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References from The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiation in medicine: origins, risks and aspirations
10.5339/gcsp.2014.57 · 2014 · External reference
Unresolved reference
2011 · External reference
Health effects of radiation and other health problems in the aftermath of nuclear accidents, with an emphasis on Fukushima
10.1016/s0140-6736(15)61106-0 · 2015 · External reference
Epidemiological studies of atomic bomb radiation at the radiation effects research foundation
10.1080/09553002.2019.1569778 · 2019 · External reference
Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study
10.1136/bmj-2022-074520 · 2023 · External reference
A risk comparison between lifestyle, socioeconomic status, and radiation: a cohort study of cancer mortality among Japanese nuclear workers (J-EPISODE)
10.1097/hp.0000000000001525 · 2022 · External reference
Insights into radiation carcinogenesis based on dose-rate effects in tissue stem cells
10.1080/09553002.2023.2194398 · 2023 · External reference
Radiation carcinogenesis in mouse thymic lymphomas
10.1111/j.1349-7006.2006.00218.x · 2006 · External reference
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
2000 · External reference
Reexamining the role of tissue inflammation in radiation carcinogenesis: a hypothesis to explain an earlier onset of cancer
10.1080/09553002.2021.1955998 · 2021 · External reference
An examination of the dose rate effect in mice assuming that the carcinogenic effect of radiation is life shortening resulting from a tissue reaction
10.1080/09553002.2024.2442690 · 2025 · External reference
Nuclear DNA damage-triggered ATM-dependent AMPK activation regulates the mitochondrial radiation response
10.1080/09553002.2023.2295297 · 2024 · External reference
Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage
10.1038/s41598-025-04845-0 · 2025 · External reference
Differential collagen and fibronectin production by thy 1+ and thy 1- lung fibroblast subpopulations
10.1152/ajplung.1992.263.2.l283 · 1992 · External reference
Elastic fiber production in cardiovascular tissue-equivalents
10.1016/s0945-053x(03)00052-0 · 2003 · External reference
Impact of matrix stiffness on fibroblast function
10.1016/j.msec.2017.02.001 · 2017 · External reference
Growth factors and cytokines in wound healing
10.1111/j.1524-475x.2008.00410.x · 2008 · External reference
Fibroblasts and myofibroblasts in wound healing
10.2147/ccid.s50046 · 2014 · External reference
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
10.1038/s41580-024-00716-0 · 2024 · External reference
Long-term overproduction of collagen in radiation-induced fibrosis
10.2307/3577976 · 1991 · External reference
Immune-inflammatory functions of fibroblasts
10.1183/09031936.94.07122212 · 1994 · External reference
Fibroblasts as immune regulators in infection, inflammation and cancer
10.1038/s41577-021-00540-z · 2021 · External reference
Radiation-induced myofibroblasts promote tumor growth via mitochondrial ROS-activated TGFβ Signaling
10.1158/1541-7786.mcr-18-0321 · 2018 · External reference
The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment
10.3389/fimmu.2019.01835 · 2019 · External reference
Fibroblast heterogeneity and immunosuppressive environment in human breast cancer
10.1016/j.ccell.2018.01.011 · 2018 · External reference
Cytoplasmic DNA: sources, sensing, and role in aging and disease
10.1016/j.cell.2021.09.034 · 2021 · External reference
CpG methylation patterns of human mitochondrial DNA
10.1038/srep23421 · 2016 · External reference
Mitochondrial DNA stress primes the antiviral innate immune response
10.1038/nature14156 · 2015 · External reference
The role of DNA-PK in aging and energy metabolism
10.1111/febs.14410 · 2018 · External reference
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson’s disease
10.1038/s41467-021-23452-x · 2021 · External reference
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
10.1126/science.aao6047 · 2018 · External reference
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
10.1016/j.molcel.2022.01.008 · 2022 · External reference
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis
10.15252/embj.201899238 · 2018 · External reference
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
10.1126/science.aav4011 · 2019 · External reference
Cytosolic release of mitochondrial DNA and associated cGAS Signaling mediates radiation-induced hematopoietic injury of mice
10.3390/ijms24044020 · 2023 · External reference
Mitochondrial DNA release via the mitochondrial permeability transition pore activates the cGAS-STING pathway, exacerbating inflammation in acute Kawasaki disease
10.1186/s12964-024-01677-9 · 2024 · External reference
Release of mitochondrial DNA fragments from brain mitochondria of irradiated mice
10.1016/j.mito.2005.12.001 · 2006 · External reference
Molecular mechanisms of mtDNA-mediated inflammation
10.3390/cells10112898 · 2021 · External reference
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
10.1038/s41467-023-40680-5 · 2023 · External reference
Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases
10.3389/fimmu.2018.00832 · 2018 · External reference
The roles of mitochondrial damage-associated molecular patterns in diseases
10.1089/ars.2015.6407 · 2015 · External reference
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
10.1038/s41598-018-19216-1 · 2018 · External reference
Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet’s syndrome
10.15252/embj.2022112573 · 2023 · External reference
