Research graph
References from Potential Health Effects of the Natural Alkaloid Berberine: A Narrative Review. Local targets link to admitted publications; unresolved targets remain external evidence.
Berberine: a novel therapeutic strategy for cancer
10.1002/iub.2350 · 2020 · External reference
Addressing the preventive and therapeutic perspective of berberine against diabetes
10.1016/j.heliyon.2023.e21233 · 2023 · External reference
Biological properties and clinical applications of berberine
10.1007/s11684-019-0724-6 · 2020 · External reference
Studies on synthesis, physicochemical properties, biological activities of two novel berberine-based salts with dl-mandelate and cinnamate anions
10.1016/j.molstruc.2023.136359 · 2023 · External reference
Development of an innovative berberine food-grade formulation with an ameliorated absorption: in vitro evidence confirmed by healthy human volunteers pharmacokinetic study
10.1155/2021/7563889 · 2021 · External reference
The anti-cancer mechanisms of berberine: a review
10.2147/cmar.s242329 · 2020 · External reference
Polylactide-based films incorporated with berberine-physicochemical and antibacterial properties
10.3390/foods12010091 · 2022 · External reference
Berberine for prevention of dementia associated with diabetes and its comorbidities: a systematic review
10.1016/j.joim.2020.01.004 · 2020 · External reference
Overall and sex-specific effect of berberine for the treatment of dyslipidemia in adults: a systematic review and meta-analysis of randomized placebo-controlled trials
10.1007/s40265-023-01841-4 · 2023 · External reference
Regulatory effects of berberine on microRNome in cancer and other conditions
10.1016/j.critrevonc.2017.05.008 · 2017 · External reference
Berberine as a potential anticancer agent: a comprehensive review
10.3390/molecules26237368 · 2021 · External reference
Berberine-a promising therapeutic approach to polycystic ovary syndrome in infertile/pregnant women
10.3390/life13010125 · 2023 · External reference
Research progress on pharmacological effects and bioavailability of berberine
10.1007/s00210-024-03199-0 · 2024 · External reference
A review of Fibraurea tinctoria and its component, berberine, as an antidiabetic and antioxidant
10.3390/molecules28031294 · 2023 · External reference
Micro- and nanoencapsulated hybrid delivery system (mnehds): a novel approach for colon-targeted oral delivery of berberine
10.1021/acs.molpharmaceut.0c00970 · 2021 · External reference
Spray-dried solid lipid nanoparticles for enhancing berberine bioavailability via oral administration
10.2174/0113816128263982231102062745 · 2023 · External reference
10.1007/978-3-030-75506-5_25
10.1007/978-3-030-75506-5_25 · 2022 · External reference
Solid lipid nanoformulation of berberine attenuates doxorubicin triggered in vitro inflammation in H9c2 rat cardiomyocytes
10.2174/1386207325666220617113744 · 2022 · External reference
Chitosan-coated solid lipid nano-encapsulation improves the therapeutic antiairway inflammation effect of berberine against COPD in cigarette smoke-exposed rats
10.1155/2022/8509396 · 2022 · External reference
Bioavailability and hepatoprotection enhancement of berberine and its nanoparticles prepared by liquid antisolvent method
10.1016/j.sjbs.2020.10.006 · 2021 · External reference
Development of natural polysaccharide-based nanoparticles of berberine to enhance oral bioavailability: formulation, optimization, ex vivo, and in vivo assessment
10.3390/polym13213833 · 2021 · External reference
Optimization of hyaluronate-based liposomes to augment the oral delivery and the bioavailability of berberine
10.3390/ma14195759 · 2021 · External reference
Membrane composition allows the optimization of berberine encapsulation in liposomes
10.1021/acs.molpharmaceut.4c00830 · 2024 · External reference
Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity
10.1038/s41401-018-0183-7 · 2019 · External reference
Monodisperse microparticles loaded with the self-assembled berberine-phospholipid complex-based phytosomes for improving oral bioavailability and enhancing hypoglycemic efficiency
10.1016/j.ejpb.2016.03.019 · 2016 · External reference
Co-encapsulation of berberine and piperine in coaxial electrosprayed chitosan nanoparticles for sustained release and improved berberine bioavailability
10.1007/s11696-024-03381-x · 2024 · External reference
Improving the ameliorative effects of berberine and curcumin combination via dextran-coated bilosomes on non-alcohol fatty liver disease in mice
10.1186/s12951-021-00979-1 · 2021 · External reference
Antiviral activity of berberine
