References

Elevated LDL triglycerides and atherosclerotic risk

10.1016/j.jacc.2022.10.019 · 2023 · External reference

Effects of low-energy diet or exercise on cardiovascular function in working-age adults with type 2 diabetes: a prospective, randomized, open-label, blinded end point trial

10.2337/dc20-0129 · 2020 · External reference

Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK biobank study

10.1093/eurheartj/ehad337 · 2023 · External reference

High-density lipoprotein subclasses, coronary artery disease, and cardiovascular mortality

10.1373/clinchem.2017.275636 · 2017 · External reference

High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease—could extracellular vesicles be at play?

10.1042/cs20200892 · 2020 · External reference

Mediterranean diet improves high-density lipoprotein function in high-cardiovascular-risk individuals: a randomized controlled trial

10.1161/circulationaha.116.023712 · 2017 · External reference

Blood pressure variability and cardiovascular disease: systematic review and meta-analysis

10.1136/bmj.i4098 · 2016 · External reference

Threshold and target for blood pressure lowering in the elderly

10.1007/s11883-016-0627-9 · 2016 · External reference

Triglyceride-glucose index, low-density lipoprotein levels, and cardiovascular outcomes in chronic stable cardiovascular disease: results from the ONTARGET and TRANSCEND trials

10.1093/eurjpc/zwad340 · 2024 · External reference

Global risk assessment to guide blood pressure management in cardiovascular disease prevention

10.1161/hypertensionaha.116.08249 · 2017 · External reference

Effects of different exercises combined with different dietary interventions on body composition: a systematic review and network meta-analysis

10.3390/nu16173007 · 2024 · External reference

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial

10.1038/s41591-024-02951-6 · 2024 · External reference

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

10.1073/pnas.0308291101 · 2004 · External reference

The effects of eight weeks’ very low-calorie ketogenic diet (VLCKD) on liver health in subjects affected by overweight and obesity

10.3390/nu15040825 · 2023 · External reference

Effects of an eight week very low-calorie ketogenic diet (VLCKD) on white blood cell and platelet counts in relation to metabolic dysfunction-associated steatotic liver disease (MASLD) in subjects with overweight and obesity

10.3390/nu15204468 · 2023 · External reference

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

10.1152/ajpendo.00102.2007 · 2007 · External reference

Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals

10.1016/j.atherosclerosis.2008.05.036 · 2009 · External reference

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women

10.1210/jc.2010-1971 · 2011 · External reference

Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: a pilot randomized controlled trial

10.1016/j.metabol.2019.01.002 · 2019 · External reference

Clinical review: regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity

10.1210/jc.2011-2525 · 2012 · External reference

Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise

10.3390/nu10111814 · 2018 · External reference

Exercise and weight loss effects on cardiovascular risk factors in overweight men

10.1152/japplphysiol.01092.2017 · 2018 · External reference

Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids

10.1161/hypertensionaha.109.149153 · 2010 · External reference

Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial

10.3945/ajcn.116.131391 · 2016 · External reference

Diet and exercise in the management of obstructive sleep apnoea and cardiovascular disease risk

10.1183/16000617.0110-2016 · 2017 · External reference

A comparison of the impact of exercise training with dietary intervention versus dietary intervention alone on insulin resistance and glucose regulation in individual with overweight or obesity: a systemic review and meta-analysis

10.1080/10408398.2022.2064424 · 2023 · External reference

Exercise training, dietary intervention, or combined interventions and their effects on lipid profiles in adults with overweight and obesity: a systematic review and meta-analysis of randomized clinical trials

10.1016/j.numecd.2023.05.024 · 2023 · External reference

The impact of exercise and dietary interventions on circulating leptin and adiponectin in individuals who are overweight and those with obesity: a systematic review and meta-analysis

10.1016/j.advnut.2022.10.001 · 2023 · External reference

Effects of dietary and exercise intervention on weight loss and body composition in obese postmenopausal women: a systematic review and meta-analysis

