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Piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells

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The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC

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Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary

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piRNA-mediated transgenerational inheritance of an acquired trait

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An epigenetic role for maternally inherited piRNAs in transposon silencing

10.1126/science.1165171 · 2008 · External reference

Gender-specific hierarchy in nuage localization of PIWI-interacting RNA factors in Drosophila

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Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC

10.1101/gad.174110.111 · 2011 · External reference

The tudor domain protein kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila

10.1038/emboj.2011.449 · 2012 · External reference

Heterotypic piRNA ping-pong requires qin, a protein with both E3 ligase and Tudor domains

10.1016/j.molcel.2011.10.011 · 2011 · External reference

The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification

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Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation

10.1038/ng.743 · 2011 · External reference

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

10.1038/nature08739 · 2010 · External reference

MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis

10.1073/pnas.0605506103 · 2006 · External reference

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

10.1101/gad.1425706 · 2006 · External reference

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish

10.1016/j.cell.2007.03.026 · 2007 · External reference

Zili is required for germ cell differentiation and meiosis in zebrafish

10.1038/emboj.2008.204 · 2008 · External reference

High-resolution profiling and discovery of planarian small RNAs

10.1073/pnas.0905222106 · 2009 · External reference

Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans

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A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis

10.1016/j.cub.2008.05.009 · 2008 · External reference

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans

10.1016/j.molcel.2008.06.002 · 2008 · External reference

PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells

10.1073/pnas.1320965111 · 2014 · External reference

Developmentally regulated piRNA clusters implicate MILI in transposon control

10.1126/science.1142612 · 2007 · External reference

ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

10.1073/pnas.072190799 · 2002 · External reference

A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary

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The role of PIWI and the miRNA machinery in Drosophila germline determination

10.1016/j.cub.2006.08.051 · 2006 · External reference

Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C

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Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response

10.1016/j.devcel.2006.12.001 · 2007 · External reference

The RNA interference proteins and vasa locus are involved in the silencing of retrotransposons in the female germline of Drosophila melanogaster

10.4161/rna.1.1.943 · 2004 · External reference

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis

10.1242/dev.00973 · 2004 · External reference

Two mouse piwi-related genes: miwi and mili

10.1016/s0925-4773(01)00499-3 · 2001 · External reference

Miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis

10.1016/s1534-5807(02)00165-x · 2002 · External reference

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline

10.1016/j.devcel.2007.03.001 · 2007 · External reference

MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation

10.1074/jbc.m809104200 · 2009 · External reference

Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice

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Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis

10.1038/nsmb.2347 · 2012 · External reference

Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults

10.1016/s1567-133x(02)00052-2 · 2002 · External reference

The germ line and somatic stem cell gene Cniwi in the jellyfish Podocoryne carnea

10.1387/ijdb.15005568 · 2004 · External reference

Two Piwi proteins, Xiwi and Xili, are expressed in the Xenopus female germline

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10.1038/sj.cr.7290297 · 2005 · External reference

piRNA production requires heterochromatin formation in Drosophila

10.1016/j.cub.2011.06.057 · 2011 · External reference

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

10.1073/pnas.1013106107 · 2010 · External reference

Genomic structure and expression of the mouse ESET gene encoding an ERG-associated histone methyltransferase with a SET domain

10.1016/s0167-4781(03)00155-6 · 2003 · External reference

RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis

10.1242/dev.02003 · 2005 · External reference

Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice

10.1073/pnas.0601878103 · 2006 · External reference

Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression

10.1016/j.cub.2009.02.047 · 2009 · External reference

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline

10.1038/emboj.2013.121 · 2013 · External reference

Cytoplasmic compartmentalization of the fetal piRNA pathway in mice

10.1371/journal.pgen.1000764 · 2009 · External reference

Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice

10.1016/j.ydbio.2006.10.046 · 2007 · External reference

The GAF domain: an evolutionary link between diverse phototransducing proteins

10.1016/s0968-0004(97)01148-1 · 1997 · External reference

Cutoff and aubergine mutations result in retrotransposon upregulation and checkpoint activation in Drosophila

10.1016/j.cub.2007.02.027 · 2007 · External reference

[The role of piRNAs in mouse spermatogenesis.]