10.1007/s00705-020-04706-3 · 2020 · External reference
Pharmacokinetics and pharmacological activities of berberine in diabetes mellitus treatment
10.1155/2021/9987097 · 2021 · External reference
Pharmacokinetics and excretion of berberine and its nine metabolites in rats
10.3389/fphar.2020.594852 · 2021 · External reference
Pharmacokinetics, tissue distribution and excretion of demethyleneberberine, a metabolite of berberine, in rats and mice
10.3390/molecules28237725 · 2023 · External reference
Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders
10.1007/s43440-021-00348-7 · 2022 · External reference
A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome
10.22038/ijbms.2017.8682 · 2017 · External reference
Structure, diversity, and composition of bacterial communities in rhizospheric soil of coptis chinensis franch under continuously cropped fields
10.3390/d12020057 · 2020 · External reference
Therapeutic effect of berberine on metabolic diseases: both pharmacological data and clinical evidence
10.1016/j.biopha.2020.110984 · 2021 · External reference
Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders
10.3389/fphar.2018.00557 · 2018 · External reference
Recent advances of application of berberin on phospholipase a2 (pla2): a novel and potent therapeutic inhibitor in targeting lung cancer
10.1016/b978-0-323-95699-4.00012-8 · 2023 · External reference
Nano formulation of berberine (Brb): transforming a natural alkaloid into advanced therapeutics
10.7324/japs.2024.657635 · 2024 · External reference
Application of berberine on skin diseases: a review
10.52711/0975-4377.2022.00050 · 2022 · External reference
Elucidating berberine’s therapeutic and photosensitizer potential through nanomedicine tools
10.3390/pharmaceutics15092282 · 2023 · External reference
Biological activity of berberine—a summary update
10.3390/toxins12110713 · 2020 · External reference
Update on the benefits and mechanisms of action of the bioactive vegetal alkaloid berberine on lipid metabolism and homeostasis
10.1155/2018/7173920 · 2018 · External reference
A descriptive review of the antioxidant effects and mechanisms of action of berberine and silymarin
10.3390/molecules29194576 · 2024 · External reference
Anti-inflammatory, antioxidant, and immunomodulatory effects of berberis vulgaris and its constituent berberine, experimental and clinical, a review
10.1002/ptr.8077 · 2024 · External reference
Antioxidant and antiarthritic potential of berberine: in vitro and in vivo studies
10.1016/j.chmed.2023.02.007 · 2023 · External reference
Effects of dietary berberine on growth performance, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus) fed high-fat diets
10.1007/s10695-022-01143-8 · 2023 · External reference
Protective effects of berberine as a natural antioxidant and anti-inflammatory agent against nephrotoxicity induced by cyclophosphamide in mice
10.1007/s00210-021-02182-3 · 2022 · External reference
Investigation of antioxidant and anti-inflammatory properties of berberine nanomicelles: in vitro and in vivo studies
10.2174/0115672018258030230920035222 · 2024 · External reference
Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats
10.1515/jbcpp-2020-0173 · 2021 · External reference
Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway
10.1016/j.bioorg.2022.106210 · 2023 · External reference
Inhibition of inflammation by berberine: molecular mechanism and network pharmacology analysis
10.1016/j.phymed.2023.155258 · 2024 · External reference
Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects
10.1016/j.apsb.2022.12.009 · 2023 · External reference
Acetylation of p65Lys310by p300 in macrophages mediates anti-inflammatory property of berberine
10.1016/j.redox.2023.102704 · 2023 · External reference
Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers
10.1111/jfbc.14389 · 2022 · External reference
Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury in mice by inhibiting NF-κB activation via PI3K/AKT and PPARγ signaling pathways
10.1016/j.bbrc.2024.150772 · 2024 · External reference
In vitro antimicrobial activity and the mechanism of berberine against methicillin-resistant Staphylococcus aureus isolated from bloodstream infection patients
10.2147/idr.s357077 · 2022 · External reference
The mechanism of berberine on methicillin resistant Staphylococcus aureus in vitro
10.3760/cma.j.cn112150-20230206-00081 · 2023 · External reference
Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: a randomized controlled trial
10.1097/cm9.0000000000002696 · 2023 · External reference
A randomized, multicenter and noninferiority study of amoxicillin plus berberine vs tetracycline plus furazolidone in quadruple therapy for Helicobacter pylori rescue treatment
