Research graph
References from Hippo signaling regulates spontaneous human trophoblast syncytialization in three-dimensional cultures. Local targets link to admitted publications; unresolved targets remain external evidence.
Novel 3D human trophoblast culture to explore T. cruzi infection in the placenta
10.3389/fcimb.2024.1433424 · 2024 · External reference
Spatial multiomics map of trophoblast development in early pregnancy
10.1038/s41586-023-05869-0 · 2023 · External reference
Gene Ontology: tool for the unification of biology
10.1038/75556 · 2000 · External reference
YAP1 increases organ size and expands undifferentiated progenitor cells
10.1016/j.cub.2007.10.039 · 2007 · External reference
Induction of human trophoblast stem cells from somatic cells and pluripotent stem cells
10.1016/j.celrep.2020.108419 · 2020 · External reference
Elucidation of a universal size-control mechanism in Drosophila and mammals
10.1016/j.cell.2007.07.019 · 2007 · External reference
Nuclear matrix association: switching to the invasive cytotrophoblast
10.1016/j.placenta.2010.02.012 · 2010 · External reference
Role of YAP/TAZ in mechanotransduction
10.1038/nature10137 · 2011 · External reference
Morphological differentiation of human choriocarcinoma cells induced by methotrexate
1979 · External reference
A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals
10.1242/dev.201112 · 2023 · External reference
Establishment and characterization of first trimester human trophoblast cells with extended lifespan
10.1006/excr.1993.1139 · 1993 · External reference
Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta
10.1073/pnas.2120667119 · 2022 · External reference
Self-renewing trophoblast organoids recapitulate the developmental program of the early human placenta
10.1016/j.stemcr.2018.07.004 · 2018 · External reference
Decorin production by the human decidua: role in decidual cell maturation
10.1093/molehr/gaaa058 · 2020 · External reference
Trophoblast stem cell-based organoid models of the human placental barrier
10.1038/s41467-024-45279-y · 2024 · External reference
Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors
10.1210/en.2008-0780 · 2008 · External reference
Capturing human trophoblast development with naive pluripotent stem cells in vitro
10.1016/j.stem.2021.03.013 · 2021 · External reference
The multifaceted role of GCM1 during trophoblast differentiation in the human placenta
10.1073/pnas.2203071119 · 2022 · External reference
KEGG: Kyoto Encyclopedia of Genes and Genomes
10.1093/nar/28.1.27 · 2000 · External reference
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens
10.1016/j.stem.2022.04.004 · 2022 · External reference
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues
10.1038/s41467-021-23395-3 · 2021 · External reference
Organoids: modeling development and the stem cell niche in a dish
10.1016/j.devcel.2016.08.014 · 2016 · External reference
Mechanisms in decorin regulation of vascular endothelial growth factor-induced human trophoblast migration and acquisition of endothelial phenotype
10.1095/biolreprod.111.097881 · 2012 · External reference
Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: the role of decorin
10.1080/19336918.2015.1106669 · 2016 · External reference
Transcriptomic comparison of in vitro models of the human placenta
10.1016/j.placenta.2024.11.007 · 2025 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential
10.1002/mco2.375 · 2023 · External reference
Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta
10.1073/pnas.2002630117 · 2020 · External reference
Inhibition of YAP/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast
10.1093/molehr/gaac032 · 2022 · External reference
Human trophoblast stem cell self-renewal and differentiation: role of decorin
10.1038/s41598-018-27119-4 · 2018 · External reference
The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation
10.3389/fphys.2018.01091 · 2018 · External reference
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
10.1016/j.mod.2007.11.002 · 2008 · External reference
Derivation of human trophoblast stem cells
10.1016/j.stem.2017.11.004 · 2018 · External reference
The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro
1968 · External reference
Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast
10.2353/ajpath.2006.050686 · 2006 · External reference
LATS1 controls CTCF chromatin occupancy and hormonal response of 3D-grown breast cancer cells
10.1038/s44318-024-00080-x · 2024 · External reference
Hippo signaling cofactor, WWTR1, at the crossroads of human trophoblast progenitor self-renewal and differentiation
10.1073/pnas.2204069119 · 2022 · External reference
Current topic: pre-eclampsia and the placenta
10.1016/0143-4004(91)90339-h · 1991 · External reference
How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation
10.1007/s00018-022-04475-z · 2022 · External reference
TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: an implication in early human pregnancy loss
10.1073/pnas.2002449117 · 2020 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
The immunology of syncytialized trophoblast
10.3390/ijms22041767 · 2021 · External reference
Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
10.1242/dev.199840 · 2022 · External reference
Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms
10.1016/j.devcel.2024.01.023 · 2024 · External reference
Characterization of primary models of human trophoblast
10.1242/dev.199749 · 2021 · External reference
Role of Hippo signaling pathway in early placental development
10.1073/pnas.2013559117 · 2020 · External reference
SRplot: a free online platform for data visualization and graphing
10.1371/journal.pone.0294236 · 2023 · External reference
Trophoblast organoids as a model for maternal–fetal interactions during human placentation
10.1038/s41586-018-0753-3 · 2018 · External reference
Development of the human placenta
10.1242/dev.163428 · 2019 · External reference
Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape
10.1038/s41467-023-40424-5 · 2023 · External reference
Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids
10.1038/s41467-023-41158-0 · 2023 · External reference
Trophoblast organoids with physiological polarity model placental structure and function
10.1242/jcs.261528 · 2024 · External reference
Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface
10.7554/elife.79794 · 2022 · External reference
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
10.1016/j.stem.2023.08.002 · 2023 · External reference
Development of apical out trophoblast stem cell derived organoids to model early human pregnancy
10.1016/j.isci.2025.112099 · 2025 · External reference
