better management via resveratrol-loaded oral bilosomes
10.3390/pharmaceutics13101635 · 2021 · External reference
MitoQ alleviates hippocampal damage after cerebral ischemia: the potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation
10.1016/j.lfs.2023.121895 · 2023 · External reference
Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice
10.1016/j.brainresbull.2020.07.019 · 2020 · External reference
Pentylenetetrazole: a review
10.1016/j.neuint.2024.105841 · 2024 · External reference
Inhibition of NMDA receptors downregulates astrocytic AQP4 to suppress seizures
10.1007/s10571-020-00813-6 · 2020 · External reference
Astrocytes in the epileptic brain
10.1016/j.neuron.2008.04.002 · 2008 · External reference
Anticonvulsant effect of Stachydrine on pentylenetetrazole-induced kindling seizure mouse model via notch and NMDAR signaling pathways
10.1016/j.jep.2025.119975 · 2025 · External reference
Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats
10.1016/j.lfs.2021.119904 · 2021 · External reference
Astrocyte-derived endothelin-1 inhibits remyelination through notch activation
10.1016/j.neuron.2013.11.015 · 2014 · External reference
Neurovascular coupling dysfunction in encephalopathy: pathophysiological advances and clinical implications
10.3389/fneur.2025.1522485 · 2025 · External reference
Salidroside alleviates diabetic cognitive dysfunction via B3galt2/F3/contactin signaling pathway in mice
10.1016/j.neuroscience.2022.12.008 · 2023 · External reference
Role of the adhesion molecule F3/contactin in synaptic plasticity and memory
10.1016/j.mcn.2016.12.003 · 2017 · External reference
Age-related decline of F3/contactin in rat hippocampus
10.1016/s0304-3940(98)00179-7 · 1998 · External reference
F3/contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice
10.1002/hipo.22186 · 2013 · External reference
Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice
10.1016/j.neurobiolaging.2015.01.004 · 2015 · External reference
Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system
10.1073/pnas.1313769110 · 2014 · External reference
Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistry
10.1046/j.1365-2990.2000.00229.x · 2000 · External reference
In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy
10.1002/hbm.26212 · 2023 · External reference
Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model
10.1016/j.ejps.2016.09.016 · 2017 · External reference
Epileptic seizures and hippocampal damage after cuprizone-induced demyelination in C57BL/6 mice
10.1016/j.expneurol.2007.11.005 · 2008 · External reference
Signalling pathways that inhibit the capacity of precursor cells for myelin repair
10.3390/ijms14011031 · 2013 · External reference
Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors
10.1002/dvdy.10278 · 2003 · External reference
Kindling-induced learning deficiency and possible cellular and molecular involved mechanisms
10.1007/s10072-012-1142-6 · 2013 · External reference
SnRNA-seq interprets mechanisms by which three glial cell types influence myelin regeneration in adult drug-resistant epilepsy-related cognitive impairment
10.1007/s12035-025-05206-8 · 2025 · External reference
Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1β production
10.1016/j.nbd.2008.05.007 · 2008 · External reference
Astrocytes regulate angiogenesis through the Jagged1-mediated Notch1 pathway after status epilepticus
10.1007/s12035-015-9492-8 · 2016 · External reference
Astrocytes and microglia as major players of myelin production in Normal and pathological conditions
10.3389/fncel.2020.00079 · 2020 · External reference
The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system
10.1177/0271678x221137762 · 2023 · External reference
Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice
10.1038/s41467-022-28777-9 · 2022 · External reference
Astrocyte-neuron circuits in epilepsy
10.1016/j.nbd.2023.106058 · 2023 · External reference