10.1097/gme.0000000000001085 · 2018 · External reference

Long-term effectiveness of diet-plus-exercise interventions vs. diet-only interventions for weight loss: a meta-analysis

10.1111/j.1467-789x.2008.00547.x · 2009 · External reference

The impact of exercise training versus caloric restriction on inflammation markers: a systemic review and meta-analysis

10.1080/10408398.2021.1873732 · 2022 · External reference

Sex differences in blood pressure associations with cardiovascular outcomes

10.1161/circulationaha.120.049360 · 2021 · External reference

Impact of caloric restriction and exercise on trimethylamine N-oxide metabolism in women with obesity

10.3390/nu15061455 · 2023 · External reference

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

10.1371/journal.pmed.1000097 · 2009 · External reference

Lifestyle intervention involving calorie restriction with or without aerobic exercise training improves liver fat in adults with visceral adiposity

10.1155/2014/197216 · 2014 · External reference

Concurrent aerobic and strength training with caloric restriction reduces insulin resistance in obese premenopausal women: a randomized controlled trial

10.3390/medicina59071193 · 2023 · External reference

Benefits of moderate-intensity exercise during a calorie-restricted low-fat diet

10.1177/0017896911398235 · 2012 · External reference

Caloric restriction, aerobic exercise training and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese post-menopausal women

10.1038/ijo.2010.199 · 2011 · External reference

Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women

10.1210/jc.2008-2706 · 2009 · External reference

The effects of intermittent exercise on physiological outcomes in an obese population: continuous versus interval walking

2010 · External reference

Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults

10.1016/j.metabol.2012.04.012 · 2012 · External reference

Improvement in insulin sensitivity by weight loss does not affect hyperinsulinemia-mediated reduction in total and high molecular weight adiponectin: a MONET study

10.1139/h10-106 · 2011 · External reference

A low-calorie diet raises β-aminoisobutyric acid in relation to glucose regulation and leptin independent of exercise in women with obesity

10.3389/fphys.2023.1210567 · 2023 · External reference

Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots

10.1159/000342467 · 2012 · External reference

Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults a randomized trial

10.1001/jama.2010.1505 · 2010 · External reference

Obesity in older adults: effect of degree of weight loss on cardiovascular markers and medications

10.1111/cob.12316 · 2019 · External reference

Moderate walking enhances the effects of an energy-restricted diet on fat mass loss and serum insulin in overweight and obese adults in a 12-week randomized controlled trial

10.3945/jn.117.251744 · 2017 · External reference

Six-month calorie restriction in overweight individuals elicits transcriptomic response in subcutaneous adipose tissue that is distinct from effects of energy deficit

10.1093/gerona/glv194 · 2016 · External reference

A randomized clinical trial of home-based exercise combined with a slight caloric restriction on obesity prevention among women

10.1016/j.ypmed.2010.07.012 · 2010 · External reference

Fitness, strength and body composition during weight loss in women with clinically severe obesity: a randomised clinical trial

10.1159/000506643 · 2020 · External reference

Effects of dietary restriction combined with different exercise programs or physical activity recommendations on blood lipids in overweight adults

10.3305/nh.2012.27.6.6057 · 2012 · External reference

Effects of diet with or without exercise on leptin and anticoagulation proteins levels in obesity

10.1097/01.mbc.0000278929.87251.5d · 2007 · External reference

Effects of caloric restriction on cardiorespiratory fitness, fatigue, and disability responses to aerobic exercise in older adults with obesity: a randomized controlled trial

10.1093/gerona/gly159 · 2019 · External reference

Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial

10.3945/ajcn.2008.26938 · 2009 · External reference

Resistance exercise and aerobic exercise when paired with dietary energy restriction both reduce the clinical components of metabolic syndrome in previously physically inactive males

10.1007/s00421-011-2174-y · 2012 · External reference

The effects of lifestyle interventions in dynapenic-obese postmenopausal women

10.1097/gme.0b013e318248f50f · 2012 · External reference

The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women

10.14814/phy2.13026 · 2016 · External reference

Prediction of high-altitude cardiorespiratory fitness impairment using a combination of physiological parameters during exercise at sea level and genetic information in an integrated risk model