Causes and consequences of micronuclei
10.1016/j.ceb.2021.01.004 · 2021 · External reference
Altered nuclear envelope structure and proteasome function of micronuclei
10.1016/j.yexcr.2018.08.029 · 2018 · External reference
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
10.1126/science.adj7446 · 2024 · External reference
Micronucleus is not a potent inducer of the cGAS/STING pathway
10.26508/lsa.202302424 · 2024 · External reference
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING
10.1016/j.molcel.2024.04.017 · 2024 · External reference
Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen
2001 · External reference
Mitochondrial Signaling pathways associated with DNA damage responses
10.3390/ijms24076128 · 2023 · External reference
ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts
10.1080/15384101.2017.1387697 · 2017 · External reference
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
10.1073/pnas.94.2.514 · 1997 · External reference
Minimizing the damage: repair pathways keep mitochondrial DNA intact
10.1038/nrm3439 · 2012 · External reference
Mitochondrial DNA damage: prevalence, biological consequence, and emerging pathways
10.1021/acs.chemrestox.0c00083 · 2020 · External reference
Parkinson’s disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons
10.1016/s0002-9440(10)65396-5 · 1999 · External reference
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
10.1016/j.immuni.2012.01.009 · 2012 · External reference
Radiation-induced cell death and its mechanisms
10.1097/hp.0000000000001601 · 2022 · External reference
Low-dose non-targeted effects and mitochondrial control
10.3390/ijms241411460 · 2023 · External reference
Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections
10.1007/s00705-016-3130-2 · 2017 · External reference
Activation of the JAK-STAT pathway by reactive oxygen species
10.1152/ajpcell.1998.275.6.c1640 · 1998 · External reference
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation
10.1080/13510002.2021.1971363 · 2021 · External reference
Dose-dependent effects of radiation on mitochondrial morphology and clonogenic cell survival in human microvascular endothelial cells
10.3390/cells13010039 · 2024 · External reference
Molecular mechanisms and cellular functions of cGAS-STING signalling
10.1038/s41580-020-0244-x · 2020 · External reference
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
10.1038/s41392-021-00554-y · 2021 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
STING operation at the ER/Golgi Interface
10.3389/fimmu.2021.646304 · 2021 · External reference
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
10.1016/j.immuni.2008.09.003 · 2008 · External reference
The cGAS-STING Defense pathway and its counteraction by viruses
10.1016/j.chom.2016.01.010 · 2016 · External reference
Regulation of type I interferon responses
10.1038/nri3581 · 2014 · External reference
STING, DCs and the link between innate and adaptive tumor immunity
10.1016/j.molimm.2017.12.001 · 2019 · External reference
Antigen presentation and T cell stimulation by dendritic cells
10.1146/annurev.immunol.20.100301.064828 · 2002 · External reference
Inflammatory signaling in genomically instable cancers
10.1080/15384101.2019.1638192 · 2019 · External reference
Mechanisms regulating PD-L1 expression on tumor and immune cells
10.1186/s40425-019-0770-2 · 2019 · External reference
Microprinted feeder cells guide embryonic stem cell fate
10.1002/bit.23190 · 2011 · External reference
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity
10.1016/s0896-6273(00)00083-0 · 2000 · External reference
Radiation, inflammation, and immune responses in cancer
10.3389/fonc.2012.00058 · 2012 · External reference
Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications
10.1080/09553002.2018.1440092 · 2018 · External reference
Inflammation in wound repair: molecular and cellular mechanisms
10.1038/sj.jid.5700701 · 2007 · External reference
Nonresolving inflammation
10.1016/j.cell.2010.02.029 · 2010 · External reference
The immunological consequences of radiation-induced DNA damage
10.1002/path.5232 · 2019 · External reference
DNA damage and activation of cGAS/STING pathway induce tumor microenvironment remodeling
10.3389/fcell.2021.828657 · 2021 · External reference
Hydrogen peroxide as second messenger in lymphocyte activation
10.1038/ni1202-1129 · 2002 · External reference
Cytokines. 1. Overview
10.1136/thx.48.6.660 · 1993 · External reference
The role of inflammatory cytokines in the pathogenesis of colorectal carcinoma-recent findings and review
10.3390/biomedicines10071670 · 2022 · External reference
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
10.1038/nrclinonc.2018.8 · 2018 · External reference
Chronic inflammation and cytokines in the tumor microenvironment
10.1155/2014/149185 · 2014 · External reference
IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation
10.4049/jimmunol.1102048 · 2011 · External reference
The interleukin-8 pathway in cancer
10.1158/1078-0432.ccr-07-4843 · 2008 · External reference
Radiation-induced fibrosis: mechanisms and implications for therapy
10.1007/s00432-015-1974-6 · 2015 · External reference
Why does chronic inflammation persist: an unexpected role for fibroblasts
10.1016/j.imlet.2011.02.010 · 2011 · External reference
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
10.1016/s1471-4906(01)01863-4 · 2001 · External reference
Stromal fibroblasts in cancer: a novel tumor-promoting cell type
10.4161/cc.5.15.3112 · 2006 · External reference