Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from MAPK-driven glioma progression and reprogramming of the tumor-associated immune response. Local targets link to admitted publications; unresolved targets remain external evidence.
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets
10.1038/s43018-022-00475-x · 2022 · External reference
The role of microglia and macrophages in glioma maintenance and progression
10.1038/nn.4185 · 2016 · External reference
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective
10.1016/j.cell.2023.12.013 · 2024 · External reference
Molecular, pathological, radiological, and immune profiling of non-brainstem pediatric high-grade glioma from the HERBY phase II randomized trial
10.1016/j.ccell.2018.04.004 · 2018 · External reference
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
10.1016/j.ccell.2017.06.003 · 2017 · External reference
Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
10.1371/journal.pone.0043339 · 2012 · External reference
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations
10.1016/j.immuni.2024.09.007 · 2024 · External reference
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
10.1172/jci90644 · 2017 · External reference
Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma
10.1016/j.ccell.2017.08.017 · 2017 · External reference
CXCL14 promotes a robust brain tumor-associated immune response in glioma
10.1158/1078-0432.ccr-21-2830 · 2022 · External reference
Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas
10.1172/jci151239 · 2022 · External reference
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
10.1126/scitranslmed.aaa0984 · 2017 · External reference
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
10.1038/s41591-019-0349-y · 2019 · External reference
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma
10.1038/s43018-021-00260-2 · 2021 · External reference
Glioma-intrinsic MAPK/ERK signaling promotes immunotherapy efficacy through T cell infiltration and interferon responses.
10.1038/s41467-026-74124-7 · External reference
Pleomorphic xanthoastrocytoma: natural history and long-term follow-up
10.1111/bpa.12217 · 2015 · External reference
The genetic landscape of anaplastic pleomorphic xanthoastrocytoma
10.1111/bpa.12639 · 2019 · External reference
Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation
10.1007/s00401-016-1616-3 · 2016 · External reference
Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence
10.1016/j.ccell.2025.11.006 · 2026 · External reference
The automated computational workflow QUICHE reveals structural definitions of antitumor responses in triple-negative breast cancer
10.1038/s43018-026-01122-5 · 2026 · External reference
An integrative model of cellular states, plasticity, and genetics for glioblastoma
10.1016/j.cell.2019.06.024 · 2019 · External reference
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
10.1016/j.ccell.2022.12.007 · 2023 · External reference
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
10.1073/pnas.1121623109 · 2012 · External reference
Programs, origins and immunomodulatory functions of myeloid cells in glioma
10.1038/s41586-025-08633-8 · 2025 · External reference
Integrated analysis of multimodal single-cell data
10.1016/j.cell.2021.04.048 · 2021 · External reference
Transcription factor HIF1A: downstream targets, associated pathways, polymorphic hypoxia response element (HRE) sites, and initiative for standardization of reporting in scientific literature
10.1007/s13277-016-5331-4 · 2016 · External reference
Integrative spatial analysis reveals a multi-layered organization of glioblastoma
10.1016/j.cell.2024.03.029 · 2024 · External reference
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
10.1215/s1152851704001115 · 2005 · External reference
Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites
10.1016/j.celrep.2017.08.078 · 2017 · External reference
Identification and classification of distinct surface markers of T regulatory cells
10.3389/fimmu.2022.1055805 · 2022 · External reference
Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III
10.4049/jimmunol.168.2.763 · 2002 · External reference
10.1101/2025.01.06.631548
10.1101/2025.01.06.631548 · 2025 · External reference
The involvement of microglia and the CXCL16-CXCR6 axis in the recruitment of CD8+ T cells to an amyloidogenic mouse brain
10.1038/s41598-025-22137-5 · 2025 · External reference
CXCL16 knockout inhibit asthma airway inflammation by suppressing H2-DM molecular mediated antigen presentation
10.1038/s41420-025-02371-6 · 2025 · External reference
The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context
10.3389/fimmu.2023.1331287 · 2023 · External reference
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology
10.1038/s41590-023-01604-z · 2023 · External reference
Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination
10.1186/s13073-022-01111-0 · 2022 · External reference
CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression
10.1038/s41388-019-0911-6 · 2019 · External reference
Exploring DNA methylation for prognosis and analyzing the tumor microenvironment in pleomorphic xanthoastrocytoma
10.1093/jnen/nlaa051 · 2020 · External reference
Recurrent copy number alterations in low-grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation
10.1111/bpa.12495 · 2018 · External reference
Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival
10.1186/s40478-021-01308-1 · 2022 · External reference
Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: an analysis of 469 tumors
10.1093/noajnl/vdaf089 · 2025 · External reference
Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy
10.1172/jci163446 · 2023 · External reference
Macrophages at CNS interfaces: ontogeny and function in health and disease
10.1038/s41583-019-0201-x · 2019 · External reference
Macrophage-mediated myelin recycling fuels brain cancer malignancy
10.1016/j.cell.2024.07.030 · 2024 · External reference
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
10.1038/s41593-020-00789-y · 2021 · External reference
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
10.1186/s13073-024-01321-8 · 2024 · External reference
Immunophenotyping of newly diagnosed and recurrent glioblastoma defines distinct immune exhaustion profiles in peripheral and tumor-infiltrating lymphocytes
10.1158/1078-0432.ccr-17-2617 · 2018 · External reference
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
10.1016/j.immuni.2023.06.017 · 2023 · External reference
Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma
10.1038/sj.onc.1202424 · 1999 · External reference
Distinct myeloid-derived suppressor cell populations in human glioblastoma
10.1126/science.abm5214 · 2025 · External reference
Survival and proliferation of neural progenitor-derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 autocrine-positive feedback mechanism
10.1158/1078-0432.ccr-15-2888 · 2017 · External reference
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment
10.1016/j.cell.2021.07.015 · 2021 · External reference
Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo
10.4049/jimmunol.174.9.5490 · 2005 · External reference
10.1002/pdi3.2514
10.1002/pdi3.2514 · 2025 · External reference
CXCL14 is an essential modulator of TLR9 agonist-induced antitumor immune responses
10.1093/jimmun/vkaf080 · 2025 · External reference
