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Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia

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Simvastatin augments the efficacy of therapeutic angiogenesis induced by bone marrow-derived mesenchymal stem cells in a murine model of hindlimb ischemia

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Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells

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Statins have biphasic effects on angiogenesis

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Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization

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Association of statin use with the risk of developing diabetic retinopathy

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HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

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Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures

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Statins: candidates for promoting bone formation via BMP-2

10.3353/omp.14.81 · 2010 · External reference

Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts

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Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells

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Statin-induced calcification in human mesenchymal stem cells is cell death related

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Rosuvastatin promotes osteoblast differentiation and regulates SLCO1A1 transporter gene expression in MC3T3-E1 cells

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Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon

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The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway

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Simvastatin improves fracture healing in mice

10.1359/jbmr.2002.17.11.2004 · 2002 · External reference

Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats

10.1590/s0103-64402006000400001 · 2006 · External reference

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

10.1016/j.biomaterials.2010.01.016 · 2010 · External reference

Simvastatin promotes osteogenesis around titanium implants

10.1046/j.1600-0501.2003.01015.x · 2004 · External reference

Effects of simvastatin on bone healing around titanium implants in osteoporotic rats

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Influence of statins locally applied from orthopedic implants on osseous integration

10.1186/1471-2474-13-208 · 2012 · External reference

Osseointegration of biochemically modified implants in an osteoporosis rodent model

10.22203/ecm.v025a23 · 2013 · External reference

Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats

10.1016/j.tripleo.2008.07.013 · 2009 · External reference

Muscular side effects of statins

10.1097/00005344-200208000-00001 · 2002 · External reference

An assessment of statin safety by hepatologists

10.1016/j.amjcard.2005.12.014 · 2006 · External reference

Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration

10.1016/j.biomaterials.2006.06.031 · 2006 · External reference

Multifunctional hydrogels that promote osteogenic human mesenchymal stem cell differentiation through stimulation and sequestering of bone morphogenic protein 2

10.1002/adfm.200700012 · 2007 · External reference

Development of an injectable two-phase drug delivery system for sequential release of antiresorptive and osteogenic drugs

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Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing

10.1002/jbmr.1558 · 2012 · External reference

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study

10.1016/j.tripleo.2008.06.025 · 2009 · External reference

In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects

10.1016/j.actbio.2009.09.027 · 2010 · External reference

Alternating release of different bioactive molecules from a complexation polymer system

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Molecular and cellular mechanisms of the anabolic effect of intermittent PTH

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Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts

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Evaluation of the osteoconductivity of α-tricalcium phosphate, β-tricalcium phosphate, and hydroxyapatite combined with or without simvastatin in rat calvarial defect

10.1002/jbm.a.33117 · 2011 · External reference

Simvastatin-loaded macroporous calcium phosphate cement: preparation, in vitro characterization, and evaluation of in vivo performance

10.1002/jbm.a.34228 · 2012 · External reference

Controlled release of simvastatin from biomimetic β-TCP drug delivery system

10.1371/journal.pone.0054676 · 2013 · External reference

Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect

10.1254/jphs.sc0070184 · 2007 · External reference

Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair

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Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration

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The effect of simvastatin on remodelling of the alveolar bone following tooth extraction

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Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application

10.1016/j.bone.2009.05.010 · 2009 · External reference

In vivo performance of simvastatin-loaded electrospun spiral-wound polycaprolactone scaffolds in reconstruction of cranial bone defects in the rat model

10.1002/jbm.a.32157 · 2009 · External reference

Biodegradable composite scaffolds incorporating an intramedullary rod and delivering bone morphogenetic protein-2 for stabilization and bone regeneration in segmental long bone defects

10.1016/j.actbio.2011.06.043 · 2011 · External reference

Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells

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10.1186/ar399 · 2002 · Admitted local publication

Infection, inflammation, and bone regeneration: a paradoxical relationship

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Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells

10.1002/jcb.20074 · 2004 · External reference

Selective inhibition of primary acute myeloid leukaemia cell growth by lovastatin

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A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin and pravastatin on leukaemic and normal bone marrow progenitors

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