10.3389/fcvm.2021.719776 · 2021 · External reference

Physical activity and low glycemic index mediterranean diet: main and modification effects on NAFLD score. Results from a randomized clinical trial

10.3390/nu13010066 · 2020 · External reference

Effect of a lifestyle intervention program with energy-restricted mediterranean diet and exercise on weight loss and cardiovascular risk factors: one-year results of the PREDIMED-plus trial

10.2337/dc18-0836 · 2019 · External reference

Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association

10.1177/2047487312460484 · 2013 · External reference

AMPK phosphorylation of raptor mediates a metabolic checkpoint

10.1016/j.molcel.2008.03.003 · 2008 · External reference

Intramuscular anabolic signaling and endocrine response following resistance exercise: implications for muscle hypertrophy

10.1007/s40279-015-0450-4 · 2016 · External reference

Strength training protects high-fat-fed ovariectomized mice against insulin resistance and hepatic steatosis

10.3390/ijms25105066 · 2024 · External reference

Lipoprotein subclass metabolism in nonalcoholic steatohepatitis

10.1194/jlr.p054387 · 2014 · External reference

Functions of AMP-activated protein kinase in adipose tissue

10.1113/jphysiol.2006.111484 · 2006 · External reference

Associations of insulin resistance, inflammation and liver synthetic function with very low density lipoprotein: the cardiovascular health study

10.1016/j.metabol.2015.10.017 · 2016 · External reference

JNK regulates muscle remodeling via myostatin/SMAD inhibition

10.1038/s41467-018-05439-3 · 2018 · External reference

Vitamin D3 supplementation does not enhance the effects of resistance training in older adults

10.1002/jcsm.12688 · 2021 · External reference

Comparison of power training vs traditional strength training on physical function in older adults

10.1001/jamanetworkopen.2022.11623 · 2022 · External reference

Pea peptide supplementation in conjunction with resistance exercise promotes gains in muscle mass and strength

10.3389/fnut.2022.878229 · 2022 · External reference

Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

10.18632/aging.103218 · 2020 · External reference

A randomized, controlled trial of resistance training added to caloric restriction plus aerobic exercise training in obese heart failure with preserved ejection fraction

10.1161/circheartfailure.122.010161 · 2023 · External reference

Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial

10.1002/jcsm.12394 · 2019 · External reference

High-frequency stimulation on skeletal muscle maintenance in female cachectic mice

10.1249/mss.0000000000001991 · 2019 · External reference

AMPKα pathway involved in hepatic triglyceride metabolism disorder in diet-induced obesity mice following escherichia coli infection

10.18632/aging.101623 · 2018 · External reference

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

10.1096/fj.201500128 · 2016 · External reference

The protective effects of salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1 α–NRF1/NRF2 pathway and mitochondrial respiratory function in rats

10.1155/2015/876825 · 2015 · External reference

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

10.1016/j.cmet.2011.01.003 · 2011 · External reference

SAK-HV triggered a short-period lipid-lowering biotherapy based on the energy model of liver proliferation via a novel pathway

10.7150/thno.18415 · 2017 · External reference

Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid–induced HepG2 cells and high-fat/high-fructose diet-fed mice

10.1016/j.jgr.2019.09.004 · 2020 · External reference

Caloric restriction and/or mild exercise: effects on serum lipids and body composition

10.1093/ajcn/33.5.1002 · 1980 · External reference

Effects of acute caloric restriction on cholesterol metabolism in man

10.1093/ajcn/30.7.1135 · 1977 · External reference

Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice

10.1016/j.molmet.2022.101603 · 2022 · External reference

Heat-killed enterococcus faecalis EF-2001 attenuate lipid accumulation in diet-induced obese (DIO) mice by activating AMPK signaling in liver

10.3390/foods11040575 · 2022 · External reference

The role of nutraceutical supplements, monacolin K and astaxanthin, and diet in blood cholesterol homeostasis in patients with myopathy

