References

The immunomodulatory effects of honey and associated flavonoids in cancer

10.3390/nu13041269 · 2021 · External reference

Flavonoids: overview of biosynthesis, biological activity, and current extraction techniques

10.3390/plants12142732 · 2023 · External reference

Characterization and metabolic diversity of flavonoids in citrus species

10.1038/s41598-017-10970-2 · 2017 · External reference

Chemistry and biological activities of flavonoids: an overview

10.1155/2013/162750 · 2013 · External reference

Flavonoids in human health: from structure to biological activity

10.2174/157340109790218049 · 2009 · External reference

Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms

10.1016/j.biopha.2021.112442 · 2022 · External reference

Strategies used by nature to fix the red, purple and blue colours in plants: a physical chemistry approach

10.1039/d1cp03034e · 2021 · External reference

Proanthocyanidin biosynthesis–still more questions than answers?

10.1016/j.phytochem.2005.01.008 · 2005 · External reference

Flavonoids in medicine and food homology substances: structure–activity relationship, application challenges, and cutting-edge technological breakthroughs

10.3390/foods15040658 · 2026 · External reference

Anticancer potential of quercetin, epigallocatechin gallate, kaempferol, apigenin, and curcumin against several human carcinomas

10.2174/0118715303320523240910072723 · 2025 · External reference

Steroid hormone activity of flavonoids and related compounds

10.1023/a:1006422302173 · 2000 · External reference

Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro

10.1080/01635589709514498 · 1997 · External reference

Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations

10.1093/carcin/bgi370 · 2006 · External reference

Flavonoids and steroid hormone-dependent cancers

10.1016/s1570-0232(02)00213-1 · 2002 · External reference

A review of the clinical and epidemiologic evidence relevant to the ımpact of postdiagnosis ısoflavone ıntake on breast cancer outcomes

10.1007/s13668-025-00640-5 · 2025 · External reference

Soy food ıntake and breast cancer survival

10.1001/jama.2009.1783 · 2009 · External reference

Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies

10.7314/apjcp.2013.14.4.2407 · 2013 · External reference

Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women123

10.3945/ajcn.112.035972 · 2012 · External reference

Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer—Considerations concerning related efficacy and safety

10.1016/j.jsbmb.2012.12.010 · 2014 · External reference

Determination of the isoflavone composition and estrogenic activity of commercial dietary supplements based on soy or red clover

10.1039/c5fo00308c · 2015 · External reference

Isoflavonhaltige Nahrungsergänzungsmittel

10.1007/s00103-016-2497-2 · 2017 · External reference

Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels

10.1016/j.fct.2007.07.002 · 2008 · External reference

The mechanisms behind the biological activity of flavonoids

10.2174/0929867325666180706104829 · 2019 · External reference

High diversity of dietary flavonoid intake is associated with a lower risk of all-cause mortality and major chronic diseases

10.1038/s43016-025-01176-1 · 2025 · External reference

Quercetin, a natural flavonoid ınteracts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis

10.1038/srep24049 · 2016 · External reference

Associations between habitual flavonoid intake and hospital admissions for atherosclerotic cardiovascular disease: a prospective cohort study

10.1016/s2542-5196(19)30212-8 · 2019 · External reference

A review of biologically active flavonoids as inducers of autophagy and apoptosis in neoplastic cells and as cytoprotective agents in non-neoplastic cells

10.1002/cbin.11813 · 2022 · External reference

Advances in the biotechnological glycosylation of valuable flavonoids

10.1016/j.biotechadv.2014.04.006 · 2014 · External reference

Flavonoids and colorectal cancer prevention

10.3390/antiox7120187 · 2018 · External reference

Flavonoids in cancer and apoptosis

10.3390/cancers11010028 · 2018 · External reference

Flavonoids overcome drug resistance to cancer chemotherapy by epigenetically modulating multiple mechanisms

