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References from Apoptosome and inflammasome: conserved machineries for caspase activation. Local targets link to admitted publications; unresolved targets remain external evidence.
Cell death: critical control points
10.1016/s0092-8674(04)00046-7 · 2004 · External reference
Worms, life, and death (nobel lecture)
10.1002/cbic.200300614 · 2003 · External reference
Regulation of apoptosis in Drosophila
10.1038/cdd.2008.50 · 2008 · External reference
Caspases: enemies within
10.1126/science.281.5381.1312 · 1998 · External reference
Mechanisms of caspase inhibition and activation during apoptosis
10.1016/s1097-2765(02)00482-3 · 2002 · External reference
A decade of caspases
10.1038/sj.onc.1207107 · 2003 · External reference
Molecular mechanisms of caspase regulation during apoptosis
10.1038/nrm1496 · 2004 · External reference
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
10.1038/356768a0 · 1992 · External reference
Molecular cloning of the interleukin-1 beta converting enzyme
10.1126/science.1373520 · 1992 · External reference
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
10.1111/j.1462-5822.2006.00751.x · 2005 · External reference
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells
10.1128/iai.73.4.1907-1916.2005 · 2005 · External reference
Inflammatory caspases and inflammasomes: master switches of inflammation
10.1038/sj.cdd.4402038 · 2007 · External reference
The C. elegans cell death gene Ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
10.1016/0092-8674(93)90485-9 · 1993 · External reference
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
10.1101/gad.10.9.1073 · 1996 · External reference
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans
10.1371/journal.pgen.1003341 · 2013 · External reference
Caspase activation: the induced-proximity model
10.1073/pnas.96.20.10964 · 1999 · External reference
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
10.1016/s0092-8674(01)00544-x · 2001 · External reference
Structural basis for the activation of human procaspase-7
10.1073/pnas.221580098 · 2001 · External reference
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
10.1073/pnas.1306759110 · 2013 · External reference
An APAF-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
10.1074/jbc.274.17.11549 · 1999 · External reference
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
10.1002/j.1460-2075.1995.tb00245.x · 1995 · External reference
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
10.1074/jbc.c200179200 · 2002 · External reference
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
10.1016/s1097-2765(02)00599-3 · 2002 · External reference
Caspase-9 can be activated without proteolytic processing
10.1074/jbc.274.13.8359 · 1999 · External reference
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO mediates opposing effects on caspase activity and apoptosis
10.1038/35065125 · 2001 · External reference
Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9
10.1074/jbc.m112.441568 · 2013 · External reference
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding and activation
10.1016/s1097-2765(02)00442-2 · 2002 · External reference
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
10.1074/jbc.274.25.17941 · 1999 · External reference
Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
10.1093/emboj/18.13.3586 · 1999 · External reference
Caspase-9 and Apaf-1 form an active holoenzyme
10.1101/gad.13.24.3179 · 1999 · External reference
Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex
10.1074/jbc.274.32.22686 · 1999 · External reference
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
10.1038/12984 · 1999 · External reference
HAC-1, a Drosophila homolog of Apaf-1 and CED-4 functions in developmental and radiation-induced apoptosis
10.1016/s1097-2765(00)80385-8 · 1999 · External reference
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
10.1016/s1097-2765(00)80386-x · 1999 · External reference
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
10.1242/dev.116.2.309 · 1992 · External reference
Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED-3 and CED-4
10.1016/s0014-5793(97)00271-8 · 1997 · External reference
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
10.1016/s0960-9822(06)00216-8 · 1997 · External reference
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
10.1126/science.275.5303.1122 · 1997 · External reference
Interaction and regulation of subcellular localization of CED-4 by CED-9
10.1126/science.275.5303.1126 · 1997 · External reference
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
10.1126/science.281.5381.1355 · 1998 · External reference
Inflammasomes and their roles in health and disease
10.1146/annurev-cellbio-101011-155745 · 2012 · External reference
Chavarría-Smith J, RE V, recognition of bacteria by inflammasomes
10.1146/annurev-immunol-032712-095944 · 2013 · External reference
STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer
10.1016/j.jmb.2004.08.023 · 2004 · External reference
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
10.1126/science.1095432 · 2004 · External reference