10.3390/biom12081118 · 2022 · External reference

Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis

10.4049/jimmunol.2001022 · 2021 · External reference

Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis

10.1172/jci83136 · 2016 · External reference

Altered PPARγ expression promotes myelin-induced foam cell formation in macrophages in multiple sclerosis

10.3390/ijms21239329 · 2020 · External reference

Melanocortin 1 receptor signaling regulates cholesterol transport in macrophages

10.1161/circulationaha.116.025889 · 2017 · External reference

Aspirin induces lysosomal biogenesis and attenuates amyloid plaque pathology in a mouse model of Alzheimer’s disease via PPARα

10.1523/jneurosci.0054-18.2018 · 2018 · External reference

Skeletal muscle PGC1α −1 nucleosome position and −260 nt DNA methylation determine exercise response and prevent ectopic lipid accumulation in men

10.1210/en.2017-00051 · 2017 · External reference

Treadmill exercise reduces α-synuclein spreading via PPARα

10.1016/j.celrep.2022.111058 · 2022 · External reference

Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet

10.3389/fnut.2022.971581 · 2022 · External reference

Timosaponin A3 inhibits palmitate and stearate through suppression of SREBP-1 in pancreatic cancer

10.3390/pharmaceutics14050945 · 2022 · External reference

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

10.1073/pnas.1213343109 · 2012 · External reference

Combined exercise training performed by elderly women reduces redox indexes and proinflammatory cytokines related to atherogenesis

10.1155/2019/6469213 · 2019 · External reference

Increased low-density lipoprotein cholesterol on a low-carbohydrate diet in adults with normal but not high body weight: a meta-analysis

10.1016/j.ajcnut.2024.01.009 · 2024 · External reference

Clinical heterogeneity and transitions of obesity in Mexico. A longitudinal analysis of multiple representative national surveys

10.1210/clinem/dgaf158 · 2025 · External reference

Antioxidant and antifatigue activities of polygonatum alte-lobatum hayata rhizomes in rats

10.3390/nu6115327 · 2014 · External reference

Effects of nutrient intake timing on post-exercise glycogen accumulation and its related signaling pathways in mouse skeletal muscle

10.3390/nu11112555 · 2019 · External reference

A multi-ingredient formula ameliorates exercise-induced fatigue by changing metabolic pathways and increasing antioxidant capacity in mice

10.3390/foods10123120 · 2021 · External reference

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

10.1038/s41467-021-26095-0 · 2021 · External reference

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

10.1016/j.isci.2021.103089 · 2021 · External reference

Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord

10.1016/j.celrep.2022.110423 · 2022 · External reference

Untrained young men have dysfunctional HDL compared with strength-trained men irrespective of body weight status

10.1152/japplphysiol.00359.2013 · 2013 · External reference

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension

10.1177/2047487319848199 · 2019 · External reference

HDL-mediated mechanisms of protection in cardiovascular disease

10.1093/cvr/cvu147 · 2014 · External reference

Basal very low-density lipoprotein metabolism in response to exercise: mechanisms of hypotriacylglycerolemia

10.1016/j.plipres.2009.02.003 · 2009 · External reference

An apolipoprotein B100 mimotope prevents obesity in mice

10.1042/cs20150423 · 2016 · External reference

The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls

10.1093/eurheartj/ehp221 · 2009 · External reference

Association of the serum myeloperoxidase/high-density lipoprotein particle ratio and incident cardiovascular events in a multi-ethnic population: observations from the Dallas heart study

10.1016/j.atherosclerosis.2017.06.007 · 2017 · External reference

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

10.1016/j.jshs.2015.01.010 · 2016 · External reference

Serum 8-isoprostane levels and paraoxonase 1 activity in patients with stage I multiple myeloma

10.1179/1351000215y.0000000034 · 2016 · External reference

The effect of different doses of aerobic exercise training on endothelial function in postmenopausal women with elevated blood pressure: results from the DREW study