10.2174/1568009621666210203111220 · 2021 · External reference

Reversal of multidrug resistance in cancer by multi-functional flavonoids

10.3389/fonc.2019.00487 · 2019 · External reference

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

10.1186/s11658-021-00301-9 · 2022 · External reference

Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review

10.1080/13813455.2020.1773864 · 2022 · External reference

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

10.1017/s0954422419000192 · 2020 · External reference

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids1

10.3945/ajcn.116.136051 · 2017 · External reference

Adverse effects of concentrated green tea extracts

10.1002/mnfr.201000644 · 2011 · External reference

The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms

10.2174/138920006778520570 · 2006 · External reference

Flavonoid–drug interactions: effects of flavonoids on ABC transporters

10.1016/j.lfs.2005.12.003 · 2006 · External reference

Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for cancer management?

10.3390/antiox9100973 · 2020 · External reference

Flavonoids as anticancer agents

10.3390/nu12020457 · 2020 · External reference

Targeting ferroptosis with flavonoids for cancer therapy: mechanisms and opportunities

10.1016/j.bbcan.2025.189528 · 2026 · External reference

The multifaceted role of flavonoids in cancer therapy: leveraging autophagy with a double-edged sword

10.3390/antiox10071138 · 2021 · External reference

Immunomodulatory effects of flavonoids in colitis-associated colorectal cancer

10.3390/ijms27041883 · 2026 · External reference

Systematic review on effectiveness of flavonoids against breast cancer: insights from in-vitro, in-vivo studies and molecular pathway studies

10.1080/03639045.2026.2659917 · 2026 · External reference

Integrative analysis reveals luteolin’s molecular targets and mechanisms in pancreatic cancer treatment

10.1186/s40001-026-04056-x · 2026 · External reference

Understanding metabolic conversions and molecular actions of flavonoids in vivo: toward new strategies for effective utilization of natural polyphenols in human health

10.2152/jmi.65.162 · 2018 · External reference

The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids

10.1002/jsfa.5697 · 2012 · External reference

Flavonoid metabolism: the interaction of metabolites and gut microbiota

10.1080/09168451.2018.1444467 · 2018 · External reference

Honey polyphenols: regulators of human microbiota and health

10.1039/d2fo02715a · 2023 · External reference

Natural products in cancer prevention and therapy: current challenges and future directions

10.1002/mco2.70585 · 2026 · External reference

Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis1,2

10.1093/jn/135.3.525 · 2005 · External reference

United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts

10.1016/j.toxrep.2020.02.008 · 2020 · External reference

The safety of green tea and green tea extract consumption in adults – Results of a systematic review

10.1016/j.yrtph.2018.03.019 · 2018 · External reference

Flavonoids and the gastrointestinal tract: local and systemic effects

10.1016/j.mam.2018.01.001 · 2018 · External reference

Polyphenolic compounds: interactions with the gut and implications for human health

10.2174/0929867013372256 · 2001 · External reference

Flavonoids and intestinal cancers

10.1017/s0007114508965764 · 2008 · External reference

Nrf2 in cancers: a double-edged sword

10.1002/cam4.2101 · 2019 · External reference

Dual roles of Nrf2 in cancer

10.1016/j.phrs.2008.09.003 · 2008 · External reference

Potential applications of NRF2 modulators in cancer therapy

10.3390/antiox9030193 · 2020 · External reference

The effects of dietary supplements that overactivate the Nrf2/ARE system

10.2174/0929867326666190517113533 · 2020 · External reference

An updated review of functional ingredients of Manuka honey and their value-added innovations

10.1016/j.foodchem.2023.138060 · 2024 · External reference

Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: a systematic review of human studies

10.1016/j.redox.2024.103095 · 2024 · External reference

Metabolism of dietary soy isoflavones to equol by human intestinal microflora–implications for health

10.1002/mnfr.200600262 · 2007 · External reference

Is equol the key to the efficacy of soy foods?