Apoptosome structure, assembly, and procaspase activation
10.1016/j.str.2013.02.024 · 2013 · External reference
Regulation of the Apaf-1-caspase-9 apoptosome
10.1242/jcs.073643 · 2010 · External reference
Apoptosome assembly
10.1016/s0076-6879(08)01407-9 · 2008 · External reference
Induction of apoptosis program in cell-free extracts: requirement for dATP and cytochrome c
10.1016/s0092-8674(00)80085-9 · 1996 · External reference
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
10.1016/s0092-8674(00)80501-2 · 1997 · External reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · 1997 · External reference
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
10.1038/21124 · 1999 · External reference
Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9
10.1074/jbc.275.12.8461 · 2000 · External reference
Schwarzenbacher R, Shi Y, structure of the apoptotic protease activating factor 1 bound to ADP
10.1038/nature03465 · 2005 · External reference
Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis
10.1016/j.str.2011.05.013 · 2011 · External reference
Structure of an apoptosome-procaspase-9 CARD complex
10.1016/j.str.2010.04.001 · 2010 · External reference
A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform
10.1016/j.str.2005.09.006 · 2005 · External reference
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3
10.1016/j.str.2011.07.001 · 2011 · External reference
Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1
10.1016/j.molcel.2006.12.013 · 2007 · External reference
A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome
10.1074/jbc.m109.014027 · 2009 · External reference
Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1
10.1073/pnas.0507900102 · 2005 · External reference
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway
10.1126/science.1076807 · 2003 · External reference
Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome
10.1074/jbc.m107419200 · 2001 · External reference
Intracellular K(+) inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release
10.1038/sj.cdd.4402221 · 2007 · External reference
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome
10.1016/j.cell.2006.05.026 · 2006 · External reference
A nucleotide binding site in caspase-9 regulates apoptosome activation
10.1021/bi047360+ · 2005 · External reference
Mechanisms of caspase activation
10.1016/j.ceb.2003.10.009 · 2003 · External reference
Dimer formation drives the activation of the cell death protease caspase 9
10.1073/pnas.231465798 · 2001 · External reference
The apoptosome activates caspase-9 by dimerization
10.1016/j.molcel.2006.03.009 · 2006 · External reference
Crystal structure of the cysteine protease interleukin-1b-converting enzyme: a (p20/p10)2 homodimer
10.1016/0092-8674(94)90303-4 · 1994 · External reference
Structure and mechanism of interleukin-1b converting enzyme
10.1038/370270a0 · 1994 · External reference
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
10.1038/nsb0796-619 · 1996 · External reference
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine
10.1016/j.molcel.2006.03.030 · 2006 · External reference
Caspase activation: revisiting the induced proximity model
10.1016/j.cell.2004.06.007 · 2004 · External reference
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation
10.1371/journal.pbio.0030183 · 2005 · External reference
DRONC, an ecdysone-inducible Drosophila caspase
10.1073/pnas.96.8.4307 · 1999 · External reference
The apical caspase Dronc governs programmed and unprogrammed cell death in Drosophila
10.1016/j.devcel.2004.09.016 · 2004 · External reference
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis
10.1016/j.devcel.2004.09.018 · 2004 · External reference
Mechanism of Dronc activation in Drosophila cells
10.1242/jcs.01376 · 2004 · External reference
Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer
10.1016/j.jmb.2005.10.040 · 2006 · External reference
Modeling AAA + ring complexes from monomeric structures
10.1016/j.jsb.2006.04.011 · 2006 · External reference
Structure of the Drosophila apoptosome at 6.9 Å resolution
10.1016/j.str.2010.10.009 · 2011 · External reference
A biochemical analysis of the activation of the Drosophila caspase DRONC
10.1038/sj.cdd.4402288 · 2008 · External reference
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC
10.1038/cdd.2008.23 · 2008 · External reference
Structure and activation mechanism of the Drosophila initiator caspase Dronc
10.1074/jbc.m513232200 · 2006 · External reference
Genetic control of programmed cell death in the nematode Caenorhabditis elegans
1999 · External reference
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
10.1016/0092-8674(94)90506-1 · 1994 · External reference
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death
10.1126/science.287.5457.1485 · 2000 · External reference
CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9
10.1016/s0960-9822(06)00120-5 · 1997 · External reference
Interaction between the C. elegans cell-death regulators CED-9 and CED-4
10.1038/385653a0 · 1997 · External reference
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
10.1016/s0092-8674(00)81182-4 · 1998 · External reference
Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation
10.1074/jbc.273.50.33495 · 1998 · External reference
Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans
10.1016/s0021-9258(19)61498-5 · 2000 · External reference
Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors
10.1073/pnas.210391597 · 2000 · External reference
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
10.1038/nature04002 · 2005 · External reference
2:1 Stoichiometry of the CED-4-CED-9 Complex and the tetrameric CED-4: insights into the regulation of CED-3 activation
10.4161/cc.5.1.2263 · 2006 · External reference
Structural, biochemical, functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4
10.1016/j.molcel.2004.08.022 · 2004 · External reference
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
10.1016/j.cell.2010.03.017 · 2010 · External reference
Mechanistic insights into CED-4-mediated activation of CED-3
10.1101/gad.224428.113 · 2013 · External reference
Crystal structure of NLRC4 reveals its autoinhibition mechanism
10.1126/science.1236381 · 2013 · External reference
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
10.1074/jbc.c100250200 · 2001 · External reference
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
10.1038/nature10394 · 2011 · External reference
Wheel of life, wheel of death: a mechanistic insight into signaling by STAND proteins
10.1016/j.str.2009.01.001 · 2009 · External reference
Evolutionary relationships and structural mechanisms of AAA+ proteins
10.1146/annurev.biophys.35.040405.101933 · 2006 · External reference
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
10.1038/nrm1587 · 2005 · External reference
Constitutive gain-of-function mutants in a nucleotide binding site-leucine rich repeat protein encoded at the Rx locus of potato
10.1046/j.1365-313x.2002.01413.x · 2002 · External reference
Heat shock protein 90 and its co-chaperone protein phosphatase 5 interact with distinct regions of the tomato I-2 disease resistance protein
10.1111/j.1365-313x.2005.02450.x · 2005 · External reference
Autoactive alleles of the flax L6 rust resistance gene induce non-race-specific rust resistance associated with the hypersensitive response
10.1094/mpmi-18-0570 · 2005 · External reference
An NB-LRR protein required for HR signalling mediated by both extra- and intracellular resistance proteins
10.1111/j.1365-313x.2007.03027.x · 2007 · External reference
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
10.1016/j.molcel.2007.01.032 · 2007 · External reference
Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin
10.1074/jbc.m112.393512 · 2012 · External reference
The NLRP3 inflammasome: a sensor of immune danger signals
10.1016/j.smim.2009.05.002 · 2009 · External reference
Molecular mechanisms involved in inflammasome activation
10.1016/j.tcb.2009.06.002 · 2009 · External reference
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
10.1038/nri2725 · 2010 · External reference
Mechanisms of NOD-like receptor-associated inflammasome activation
10.1016/j.immuni.2013.08.037 · 2013 · External reference
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
10.1038/ni.1980 · 2011 · External reference
A role for mitochondria in NLRP3 inflammasome activation
10.1038/nature09663 · 2011 · External reference
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
10.1016/j.cell.2013.02.054 · 2013 · External reference
Mitochondrial cardiolipin is required for nlrp3 inflammasome activation
10.1016/j.immuni.2013.08.001 · 2013 · External reference
Inflammasomes in health and disease
10.1038/nature10759 · 2012 · External reference
The inflammasome NLRs in immunity, inflammation, and associated diseases
10.1146/annurev-immunol-031210-101405 · 2011 · External reference
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
10.1038/ng756 · 2001 · External reference
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
10.1086/341357 · 2002 · External reference
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
10.1002/art.10688 · 2002 · External reference
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)
10.1146/annurev.immunol.25.022106.141627 · 2009 · External reference
Familial autoinflammatory diseases: genetics, pathogenesis and treatment
10.1097/bor.0000174210.78449.6b · 2005 · External reference
The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations
10.1097/00002281-200301000-00011 · 2003 · External reference
Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling
10.1073/pnas.0611496104 · 2007 · External reference
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC
10.1074/jbc.m401178200 · 2004 · External reference
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
10.1016/j.immuni.2009.04.012 · 2009 · External reference
Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU
10.1182/blood-2003-07-2531 · 2004 · External reference
Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation
10.1104/pp.105.073510 · 2006 · External reference
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain
10.1016/j.str.2003.08.009 · 2003 · External reference
The PyMOL molecular graphics system
External reference