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References from N 6-methyladenosine promotes temozolomide resistance through mRNA stabilization in glioblastoma cells. Local targets link to admitted publications; unresolved targets remain external evidence.
RNA modifications in physiology and disease: towards clinical applications
10.1038/s41576-023-00645-2 · 2024 · External reference
The chemical diversity of RNA modifications
10.1042/bcj20180445 · 2019 · External reference
mRNA regulation by RNA modifications
10.1146/annurev-biochem-052521-035949 · 2023 · External reference
Hidden codes in mRNA: control of gene expression by m6A
10.1016/j.molcel.2022.05.029 · 2022 · External reference
Rethinking m6A readers, writers, and erasers
10.1146/annurev-cellbio-100616-060758 · 2017 · External reference
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
10.1038/nature11112 · 2012 · External reference
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
10.1038/nchembio.1432 · 2014 · External reference
A majority of m6A residues are in the last exons, allowing the potential for 3’ UTR regulation
10.1101/gad.269415.115 · 2015 · External reference
Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons
10.1016/j.cell.2012.05.003 · 2012 · External reference
The proteins of mRNA modification: writers, readers, and erasers
10.1146/annurev-biochem-052521-035330 · 2023 · External reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · 2013 · External reference
N6-methyladenosine-dependent regulation of messenger RNA stability
10.1038/nature12730 · 2014 · External reference
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex
10.1038/ncomms12626 · 2016 · External reference
YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs
10.7554/elife.31311 · 2017 · External reference
A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA
10.1016/j.cell.2020.05.012 · 2020 · External reference
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
10.1038/s41556-018-0045-z · 2018 · External reference
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
10.1101/gad.301036.117 · 2017 · External reference
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
10.1038/nchembio.687 · 2011 · External reference
RNA modifications modulate gene expression during development
10.1126/science.aau1646 · 2018 · External reference
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
10.1038/nature21355 · 2017 · External reference
The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence
10.1016/j.molcel.2017.08.003 · 2017 · External reference
Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation
10.1126/science.1261417 · 2015 · External reference
m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
10.1016/j.stem.2014.09.019 · 2014 · External reference
FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase
10.1016/j.ccell.2016.11.017 · 2017 · External reference
R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling
10.1016/j.cell.2017.11.031 · 2018 · External reference
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
10.1158/2159-8290.cd-20-0331 · 2021 · External reference
RNA m6A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/wnt/β-catenin signaling
10.1038/s41419-021-03763-z · 2021 · External reference
tRNA modifications tune m6A-dependent mRNA decay
10.1016/j.cell.2025.04.013 · 2025 · External reference
m6A alters ribosome dynamics to initiate mRNA degradation
10.1016/j.cell.2025.04.020 · 2025 · External reference
m6A sites in the coding region trigger translation-dependent mRNA decay
10.1016/j.molcel.2024.10.033 · 2024 · External reference
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
10.1038/nature14234 · 2015 · External reference
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification
10.1021/ja513080v · 2015 · External reference
m6A RNA methylation: from mechanisms to therapeutic potential
10.15252/embj.2020105977 · 2021 · External reference
Role of RNA modifications in cancer
10.1038/s41568-020-0253-2 · 2020 · External reference
Insights into the regulatory role of m6A epitranscriptome in glioblastoma
10.3390/ijms21082816 · 2020 · External reference
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
10.1038/s41586-021-03536-w · 2021 · External reference
Phase 1 dose escalation and cohort expansion study evaluating safety, PK, PD and clinical activity of STC-15, a METTL-3 inhibitor, in patients with advanced malignancies
10.1200/jco.2024.42.16_suppl.2586 · 2024 · External reference
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3
10.1002/cac2.12509 · 2024 · External reference
METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
10.1186/s13046-023-02638-9 · 2023 · External reference
METTL3 inhibitor STM2457 impairs tumor progression and enhances sensitivity to anlotinib in oscc
10.1111/odi.14864 · 2024 · External reference
METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4
10.1038/s41375-022-01696-w · 2022 · External reference
A view on drug resistance in cancer
10.1038/s41586-019-1730-1 · 2019 · External reference
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
10.1093/neuonc/noaa106 · 2020 · External reference
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
MGMT gene silencing and benefit from temozolomide in glioblastoma
10.1056/nejmoa043331 · 2005 · External reference
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
10.1056/nejm200011093431901 · 2000 · External reference
Phase II trial of temozolomide plus O6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma
10.1200/jco.2008.18.8417 · 2009 · External reference
m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells
10.1016/j.celrep.2017.02.059 · 2017 · External reference
METTL3 knockdown promotes temozolomide sensitivity of glioma stem cells via decreasing MGMT and APNG mRNA stability
10.1038/s41420-023-01327-y · 2023 · External reference