10.3945/ajcn.2009.26736t · 2009 · External reference

Equol production changes over time in pre-menopausal women

10.1017/s0007114511004223 · 2012 · External reference

The biphasic effect of flavonoids on oxidative stress and cell proliferation in breast cancer cells

10.3390/antiox11040622 · 2022 · External reference

Effects of dietary antioxidants on human DNA ex vivo

10.1080/10715760210161 · 2002 · External reference

Influence of flavonoids in ROS production and oxidative DNA damage in Caenorhabditis elegans submitted to thermal stress

10.1055/s-0034-1395000 · 2014 · External reference

Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion

10.1016/s0891-5849(98)00141-5 · 1998 · External reference

Structurally modified ‘dietary flavonoids’: are these viable drug candidates for chemoprevention?

10.2174/157488409787236065 · 2009 · External reference

Disposition of flavonoids impacts their efficacy and safety

10.2174/1389200216666150206123719 · 2014 · External reference

Flavonoid bioavailability and attempts for bioavailability enhancement

10.3390/nu5093367 · 2013 · External reference

Food matrix-flavonoid interactions and their effect on bioavailability

10.1080/10408398.2023.2232880 · 2024 · External reference

Effect of food matrix on the content and bioavailability of flavonoids

10.1016/j.tifs.2020.10.030 · 2021 · External reference

The influence of postharvest processing and storage of foodstuffs on the bioavailability of flavonoids and phenolic acids

10.1002/mnfr.200700444 · 2009 · External reference

A review on the relationship between food structure, processing, and bioavailability

10.1080/10408398.2011.619016 · 2014 · External reference

Interindividual differences in response to plant-based diets: implications for cancer risk23

10.3945/ajcn.2009.26736d · 2009 · External reference

Nano drug delivery strategies for an oral bioenhanced quercetin formulation

10.1007/s13318-023-00843-7 · 2023 · External reference

In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with ındividual-specific microbial and metabolite markers

10.1021/acs.jafc.2c00551 · 2022 · External reference

Characterization of the ınterindividual variability associated with the microbial metabolism of (−)-epicatechin

10.1021/acs.jafc.3c05491 · 2023 · External reference

Synergistic effects of flavonoids on cell proliferation in Hepa-1c1c7 and LNCaP cancer cell lines

10.1111/j.1750-3841.2006.00013.x · 2006 · External reference

Anticancer efficacy of polyphenols and their combinations

10.3390/nu8090552 · 2016 · External reference

Polyphenol-based prevention and treatment of cancer through epigenetic and combinatorial mechanisms

10.3390/nu17040616 · 2025 · External reference

Green tea and its catechins inhibit breast cancer xenografts

10.1207/s15327914nc402_11 · 2001 · External reference

Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF-7 and MDA-MB-231 breast carcinoma cells

10.3892/or.2018.6789 · 2019 · External reference

Signal transduction pathways: targets for green and black tea polyphenols

10.5483/bmbrep.2003.36.1.066 · 2003 · External reference

Tea flavonoids: bioavailability ın vivo and effects on cell signaling pathways ın vitro

10.1089/152308601317203549 · 2001 · External reference

Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response

10.1002/jps.21851 · 2010 · External reference

Flavonoids as modulators of metabolic enzymes and drug transporters

10.1111/nyas.13384 · 2017 · External reference

Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways

10.1039/c2ra01369j · 2012 · External reference

Green tea catechins as perpetrators of drug pharmacokinetic interactions

10.1002/cpt.3547 · 2025 · External reference

Pharmacokinetics and metabolism of dietary flavonoids in humans

10.1080/10715760410001727858 · 2004 · External reference

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration

10.1002/mnfr.201100554 · 2012 · External reference

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals

2003 · External reference

Pharmacodynamics and safety in relation to dose and response of plant flavonoids in treatment of cancers

10.1007/s10787-024-01581-1 · 2025 · External reference