10.1136/bjsports-2011-090025 · 2012 · External reference

Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells

10.1152/ajpheart.00438.2014 · 2015 · External reference

The inflammation, vascular repair and injury responses to exercise in fit males with and without type 1 diabetes: an observational study

10.1186/s12933-015-0235-y · 2015 · External reference

Mechanisms underlying the effects of caloric restriction on hypertension

10.1016/j.bcp.2022.115035 · 2022 · External reference

Different effects of leucine supplementation and/or exercise on systemic insulin sensitivity in mice

10.3389/fendo.2021.651303 · 2021 · External reference

Cardiorespiratory fitness and atherosclerotic cardiovascular outcomes by levels of baseline predicted cardiovascular risk: the look AHEAD study

10.1016/j.amjmed.2021.01.014 · 2021 · External reference

Exercise improves endothelial function associated with alleviated inflammation and oxidative stress of perivascular adipose tissue in type 2 diabetic mice

10.1155/2020/8830537 · 2020 · External reference

Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise

10.1016/j.redox.2020.101497 · 2020 · External reference

Dynamic resistance training improves cardiac autonomic modulation and oxidative stress parameters in chronic stroke survivors: a randomized controlled trial

10.1155/2019/5382843 · 2019 · External reference

Vascular aging detected by peripheral endothelial dysfunction is associated with ECG-derived physiological aging

10.1161/jaha.120.018656 · 2021 · External reference

Calorie restriction improves physical performance and modulates the antioxidant and inflammatory responses to acute exercise

10.3390/nu12040930 · 2020 · External reference

Acute exertion elicits a H2O2–dependent vasodilator mechanism in the microvasculature of exercise trained but not sedentary adults

10.1161/hypertensionaha.114.04540 · 2015 · External reference

Comparison of the cardiovascular benefits of resistance, aerobic, and combined exercise (CardioRACE): rationale, design, and methods

10.1016/j.ahj.2019.08.008 · 2019 · External reference

Impact of resistance training on blood pressure and other cardiovascular risk factors: a meta-analysis of randomized, controlled trials

10.1161/hypertensionaha.111.177071 · 2011 · External reference

Effects of endurance training on blood pressure, blood pressure–regulating mechanisms, and cardiovascular risk factors

10.1161/01.hyp.0000184225.05629.51 · 2005 · External reference

Exercise modalities and endothelial function: a systematic review and dose–response meta-analysis of randomized controlled trials

10.1007/s40279-014-0272-9 · 2015 · External reference

Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease

10.1053/j.gastro.2008.09.018 · 2008 · External reference

Calorie restricted high protein diets downregulate lipogenesis and lower intrahepatic triglyceride concentrations in male rats

10.3390/nu8090571 · 2016 · External reference

Effectiveness of high cardiorespiratory fitness in cardiometabolic protection in prediabetic rats

10.1186/s10020-022-00458-9 · 2022 · External reference

ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

10.1194/jlr.m063354 · 2015 · External reference

Branched-chain amino acid deprivation decreases lipid oxidation and lipogenesis in C2C12 myotubes

10.3390/metabo12040328 · 2022 · External reference

Exercise reduces liver lipids and visceral adiposity in patients with nonalcoholic steatohepatitis in a randomized controlled trial

10.1016/j.cgh.2016.07.031 · 2017 · External reference

Exercise training adds cardiometabolic benefits of a paleolithic diet in type 2 diabetes mellitus

10.1161/jaha.118.010634 · 2019 · External reference

Fitness change effects on midlife metabolic outcomes: the CARDIA study

10.1249/mss.0000000000000481 · 2015 · External reference

Bacillus subtilis spore-trained dendritic cells enhance the generation of memory T cells via ICAM1

10.3390/cells10092267 · 2021 · External reference

Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: a large-scale genetic correlation study

10.3389/fendo.2022.1011896 · 2022 · External reference

Effects of non-periodized and linear periodized combined exercise training on insulin resistance indicators in adults with obesity: a randomized controlled trial

10.1186/s40798-021-00359-x · 2021 · External reference