Research graph
References from No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk. Local targets link to admitted publications; unresolved targets remain external evidence.
The changing tide of human fertility
10.1093/humrep/deac011 · 2022 · External reference
Cancer across the tree of life: cooperation and cheating in multicellularity
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Modern reproductive patterns associated with estrogen receptor positive but not negative breast cancer susceptibility
10.1093/emph/eou028 · 2015 · External reference
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10.1111/eva.12034 · 2013 · External reference
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
10.1038/ng.3698 · 2016 · External reference
Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer registry
10.1002/cncr.22618 · 2007 · External reference
Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring
10.1038/s43587-024-00733-w · 2024 · External reference
Reduced signal for polygenic adaptation of height in UK Biobank
10.7554/elife.39725 · 2019 · External reference
Approximately independent linkage disequilibrium blocks in human populations
10.1093/bioinformatics/btv546 · 2016 · External reference
Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk
10.3389/fevo.2023.912083 · 2023 · External reference
Cancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defences
10.1098/rstb.2014.0220 · 2015 · External reference
Cross-trait assortative mating is widespread and inflates genetic correlation estimates
10.1126/science.abo2059 · 2022 · External reference
An atlas of genetic correlations across human diseases and traits
10.1038/ng.3406 · 2015 · External reference
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
10.1038/ng.3211 · 2015 · External reference
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
10.1371/journal.pgen.1006328 · 2017 · External reference
Colloquium papers: natural selection in a contemporary human population
10.1073/pnas.0906199106 · 2010 · External reference
Antagonistic pleiotropy in human disease
10.1007/s00239-019-09923-2 · 2020 · External reference
Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive
10.1155/2007/971816 · 2007 · External reference
Unresolved reference
1980 · External reference
The human breast and the ancestral reproductive cycle: a preliminary inquiry into breast cancer etiology
10.1007/bf02734139 · 1995 · External reference
Risk factors for breast cancer according to estrogen and progesterone receptor status
10.1093/jnci/djh025 · 2004 · External reference
The transition to modernity and chronic disease: mismatch and natural selection
10.1038/s41576-018-0012-3 · 2018 · External reference
Positive selection in the evolution of cancer
10.1017/s1464793106007056 · 2006 · External reference
Estrogen receptor subtypes dictate the proliferative nature of the mammary gland
10.1530/joe-17-0582 · 2018 · External reference
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
10.1038/ng.3841 · 2017 · External reference
Locus- and gene-level insights into the inverse association between Alzheimer's disease and cancer
10.3390/ijms27062900 · 2026 · External reference
Modern dietary pattern is prospectively associated with earlier age at menarche: data from the CHNS 1997–2015
10.1186/s12937-020-00622-z · 2020 · External reference
Cancer susceptibility as a cost of reproduction and contributor to life history evolution
10.3389/fevo.2022.861103 · 2022 · External reference
Women's reproductive cancers in evolutionary context
10.1086/418650 · 1994 · External reference
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
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10.5962/bhl.title.27468
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Unresolved reference
2021 · External reference
PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer
2000 · External reference
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
10.1371/journal.pgen.1004383 · 2014 · External reference
Height and cancer incidence in the million women study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk
10.1016/s1470-2045(11)70154-1 · 2011 · External reference
Dates and times made easy with lubridate
10.18637/jss.v040.i03 · 2011 · External reference
Unresolved reference
1941 · External reference
The measurement of natural selection
10.4324/9781315768694-14 · 1954 · External reference
New role of fat-free mass in cancer risk linked with genetic predisposition
10.1038/s41598-024-54291-7 · 2024 · External reference
Is estrogen receptor negative breast cancer risk associated with a fast life history strategy?