10.1111/1751-2980.12870 · 2020 · External reference
Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection
10.1038/srep42473 · 2017 · External reference
Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases
10.1016/j.cbi.2020.108947 · 2020 · External reference
Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
10.1186/s12985-016-0674-4 · 2017 · External reference
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus
10.1007/s00044-023-03138-3 · 2023 · External reference
Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein
10.1016/j.phymed.2018.09.025 · 2019 · External reference
Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice
10.1002/ptr.6196 · 2018 · External reference
Berberine and obatoclax inhibit SARS-Cov-2 replication in primary human nasal epithelial cells ın vitro
10.3390/v13020282 · 2021 · External reference
Berberine inhibitory action against Zika and dengue viruses in cell cultures
10.3389/av.2023.11931 · 2023 · External reference
Identification of berberine as a potential therapeutic strategy for kidney clear cell carcinoma and COVID-19 based on analysis of large-scale datasets
10.3389/fimmu.2023.1038651 · 2023 · External reference
Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication
10.1016/j.antiviral.2024.106027 · 2024 · External reference
Evaluation of berberine pellet effect on clinical recovery time in COVID-19 outpatients: a pilot clinical trial
10.22038/ajp.2022.21539 · 2023 · External reference
What’s behind the obesity epidemic
10.1007/978-3-319-49299-5_1 · External reference
The effect of berberine on weight loss in order to prevent obesity: a systematic review
10.1016/j.biopha.2020.110137 · 2020 · External reference
Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway
10.1016/j.lfs.2020.117277 · 2020 · External reference
Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
10.2147/dmso.s181572 · 2018 · External reference
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of streptozotocin induced diabetic rats
10.1016/j.biopha.2017.08.040 · 2017 · External reference
Berberine in cardiovascular and metabolic diseases: from mechanisms to therapeutics
10.7150/thno.30787 · 2019 · External reference
Berberine reduces lipid accumulation in obesity via mediating transcriptional function of PPARδ
10.3390/ijms241411600 · 2023 · External reference
Berberine inhibits adipogenesis in porcine adipocytes via AMP-activated protein kinase-dependent and-independent mechanisms
10.1002/lipd.12200 · 2019 · External reference
Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes
10.1210/endocr/bqad035 · 2023 · External reference
Development of a novel anti-obesity compound with inhibiting properties on the lipid accumulation in 3T3-L1 adipocytes
10.29252/ibj.24.3.155 · 2020 · External reference
Berberine attenuates obesity-induced insulin resistance by inhibiting miR-27a secretion
10.1111/dme.15319 · 2024 · External reference
Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway
10.1016/j.phymed.2023.155268 · 2024 · External reference
The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity-induced insulin resistance
10.1002/ptr.8233 · 2024 · External reference
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice
10.1038/s41598-025-89297-2 · 2025 · External reference
Berberine improves glucose and lipid metabolism in obese mice through the reduction of IRE1/GSK-3β axis-mediated inflammation
10.2174/0118715303319434241113161606 · 2025 · External reference
Tetrahydroberberrubine exhibits preventive effect on obesity by activating PGC1α-mediated thermogenesis in white and brown adipose tissue
10.1016/j.bcp.2024.116381 · 2024 · External reference
IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
10.1016/j.diabres.2021.109119 · 2022 · External reference
A descriptive review of the action mechanisms of berberine, quercetin and silymarin on insulin resistance/hyperinsulinemia and cardiovascular prevention
10.3390/molecules28114491 · 2023 · External reference
Berberine, a herbal metabolite in the metabolic syndrome: the risk factors, course, and consequences of the disease
10.3390/molecules27041351 · 2022 · External reference
Berberine and its study as an antidiabetic compound
10.3390/biology12070973 · 2023 · External reference
Metformin and berberine, two versatile drugs in treatment of common metabolic diseases
10.18632/oncotarget.20807 · 2017 · External reference
Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis
10.1507/endocrj.ej18-0109 · 2019 · External reference