10.1051/jbio:2007912 · 2007 · External reference

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

10.1126/science.1092653 · 2004 · External reference

Drosophila PIWI associates with chromatin and interacts directly with HP1a

10.1101/gad.1564307 · 2007 · External reference

piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline

10.1016/j.cell.2012.06.015 · 2012 · External reference

piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans

10.1016/j.cell.2012.06.018 · 2012 · External reference

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

10.1016/j.molcel.2008.09.003 · 2008 · External reference

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

10.1101/gad.1640708 · 2008 · External reference

A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity

10.1016/j.cell.2012.02.057 · 2012 · External reference

Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene

10.1534/genetics.166.3.1313 · 2004 · External reference

Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline

10.1101/gad.370206 · 2006 · External reference

A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary

10.1128/jvi.01980-06 · 2007 · External reference

Characterization of Drosophila telomeric retroelement TAHRE: transcription, transpositions, and RNAi-based regulation of expression

10.1093/molbev/msm205 · 2007 · External reference

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10.1242/dev.00310 · 2003 · External reference

Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression

10.1016/j.cell.2012.10.040 · 2012 · External reference

The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters

10.1016/j.cell.2009.07.014 · 2009 · External reference

The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline

10.1038/emboj.2011.334 · 2011 · External reference

Conserved themes in small-RNA-mediated transposon control

10.1016/j.tcb.2008.01.004 · 2008 · External reference

Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway

10.1016/j.ydbio.2013.12.007 · 2014 · External reference

A broadly conserved pathway generates 3′UTR-directed primary piRNAs

10.1016/j.cub.2009.11.064 · 2009 · External reference

A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

10.1038/nature08501 · 2009 · External reference

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

10.1038/nature09465 · 2010 · External reference

Gene silencing mechanisms mediated by Aubergine piRNA complexes in Drosophila male gonad

10.1261/rna.744307 · 2007 · External reference

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

10.1128/mcb.00128-07 · 2007 · External reference

piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline

10.1083/jcb.200904063 · 2009 · External reference

Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins

10.1016/j.mod.2008.06.005 · 2008 · External reference

PIWI proteins are essential for early Drosophila embryogenesis

10.1016/j.ydbio.2013.10.017 · 2014 · External reference

RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila

10.1016/s1097-2765(02)00440-9 · 2002 · External reference

The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians

10.1261/rna.1085008 · 2008 · External reference

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells

10.1126/science.1116110 · 2005 · External reference

Identification of piRNAs in the central nervous system

10.1261/rna.2565011 · 2011 · External reference

Expression of the Argonaute protein PiwiL2 and piRNAs in adult mouse mesenchymal stem cells

10.1016/j.bbrc.2010.05.022 · 2010 · External reference

Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi

10.1182/blood.v97.2.426 · 2001 · External reference

Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway

10.1093/hmg/ddi430 · 2006 · External reference

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas

10.1038/sj.onc.1205505 · 2002 · External reference

Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells

10.1002/ijc.21575 · 2006 · External reference

The universal overexpression of a cancer testis antigen hiwi is associated with cancer angiogenesis

2010 · External reference

piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells

10.1016/j.cca.2011.05.015 · 2011 · External reference

Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer

10.1007/s12094-012-0966-0 · 2013 · External reference

Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma

10.1016/j.jhep.2013.01.032 · 2013 · External reference

Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila

10.1126/science.1195481 · 2010 · External reference

Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuleen

10.1242/dev.01809 · 2005 · External reference

Arginine methylation of vasa protein is conserved across phyla

10.1074/jbc.m109.089821 · 2010 · External reference

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs

10.1073/pnas.1007158107 · 2010 · External reference

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

10.1073/pnas.1003953107 · 2010 · External reference

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

10.1038/nature11509 · 2012 · External reference

piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling

10.1016/j.devcel.2011.01.004 · 2011 · External reference

MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline

10.1016/j.devcel.2011.01.005 · 2011 · External reference

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

10.1093/hmg/ddl158 · 2006 · External reference

The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs

10.1261/rna.659307 · 2007 · External reference

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing

10.1016/j.molcel.2012.07.019 · 2012 · External reference

PIWI-interacting RNAs: from generation to transgenerational epigenetics

10.1038/nrg3495 · 2013 · External reference