10.1093/emph/eov034 · 2016 · External reference
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
10.1038/s41588-022-01062-7 · 2022 · External reference
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
10.1038/ng.2354 · 2012 · External reference
Unresolved reference
2012 · External reference
Cancer: a disease at the crossroads of trade-offs
10.1111/eva.12444 · 2017 · External reference
Human reproduction and health: an evolutionary perspective
10.1016/s0140-6736(17)30573-1 · 2017 · External reference
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
10.1038/s41588-024-01736-4 · 2024 · External reference
Shared heritability and functional enrichment across six solid cancers
10.1038/s41467-018-08054-4 · 2019 · External reference
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans
10.1073/pnas.0904280106 · 2009 · External reference
Life history traits and cancer prevalence in birds
10.1093/emph/eoae011 · 2024 · External reference
Epidemiology and prevention of breast cancer
10.1146/annurev.pu.17.050196.000403 · 1996 · External reference
Reproductive factors and breast cancer
10.1093/oxfordjournals.epirev.a036115 · 1993 · External reference
Leveraging polygenic functional enrichment to improve GWAS power
10.1016/j.ajhg.2018.11.008 · 2019 · External reference
Demographic transition theory
10.1080/0032472031000149536 · 1996 · External reference
The nature of nurture: effects of parental genotypes
10.1126/science.aan6877 · 2018 · External reference
The measurement of selection on correlated characters
10.1111/j.1558-5646.1983.tb00236.x · 1983 · External reference
Applying an evolutionary mismatch framework to understand disease susceptibility
10.1371/journal.pbio.3002311 · 2023 · External reference
Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood
10.1093/bioinformatics/bts474 · 2012 · External reference
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystatin-c activation of TREM2
10.1016/j.cell.2025.12.020 · 2026 · External reference
Mixed-model association for biobank-scale datasets
10.1038/s41588-018-0144-6 · 2018 · External reference
Evidence for the role of selection for reproductively advantageous alleles in human aging
10.1126/sciadv.adh4990 · 2023 · External reference
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
10.1038/s41562-023-01528-6 · 2023 · External reference
Unresolved reference
External reference
Cancer as an evolutionary and ecological process
10.1038/nrc2013 · 2006 · External reference
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
10.1038/ng.2563 · 2013 · External reference
Association analysis identifies 65 new breast cancer risk loci
10.1038/nature24284 · 2017 · External reference
A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
10.1186/s13058-023-01691-8 · 2023 · External reference
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
10.1038/s41562-021-01135-3 · 2021 · External reference
The GWAS diversity monitor tracks diversity by disease in real time
10.1038/s41588-020-0580-y · 2020 · External reference
Epidemiological characteristics of and risk factors for breast cancer in the world
10.2147/bctt.s176070 · 2019 · External reference
Ten questions for evolutionary studies of disease vulnerability
10.1111/j.1752-4571.2010.00181.x · 2011 · External reference
Unresolved reference
2019 · External reference
Nutrient intake through childhood and early menarche onset in girls: systematic review and meta-analysis
10.3390/nu12092544 · 2020 · External reference
The real war on cancer: the evolutionary dynamics of cancer suppression
10.1111/eva.12018 · 2013 · External reference
Size matters: height, cell number and a person's risk of cancer
10.1098/rspb.2018.1743 · 2018 · External reference
The effect of body size and inbreeding on cancer mortality in breeds of the domestic dog: a test of the multi-stage model of carcinogenesis
10.1098/rsos.231356 · 2024 · External reference
Association between Alzheimer disease and cancer with evaluation of study biases: a systematic review and meta-analysis
10.1001/jamanetworkopen.2020.25515 · 2020 · External reference
The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration
10.1210/er.2002-0019 · 2003 · External reference
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
10.1038/nature13545 · 2014 · External reference
Molecular insights into the aetiology of female reproductive ageing
10.1038/nrendo.2015.167 · 2015 · External reference
10.1101/2024.02.02.24301815
10.1101/2024.02.02.24301815 · External reference
Living fast and dying young: a comparative analysis of life-history variation among mammals
10.1111/j.1469-7998.1990.tb04316.x · 1990 · External reference
Unresolved reference
2023 · External reference
Menarche when and why?