Effect of a new formulation of nutraceuticals as an add-on to metformin monotherapy for patients with type 2 diabetes and suboptimal glycemic control: a randomized controlled trial
10.3390/nu13072373 · 2021 · External reference
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
10.1038/s41467-021-25952-2 · 2021 · External reference
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats
10.3748/wjg.v27.i8.708 · 2021 · External reference
Glucagon-like peptide 1 (GLP-1)
10.1016/j.molmet.2019.09.010 · 2019 · External reference
Berberine attenuates hyperglycemia by inhibiting the hepatic glucagon pathway in diabetic mice
10.1155/2020/6210526 · 2020 · External reference
Glucose-lowering effect of berberine on type 2 diabetes: a systematic review and meta-analysis
10.3389/fphar.2022.1015045 · 2022 · External reference
A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes
10.1038/s41467-021-25701-5 · 2021 · External reference
Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis
10.3389/fphar.2024.1455534 · 2024 · External reference
The effect of berberine supplementation on glycemic control and inflammatory biomarkers in metabolic disorders: an umbrella meta-analysis of randomized controlled trials
10.1016/j.clinthera.2023.10.019 · 2024 · External reference
Protective effects of berberine against diabetes-associated cognitive decline in mice
10.1007/s00592-024-02411-0 · 2025 · External reference
Berberine alleviates diabetic retinopathy by regulating the Th17/Treg ratio
10.1016/j.imlet.2024.106862 · 2024 · External reference
Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy
10.1016/j.ejphar.2023.176253 · 2024 · External reference
Berberine metabolites stimulate GLP-1 secretion by alleviating oxidative stress and mitochondrial dysfunction
10.1142/s0192415x24500113 · 2024 · External reference
The potential role of dietary plant ingredients against mammary cancer: a comprehensive review
10.1080/10408398.2020.1855413 · 2022 · External reference
Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system
10.1038/aps.2016.125 · 2017 · External reference
Berberine-induced nucleolar stress response in a human breast cancer cell line
10.1016/j.bbrc.2020.05.020 · 2020 · External reference
Berberine inhibits proliferative ability of breast cancer cells by reducing metadherin
10.12659/msm.914486 · 2019 · External reference
Berberine impairs the survival of triple-negative breast cancer cells: cellular and molecular analyses
10.3390/molecules25030506 · 2020 · External reference
Berberine—a potent chemosensitizer and chemoprotector to conventional cancer therapies
10.1002/ptr.7032 · 2021 · External reference
Berberine improves chemo-sensitivity to cisplatin by enhancing cell apoptosis and repressing PI3K/AKT/mTOR signaling pathway in gastric cancer
10.3389/fphar.2020.616251 · 2020 · External reference
Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells
10.3892/or.2018.6318 · 2018 · External reference
Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells
10.1016/j.jbior.2019.04.003 · 2019 · External reference
Berberine sensitizes nasopharyngeal carcinoma cells to radiation through inhibition of Sp1 and EMT
10.3892/or.2017.5499 · 2017 · External reference
Berberine restrains non-small cell lung cancer cell growth, invasion and glycolysis via inactivating the SPC25/NUF2 pathway
10.1007/s00210-024-03729-w · 2025 · External reference
Berberine inhibits breast cancer stem cell development and decreases inflammation: involvement of miRNAs and IL-6
10.1016/j.cdnut.2024.104532 · 2024 · External reference
Berberine decorated zinc oxide loaded chitosan nanoparticles: a potent anticancer agent against breast cancer
10.1038/s41598-025-87445-2 · 2025 · External reference
Efficacy and underlying mechanisms of berberine against lipid metabolic diseases: a review
10.3389/fphar.2023.1283784 · 2023 · External reference
Cluster of differentiation 36 deficiency aggravates macrophage infiltration and hepatic inflammation by upregulating monocyte chemotactic protein-1 expression of hepatocytes through histone deacetylase 2-dependent pathway
10.1089/ars.2016.6808 · 2017 · External reference
Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway
10.1124/mol.116.106617 · 2017 · External reference
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
10.1016/j.celrep.2021.108873 · 2021 · External reference
Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content via reversing the abnormal expression of MTTP and LDLR
10.3892/etm.2021.10543 · 2021 · External reference
The pharmacological activity of berberine: a review for liver protection
10.1016/j.ejphar.2020.173655 · 2021 · External reference
Promising antioxidative effect of berberine in cardiovascular diseases