BAP1 links metabolic regulation of ferroptosis to tumour suppression
10.1038/s41556-018-0178-0 · 2018 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Salmon provides fast and bias-aware quantification of transcript expression
10.1038/nmeth.4197 · 2017 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
ShinyGO: a graphical gene-set enrichment tool for animals and plants
10.1093/bioinformatics/btz931 · 2020 · External reference
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
10.1186/1471-2105-14-128 · 2013 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
Gene set knowledge discovery with Enrichr
10.1002/cpz1.90 · 2021 · External reference
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)
10.1038/nmeth.3810 · 2016 · External reference
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
10.1101/gr.209601.116 · 2017 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
10.1038/nsmb.1545 · 2009 · External reference
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges
10.1038/nsmb.2699 · 2013 · External reference
PureCLIP: capturing target-specific protein–RNA interaction footprints from single-nucleotide CLIP-seq data
10.1186/s13059-017-1364-2 · 2017 · External reference
STREME: accurate and versatile sequence motif discovery
10.1093/bioinformatics/btab203 · 2021 · External reference
A user guide to RT-based mapping of RNA modifications
10.1016/bs.mie.2024.07.006 · 2024 · External reference
Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation
10.1016/j.molcel.2021.11.003 · 2021 · External reference
Next-generation characterization of the Cancer Cell Line Encyclopedia
10.1038/s41586-019-1186-3 · 2019 · External reference
Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review
10.20517/cdr.2020.79 · 2021 · External reference
Glioma actively orchestrate a self-advantageous extracellular matrix to promote recurrence and progression
10.1186/s12885-024-12751-3 · 2024 · External reference
Extracellular matrix in glioblastoma: opportunities for emerging therapeutic approaches
2021 · External reference
Comparative Toxicogenomics Database’s 20th anniversary: update 2025
10.1093/nar/gkae883 · 2025 · External reference
MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges
10.1093/neuonc/noy132 · 2019 · External reference
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
10.1093/nar/gkz619 · 2019 · External reference
N(6-)methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
10.1038/s41589-018-0184-3 · 2019 · External reference
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA
10.1093/nar/gkz1147 · 2020 · External reference
The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
10.1016/j.jbc.2022.101590 · 2022 · External reference
Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation
10.1016/j.celrep.2024.114165 · 2024 · External reference
N6-Methyladenosine modification activates the serine synthesis pathway to mediate therapeutic resistance in liver cancer
10.1016/j.ymthe.2024.10.025 · 2024 · External reference
Identification of m6A residues at single-nucleotide resolution using eCLIP and an accessible custom analysis pipeline
10.1261/rna.078543.120 · 2021 · External reference
Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq
10.1038/s41596-022-00680-z · 2022 · External reference
RBPmap: a web server for mapping binding sites of RNA-binding proteins
10.1093/nar/gku406 · 2014 · External reference
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
10.1038/nature07385 · 2008 · External reference
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1α from pVHL-independent degradation
10.1074/jbc.m310164200 · 2004 · External reference
Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells
10.1186/s10020-019-0116-z · 2019 · External reference
IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma
10.1007/s12094-019-02251-3 · 2020 · External reference
TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway
10.1038/onc.2013.593 · 2015 · External reference
Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis
10.1172/jci175703 · 2024 · External reference
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms
10.1016/j.celrep.2025.115484 · 2025 · External reference
METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma
10.1038/s44318-024-00299-8 · 2024 · External reference
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation
10.1016/j.molcel.2020.06.017 · 2020 · External reference
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
10.1038/s41556-023-01213-w · 2023 · External reference
The SMAD2/3 interactome reveals that tgfβ controls m6A mRNA methylation in pluripotency
10.1038/nature25784 · 2018 · External reference
Posttranslational regulation of O6-methylguanine–DNA methyltransferase (MGMT) and new opportunities for treatment of brain cancers
10.2174/1389557515666150722101046 · 2016 · External reference
Regulatory mechanisms of O6-methylguanine methyltransferase expression in glioma cells
10.1177/00368504251345014 · 2025 · External reference
The changes in MGMT promoter methylation status in initial and recurrent glioblastomas
10.1593/tlo.12253 · 2012 · External reference
Changes of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation in glioblastoma relapse—A meta-analysis type literature review
10.3390/cancers11121837 · 2019 · External reference
Phase I trial of Temozolomide plus O6 -benzylguanine for patients with recurrent or progressive malignant glioma
10.1200/jco.2005.06.502 · 2005 · External reference
Enhancing temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)
10.1007/s11060-024-04708-0 · 2024 · External reference
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
10.1038/nature08617 · 2009 · External reference
Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
10.1016/j.celrep.2025.115611 · 2025 · External reference
Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma
10.1093/narcan/zcae004 · 2024 · External reference