10.1016/0140-6736(93)92746-g · 1993 · External reference
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
10.18632/aging.205745 · 2024 · External reference
A mathematical model of the culling process in dairy cattle
10.1017/s0003356100037752 · 1966 · External reference
Antagonistic pleiotropy and mutation accumulation influence human senescence and disease
10.1038/s41559-016-0055 · 2017 · External reference
Unresolved reference
1992 · External reference
Cohort profile: LifeLines, a three-generation cohort study and biobank
10.1093/ije/dyu229 · 2015 · External reference
Mechanisms of cancer resistance in long-lived mammals
10.1038/s41568-018-0004-9 · 2018 · External reference
Local genetic correlation gives insights into the shared genetic architecture of complex traits
10.1016/j.ajhg.2017.09.022 · 2017 · External reference
The evolution of human reproduction
10.1098/rspb.1976.0095 · 1976 · External reference
Effects of BRCA1 and BRCA2 mutations on female fertility
10.1098/rspb.2011.1697 · 2012 · External reference
Distinct genetic architecture in the tails of complex traits
10.1038/s41586-026-10516-5 · 2026 · External reference
The evolution of life history traits: a critique of the theory and a review of the data
10.1146/annurev.es.08.110177.001045 · 1977 · External reference
Unresolved reference
1992 · External reference
The importance of regulatory network structure for complex trait heritability and evolution
10.1093/molbev/msaf174 · 2025 · External reference
Menstrual cycling and breast cancer: an evolutionary perspective
10.1089/jwh.1999.8.193 · 1999 · External reference
The androgen receptor and prostate cancer: a role for sexual selection and sexual conflict?
10.1016/j.mehy.2007.04.044 · 2008 · External reference
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21660 · 2021 · External reference
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A map of human genome variation from population-scale sequencing
10.1038/nature09534 · 2010 · External reference
Whole-genome sequence variation, population structure and demographic history of the Dutch population
10.1038/ng.3021 · 2014 · External reference
The evolution of human cancer gene duplications across mammals
10.1093/molbev/msaa125 · 2020 · External reference
Human fertility, molecular genetics, and natural selection in modern societies
10.1371/journal.pone.0126821 · 2015 · External reference
Apolipoprotein-ε4 is associated with higher fecundity in a natural fertility population
10.1126/sciadv.ade9797 · 2023 · External reference
Genetic correlations of polygenic disease traits: from theory to practice
10.1038/s41576-019-0137-z · 2019 · External reference
Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra
10.7554/elife.82558 · 2022 · External reference
Statistical power to detect genetic (co)variance of Complex traits using SNP data in unrelated samples
10.1371/journal.pgen.1004269 · 2014 · External reference
Genetic links between post-reproductive lifespan and family size in Framingham
10.1093/emph/eot013 · 2013 · External reference
Welcome to the tidyverse
10.21105/joss.01686 · 2019 · External reference
Pleiotropy, natural selection, and the evolution of senescence
10.1111/j.1558-5646.1957.tb02911.x · 1957 · External reference
Using human genetics to understand the phenotypic association between chronotype and breast cancer
10.1111/jsr.13973 · 2024 · External reference
Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: evidence for antagonistic pleiotropy in humans
10.7554/elife.102447 · 2025 · External reference
Common SNPs explain a large proportion of the heritability for human height
10.1038/ng.608 · 2010 · External reference
GCTA: a tool for genome-wide complex trait analysis
10.1016/j.ajhg.2010.11.011 · 2011 · External reference
Advantages and pitfalls in the application of mixed-model association methods
10.1038/ng.2876 · 2014 · External reference
The shape of age–incidence curves of female breast cancer by hormone-receptor status
10.1023/a:1008970121595 · 1999 · External reference
Decreasing birth rate determining worldwide incidence and regional variation of female breast cancer
10.4236/abcr.2018.71001 · 2018 · External reference
Mendelian imputation of parental genotypes improves estimates of direct genetic effects
10.1038/s41588-022-01085-0 · 2022 · External reference
Genome-wide association studies have problems due to confounding: are family-based designs the answer?
10.1371/journal.pbio.3002568 · 2024 · External reference
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
10.1038/s41588-020-0609-2 · 2020 · External reference
Relationship between age at menarche and breast cancer in individuals, as well as in first-degree kin and estrogen receptor status: a Mendelian randomization study
10.3389/fonc.2024.1408132 · 2024 · External reference