10.3389/fphar.2022.865353 · 2022 · External reference
Berberine attenuates cholesterol accumulation in macrophage foam cells by suppressing AP-1 activity and activation of the Nrf2/HO-1 pathway
10.1097/fjc.0000000000000769 · 2020 · External reference
Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE-/- mice
10.3389/fphar.2020.00223 · 2020 · External reference
The effective role of natural product berberine in modulating oxidative stress and inflammation related atherosclerosis: novel ınsights ınto the gut-heart axis evidenced by genetic sequencing analysis
10.3389/fphar.2021.764994 · 2021 · External reference
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis
10.1016/j.lfs.2020.118903 · 2021 · External reference
Effects of berberine on atherosclerosis
10.3389/fphar.2021.764175 · 2021 · External reference
Effect of a food supplement containing berberine, monacolin K, hydroxytyrosol and coenzyme Q10 on lipid levels: a randomized, double-blind, placebo controlled study
10.2147/dddt.s128623 · 2017 · External reference
Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway
10.1016/j.ejphar.2024.177228 · 2025 · External reference
Berberine for the treatment of hypertension: a systematic review
10.1016/j.ctcp.2020.101287 · 2021 · External reference
Berberine ameliorates vascular dysfunction by a global modulation of lncRNA and mRNA expression profiles in hypertensive mouse aortae
10.1371/journal.pone.0247621 · 2021 · External reference
Berberine reduced blood pressure and improved vasodilation in diabetic rats
10.1530/jme-17-0014 · 2017 · External reference
Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension
10.1016/j.micres.2024.127824 · 2024 · External reference
Berberine ameliorates seizure activity and cardiac dysfunction in pentylenetetrazol-kindling seizures in rats: modulation of Sigma1 receptor, Akt/eNOS signaling, and ferroptosis
10.1016/j.neuropharm.2025.110295 · 2025 · External reference
Neuroprotective properties of berberine: molecular mechanisms and clinical implications
10.3390/antiox12101883 · 2023 · External reference
Coptidis rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
10.1080/13880209.2019.1577466 · 2019 · External reference
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway
10.3892/ijmm.2024.5373 · 2024 · External reference
Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease
10.3389/fendo.2023.1217165 · 2023 · External reference
Protective effects of lactobacillus rhamnosus peptides against DSS-induced inflammatory and oxidative damages in human colonic epithelial cells through NF-κB/Nrf2/HO-1 signaling pathway
10.1007/s10989-022-10425-x · 2022 · External reference
Lactobacillus paracasei Jlus66 relieves DSS-induced ulcerative colitis in a murine model by maintaining intestinal barrier integrity, inhibiting inflammation, and improving intestinal microbiota structure
10.1007/s00394-024-03419-6 · 2024 · External reference
Therapeutic mechanisms of berberine to improve the intestinal barrier function via modulating gut microbiota, TLR4/NF-κ B/MTORC pathway and autophagy in cats
10.3389/fmicb.2022.961885 · 2022 · External reference
Berberine suppresses colonic inflammation in dextran sulfate sodium-induced murine colitis through inhibition of cytosolic phospholipase A2 activity
10.3389/fphar.2020.576496 · 2020 · External reference
Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine
10.1016/j.jpha.2021.10.003 · 2022 · External reference
Berberine pharmacology and the gut microbiota: a hidden therapeutic link
10.1016/j.phrs.2020.104722 · 2020 · External reference
Inhibition of berberine hydrochloride on Candida albicans biofilm formation
10.1007/s10529-020-02938-6 · 2020 · External reference
Berberine damages the cell surface of methicillin-resistant Staphylococcus aureus
10.3389/fmicb.2020.00621 · 2020 · External reference
Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats
10.1007/s00253-019-10307-1 · 2020 · External reference
A holistic view of berberine inhibiting intestinal carcinogenesis in conventional mice based on microbiome-metabolomics analysis
10.3389/fimmu.2020.588079 · 2020 · External reference
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis
10.1016/j.intimp.2020.106270 · 2020 · External reference
Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice
10.1016/j.biopha.2019.109131 · 2019 · External reference
Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation
10.1038/s41401-020-00601-4 · 2021 · External reference
Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome
10.3389/fnut.2024.1494348 · 2024 · External reference
Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-E. P2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis
10.1016/j.bbrc.2023.149411 · 2024 · External reference
Colon-targeted self-assembled nanoparticles loaded with berberine double salt ameliorate ulcerative colitis by improving intestinal mucosal barrier and gut microbiota
10.1016/j.colsurfb.2024.114353 · 2025 · External reference
Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis
10.1038/s41419-018-0890-5 · 2018 · External reference
Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway
10.1016/j.bbrc.2018.03.003 · 2018 · External reference
Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E-NTPDase in acute hyperlipidemia
10.1002/ddr.22166 · 2024 · External reference
Berberine protects against diabetic kidney disease via promoting PGC-1α-regulated mitochondrial energy homeostasis
10.1111/bph.14935 · 2020 · External reference
Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt
10.1007/s11010-019-03529-4 · 2019 · External reference
Berberine inhibits MDA-MB-231 cells by attenuating their inflammatory responses
10.1155/2020/3617514 · 2020 · External reference
Berberine reverses hypoxia-induced chemoresistance in breast cancer through the inhibition of AMPK-HIF-1α
10.7150/ijbs.18969 · 2017 · External reference
Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study
10.1016/j.pharep.2018.07.005 · 2019 · External reference
Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs
10.1111/jcmm.14560 · 2019 · External reference
Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer
10.1111/cpr.12393 · 2017 · External reference
Berberine inhibits the apoptosis-induced metastasis by suppressing the iPLA2/LOX-5/LTB4 pathway in hepatocellular carcinoma
10.2147/ott.s243357 · 2020 · External reference
Regulation of Akt/FoxO3a/Skp2 axis is critically involved in berberine-induced cell cycle arrest in hepatocellular carcinoma cells
10.3390/ijms19020327 · 2018 · External reference
Janus nanocarrier-based co-delivery of doxorubicin and berberine weakens chemotherapy-exacerbated hepatocellular carcinoma recurrence
10.1016/j.actbio.2019.09.034 · 2019 · External reference
Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells
10.1038/onc.2017.296 · 2017 · External reference
Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth
10.1038/labinvest.2017.71 · 2017 · External reference
10.1371/journal.pone.0306783 · 2024 · Admitted local publication
Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease
10.1186/s12902-017-0165-7 · 2017 · External reference
Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats via activation of SIRT3/AMPK/ACC pathway
10.1007/s11596-019-1997-3 · 2019 · External reference
Effects of berberine on growth, liver histology, and expression of lipid-related genes in blunt snout bream (Megalobrama amblycephala) fed high-fat diets
10.1007/s10695-018-0536-7 · 2019 · External reference
Amelioration of intestinal barrier dysfunction by berberine in the treatment of nonalcoholic fatty liver disease in rats
10.4103/pm.pm_584_16 · 2017 · External reference
Berberine improves diabetic encephalopathy through the SIRT1/ER stress pathway in db/db mice
10.1089/rej.2017.1972 · 2018 · External reference
Berberine ameliorates glucose metabolism in diabetic rats through the alpha7 nicotinic acetylcholine receptor-related cholinergic anti-inflammatory pathway
10.1055/a-1385-8015 · 2022 · External reference
Comparative effects of Gymnema sylvestre and berberine on adipokines, body composition, and metabolic parameters in obese patients: a randomized study
10.3390/nu16142284 · 2024 · External reference
Methylglyoxal and insulin resistance in berberine-treated type 2 diabetic patients
10.4103/jrms.jrms_1078_17 · 2018 · External reference
The effects of active ingredients of barberry root (berberine) on glycemic control and insulin resistance in type 2 diabetic patients
10.5812/jjnpp.64180 · 2018 · External reference
Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes
10.14814/phy2.16146 · 2024 · External reference
Berberine influences multiple diseases by modifying gut microbiota
10.3389/fnut.2023.1187718 · 2023 · External reference
Toxicological effects of berberine and sanguinarine
10.3389/fmolb.2018.00021 · 2018 · External reference
Cardiovascular effects of berberine: a review of the literature
10.14200/jrm.2017.6.0100 · 2017 · External reference
Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method
10.1186/s40360-021-00541-7 · 2022 · External reference
Estimation of heavy metals in different Berberis species and its market samples
10.1007/s10661-006-7395-x · 2006 · External reference
